LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 10 of total 19

Search options

  1. Article: Evaluation of clinical status, diagnosis, treatment and radiological findings of pulmonary hydatid cyst: 5-years' experience at tertiary lung center.

    Sheikhy, Kambiz / Rouhani, Ramin / Pejhan, Saviz / Sanei Motlagh, Alireza / Sheikhy, Ali

    Caspian journal of internal medicine

    2022  Volume 13, Issue 1, Page(s) 44–50

    Abstract: Background: Hydatidosis is one of the most critical worldwide parasitic zoonotic diseases. The lung is the second most common site of hydatidosis. This study aimed to evaluate the clinical status, diagnosis, treatment, and radiological findings of ... ...

    Abstract Background: Hydatidosis is one of the most critical worldwide parasitic zoonotic diseases. The lung is the second most common site of hydatidosis. This study aimed to evaluate the clinical status, diagnosis, treatment, and radiological findings of pulmonary hydatid cyst in patients referred to tertiary lung center.
    Methods: From April 2014 to July 2019, patients referred to Masih Daneshvari University Medical Center with the impression of alveolar hydatidosis included. Demographic data of 304 patients were collected including clinical symptoms, laboratory studies, radiological findings, location of the lung involvement, and cyst characteristics. Also, surgical procedures, medical treatments, and post-operative complications were recorded.
    Results: Pulmonary hydatidosis was confirmed for 234 patients. 55% of patients were males with the mean age of 45.1±16.6 years. The most common symptoms were cough (59.8%), dyspnea (31.1%), and hemoptysis (26%). Left lung, right lung, and bilateral involvement were reported in 40.1%, 55.1%, and 4.8% of cases, respectively. Cyst perforation (39.8%) was the most common intra-operative finding. Surgical interventions included thoracotomy, rigid bronchoscopy, cyst aspiration, and enucleation. The liver was the most concomitant organ involved due to pulmonary hydatidosis (16.6%). The most common postoperative complication was atelectasis, with the rate of 35.7%. 52.2% of patients were discharged within 10 days after surgery. No mortality was reported.
    Conclusion: Sometimes atypical findings in different imaging modalities make the hydatid cyst diagnosis challenging. Although lobe involvement more than 50% has the indication for lobectomy, we conserved lobes with about 70% involvement in our institution, and patients had no postoperative complications.
    Language English
    Publishing date 2022-02-07
    Publishing country Iran
    Document type Journal Article
    ZDB-ID 2971933-1
    ISSN 2008-6172 ; 2008-6164
    ISSN (online) 2008-6172
    ISSN 2008-6164
    DOI 10.22088/cjim.13.1.44
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  2. Article ; Online: Evaluation of clinical status, diagnosis, treatment and radiological findings of pulmonary hydatid cyst

    Kambiz Sheikhy / Ramin Rouhani / Saviz Pejhan / Alireza Sanei Motlagh / Ali Sheikhy

    Caspian Journal of Internal Medicine, Vol 13, Iss 1, Pp 44-

    5-years\' experience at tertiary lung center

    2022  Volume 50

    Abstract: Background: Hydatidosis is one of the most critical worldwide parasitic zoonotic diseases. The lung is the second most common site of hydatidosis. This study aimed to evaluate the clinical status, diagnosis, treatment, and radiological findings of ... ...

    Abstract Background: Hydatidosis is one of the most critical worldwide parasitic zoonotic diseases. The lung is the second most common site of hydatidosis. This study aimed to evaluate the clinical status, diagnosis, treatment, and radiological findings of pulmonary hydatid cyst in patients referred to tertiary lung center. Methods: From April 2014 to July 2019, patients referred to Masih Daneshvari University Medical Center with the impression of alveolar hydatidosis included. Demographic data of 304 patients were collected including clinical symptoms, laboratory studies, radiological findings, location of the lung involvement, and cyst characteristics. Also, surgical procedures, medical treatments, and post-operative complications were recorded. Results: Pulmonary hydatidosis was confirmed for 234 patients. 55% of patients were males with the mean age of 45.1±16.6 years. The most common symptoms were cough (59.8%), dyspnea (31.1%), and hemoptysis (26%). Left lung, right lung, and bilateral involvement were reported in 40.1%, 55.1%, and 4.8% of cases, respectively. Cyst perforation (39.8%) was the most common intra-operative finding. Surgical interventions included thoracotomy, rigid bronchoscopy, cyst aspiration, and enucleation. The liver was the most concomitant organ involved due to pulmonary hydatidosis (16.6%). The most common postoperative complication was atelectasis, with the rate of 35.7%. 52.2% of patients were discharged within 10 days after surgery. No mortality was reported. Conclusion: Sometimes atypical findings in different imaging modalities make the hydatid cyst diagnosis challenging. Although lobe involvement more than 50% has the indication for lobectomy, we conserved lobes with about 70% involvement in our institution, and patients had no postoperative complications.
    Keywords pulmonary hydatid cyst ; radiological findings ; treatment ; thoracic surgery ; Internal medicine ; RC31-1245
    Subject code 610
    Language English
    Publishing date 2022-01-01T00:00:00Z
    Publisher Babol University of Medical Sciences
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    More links

    Kategorien

  3. Article ; Online: Interventional pulmonary procedures and their outcomes in patients with STAT3 hyper IgE syndrome.

    Mahdaviani, Seyed Alireza / Ghadimi, Soodeh / Fallahi, Mazdak / Hashemi-Moghaddam, Seyedeh Atefeh / Chavoshzadeh, Zahra / Puel, Anne / Rezaei, Nima / Rekabi, Mahsa / Daneshmandi, Zahra / Sheikhy, Kambiz / Kakhki, Abolghasem Daneshvar / Saghebi, Seyed Reza / Pejhan, Saviz / Jamee, Mahnaz

    BMC surgery

    2023  Volume 23, Issue 1, Page(s) 289

    Abstract: Background: STAT3 hyperimmunoglobulin E syndrome (STAT3-HIES) also referred to as autosomal dominant HIES (AD-HIES) is an inborn error of immunity characterized by the classic triad of eczema, frequent opportunistic infections, and elevated serum IgE ... ...

    Abstract Background: STAT3 hyperimmunoglobulin E syndrome (STAT3-HIES) also referred to as autosomal dominant HIES (AD-HIES) is an inborn error of immunity characterized by the classic triad of eczema, frequent opportunistic infections, and elevated serum IgE levels. As a consequence of lung sequels due to repeated infections and impaired tissue healing, patients may require interventional pulmonary procedures.
    Method: Four patients with dominant-negative STAT3 mutations who had received interventional pulmonary procedures were enrolled. The demographic, clinical, and molecular characteristics were gathered through a medical record search. All reported STAT3-HIES patients in the literature requiring pulmonary procedures as part of their treatment were reviewed.
    Result: Recurrent episodes of pneumonia and lung abscess were the most prevalent symptoms. The most common non-immunological features were scoliosis, failure to thrive, and dental problems such as primary teeth retention and disseminated decays. Bronchiectasis, lung abscess, pneumatocele, and cavitary lesion were the most prevalent finding on high-resolution computed tomography at the earliest recording. All patients underwent pulmonary surgery and two of them experienced complications.
    Conclusion: Patients with STAT3-HIES have marked pulmonary infection susceptibility which may necessitate thoracic surgeries. Since surgical procedures involve a high risk of complication, surgical options are recommended to be utilized only in cases of drug resistance or emergencies.
    MeSH term(s) Humans ; Lung Abscess ; Job Syndrome/complications ; Patients ; Scoliosis ; Lung ; STAT3 Transcription Factor
    Chemical Substances STAT3 protein, human ; STAT3 Transcription Factor
    Language English
    Publishing date 2023-09-23
    Publishing country England
    Document type Journal Article
    ZDB-ID 2050442-1
    ISSN 1471-2482 ; 1471-2482
    ISSN (online) 1471-2482
    ISSN 1471-2482
    DOI 10.1186/s12893-023-02193-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  4. Article: Fatal Outcome of Ruptured Pulmonary Hydatid Cyst.

    Sheikhy, Kambiz / Abbasi Dezfuli, Azizollah / Pejhan, Saviz / Sadegh Beigee, Farahnaz

    Tanaffos

    2018  Volume 17, Issue 2, Page(s) 138–141

    Abstract: Most authors believe that the optimal treatment for pulmonary hydatid cyst is surgery. Albendazole has been used as a prophylactic measure for reducing recurrence rate but there are some controversies about this strategy. Some researchers have described ... ...

    Abstract Most authors believe that the optimal treatment for pulmonary hydatid cyst is surgery. Albendazole has been used as a prophylactic measure for reducing recurrence rate but there are some controversies about this strategy. Some researchers have described the increased risk of spontaneous rupture of cysts following albendazole treatment. In this case report, we present a case of spontaneous rupture of pulmonary hydatid cyst with fatal outcome that may be the adverse cause of albendazole.
    Language English
    Publishing date 2018-12-05
    Publishing country Iran
    Document type Case Reports
    ZDB-ID 2233372-1
    ISSN 1735-0344
    ISSN 1735-0344
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  5. Article ; Online: Expression of miRNA1, miRNA133, miRNA191, and miRNA24, as Good Biomarkers, in Non-Small Cell Lung Cancer Using Real-Time PCR Method.

    Kazempour Dizaji, Mehdi / Farzanegan, Behrooz / Bahrami, Naghmeh / Khoshnam, Zahra / Fathi, Mohammad / Dargahi, Hossein / Pejhan, Saviz / Khosravi, Adnan / Shirian, Sadegh / Narimani, Armita / Emami, Maral / Rekabi, Mahsa / Mohamadnia, Abdolreza

    Asian Pacific journal of cancer prevention : APJCP

    2022  Volume 23, Issue 5, Page(s) 1565–1570

    Abstract: Background: Lung cancer has recently shown the highest incidence among all cancers. microRNAs (miRNAs) are the molecules playing a role in regulating gene expression and contributing to many pathogenic mechanisms. Therefore, these molecules could be ... ...

    Abstract Background: Lung cancer has recently shown the highest incidence among all cancers. microRNAs (miRNAs) are the molecules playing a role in regulating gene expression and contributing to many pathogenic mechanisms. Therefore, these molecules could be used as biomarkers for the detection, anticipation, and treatment of cancer. With this in mind, we decided to investigate and compare the expression of miR-1, miR-133, miR-191, and miR-24 and also the expression differences in these four RNA molecules between lung cancer patients and the controls.
    Methods: A total of 50 patients with lung cancer participated in this study. In addition, 50 healthy blood samples were selected as the control group. Real-time PCR determined the expression levels of miRNA. The RNAs extracted from the patients' white blood cells were initially synthesized, and then cDNA was extracted. Finally, the synthesized cDNA was amplified using real-time PCR, and its expression was compared with the control group.
    Results: The result indicated a low expression level of miR-1 and miR-133, and a high expression level of miR-191 and miR-24 in the blood of patients with lung cancer compared to the healthy subjects.
    Conclusion: Our findings revealed that miR-1, miR-133, miR-191, and miR-24 are oncogenes, and their expression could result in cancer. It appears that a therapy to overexpress miR-1 and miR-133 and downexpress miR-191 and miR-24 could contribute to the treatment of lung cancer.
    MeSH term(s) Biomarkers, Tumor/genetics ; Carcinoma, Non-Small-Cell Lung/diagnosis ; Carcinoma, Non-Small-Cell Lung/genetics ; DNA, Complementary ; Humans ; Lung Neoplasms/diagnosis ; Lung Neoplasms/genetics ; MicroRNAs/genetics ; Real-Time Polymerase Chain Reaction
    Chemical Substances Biomarkers, Tumor ; DNA, Complementary ; MIRN1 microRNA, human ; MIRN133 microRNA, human ; MIRN191 microRNA, human ; MIRN24 microRNA, human ; MicroRNAs
    Language English
    Publishing date 2022-05-01
    Publishing country Thailand
    Document type Journal Article
    ZDB-ID 2218955-5
    ISSN 2476-762X ; 1513-7368
    ISSN (online) 2476-762X
    ISSN 1513-7368
    DOI 10.31557/APJCP.2022.23.5.1565
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  6. Article: A Safe Method of Tracheal Polyflex Stent Placement: A Review of 20 Patients.

    Pejhan, Saviz / Javaherzadeh, Mojtaba / Daneshvar, Abolghasem / Farzanegan, Roya

    Iranian Red Crescent medical journal

    2015  Volume 17, Issue 8, Page(s) e13798

    Abstract: Background: Surgery is an appropriate therapeutic approach for tracheal stenosis due to various benign and malignant conditions. When surgery is postponed for certain reasons, other options are chosen for airway patency. One alternative is using airway ... ...

    Abstract Background: Surgery is an appropriate therapeutic approach for tracheal stenosis due to various benign and malignant conditions. When surgery is postponed for certain reasons, other options are chosen for airway patency. One alternative is using airway stents.
    Objectives: We aimed to introduce a safe method of tracheal polyflex stent placement in patients with tracheal stenoses.
    Patients and methods: During a 7-year period (2002 - 2008), polyflex stents were used 29 times among 20 patients for various indications. After encountering many difficulties in earlier cases, we gradually developed our new method and used it in most of our patients. In this method, without using large rigid bronchoscopes, the introducer tube could be used as a bronchoscope with the aid of a zero-degree lens and ventilating apparatus. In this method, the rate of possible trauma to the airway can be minimized by avoiding the use of thick rigid bronchoscopies and the stent can be placed faster and more accurately.
    Results: Polyflex stents were used in 11 men (55%) and 9 women with a mean age of 38.5 years. Stents were removed and changed in 12 cases and replaced with another type of stent in 3 patients. Indications were recurrence of tracheal stenosis (7), multisegmental tracheal stenosis (3), anesthesia limitations (3), tracheal tumors (2), dehiscence of tracheal anastomosis (1), severe inflammation of the tracheal mucosa (1), esophagobronchial fistula (1), and external pressure on the left main bronchus (1). In one patient, a stent was used to open a kinked Dumon stent as a temporary life-saving procedure. We found 6 cases of stent migration, 3 cases of granulation tissue formation, 1 case of infection, and 1 case of surgical site dehiscence.
    Conclusions: Stents would be regarded as a temporary means of reaching the ideal condition for resection and reconstruction in most patients with tracheal stenoses. Although an optimal stent has not been introduced yet, we used polyflex stents in most of our patients with tracheal stenosis due to its availability and ease of use. We suggest that this method is safe and less time consuming than its traditional method of placement.
    Language English
    Publishing date 2015-08-29
    Publishing country Iran
    Document type Journal Article
    ZDB-ID 2415781-8
    ISSN 2074-1812 ; 1561-4395 ; 2074-1804
    ISSN (online) 2074-1812 ; 1561-4395
    ISSN 2074-1804
    DOI 10.5812/ircmj.13798
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  7. Article ; Online: Ten years' experience in surgical treatment of right middle lobe syndrome.

    Pejhan, Saviz / Salehi, Farshid / Niusha, Shanay / Farzanegan, Behrooz / Sheikhy, Kambiz

    Annals of thoracic and cardiovascular surgery : official journal of the Association of Thoracic and Cardiovascular Surgeons of Asia

    2015  Volume 21, Issue 4, Page(s) 354–358

    Abstract: Purpose: In this study we present the clinical, radiological, pathological, bronchoscopic and surgical results of 40 patients with diagnosis of middle lobe syndrome who were referred to our thoracic surgery unit for surgical intervention in a 10 years ... ...

    Abstract Purpose: In this study we present the clinical, radiological, pathological, bronchoscopic and surgical results of 40 patients with diagnosis of middle lobe syndrome who were referred to our thoracic surgery unit for surgical intervention in a 10 years period.
    Methods: Forty patients with obstructive and non-obstructive causes of middle lobe syndrome referred to our thoracic surgery unit. Clinical data were collected from the patients' records in a ten years period. This study evaluates diagnostic approaches and surgical treatments in right middle lobe syndrome.
    Results: We studied 23 females (57.5%) and 17 males (42.5%) with a mean age of 31.7. Clinical findings were cough 95%, sputum 80% and intermittent hemoptysis in 50% of patients. Middle lobe collapse was seen in CT scan of all patients. Bronchiectasis was the most common pathologic finding (55%). Tuberculosis was not rare and was final pathology in 20% of patients. In three patients ruptured hydatid cyst was final finding. Surgery was done without mortality and with only minor complications.
    Conclusion: Lobectomy of right middle lobe is a good therapeutic option in these patients. Due to high prevalence of tuberculosis and hydatid cyst in Middle Eastern countries these two must be considered as causes of middle lobe syndrome.
    MeSH term(s) Adult ; Bronchiectasis/etiology ; Cough/etiology ; Female ; Follow-Up Studies ; Hemoptysis/etiology ; Humans ; Iran ; Male ; Middle Lobe Syndrome/complications ; Middle Lobe Syndrome/diagnosis ; Middle Lobe Syndrome/surgery ; Pain/etiology ; Pneumonectomy/methods ; Retrospective Studies ; Risk Factors ; Sputum/secretion ; Treatment Outcome
    Language English
    Publishing date 2015
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 2019756-1
    ISSN 2186-1005 ; 1341-1098
    ISSN (online) 2186-1005
    ISSN 1341-1098
    DOI 10.5761/atcs.oa.14-00273
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  8. Article ; Online: Postintubation Multisegmental Tracheal Stenosis: A 24-Year Experience.

    Farzanegan, Roya / Zangi, Mahdi / Abbasidezfouli, Azizollah / Pejhan, Saviz / Sadeghbeigee, Farahnaz / Daneshvarkakhki, Abolghasem / Sheikhy, Kambiz / Saghebi, Seyed Reza / Nazemy, Sina / Jahanshahi, Nahid / Shadmehr, Mohammad Behgam

    The Annals of thoracic surgery

    2020  Volume 112, Issue 4, Page(s) 1101–1108

    Abstract: Background: Management of multisegmental tracheal stenosis is challenging. In this 24-year longitudinal single-center study, we present an algorithmic treatment approach.: Methods: A retrospective analysis of 2167 patients with postintubation ... ...

    Abstract Background: Management of multisegmental tracheal stenosis is challenging. In this 24-year longitudinal single-center study, we present an algorithmic treatment approach.
    Methods: A retrospective analysis of 2167 patients with postintubation tracheal stenosis indicated 83 (3.83%) patients with multisegmental tracheal stenosis. Patients were assigned to 4 management groups according to the length, location, and severity of stenoses; tracheal infection/mucositis; laryngeal function; symptoms; general condition; and comorbid diseases. Type 1 (n = 13): 1-stage resection of both strictures, Type 2 (n = 6): 2-stage resection of both strictures, Type 3 (n = 40): resection of 1 stricture and nonresectional management of the other, Type 4 (n = 24): nonresectional management of both strictures. Outcomes were categorized as Good, Acceptable, or Poor. Univariate analyses for factors predictive of recurrence and outcome were performed.
    Results: Follow-ups were completed in 70 (84.34%) patients (median, 22.5 months). Outcome was assessed as Good in 56 (82.35%), Acceptable in 10 (14.71%), Poor in 2 (2.94%), and mortality in 2 (2.94%) patients. The median length of airway resection was 46, 67.5, and 40 mm in Types 1-3, respectively. Only 11 (13.25%) patients had no history of tracheostomy or tracheal surgery. By univariate analysis, a shorter intubation period was associated with Good outcome (P = .017). No factors predictive of recurrence or outcome were ascertained.
    Conclusions: Multisegmental tracheal stenosis, generally caused by performing an inappropriate tracheostomy, is an iatrogenic disease that can be prevented. Although resection of both strictures may be feasible and is associated with Good results, in the majority of cases, a combination of surgical resection and non-resectional methods are sufficient to achieve Good results.
    MeSH term(s) Adolescent ; Adult ; Bronchoscopy ; Child ; Child, Preschool ; Combined Modality Therapy ; Female ; Humans ; Iatrogenic Disease ; Intubation, Intratracheal/adverse effects ; Male ; Middle Aged ; Postoperative Complications ; Retrospective Studies ; Stents ; Trachea/surgery ; Tracheal Stenosis/diagnosis ; Tracheal Stenosis/etiology ; Tracheal Stenosis/surgery ; Tracheal Stenosis/therapy ; Tracheostomy/adverse effects
    Language English
    Publishing date 2020-11-21
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 211007-6
    ISSN 1552-6259 ; 0003-4975
    ISSN (online) 1552-6259
    ISSN 0003-4975
    DOI 10.1016/j.athoracsur.2020.10.026
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  9. Article ; Online: Surgically treatable pulmonary arteriovenous fistula.

    Pejhan, Saviz / Rahmanijoo, Nasrin / Farzanegan, Roya / Rahimi, Mostafa

    Annals of thoracic and cardiovascular surgery : official journal of the Association of Thoracic and Cardiovascular Surgeons of Asia

    2011  Volume 18, Issue 1, Page(s) 36–38

    Abstract: Arteriovenous fistuli are congenital malformations. Usually symptoms depend on size of the lesion. Lesions smaller than 2 cm are often asymptomatic. The most common symptoms are dyspnea, palpitation and fatigue. Cyanosis is indicative of right to left ... ...

    Abstract Arteriovenous fistuli are congenital malformations. Usually symptoms depend on size of the lesion. Lesions smaller than 2 cm are often asymptomatic. The most common symptoms are dyspnea, palpitation and fatigue. Cyanosis is indicative of right to left shunt. Helical computed tomography (CT) scan is a helpful diagnostic tool in this case. Surgery is the treatment of choice in patients with isolated lesions. Embolization is a selective method in patients with multiple or bilateral lesions. The patient was a 13-year-old boy complaining of cyanosis of lips and nails as well as dyspnea for 5 years. Definite diagnosis of pulmonary arteriovenous malformation (PAVM) in the right middle lobe was based on CT angiography. The patient underwent a thoracotomy and lobectomy of the right middle lobe. After surgery cyanosis and dyspnea were completely resolved.
    MeSH term(s) Adolescent ; Angiography ; Arteriovenous Malformations/diagnostic imaging ; Arteriovenous Malformations/surgery ; Diagnosis, Differential ; Humans ; Male ; Pneumonectomy ; Pulmonary Artery/abnormalities ; Pulmonary Artery/diagnostic imaging ; Pulmonary Veins/abnormalities ; Pulmonary Veins/diagnostic imaging ; Thoracotomy ; Tomography, X-Ray Computed
    Language English
    Publishing date 2011-09-29
    Publishing country Japan
    Document type Case Reports ; Journal Article
    ZDB-ID 2019756-1
    ISSN 2186-1005 ; 1341-1098
    ISSN (online) 2186-1005
    ISSN 1341-1098
    DOI 10.5761/atcs.cr.11.01661
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  10. Article ; Online: The Role of Systemic Steroids in Postintubation Tracheal Stenosis: A Randomized Clinical Trial.

    Shadmehr, Mohammad Behgam / Abbasidezfouli, Azizollah / Farzanegan, Roya / Pejhan, Saviz / Daneshvar Kakhaki, Abolghasem / Sheikhy, Kambiz / Saghebi, Seyed Reza / Sadeghbeigee, Farahnaz / Gharedaghi, Abasad / Jahanshahi, Nahid / Zangi, Mahdi

    The Annals of thoracic surgery

    2017  Volume 103, Issue 1, Page(s) 246–253

    Abstract: Background: Most patients with postintubation tracheal stenosis are not ideal candidates for airway resection at presentation and their airways must be temporarily kept open by repeated bronchoscopic dilation (RBD). Meanwhile, some sufficiently recover ... ...

    Abstract Background: Most patients with postintubation tracheal stenosis are not ideal candidates for airway resection at presentation and their airways must be temporarily kept open by repeated bronchoscopic dilation (RBD). Meanwhile, some sufficiently recover by RBD without further airway resection requirement. We hypothesized whether systemic corticosteroids could lengthen RBD intervals, decrease the number of patients who eventually need airway resection, and shorten the required length of airway resection.
    Methods: Between February 2009 and November 2012, a randomized double-blind clinical trial with a 1:1 ratio (corticosteroids group [group C], prednisolone 15 mg/day; placebo group [group P]) was conducted on 120 patients without tracheostomy or T tube and in no ideal situation for airway resection at presentation, whose precipitating injury had occurred recently. All underwent RBD until they became asymptomatic or prepared for airway resection. Asymptomatic patients received the capsules (prednisolone or placebo) for 6 months; others discontinued them before surgery. Those requiring RBD at short intervals underwent tracheostomy or T tube placement and were then excluded. Follow-up terminated 6 months after airway resection or capsule discontinuation.
    Results: There were 105 patients (72 male; 50 in group C), aged 15 to 64 years, who completed their follow-up. There was no significant difference between the two groups in age, sex, history of tracheostomy, intubation cause and duration, time interval between intubation and initial bronchoscopy, length of stenosis, and subglottic involvement. Our study showed a trend for RBD with longer intervals (22 days), and fewer operations, 17% (28 of 50 versus 40 of 55) in group C, although statistically insignificant. Furthermore, the required airway resection length became significantly shorter (5.3 mm) in group C.
    Conclusions: Early low-dose systemic corticosteroids can be beneficial in postintubation tracheal stenosis management.
    MeSH term(s) Adolescent ; Adult ; Bronchoscopy ; Dose-Response Relationship, Drug ; Double-Blind Method ; Female ; Follow-Up Studies ; Glucocorticoids/administration & dosage ; Humans ; Intubation, Intratracheal/adverse effects ; Male ; Middle Aged ; Prednisolone/administration & dosage ; Retrospective Studies ; Time Factors ; Tracheal Stenosis/diagnosis ; Tracheal Stenosis/drug therapy ; Tracheal Stenosis/etiology ; Treatment Outcome ; Young Adult
    Chemical Substances Glucocorticoids ; Prednisolone (9PHQ9Y1OLM)
    Language English
    Publishing date 2017-01
    Publishing country Netherlands
    Document type Journal Article ; Randomized Controlled Trial
    ZDB-ID 211007-6
    ISSN 1552-6259 ; 0003-4975
    ISSN (online) 1552-6259
    ISSN 0003-4975
    DOI 10.1016/j.athoracsur.2016.05.063
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

To top