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Article ; Online: Longitudinal In Vivo Changes in Retinal Ganglion Cell Dendritic Morphology After Acute and Chronic Optic Nerve Injury.

Henderson, Delaney C M / Vianna, Jayme R / Gobran, John / Di Pierdomenico, Johnny / Hooper, Michele L / Farrell, Spring R M / Chauhan, Balwantray C

Investigative ophthalmology & visual science

2021 Volume 62, Issue 9, Page(s) 5

Abstract: Purpose: To characterize in vivo dendritic changes in retinal ganglion cells (RGCs) after acute (optic nerve transection, ONT) and chronic (experimental glaucoma, EG) optic nerve injury.: Methods: ONT and EG (microbead model) were carried out in Thy1- ...

Abstract	Purpose: To characterize in vivo dendritic changes in retinal ganglion cells (RGCs) after acute (optic nerve transection, ONT) and chronic (experimental glaucoma, EG) optic nerve injury. Methods: ONT and EG (microbead model) were carried out in Thy1-YFP mice in which the entire RGC dendritic arbor was imaged with confocal fluorescence scanning laser ophthalmoscopy over two weeks in the ONT group and over two and six months, respectively, in two (groups 1 and 2) EG groups. Sholl analysis was used to quantify dendritic structure with the parameters: area under the curve (AUC), radius of the dendritic field, peak number of intersections (PI), and distance to the PI (PD). Results: Dendritic changes were observed after three days post-ONT with significant decreases in all parameters at two weeks. In group 1 EG mice, mean (SD) intraocular pressure (IOP) was 15.2 (1.1) and 9.8 (0.3) mmHg in the EG and untreated contralateral eyes, respectively, with a significant corresponding decrease in AUC, PI, and PD, but not radius. In group 2 mice, the respective IOP was 13.1 (1.0) and 8.8 (0.1) mmHg, peaking at two months before trending towards baseline. Over the first two months, AUC, PI, and PD decreased significantly, with no further subsequent changes. The rates of change of the parameters after ONT was 5 to 10 times faster than in EG. Conclusions: Rapid dendritic changes occurred after ONT, while changes in EG were slower and associated with level of IOP increase. The earliest alterations were loss of inner neurites without change in dendritic field.
MeSH term(s)	Acute Disease ; Animals ; Chronic Disease ; Dendritic Cells/pathology ; Disease Models, Animal ; Disease Progression ; Glaucoma/complications ; Glaucoma/diagnosis ; Glaucoma/physiopathology ; Intraocular Pressure/physiology ; Mice ; Microscopy, Confocal ; Optic Nerve Injuries/diagnosis ; Optic Nerve Injuries/etiology ; Retinal Ganglion Cells/pathology
Language	English
Publishing date	2021-11-22
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	391794-0
ISSN	1552-5783 ; 0146-0404
ISSN (online)	1552-5783
ISSN	0146-0404
DOI	10.1167/iovs.62.9.5
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Article: Tending to the musculoskeletal problems of obesity.

Hooper, Michele M

Cleveland Clinic journal of medicine

2006 Volume 73, Issue 9, Page(s) 839–845

Abstract: When an overweight or obese patient complains of musculoskeletal problems such as knee or back pain, it may be an oversimplification to say that the excess weight caused the problem and that losing weight will solve it. Nevertheless, weight loss can help ...

Abstract	When an overweight or obese patient complains of musculoskeletal problems such as knee or back pain, it may be an oversimplification to say that the excess weight caused the problem and that losing weight will solve it. Nevertheless, weight loss can help and is worthwhile for cardiovascular health and other reasons.
MeSH term(s)	Carpal Tunnel Syndrome/physiopathology ; Disease Progression ; Exercise Therapy ; Gastric Bypass ; Humans ; Musculoskeletal Diseases/physiopathology ; Musculoskeletal Diseases/prevention & control ; Obesity/physiopathology ; Obesity/therapy ; Osteoarthritis, Knee/physiopathology ; Weight Loss
Language	English
Publishing date	2006-09-12
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	639116-3
ISSN	0891-1150
ISSN	0891-1150
DOI	10.3949/ccjm.73.9.839
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Article ; Online: Effects of 3D Stratification of Retinal Ganglion Cells in Sholl Analysis.

Gobran, John / Rawlyk, Brooklyn / Henderson, Delaney C / Hooper, Michele L / Farrell, Spring R M / Chauhan, Balwantray C

Journal of neuroscience methods

2020 Volume 346, Page(s) 108907

Abstract: Background: Sholl analysis is used to quantify the dendritic complexity of neurons. Differences between two-dimensional (2D) and three-dimensional (3D) Sholl analysis can exist in neurons with extensive axial stratification of dendrites, however, in ... ...

Abstract	Background: Sholl analysis is used to quantify the dendritic complexity of neurons. Differences between two-dimensional (2D) and three-dimensional (3D) Sholl analysis can exist in neurons with extensive axial stratification of dendrites, however, in retinal ganglion cells (RGCs), only 2D analysis is typically reported despite varying degrees of stratification within the retinal inner plexiform layer. We determined the impact of this stratification by comparing 2D and 3D analysis of the same RGCs. New method: Twelve retinas of mice expressing yellow fluorescent protein in RGCs under the control of the Thy1 promotor were whole-mounted. The entire dendritic arbor of 120 RGCs was traced, after which 2D and 3D Sholl analysis was performed. Two parameters describing dendritic complexity; area under the curve (AUC) and peak number of intersections (PNI) were then derived and analyzed. Results and comparison with existing methods: The AUC and PNI were significantly higher with 3D analysis compared to 2D analysis with medians of 2805 and 2508 units, and 31 and 27, respectively (P < 0.01). Both 2D and 3D AUC increased with arbor thickness. The discrepancy in AUC between the two methods depended on mean AUC (with every 1 unit increase in mean AUC resulting in a discrepancy of 0.1 unit), but not arbor thickness. Conclusion: In RGCs imaged in vitro, there is a difference in AUC and PNI derived with 2D and 3D Sholl analysis. Where possible, 3D Sholl analysis of RGCs should be performed for more accurate quantitative analysis of dendritic structure.
MeSH term(s)	Animals ; Dendrites ; Mice ; Retina ; Retinal Ganglion Cells
Language	English
Publishing date	2020-08-11
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	282721-9
ISSN	1872-678X ; 0165-0270
ISSN (online)	1872-678X
ISSN	0165-0270
DOI	10.1016/j.jneumeth.2020.108907
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Article ; Online: Age and intraocular pressure in murine experimental glaucoma.

Di Pierdomenico, Johnny / Henderson, Delaney C M / Giammaria, Sara / Smith, Victoria L / Jamet, Aliénor J / Smith, Corey A / Hooper, Michele L / Chauhan, Balwantray C

Progress in retinal and eye research

2021 Volume 88, Page(s) 101021

Abstract: Age and intraocular pressure (IOP) are the two most important risk factors for the development and progression of open-angle glaucoma. While IOP is commonly considered in models of experimental glaucoma (EG), most studies use juvenile or adult animals ... ...

Abstract	Age and intraocular pressure (IOP) are the two most important risk factors for the development and progression of open-angle glaucoma. While IOP is commonly considered in models of experimental glaucoma (EG), most studies use juvenile or adult animals and seldom older animals which are representative of the human disease. This paper provides a concise review of how retinal ganglion cell (RGC) loss, the hallmark of glaucoma, can be evaluated in EG with a special emphasis on serial in vivo imaging, a parallel approach used in clinical practice. It appraises the suitability of EG models for the purpose of in vivo imaging and argues for the use of models that provide a sustained elevation of IOP, without compromise of the ocular media. In a study with parallel cohorts of adult (3-month-old, equivalent to 20 human years) and old (2-year-old, equivalent to 70 human years) mice, we compare the effects of elevated IOP on serial ganglion cell complex thickness and individual RGC dendritic morphology changes obtained in vivo. We also evaluate how age modulates the impact of elevated IOP on RGC somal and axonal density in histological analysis as well the density of melanopsin RGCs. We discuss the challenges of using old animals and emphasize the potential of single RGC imaging for understanding the pathobiology of RGC loss and evaluating new therapeutic avenues.
MeSH term(s)	Animals ; Disease Models, Animal ; Glaucoma/pathology ; Glaucoma, Open-Angle ; Humans ; Intraocular Pressure ; Mice ; Tonometry, Ocular
Language	English
Publishing date	2021-11-18
Publishing country	England
Document type	Journal Article ; Review ; Research Support, Non-U.S. Gov't
ZDB-ID	1182683-6
ISSN	1873-1635 ; 1350-9462
ISSN (online)	1873-1635
ISSN	1350-9462
DOI	10.1016/j.preteyeres.2021.101021
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Article: Participants with restricted dominant shoulder internal rotation range of motion demonstrate no side-to-side difference in humeral head translation; and no difference before and after joint mobilization: a pilot study.

Hoops, John F / Hooper, Troy L / Sobczak, Stéphane / Kapila, Jeegisha / Dewan, Birendra M / Matthijs, Omer C / Brismée, Jean-Michel

Journal of physical therapy science

2024 Volume 36, Issue 5, Page(s) 259–266

Abstract: Purpose] To compare humeral head translation (HHT) during shoulder elevation between dominant and non-dominant shoulders in participants with limited dominant shoulder internal rotation range of motion (ROM). To determine if joint mobilization alters ... ...

Abstract	[Purpose] To compare humeral head translation (HHT) during shoulder elevation between dominant and non-dominant shoulders in participants with limited dominant shoulder internal rotation range of motion (ROM). To determine if joint mobilization alters HHT, and if relationships exist between the bicipital forearm angle and HHT. [Participants and Methods] Fifteen (9 female) participants (age 25.7 ± 6.8 years) with a minimum 15-degree dominant shoulder internal rotation ROM deficit compared to the opposite shoulder participated. All participants underwent bicipital forearm angle (BFA) measurements and ultrasound imaging to measure acromiohumeral and posterior glenohumeral distances in 3 positions: Resting, 90 degrees of shoulder flexion, and 60 degrees of shoulder abduction with full external rotation. Ultrasound images were used to calculate HHT. Participants' dominant shoulders underwent posterior glide mobilization, followed immediately by repeated ultrasound images and ROM measures. [Results] There was no dominant to non-dominant shoulder, or before and after mobilization HHT differences. No correlations existed between bicipital forearm angles and HHT or ROM gains after mobilization. [Conclusion] Participants with internal rotation ROM loss demonstrated symmetrical HHT. Joint mobilization increased ROM, but HHT was unchanged. No relationships existed between BFA and HHT.
Language	English
Publishing date	2024-05-01
Publishing country	Japan
Document type	Journal Article
ZDB-ID	2038898-6
ISSN	0915-5287
ISSN	0915-5287
DOI	10.1589/jpts.36.259
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Article ; Online: Retinal Characterization of the Thy1-GCaMP3 Transgenic Mouse Line After Optic Nerve Transection.

Blandford, Stephanie N / Hooper, Michele L / Yabana, Takeshi / Chauhan, Balwantray C / Baldridge, William H / Farrell, Spring R M

Investigative ophthalmology & visual science

2019 Volume 60, Issue 1, Page(s) 183–191

Abstract: Purpose: GCaMP3 is a genetically encoded calcium indicator for monitoring intracellular calcium dynamics. We characterized the expression pattern and functional properties of GCaMP3 in the Thy1-GCaMP3 transgenic mouse retina.: Methods: To determine ... ...

Abstract	Purpose: GCaMP3 is a genetically encoded calcium indicator for monitoring intracellular calcium dynamics. We characterized the expression pattern and functional properties of GCaMP3 in the Thy1-GCaMP3 transgenic mouse retina. Methods: To determine the specificity of GCaMP3 expression, Thy1-GCaMP3 (B6; CBA-Tg(Thy1-GCaMP3)6Gfng/J) retinas were processed for immunohistochemistry with anti-green fluorescent protein (anti-GFP, to enhance GCaMP3 fluorescence), anti-RBPMS (retinal ganglion cell [RGC]-specific marker), and antibodies against amacrine cell markers (ChAT, GABA, GAD67, syntaxin). Calcium imaging was used to characterize functional responses of GCaMP3-expressing (GCaMP+) cells by recording calcium transients evoked by superfusion of kainic acid (KA; 10, 50, or 100 μM). In a subset of animals, optic nerve transection (ONT) was performed 3, 5, or 7 days prior to calcium imaging. Results: GFP immunoreactivity colocalized with RBPMS but not amacrine cell markers in both ONT and non-ONT (control) groups. Calcium transients evoked by KA were reduced after ONT (50 μM KA; ΔF/F0 [SD]; control: 1.00 [0.67], day 3: 0.50 [0.35], day 5: 0.31 [0.28], day 7: 0.35 [0.36]; P < 0.05 versus control). There was also a decrease in the number of GCaMP3+ cells after ONT (cells/mm2 [SD]; control: 2198 [453], day 3: 2224 [643], day 5: 1383 [375], day 7: 913 [178]; P < 0.05). Furthermore, the proportion of GCaMP3+ cells that responded to KA decreased after ONT (50 μM KA, 97%, 54%, 47%, and 58%; control, 3, 5, and 7 days, respectively). Conclusions: Following ONT, functional RGC responses are lost prior to the loss of RGC somata, suggesting that anatomical markers of RGCs may underestimate the extent of RGC dysfunction.
MeSH term(s)	Amacrine Cells/metabolism ; Animals ; Biomarkers/metabolism ; Calcium/metabolism ; Cyclic GMP/metabolism ; Excitatory Amino Acid Agonists/pharmacology ; Gene Expression Regulation/physiology ; Green Fluorescent Proteins/metabolism ; Immunohistochemistry ; Kainic Acid/pharmacology ; Mice ; Mice, Inbred C57BL ; Mice, Inbred CBA ; Mice, Transgenic ; Microscopy, Fluorescence ; Optic Nerve Injuries ; Retinal Ganglion Cells/drug effects ; Retinal Ganglion Cells/metabolism ; Thy-1 Antigens/genetics ; Thy-1 Antigens/metabolism
Chemical Substances	Biomarkers ; Excitatory Amino Acid Agonists ; Thy-1 Antigens ; Green Fluorescent Proteins (147336-22-9) ; Cyclic GMP (H2D2X058MU) ; Kainic Acid (SIV03811UC) ; Calcium (SY7Q814VUP)
Language	English
Publishing date	2019-01-11
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	391794-0
ISSN	1552-5783 ; 0146-0404
ISSN (online)	1552-5783
ISSN	0146-0404
DOI	10.1167/iovs.18-25861
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Article ; Online: Real-World Evidence of Axicabtagene Ciloleucel for the Treatment of Large B Cell Lymphoma in the United States.

Transplantation and cellular therapy

2022 Volume 28, Issue 9, Page(s) 581.e1–581.e8

Abstract: Axicabtagene ciloleucel (axi-cel) is a standard-of-care for patients with relapsed or refractory (r/r) large B cell lymphoma who have received 2 or more lines of prior therapy. Patients receiving axi-cel in the real world could have broader a demographic, ...

Abstract	Axicabtagene ciloleucel (axi-cel) is a standard-of-care for patients with relapsed or refractory (r/r) large B cell lymphoma who have received 2 or more lines of prior therapy. Patients receiving axi-cel in the real world could have broader a demographic, disease, and treatment profile compared with that of the cohort in the pivotal ZUMA-1 trial. The present study was conducted to evaluate the outcomes of axi-cel therapy in the real-world setting. A total of 1297 patients receiving commercial axi-cel between 2017 and 2020 were selected from the Center for International Blood and Marrow Transplant Research's data registry, of whom 739 (57%) would have been ineligible for inclusion in the ZUMA-1 cohort. Efficacy and safety outcomes were described for the entire cohort and by ZUMA-1 eligibility. Their associations with age, Eastern Cooperative Oncology Group Performance Score, and comorbidities were evaluated using multivariable logistic and Cox regressions. At a median follow-up of 12.9 months, the overall response rate (ORR) was 73%, with a 56% complete response (CR) rate. Median overall survival (OS) and progression-free survival (PFS) were 21.8 months (95% confidence interval [CI], 17.4 to 28.8 months) and 8.6 months (95% CI, 6.5 to 12.1 months), respectively. Duration of response (DOR) was comparable in the ZUMA-1 ineligible patients and ZUMA-1 eligible patients (62% by 1 year [95% CI, 57% to 66%] versus 67% [95% CI, 62% to 72%]). Patients age ≥65 years had favorable ORR (odds ratio [OR], 1.39; 95% CI, 1.05 to 1.83) despite having a higher risk of cytokine release syndrome (CRS) (OR, 1.41; 95% CI, 1.02 to 1.94) and immune effector cell-associated neurotoxicity syndrome (ICANS) (OR, 1.77; 95% CI, 1.39-2.26). Eastern Cooperative Oncology Group Performance Score ≥2 was associated with inferior efficacy outcomes (OR for ORR, 0.32; 95% CI, 0.18-0.56; hazard ratio [HR] for OS, 3.27; 95% CI, 2.37 to 4.52) and higher incidence of ICANS (OR, 2.63; 95% CI, 1.40 to 4.93). The patients ineligible for ZUMA-1 still had a durable response with axi-cel. Elderly patients had favorable efficacy outcomes despite higher rates of CRS and ICANS. Patient selection for standard-of-care axi-cel should consider comorbidities and risk-to-benefit ratio rather than be based strictly on ZUMA-1 eligibility.
MeSH term(s)	Aged ; Antigens, CD19 ; Biological Products ; Cytokine Release Syndrome ; Humans ; Immunotherapy, Adoptive ; Lymphoma, Large B-Cell, Diffuse ; United States
Chemical Substances	Antigens, CD19 ; Biological Products ; axicabtagene ciloleucel (U2I8T43Y7R)
Language	English
Publishing date	2022-05-21
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	3062231-1
ISSN	2666-6367
ISSN (online)	2666-6367
DOI	10.1016/j.jtct.2022.05.026
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Article ; Online: Modulation of Cervical Facet Joint Nociception and Pain Attenuates Physical and Psychological Features of Chronic Whiplash: A Prospective Study.

Smith, Ashley Dean / Jull, Gwendolen / Schneider, Geoff M / Frizzell, Bevan / Hooper, Robert A / Sterling, Michele

PM & R : the journal of injury, function, and rehabilitation

2015 Volume 7, Issue 9, Page(s) 913–921

Abstract: Objective: To investigate changes in clinical (physical and psychological) features of individuals with chronic whiplash-associated disorder who had previously undergone cervical radiofrequency neurotomy at the time point when the effects of ... ...

Abstract	Objective: To investigate changes in clinical (physical and psychological) features of individuals with chronic whiplash-associated disorder who had previously undergone cervical radiofrequency neurotomy at the time point when the effects of radiofrequency neurotomy had dissipated and pain returned. Design: Prospective cohort observational trial of consecutive patients. Setting: Tertiary spinal intervention centre in Calgary, Alberta, Canada. Patients: A total of 53 consecutive individuals with chronic whiplash-associated disorder. Methods: Individuals underwent radiofrequency neurotomy and were assessed before radiofrequency neurotomy, at 1 and 3 months postprocedure, and then after the return of pain (approximately 10 months postprocedure). Main outcome measurements: Quantitative sensory tests (pressure; thermal pain thresholds; brachial plexus provocation test), nociceptive flexion reflex, and motor function (cervical range of movement; craniocervical flexion test) were measured. Self-reported disability, psychological distress, pain catastrophization, and posttraumatic stress disorder symptoms also were measured. Results: Upon the return of pain after radiofrequency neurotomy, levels of disability increased (P < .0001), and were no different to those before radiofrequency neurotomy (P = .99). There also was a significant deterioration in quantitative sensory testing measures and reduced cervical range of motion after the return of pain (all P < .05); all approaching values were recorded before radiofrequency neurotomy (P > .22). There were no significant changes in pressure hyperalgesia (P > .054) or craniocervical flexion test performance (P > .07) after the return of pain. Psychological distress and pain catastrophizing increased significantly after the return of pain (P < .01), and again were no different than measures taken prior to radiofrequency neurotomy (P > .13). However, there was no difference in number or severity of posttraumatic stress symptoms after the return of pain (P > .30). Conclusions: Physical and psychological features of chronic whiplash-associated disorder are modulated dynamically with cervical radiofrequency neurotomy. These findings indicate that peripheral nociception is involved in the manifestations of chronic whiplash-associated disorder in this cohort of individuals.
MeSH term(s)	Adolescent ; Adult ; Aged ; Brachial Plexus/physiopathology ; Brachial Plexus/surgery ; Catheter Ablation/methods ; Cervical Vertebrae/injuries ; Chronic Disease ; Female ; Follow-Up Studies ; Humans ; Male ; Middle Aged ; Neck Pain/diagnosis ; Neck Pain/etiology ; Neck Pain/physiopathology ; Nociception/physiology ; Pain Measurement ; Prospective Studies ; Range of Motion, Articular ; Whiplash Injuries/complications ; Whiplash Injuries/physiopathology ; Young Adult ; Zygapophyseal Joint/injuries ; Zygapophyseal Joint/innervation ; Zygapophyseal Joint/physiopathology
Language	English
Publishing date	2015-03-21
Publishing country	United States
Document type	Clinical Trial ; Journal Article ; Observational Study
ZDB-ID	2608988-9
ISSN	1934-1563 ; 1934-1482
ISSN (online)	1934-1563
ISSN	1934-1482
DOI	10.1016/j.pmrj.2015.03.014
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Article: A Case of Succinyl-CoA:3-Oxoacid CoA Transferase Deficiency Presenting with Severe Acidosis in a 14-Month-Old Female: Evidence for Pathogenicity of a Point Mutation in the

Zheng, Daniel J / Hooper, Michael / Spencer-Manzon, Michele / Pierce, Richard W

Journal of pediatric intensive care

2017 Volume 7, Issue 1, Page(s) 62–66

Abstract: We describe a case of succinyl-CoA:3-oxoacid CoA transferase (SCOT) deficiency in an otherwise healthy 14 month-old female. She presented with lethargy, tachypnea, and hyperpnea with hypoglycemia and a severe anion gap metabolic acidosis. Early ... ...

Abstract	We describe a case of succinyl-CoA:3-oxoacid CoA transferase (SCOT) deficiency in an otherwise healthy 14 month-old female. She presented with lethargy, tachypnea, and hyperpnea with hypoglycemia and a severe anion gap metabolic acidosis. Early management included correction of the acidosis and metabolic support with dextrose and insulin. Inborn errors of metabolism are rare outside the neonatal period. However, SCOT deficiency may present at older ages. Maintaining a high index of suspicion, immediate transfer to a pediatric intensive care unit, and prompt metabolic support are key to achieving a favorable outcome.
Language	English
Publishing date	2017-07-19
Publishing country	Germany
Document type	Case Reports
ISSN	2146-4618
ISSN	2146-4618
DOI	10.1055/s-0037-1604270
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Article ; Online: Smart-device environmental control systems: experiences of people with cervical spinal cord injuries.

Hooper, Bethany / Verdonck, Michele / Amsters, Delena / Myburg, Michelle / Allan, Emily

Disability and rehabilitation. Assistive technology

2017 Volume 13, Issue 8, Page(s) 724–730

Abstract: Background: Environmental control systems (ECS) are devices that enable people with severe physical limitations to independently control household appliances. Recent advancements in the area of environmental control technology have led to the ... ...

Abstract	Background: Environmental control systems (ECS) are devices that enable people with severe physical limitations to independently control household appliances. Recent advancements in the area of environmental control technology have led to the development of ECS that can be controlled through mainstream smart-devices. There is limited research on ECS within Australia and no known research addressing smart-device ECS. The current study sought to explore users' experiences with smart-device ECS within Australia. Methods: The study followed a single embedded case study method. Participants (n = 5) were existing ECS users with a cervical spinal cord injury. Data were collected through semi-structured interviews with participants, reflexive journals and field notes. An inductive approach was used to analyze the data thematically. Results and conclusions: The experience of using a smart-device ECS presented both opportunities and costs to users. The opportunities included: independent control, choice, peace of mind, connection, effective resource use, and control over smart-phone functions and applications. The associated costs included: financial, time, frustration, and technical limitations. While findings are similar to previous research into traditional ECS this study indicates that smart-device ECS also offered a new opportunity for users to access mainstream smart-device functions and applications. Future research should investigate methods and resources that practitioners could utilize to better support new users of smart-device ECS. Implications for Rehabilitation As with traditional environmental control systems, users of smart environmental control systems report increased independence, choice and control. Smart-device environmental control systems provide users with access to mainstream smart-device functions and applications, which facilitate connection to family and the outside world. The costs to the user of smart-device environmental control systems include monetary and time investment, dealing with technical limitations and resulting frustration. Prescribers and installers must consider ways to mitigate these costs experienced by users.
MeSH term(s)	Adult ; Cervical Cord/injuries ; Computers, Handheld ; Costs and Cost Analysis ; Disabled Persons/rehabilitation ; Humans ; Interviews as Topic ; Male ; Middle Aged ; Queensland ; Self-Help Devices ; Smartphone ; Spinal Cord Injuries/rehabilitation ; Time Factors ; User-Computer Interface ; Young Adult
Language	English
Publishing date	2017-09-06
Publishing country	England
Document type	Journal Article
ZDB-ID	2221782-4
ISSN	1748-3115 ; 1748-3107
ISSN (online)	1748-3115
ISSN	1748-3107
DOI	10.1080/17483107.2017.1369591
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Order via subito

Inter-library loan at ZB MED

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito