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  1. Book ; Online: Iron and Neurodegeneration

    Zanella, Isabella / Filosto, Massimiliano / Biasiotto, Giorgio

    2020  

    Keywords Science: general issues ; Neurosciences ; iron ; neurodegeneration ; autophagy ; neuroinflammation ; exosomes
    Size 1 electronic resource (369 pages)
    Publisher Frontiers Media SA
    Document type Book ; Online
    Note English ; Open Access
    HBZ-ID HT021230121
    ISBN 9782889634514 ; 2889634515
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Article ; Online: COVID-19 therapy, from lung disease to systemic disorder.

    Pitchford, Simon / Zanella, Isabella

    Current research in pharmacology and drug discovery

    2022  Volume 3, Page(s) 100099

    Language English
    Publishing date 2022-04-01
    Publishing country Netherlands
    Document type Editorial
    ISSN 2590-2571
    ISSN (online) 2590-2571
    DOI 10.1016/j.crphar.2022.100099
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Editorial: Neurological and psychiatric disorders: The role of clathrin-mediated endocytosis (CME) and related intracellular trafficking.

    Zanella, Isabella / Daniel, James A / Zizioli, Daniela

    Frontiers in cellular neuroscience

    2023  Volume 17, Page(s) 1165675

    Language English
    Publishing date 2023-03-10
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2452963-1
    ISSN 1662-5102
    ISSN 1662-5102
    DOI 10.3389/fncel.2023.1165675
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Editorial: The Impact of Neurofilament Light Chain (NFL) Quantification in Serum and Cerebrospinal Fluid in Neurodegenerative Diseases.

    Zanella, Isabella / Blasco, Hélène / Filosto, Massimiliano / Biasiotto, Giorgio

    Frontiers in neuroscience

    2022  Volume 16, Page(s) 915115

    Language English
    Publishing date 2022-05-05
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2411902-7
    ISSN 1662-453X ; 1662-4548
    ISSN (online) 1662-453X
    ISSN 1662-4548
    DOI 10.3389/fnins.2022.915115
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Potential Diagnostic Role of Hepcidin in Anemic Patients Affected by Inflammatory Bowel Disease: A Systematic Review.

    Ferrari, Fabiana / Carini, Mattia / Zanella, Isabella / Treglia, Giorgio / Luglio, Gaetano / Bresciani, Roberto / Biasiotto, Giorgio

    Diagnostics (Basel, Switzerland)

    2024  Volume 14, Issue 4

    Abstract: Background: Anemia is the main extraintestinal comorbidity of Inflammatory Bowel Disease (IBD). Differentiating the type of anemia in these disorders is still a challenge. Hepcidin could be a promising biomarker to identify iron deficiency anemia (IDA), ...

    Abstract Background: Anemia is the main extraintestinal comorbidity of Inflammatory Bowel Disease (IBD). Differentiating the type of anemia in these disorders is still a challenge. Hepcidin could be a promising biomarker to identify iron deficiency anemia (IDA), anemia of chronic disease (ACD) and the concomitant presence of both IDA and ACD.
    Methods: To evaluate the potential role of hepcidin dosage in the management of anemia in IBD patients, we performed a systematic review by a comprehensive literature analysis of original papers reporting the dosage of hepcidin in IBD patients. In all the articles reviewed, the dosage of ferritin was reported, and the correlation between hepcidin and ferritin has been used to compare these two biomarkers.
    Results: A total of 12 articles concerning the dosage of hepcidin in IBD were included, comprising in total of 976 patients. The results of the hepcidin values in IBD patients when compared with controls were conflicting. In fact, four articles described an increase in this biomarker, three showed a decrease and five did not find significant differences. The correlation with ferritin was positive and significant. In three studies, some differences between hepcidin dosages and ferritin levels indicate a possible role when IDA and ACD could be present at the same time.
    Conclusions: Considering the contradictory data of the studies, the diagnostic role of hepcidin as a biomarker remains elusive in IBD patients. These differences could be due to the clinical characteristics of the patients enrolled that should be better defined in the future. A suitable clinical trial should be designed to outline the possible role of hepcidin in differentiating IDA, ACD and concomitant IDA and ACD in IBD patients. At the moment, ferritin still remains the best marker to diagnose these conditions, in addition to hemoglobin, transferrin saturation and CRP as recommended by the ECCO guidelines.
    Language English
    Publishing date 2024-02-09
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2662336-5
    ISSN 2075-4418
    ISSN 2075-4418
    DOI 10.3390/diagnostics14040375
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Cabotegravir Exposure of Zebrafish (

    Zizioli, Daniela / Zanella, Isabella / Mignani, Luca / Degli Antoni, Melania / Castelli, Francesco / Quiros-Roldan, Eugenia

    International journal of molecular sciences

    2023  Volume 24, Issue 3

    Abstract: As most new medications, Cabotegravir (CAB) was recently approved as an antiretroviral treatment of HIV infection without in-depth safety information on in utero exposure. Although no developmental toxicity in rats and rabbits was reported, recent ... ...

    Abstract As most new medications, Cabotegravir (CAB) was recently approved as an antiretroviral treatment of HIV infection without in-depth safety information on in utero exposure. Although no developmental toxicity in rats and rabbits was reported, recent studies demonstrated that CAB decreases pluripotency of human embryonic stem cells. CAB exposure effects during development were assessed in zebrafish embryos by the Fish Embryo Toxicity test after exposure at subtherapeutic concentrations up to 25× the human C
    MeSH term(s) Humans ; Animals ; Rabbits ; Rats ; Zebrafish ; Embryo, Nonmammalian ; HIV Infections ; Heart Rate ; Larva ; Water Pollutants, Chemical/toxicity
    Chemical Substances cabotegravir (HMH0132Z1Q) ; Water Pollutants, Chemical
    Language English
    Publishing date 2023-01-19
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms24031994
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Correction: Zanella et al. Tenofovir, Another Inexpensive, Well Known and Widely Available Old Drug Repurposed for SARS-COV-2 Infection.

    Zanella, Isabella / Zizioli, Daniela / Castelli, Francesco / Quiros-Roldan, Eugenia

    Pharmaceuticals (Basel, Switzerland)

    2021  Volume 14, Issue 8

    Abstract: Text Correction [ ... ]. ...

    Abstract Text Correction [...].
    Language English
    Publishing date 2021-08-23
    Publishing country Switzerland
    Document type Published Erratum
    ZDB-ID 2193542-7
    ISSN 1424-8247
    ISSN 1424-8247
    DOI 10.3390/ph14080827
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Editorial: Iron and Neurodegeneration.

    Biasiotto, Giorgio / Filosto, Massimiliano / Zanella, Isabella

    Frontiers in neuroscience

    2019  Volume 13, Page(s) 1382

    Language English
    Publishing date 2019-12-20
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2411902-7
    ISSN 1662-453X ; 1662-4548
    ISSN (online) 1662-453X
    ISSN 1662-4548
    DOI 10.3389/fnins.2019.01382
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: The effect of C9orf72 intermediate repeat expansions in neurodegenerative and autoimmune diseases.

    Biasiotto, Giorgio / Zanella, Isabella

    Multiple sclerosis and related disorders

    2018  Volume 27, Page(s) 42–43

    MeSH term(s) C9orf72 Protein ; DNA Repeat Expansion ; Humans ; Multiple Sclerosis ; Multiple Sclerosis, Chronic Progressive
    Chemical Substances C9orf72 Protein ; C9orf72 protein, human
    Language English
    Publishing date 2018-10-04
    Publishing country Netherlands
    Document type Letter ; Comment
    ZDB-ID 2645330-7
    ISSN 2211-0356 ; 2211-0348
    ISSN (online) 2211-0356
    ISSN 2211-0348
    DOI 10.1016/j.msard.2018.10.004
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Heterozygous APTX mutation associated with atypical multiple system atrophy-like phenotype: A case report.

    Imarisio, Alberto / Pilotto, Andrea / Lupini, Alessandro / Biasiotto, Giorgio / Zanella, Isabella / Currò, Riccardo / Vegezzi, Elisa / Cortese, Andrea / Palmieri, Ilaria / Valente, Enza Maria / Padovani, Alessandro

    Parkinsonism & related disorders

    2024  Volume 123, Page(s) 106943

    Abstract: We describe here a 73-year-old patient presenting with atypical MSA-P-like phenotype carrying a monoallelic p. W279X mutation in the APTX gene, which causes ataxia with oculomotor apraxia type 1 (AOA1) when in homozygous state. We hypothesize that rare ... ...

    Abstract We describe here a 73-year-old patient presenting with atypical MSA-P-like phenotype carrying a monoallelic p. W279X mutation in the APTX gene, which causes ataxia with oculomotor apraxia type 1 (AOA1) when in homozygous state. We hypothesize that rare monoallelic APTX variants could modulate MSA risk and phenotype.
    Language English
    Publishing date 2024-03-20
    Publishing country England
    Document type Letter
    ZDB-ID 1311489-x
    ISSN 1873-5126 ; 1353-8020
    ISSN (online) 1873-5126
    ISSN 1353-8020
    DOI 10.1016/j.parkreldis.2024.106943
    Database MEDical Literature Analysis and Retrieval System OnLINE

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