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  1. Article ; Online: Interview with Donald E Ingber.

    Ingber, Donald E

    Nanomedicine (London, England)

    2014  Volume 9, Issue 7, Page(s) 949–954

    MeSH term(s) Nanotechnology/methods ; Tissue Engineering
    Language English
    Publishing date 2014-05
    Publishing country England
    Document type Interview
    ZDB-ID 2277839-1
    ISSN 1748-6963 ; 1743-5889
    ISSN (online) 1748-6963
    ISSN 1743-5889
    DOI 10.2217/nnm.14.31
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 6617: Show issues Location:
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  2. Article ; Online: From tensegrity to human organs-on-chips: implications for mechanobiology and mechanotherapeutics.

    Ingber, Donald E

    The Biochemical journal

    2023  Volume 480, Issue 4, Page(s) 243–257

    Abstract: The field of mechanobiology, which focuses on the key role that physical forces play in control of biological systems, has grown enormously over the past few decades. Here, I provide a brief personal perspective on the development of the tensegrity ... ...

    Abstract The field of mechanobiology, which focuses on the key role that physical forces play in control of biological systems, has grown enormously over the past few decades. Here, I provide a brief personal perspective on the development of the tensegrity theory that contributed to the emergence of the mechanobiology field, the key role that crossing disciplines has played in its development, and how it has matured over time. I also describe how pursuing questions relating to mechanochemical transduction and mechanoregulation can lead to the creation of novel technologies and open paths for development of new therapeutic strategies for a broad range of diseases and disorders.
    MeSH term(s) Humans ; Biophysics ; Mechanotransduction, Cellular
    Language English
    Publishing date 2023-02-23
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 2969-5
    ISSN 1470-8728 ; 0006-2936 ; 0306-3275 ; 0264-6021
    ISSN (online) 1470-8728
    ISSN 0006-2936 ; 0306-3275 ; 0264-6021
    DOI 10.1042/BCJ20220303
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Human organs-on-chips for disease modelling, drug development and personalized medicine.

    Ingber, Donald E

    Nature reviews. Genetics

    2022  Volume 23, Issue 8, Page(s) 467–491

    Abstract: The failure of animal models to predict therapeutic responses in humans is a major problem that also brings into question their use for basic research. Organ-on-a-chip (organ chip) microfluidic devices lined with living cells cultured under fluid flow ... ...

    Abstract The failure of animal models to predict therapeutic responses in humans is a major problem that also brings into question their use for basic research. Organ-on-a-chip (organ chip) microfluidic devices lined with living cells cultured under fluid flow can recapitulate organ-level physiology and pathophysiology with high fidelity. Here, I review how single and multiple human organ chip systems have been used to model complex diseases and rare genetic disorders, to study host-microbiome interactions, to recapitulate whole-body inter-organ physiology and to reproduce human clinical responses to drugs, radiation, toxins and infectious pathogens. I also address the challenges that must be overcome for organ chips to be accepted by the pharmaceutical industry and regulatory agencies, as well as discuss recent advances in the field. It is evident that the use of human organ chips instead of animal models for drug development and as living avatars for personalized medicine is ever closer to realization.
    MeSH term(s) Animals ; Drug Development ; Humans ; Lab-On-A-Chip Devices ; Precision Medicine ; Rare Diseases
    Language English
    Publishing date 2022-03-25
    Publishing country England
    Document type Journal Article ; Review ; Research Support, U.S. Gov't, P.H.S. ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S. ; Research Support, N.I.H., Extramural
    ZDB-ID 2035157-4
    ISSN 1471-0064 ; 1471-0056
    ISSN (online) 1471-0064
    ISSN 1471-0056
    DOI 10.1038/s41576-022-00466-9
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Enabling out-of-body experiences for living organs.

    Ingber, Donald E

    The Journal of experimental medicine

    2021  Volume 218, Issue 4

    Abstract: ... a technique for culturing whole living organs outside the body. Here, Ingber reviews how this work led to a series ...

    Abstract In a 1937 issue of JEM, Carrel (1937. J. Exp. Med.https://doi.org/10.1084/jem.65.4.515) described a technique for culturing whole living organs outside the body. Here, Ingber reviews how this work led to a series of scientific, engineering, and medical breakthroughs that continue to this day.
    MeSH term(s) Animals ; History, 20th Century ; Humans ; Infusion Pumps/history ; Lab-On-A-Chip Devices/history ; Male ; Mice ; Models, Animal ; Organ Culture Techniques/history ; Organ Transplantation/history
    Language English
    Publishing date 2021-03-05
    Publishing country United States
    Document type Historical Article ; Journal Article
    ZDB-ID 218343-2
    ISSN 1540-9538 ; 0022-1007
    ISSN (online) 1540-9538
    ISSN 0022-1007
    DOI 10.1084/jem.20201756
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  5. Article: Is it Time for Reviewer 3 to Request Human Organ Chip Experiments Instead of Animal Validation Studies?

    Ingber, Donald E

    Advanced science (Weinheim, Baden-Wurttemberg, Germany)

    2020  Volume 7, Issue 22, Page(s) 2002030

    Abstract: For the past century, experimental data obtained from animal studies have been required by reviewers of scientific articles and grant applications to validate the physiological relevance of in vitro results. At the same time, pharmaceutical researchers ... ...

    Abstract For the past century, experimental data obtained from animal studies have been required by reviewers of scientific articles and grant applications to validate the physiological relevance of in vitro results. At the same time, pharmaceutical researchers and regulatory agencies recognize that results from preclinical animal models frequently fail to predict drug responses in humans. This
    Language English
    Publishing date 2020-10-12
    Publishing country Germany
    Document type Journal Article ; Review
    ZDB-ID 2808093-2
    ISSN 2198-3844
    ISSN 2198-3844
    DOI 10.1002/advs.202002030
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: What Can an Organ-on-a-Chip Teach Us About Human Lung Pathophysiology?

    Bai, Haiqing / Ingber, Donald E

    Physiology (Bethesda, Md.)

    2022  Volume 37, Issue 5

    Abstract: The intertwined relationship between structure and function has been key to understanding human organ physiology and disease pathogenesis. An organ-on-a-chip (organ chip) is a bioengineered microfluidic cell culture device lined by living cells and ... ...

    Abstract The intertwined relationship between structure and function has been key to understanding human organ physiology and disease pathogenesis. An organ-on-a-chip (organ chip) is a bioengineered microfluidic cell culture device lined by living cells and tissues that recapitulates organ-level functions in vitro. This is accomplished by recreating organ-specific tissue-tissue interfaces and microenvironmental biochemical and mechanical cues while providing dynamic perfusion through endothelium-lined vascular channels. In this review, we discuss how this emerging technology has contributed to the understanding of human lung structure-function relationships at the cell, tissue, and organ levels.
    MeSH term(s) Cell Culture Techniques ; Endothelial Cells ; Humans ; Lab-On-A-Chip Devices ; Lung
    Language English
    Publishing date 2022-06-06
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2158667-6
    ISSN 1548-9221 ; 1548-9213
    ISSN (online) 1548-9221
    ISSN 1548-9213
    DOI 10.1152/physiol.00012.2022
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    Zs.A 2164: Show issues Location:
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  7. Article ; Online: Modeling Healthy and Dysbiotic Vaginal Microenvironments in a Human Vagina-on-a-Chip.

    Gulati, Aakanksha / Jorgenson, Alicia / Junaid, Abidemi / Ingber, Donald E

    Journal of visualized experiments : JoVE

    2024  , Issue 204

    Abstract: Women's health, and particularly diseases of the female reproductive tract (FRT), have not received the attention they deserve, even though an unhealthy reproductive system may lead to life-threatening diseases, infertility, or adverse outcomes during ... ...

    Abstract Women's health, and particularly diseases of the female reproductive tract (FRT), have not received the attention they deserve, even though an unhealthy reproductive system may lead to life-threatening diseases, infertility, or adverse outcomes during pregnancy. One barrier in the field is that there has been a dearth of preclinical, experimental models that faithfully mimic the physiology and pathophysiology of the FRT. Current in vitro and animal models do not fully recapitulate the hormonal changes, microaerobic conditions, and interactions with the vaginal microbiome. The advent of Organ-on-a-Chip (Organ Chip) microfluidic culture technology that can mimic tissue-tissue interfaces, vascular perfusion, interstitial fluid flows, and the physical microenvironment of a major subunit of human organs can potentially serve as a solution to this problem. Recently, a human Vagina Chip that supports co-culture of human vaginal microbial consortia with primary human vaginal epithelium that is also interfaced with vaginal stroma and experiences dynamic fluid flow has been developed. This chip replicates the physiological responses of the human vagina to healthy and dysbiotic microbiomes. A detailed protocol for creating human Vagina Chips has been described in this article.
    MeSH term(s) Animals ; Pregnancy ; Humans ; Female ; Vagina ; Coculture Techniques ; Epithelium ; Extracellular Fluid ; Lab-On-A-Chip Devices
    Language English
    Publishing date 2024-02-16
    Publishing country United States
    Document type Journal Article ; Video-Audio Media
    ZDB-ID 2259946-0
    ISSN 1940-087X ; 1940-087X
    ISSN (online) 1940-087X
    ISSN 1940-087X
    DOI 10.3791/66486
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Human organ chips for regenerative pharmacology.

    Goyal, Girija / Belgur, Chaitra / Ingber, Donald E

    Pharmacology research & perspectives

    2023  Volume 12, Issue 1, Page(s) e01159

    Abstract: Human organs-on-chips (organ chips) are small microfluidic devices that allow human cells to perform complex organ-level functions in vitro by recreating multi-cellular and multi-tissue structures and applying in vivo-like biomechanical cues. Human Organ ...

    Abstract Human organs-on-chips (organ chips) are small microfluidic devices that allow human cells to perform complex organ-level functions in vitro by recreating multi-cellular and multi-tissue structures and applying in vivo-like biomechanical cues. Human Organ Chips are being used for drug discovery and toxicology testing as an alternative to animal models which are ethically challenging and often do not predict clinical efficacy or toxicity. In this mini-review, we summarize our presentation that reviewed the state of the art relating to these microfluidic culture devices designed to mimic specific human organ structures and functions, and the application of Organ Chips to regenerative pharmacology.
    MeSH term(s) Animals ; Humans ; Microphysiological Systems ; Lab-On-A-Chip Devices ; Models, Animal ; Drug Discovery
    Language English
    Publishing date 2023-12-23
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2740389-0
    ISSN 2052-1707 ; 2052-1707
    ISSN (online) 2052-1707
    ISSN 2052-1707
    DOI 10.1002/prp2.1159
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  9. Article ; Online: Interdisciplinarity and mechanobiology.

    Ingber, Donald E / Di Carlo, Dino

    iScience

    2022  Volume 25, Issue 5, Page(s) 104187

    Language English
    Publishing date 2022-04-28
    Publishing country United States
    Document type News
    ISSN 2589-0042
    ISSN (online) 2589-0042
    DOI 10.1016/j.isci.2022.104187
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  10. Article: Mechanical forces amplify TCR mechanotransduction in T cell activation and function.

    Jeffreys, Nicholas / Brockman, Joshua M / Zhai, Yunhao / Ingber, Donald E / Mooney, David J

    Applied physics reviews

    2024  Volume 11, Issue 1, Page(s) 11304

    Abstract: Adoptive T cell immunotherapies, including engineered T cell receptor (eTCR) and chimeric antigen receptor (CAR) T cell immunotherapies, have shown efficacy in treating a subset of hematologic malignancies, exhibit promise in solid tumors, and have many ... ...

    Abstract Adoptive T cell immunotherapies, including engineered T cell receptor (eTCR) and chimeric antigen receptor (CAR) T cell immunotherapies, have shown efficacy in treating a subset of hematologic malignancies, exhibit promise in solid tumors, and have many other potential applications, such as in fibrosis, autoimmunity, and regenerative medicine. While immunoengineering has focused on designing biomaterials to present biochemical cues to manipulate T cells
    Language English
    Publishing date 2024-02-16
    Publishing country United States
    Document type Journal Article ; Review
    ISSN 1931-9401
    ISSN 1931-9401
    DOI 10.1063/5.0166848
    Database MEDical Literature Analysis and Retrieval System OnLINE

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