Article: Mitochondrial dysfunction and quality control lie at the heart of subarachnoid hemorrhage.
2023 Volume 19, Issue 4, Page(s) 825–832
Abstract: The dramatic increase in intracranial pressure after subarachnoid hemorrhage leads to a decrease in cerebral perfusion pressure and a reduction in cerebral blood flow. Mitochondria are directly affected by direct factors such as ischemia, hypoxia, ... ...
Abstract | The dramatic increase in intracranial pressure after subarachnoid hemorrhage leads to a decrease in cerebral perfusion pressure and a reduction in cerebral blood flow. Mitochondria are directly affected by direct factors such as ischemia, hypoxia, excitotoxicity, and toxicity of free hemoglobin and its degradation products, which trigger mitochondrial dysfunction. Dysfunctional mitochondria release large amounts of reactive oxygen species, inflammatory mediators, and apoptotic proteins that activate apoptotic pathways, further damaging cells. In response to this array of damage, cells have adopted multiple mitochondrial quality control mechanisms through evolution, including mitochondrial protein quality control, mitochondrial dynamics, mitophagy, mitochondrial biogenesis, and intercellular mitochondrial transfer, to maintain mitochondrial homeostasis under pathological conditions. Specific interventions targeting mitochondrial quality control mechanisms have emerged as promising therapeutic strategies for subarachnoid hemorrhage. This review provides an overview of recent research advances in mitochondrial pathophysiological processes after subarachnoid hemorrhage, particularly mitochondrial quality control mechanisms. It also presents potential therapeutic strategies to target mitochondrial quality control in subarachnoid hemorrhage. |
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Language | English |
Publishing date | 2023-10-16 |
Publishing country | India |
Document type | Journal Article ; Review |
ZDB-ID | 2388460-5 |
ISSN | 1876-7958 ; 1673-5374 |
ISSN (online) | 1876-7958 |
ISSN | 1673-5374 |
DOI | 10.4103/1673-5374.381493 |
Database | MEDical Literature Analysis and Retrieval System OnLINE |
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