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Article ; Online: Dataset on the content of vitamin D

Othman, Ali J / Eliseeva, Ludmila G / Duksi, Fatima M / Molodkina, Polina G / Shalankina, Alyona D

2022 Volume 42, Page(s) 108153

Abstract: This dataset demonstrates the content of vitamin D ...

Abstract	This dataset demonstrates the content of vitamin D
Language	English
Publishing date	2022-04-09
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2786545-9
ISSN	2352-3409 ; 2352-3409
ISSN (online)	2352-3409
ISSN	2352-3409
DOI	10.1016/j.dib.2022.108153
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Article ; Online: Inhibiting Protein Kinase D Promotes Airway Epithelial Barrier Integrity in Mouse Models of Influenza A Virus Infection.

Veazey, Janelle M / Eliseeva, Sophia I / Hillman, Sara E / Stiles, Kristie / Smyth, Timothy R / Morrissey, Charlotte E / Tillotson, Erika J / Topham, Dave J / Chapman, Timothy J / Georas, Steve N

Frontiers in immunology

2020 Volume 11, Page(s) 580401

Abstract: Rationale: Protein kinase D (PKD) is a serine/threonine kinase family that is involved in a wide ...

Abstract	Rationale: Protein kinase D (PKD) is a serine/threonine kinase family that is involved in a wide array of signaling pathways. Although PKD has been implicated in immune responses, relatively little is known about the function of PKD in the lung or during viral infections. Objectives: We investigated the hypothesis that PKD is involved in multiple aspects of host response to viral infection. Methods: The selective PKD inhibitor CRT0010166 was administered to C57BL/6 mice prior to and during challenge with either inhaled double-stranded RNA or Influenza A Virus. PKD signaling pathways were investigated in human bronchial epithelial cells treated with CRT0010166, double-stranded RNA, and/or infected with Influenza A Virus. Measurements: Total protein and albumin accumulation in the bronchoalveolar fluid was used to asses inside/out leak. Clearance of inhaled FITC-dextran out of the airspace was used to assess outside/in leak. Cytokines and neutrophils in bronchoalveolar lavage were assayed with ELISAs and cytospins respectively. Viral RNA level was assessed with RT-PCR and protein level assessed by ELISA. Main results: PKD inhibition prevented airway barrier dysfunction and pro-inflammatory cytokine release. Epithelial cells express PKD3, and PKD3 siRNA knock-down inhibited polyI:C induced cytokine production. Lung epithelial-specific deletion of PKD3 (CC10-Cre x PKD3-floxed mice) partially attenuated polyI:C-induced barrier disruption Conclusions: Inhibiting PKD promotes barrier integrity, limit pathogenic cytokine levels, and restrict Influenza A Virus infection. Therefore, PKD is an attractive target for novel antiviral therapeutics.
MeSH term(s)	Animals ; Cells, Cultured ; Dextrans ; Disease Models, Animal ; Humans ; Influenza A virus/physiology ; Influenza, Human/immunology ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Orthomyxoviridae Infections/immunology ; Protein Kinase C/genetics ; Protein Kinase C/metabolism ; Protein Kinase Inhibitors/administration & dosage ; RNA, Small Interfering/genetics ; Respiratory Mucosa/metabolism ; Respiratory Mucosa/pathology ; Signal Transduction ; Sp1 Transcription Factor/genetics ; Sp1 Transcription Factor/metabolism
Chemical Substances	Dextrans ; Protein Kinase Inhibitors ; RNA, Small Interfering ; Sp1 Transcription Factor ; protein kinase D (EC 2.7.10.-) ; Protein Kinase C (EC 2.7.11.13)
Language	English
Publishing date	2020-12-14
Publishing country	Switzerland
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	2606827-8
ISSN	1664-3224 ; 1664-3224
ISSN (online)	1664-3224
ISSN	1664-3224
DOI	10.3389/fimmu.2020.580401
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Article ; Online: Tetranuclear d-f metallostars: synthesis, relaxometric, and luminescent properties.

Dehaen, Geert / Eliseeva, Svetlana V / Verwilst, Peter / Laurent, Sophie / Vander Elst, Luce / Muller, Robert N / De Borggraeve, Wim / Binnemans, Koen / Parac-Vogt, Tatjana N

Inorganic chemistry

2012 Volume 51, Issue 16, Page(s) 8775–8783

Abstract: A novel ditopic ligand DTPA-ph-phen, based on 1,10-phenanthroline and diethylenetriaminepentaacetic acid (DTPA) units, has been designed and fully characterized by (1)H, (13)C, and 2D-COSY NMR spectroscopy, IR and electrospray ionization mass ... ...

Abstract	A novel ditopic ligand DTPA-ph-phen, based on 1,10-phenanthroline and diethylenetriaminepentaacetic acid (DTPA) units, has been designed and fully characterized by (1)H, (13)C, and 2D-COSY NMR spectroscopy, IR and electrospray ionization mass spectrometry (ESI-MS) techniques. The DTPA core of the ligand specifically binds Ln(III) ions (Ln = Eu, Gd) resulting in formation of the [Ln{DTPA-ph-phen}(H(2)O)](-) complex. The photophysical properties of the Eu(III) compound have been investigated, and the complex shows characteristic red luminescence with an overall quantum yield of 2.2%. Reaction of [Gd{DTPA-ph-phen}(H(2)O)](-) with Ru(II) leads to further self-assembly into a heterobimetallic metallostar complex containing Gd(III) and Ru(II) in a 3:1 ratio. This tetranuclear [(Gd{DTPA-ph-phen})(3)(H(2)O)(3)Ru](-) complex (Gd(3)Ru), formed by the coordination of Ru(II) to the 1,10-phenanthroline unit, has been characterized by a range of experimental techniques and evaluated toward its feasibility as a potential bimodal optical/MRI agent. The Gd(3)Ru metallostar shows intense metal-to-ligand charge transfer (MLCT) transition resulting in intense light absorption in the visible spectral region. Upon irradiation into this MLCT band at 450 nm, the Gd(3)Ru complex exhibits red broad-band luminescence in the range of 550-800 nm centered at 610 nm with a quantum yield of 4.8%. Proton nuclear magnetic relaxation dispersion (NMRD) measurements indicate that the Gd(3)Ru complex exhibits an enhanced relaxivity value r(1) of 36.0 s(-1) mM(-1) per metallostar molecule at 20 MHz and 310 K. The ability of the complex to noncovalently bind to human serum albumin (HSA) was investigated, but no significant interaction was detected.
Language	English
Publishing date	2012-08-20
Publishing country	United States
Document type	Journal Article
ZDB-ID	1484438-2
ISSN	1520-510X ; 0020-1669
ISSN (online)	1520-510X
ISSN	0020-1669
DOI	10.1021/ic300537y
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Article: [Confocal scanning laser retinal tomography in study of 3-D topography of the optic disk in patients with papilledema].

Eliseeva, N M / Serova, N K / Shifrin, M A

Zhurnal voprosy neirokhirurgii imeni N. N. Burdenko

2008 , Issue 3, Page(s) 31–35

Abstract: Confocal scanning laser tomography (CSLT) giver the opportunity to describe stereometric parameters of the optic disk in patients with different stages of papilledema. CSLT of the optic disk (Heidelberg Retina Tomograph II) was performed in 20 healthy ... ...

Abstract	Confocal scanning laser tomography (CSLT) giver the opportunity to describe stereometric parameters of the optic disk in patients with different stages of papilledema. CSLT of the optic disk (Heidelberg Retina Tomograph II) was performed in 20 healthy volunteers (40 eyes) and in 85 patients with papilledema caused by cerebral tumors (8 eyes without papilledema, 52 eyes with early, 38 with moderate and 56 with severe stage of papilledema, and 9 with chronic papilledema and optic atrophy). Rim volume (RV) and disk area (DA) were measured. CSLT was performed during postoperative follow-up in 40 patients. The difference in RV (p < 0.01) and DA (p < 0.01) between normal optic disk and optic disk with early and moderate edema, and optic disk with severe edema, was significant. Stereometric parameters of optic disks measured by CSLT provide objective quantitative assessment of papilledema in patients with cerebral tumors. CSLT is especially valuable in monitoring of papilledema.
MeSH term(s)	Adolescent ; Adult ; Child ; Diagnostic Techniques, Ophthalmological/instrumentation ; Female ; Humans ; Intracranial Hypertension/complications ; Intracranial Hypertension/diagnosis ; Intracranial Hypertension/pathology ; Lasers ; Male ; Microscopy, Confocal ; Middle Aged ; Optic Disk/anatomy & histology ; Optic Disk/pathology ; Optic Nerve/anatomy & histology ; Optic Nerve/pathology ; Papilledema/diagnosis ; Papilledema/etiology ; Papilledema/pathology ; Retina/anatomy & histology ; Retina/pathology ; Tomography/instrumentation ; Tomography/methods ; Young Adult
Language	Russian
Publishing date	2008-07
Publishing country	Russia (Federation)
Document type	English Abstract ; Journal Article
ZDB-ID	603458-5
ISSN	0042-8817
ISSN	0042-8817
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Article ; Online: Myelin Oligodendrocyte Glycoprotein as an Autoantigen in Inflammatory Demyelinating Diseases of the Central Nervous System.

Eliseeva, Daria D / Zakharova, Maria N

Biochemistry. Biokhimiia

2023 Volume 88, Issue 4, Page(s) 551–563

Abstract: Demyelinating diseases of the central nervous system are caused by an autoimmune attack on the myelin sheath surrounding axons. Myelin structural proteins become antigenic, leading to the development of myelin lesions. The use of highly specialized ... ...

Abstract	Demyelinating diseases of the central nervous system are caused by an autoimmune attack on the myelin sheath surrounding axons. Myelin structural proteins become antigenic, leading to the development of myelin lesions. The use of highly specialized laboratory diagnostic techniques for identification of specific antibodies directed against myelin components can significantly improve diagnostic approaches. Myelin oligodendrocyte glycoprotein (MOG) antibody-associated disease (MOGAD) currently includes demyelinating syndromes with known antigens. Based on the demonstrated pathogenic role of human IgG against MOG, MOGAD was classified as a distinct nosological entity. However, generation of multiple MOG isoforms by alternative splicing hinders antigen detection even with the most advanced immunofluorescence techniques. On the other hand, MOG conformational changes ensure the structural integrity of other myelin proteins and maintain human-specific mechanisms of immune autotolerance.
MeSH term(s)	Humans ; Autoantibodies ; Autoantigens ; Central Nervous System ; Demyelinating Diseases/diagnosis ; Immunoglobulin G ; Myelin-Oligodendrocyte Glycoprotein
Chemical Substances	Autoantibodies ; Autoantigens ; Immunoglobulin G ; Myelin-Oligodendrocyte Glycoprotein ; MOG protein, human
Language	English
Publishing date	2023-04-20
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	1109-5
ISSN	1608-3040 ; 0006-2979 ; 0320-9717
ISSN (online)	1608-3040
ISSN	0006-2979 ; 0320-9717
DOI	10.1134/S0006297923040107
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Article: Mekhanizmy neirodegeneratsii pri rasseyannom skleroze.

Eliseeva, D D / Zakharova, M N

Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova

2022 Volume 122, Issue 7. Vyp. 2, Page(s) 5–13

Abstract: Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system, which results in the formation of primary demyelinating lesions in the white and gray matter, as well as diffuse axonal and neuronal damage. Although there has been ... ...

Title translation	Mechanisms of Neurodegeneration in Multiple Sclerosis.
Abstract	Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system, which results in the formation of primary demyelinating lesions in the white and gray matter, as well as diffuse axonal and neuronal damage. Although there has been substantial progress in drug research in relapsing-remitting MS, treatment of progressive forms of the disease, can be challenging. Diffuse and compartmentalized lymphocyte and macrophage infiltration of the CNS tissue inhibits the differentiation of myelinating mature oligodendrocytes, disrupting the process of remyelination. Chronic inflammation that occurs behind a closed blood-brain barrier (BBB) leads to microglia activation, which increases mitochondrial damage to axons and neurons, and therefore triggers chronic oxidative stress and histotoxic hypoxia. Thus, raising awareness about the mechanisms of neurodegeneration appears relevant. In the late stages of MS, it is caused by chronic neuroaxonal damage, disruption of the regenerative ability of the CNS, and to a great extent determines the disease outcome.
MeSH term(s)	Blood-Brain Barrier/pathology ; Gray Matter ; Humans ; Multiple Sclerosis/drug therapy ; Multiple Sclerosis, Relapsing-Remitting/complications ; Neurodegenerative Diseases ; Oligodendroglia/pathology
Language	Russian
Publishing date	2022-07-31
Publishing country	Russia (Federation)
Document type	Journal Article
ZDB-ID	1201462-x
ISSN	2309-4729 ; 1997-7298 ; 0044-4588
ISSN (online)	2309-4729
ISSN	1997-7298 ; 0044-4588
DOI	10.17116/jnevro20221220725
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Article: Tipichnyi i atipichnyi opticheskii nevrit.

Sheremet, N L / Eliseeva, D D / Kalashnikova, A K / Zakharova, M N

Vestnik oftalmologii

2024 Volume 139, Issue 6, Page(s) 175–182

Abstract: Optic neuritis (ON) is one of the most common neuro-ophthalmic causes of vision loss worldwide. Demyelinating ON can be idiopathic or be one of the symptoms of autoimmune demyelinating diseases of the central nervous system (CNS) such as multiple ... ...

Title translation	Typical and atypical optic neuritis.
Abstract	Optic neuritis (ON) is one of the most common neuro-ophthalmic causes of vision loss worldwide. Demyelinating ON can be idiopathic or be one of the symptoms of autoimmune demyelinating diseases of the central nervous system (CNS) such as multiple sclerosis (MS), neuromyelitis optica spectrum disorders (NMOSD), myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD). Demographic, clinical and radiological signs of ON in these CNS diseases have differences. In this regard, typical and atypical ON are currently distinguished. Recognizing the clinical features that differentiate typical MS-associated ON from atypical ON in NMOSD and MOGAD is important for choosing the correct disease management and treatment strategy. This review summarizes the data from clinical, laboratory, instrumental methods of management used for the differential diagnosis of optic neuritis.
MeSH term(s)	Humans ; Myelin-Oligodendrocyte Glycoprotein ; Autoantibodies ; Optic Neuritis/diagnosis ; Optic Neuritis/etiology ; Optic Neuritis/therapy ; Neuromyelitis Optica/complications ; Neuromyelitis Optica/diagnosis ; Multiple Sclerosis/complications ; Multiple Sclerosis/diagnosis
Chemical Substances	Myelin-Oligodendrocyte Glycoprotein ; Autoantibodies
Language	Russian
Publishing date	2024-01-18
Publishing country	Russia (Federation)
Document type	Review ; English Abstract ; Journal Article
ZDB-ID	962921-x
ISSN	0042-465X
ISSN	0042-465X
DOI	10.17116/oftalma2023139061175
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Article: A surgical polypragmasy: Koninckx PR, Corona R, Timmerman D, Verguts J, Adamyan L. Peritoneal full-conditioning reduces postoperative adhesions and pain: a randomised controlled trial in deep endometriosis surgery. J Ovarian Res. 2013 Dec 11;6(1):90.

Mynbaev, Ospan A / Biro, Peter / Eliseeva, Marina Yu / Tinelli, Andrea / Malvasi, Antonio / Kosmas, Ioannis P / Medvediev, Mykhailo V / Babenko, Tatiana I / Mazitova, Madina I / Simakov, Sergei S / Stark, Michael

Journal of ovarian research

2014 Volume 7, Page(s) 29

Language	English
Publishing date	2014-03-10
Publishing country	England
Document type	Comment ; Letter
ZDB-ID	2455679-8
ISSN	1757-2215
ISSN	1757-2215
DOI	10.1186/1757-2215-7-29
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Article: Povyshennaia supressornaia aktivnost' transformirovannykh ex vivo reguliatornykh T-kletok v sravnenii s nestimulirovannymi kletkami togo zhe donora.

Blinova, V G / Gladilina, Y A / Eliseeva, D D / Lobaeva, T A / Zhdanov, D D

Biomeditsinskaia khimiia

2022 Volume 68, Issue 1, Page(s) 55–67

Abstract: Regulatory T-cells CD4⁺CD25⁺FoxP3⁺CD127low (Tregs) play a key role in the maintenance of tolerance to auto antigens, inhibit function of effector T and B lymphocytes, and provide a balance between effector and regulatory arms of immunity. Patients with ... ...

Title translation	Increased suppressor activity of transformed ex vivo regulatory T-cells in comparison with unstimulated cells of the same donor.
Abstract	Regulatory T-cells CD4⁺CD25⁺FoxP3⁺CD127low (Tregs) play a key role in the maintenance of tolerance to auto antigens, inhibit function of effector T and B lymphocytes, and provide a balance between effector and regulatory arms of immunity. Patients with autoimmune diseases have decreased Treg numbers and impaired suppressive activity. Transformed ex vivo autologous Tregs could restore destroyed balance of the immune system. We developed a method for Treg precursor cell cultivation. Following the method, we were able to grown up 300-400 million of Tregs cells from 50 ml of peripheral blood during a week. Transformed ex vivo Tregs are 90-95% CD4⁺CD25⁺FoxP3⁺CD127low and have increased expression of transcription genes FoxP3 and Helios. Transformed ex vivo Tregs have increased demethylation of FoxP3 promoter and activated genes of proliferation markers Cycline B1, Ki67 and LGALS 1. Transformed ex vivo Tregs have increased suppressive activity and up to 80-90% these cells secrete cytokines TNFα и IFNγ. Our data suggest transformed ex vivo autologous Tregs have genetic, immunophenotypic and functional characteristics for regulatory T-cells and further can be used for adoptive immunotherapy autoimmune diseases and inhibition of transplantation immunity.
MeSH term(s)	Cytokines/metabolism ; Forkhead Transcription Factors/genetics ; Forkhead Transcription Factors/metabolism ; Humans ; T-Lymphocytes, Regulatory/metabolism
Chemical Substances	Cytokines ; Forkhead Transcription Factors
Language	Russian
Publishing date	2022-02-27
Publishing country	Russia (Federation)
Document type	Journal Article
ZDB-ID	2130758-1
ISSN	2310-6905 ; 2310-6972 ; 0042-8809
ISSN (online)	2310-6905
ISSN	2310-6972 ; 0042-8809
DOI	10.18097/PBMC20226801055
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Article ; Online: Modulation of Suppressive Activity and Proliferation of Human Regulatory T Cells by Splice-Switching Oligonucleotides Targeting FoxP3 Pre-mRNA.

Blinova, Varvara G / Gladilina, Yulia A / Abramova, Anna A / Eliseeva, Daria D / Vtorushina, Valentina V / Shishparenok, Anastasia N / Zhdanov, Dmitry D

Cells

2023 Volume 13, Issue 1

Abstract: The maturation, development, and function of regulatory T cells (Tregs) are under the control of the crucial transcription factor Forkhead Box Protein 3 (FoxP3). Through alternative splicing, the human FoxP3 gene produces four different splice variants: ... ...

Abstract	The maturation, development, and function of regulatory T cells (Tregs) are under the control of the crucial transcription factor Forkhead Box Protein 3 (FoxP3). Through alternative splicing, the human FoxP3 gene produces four different splice variants: a full-length variant (FL) and truncated variants with deletions of each of exons 2 (∆2 variant) or 7 (∆7 variant) or a deletion of both exons (∆2∆7 variant). Their involvement in the biology of Tregs as well as their association with autoimmune diseases remains to be clarified. The aim of this work was to induce a single FoxP3 splice variant in human Tregs by splice switching oligonucleotides and to monitor their phenotype and proliferative and suppressive activity. We demonstrated that Tregs from peripheral blood from patients with multiple sclerosis preferentially expressed truncated splice variants, while the FL variant was the major variant in healthy donors. Tregs with induced expression of truncated FoxP3 splice variants demonstrated lower suppressive activity than those expressing FL variants. Reduced suppression was associated with the decreased expression of Treg-associated suppressive surface molecules and the production of cytokines. The deletion of exons 2 and/or 7 also reduced the cell proliferation rate. The results of this study show an association between FoxP3 splice variants and Treg function and proliferation. The modulation of Treg suppressive activity by the induction of the FoxP3 FL variant can become a promising strategy for regenerative immunotherapy.
MeSH term(s)	Humans ; Cell Proliferation ; Forkhead Transcription Factors/genetics ; Oligonucleotides ; RNA Precursors/genetics ; T-Lymphocytes, Regulatory
Chemical Substances	Forkhead Transcription Factors ; Oligonucleotides ; RNA Precursors ; FOXP3 protein, human
Language	English
Publishing date	2023-12-29
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2661518-6
ISSN	2073-4409 ; 2073-4409
ISSN (online)	2073-4409
ISSN	2073-4409
DOI	10.3390/cells13010077
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