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  1. Article: Chemical Constituents of

    Hung, Hsin-Yi / Cheng, Kun-Ching / Kuo, Ping-Chung / Chen, I-Tsen / Li, Yue-Chiun / Hwang, Tsong-Long / Lam, Sio-Hong / Wu, Tian-Shung

    Antioxidants (Basel, Switzerland)

    2022  Volume 11, Issue 2

    Abstract: Seven new anthraquinones with rare 2-isopropyldihydrofuran ( ...

    Abstract Seven new anthraquinones with rare 2-isopropyldihydrofuran (
    Language English
    Publishing date 2022-02-09
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2704216-9
    ISSN 2076-3921
    ISSN 2076-3921
    DOI 10.3390/antiox11020335
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: A Modified

    Li, Yue-Chiun / Wu, Chia-Hung / Le, Thi Ha / Yuan, Qingjun / Huang, Luqi / Chen, Guo-Fen / Yang, Mei-Lin / Lam, Sio-Hong / Hung, Hsin-Yi / Sun, Handong / Wu, Yi-Hung / Kuo, Ping-Chung / Wu, Tian-Shung

    International journal of molecular sciences

    2023  Volume 24, Issue 14

    Abstract: ... A ... ...

    Abstract A previous
    MeSH term(s) Ephedrine/analysis ; Pseudoephedrine/analysis ; Ephedra/chemistry ; Alkaloids/analysis ; Proton Magnetic Resonance Spectroscopy/methods
    Chemical Substances Ephedrine (GN83C131XS) ; Pseudoephedrine (7CUC9DDI9F) ; Ephedrae herba (51QBA3IQ91) ; Alkaloids
    Language English
    Publishing date 2023-07-10
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms241411272
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Effects of morphology and pore size of mesoporous silicas on the efficiency of an immobilized enzyme.

    Kuo, Ping-Chung / Lin, Zhi-Xun / Wu, Tzi-Yi / Hsu, Chun-Han / Lin, Hong-Ping / Wu, Tian-Shung

    RSC advances

    2021  Volume 11, Issue 17, Page(s) 10010–10017

    Abstract: An investigation is performed into the efficiency of ... ...

    Abstract An investigation is performed into the efficiency of the
    Language English
    Publishing date 2021-03-08
    Publishing country England
    Document type Journal Article
    ISSN 2046-2069
    ISSN (online) 2046-2069
    DOI 10.1039/d1ra01358k
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Recent progress on the traditional Chinese medicines that regulate the blood.

    Hung, Hsin-Yi / Wu, Tian-Shung

    Journal of food and drug analysis

    2016  Volume 24, Issue 2, Page(s) 221–238

    Abstract: In traditional Chinese medicine, the herbs that regulate blood play a vital role. Here, nine herbs including Typhae Pollen, Notoginseng Root, Common Bletilla Tuber, India Madder Root and Rhizome, Chinese Arborvitae Twig, Lignum Dalbergiae Oderiferae, ... ...

    Abstract In traditional Chinese medicine, the herbs that regulate blood play a vital role. Here, nine herbs including Typhae Pollen, Notoginseng Root, Common Bletilla Tuber, India Madder Root and Rhizome, Chinese Arborvitae Twig, Lignum Dalbergiae Oderiferae, Chuanxiong Rhizoma, Corydalis Tuber, and Motherwort Herb were selected and reviewed for their recent studies on anti-tumor, anti-inflammatory and cardiovascular effects. Besides, the analytical methods developed to qualify or quantify the active compounds of the herbs are also summarized.
    MeSH term(s) Corydalis ; Drugs, Chinese Herbal ; Humans ; Medicine, Chinese Traditional ; Rhizome
    Chemical Substances Drugs, Chinese Herbal
    Language English
    Publishing date 2016-01-05
    Publishing country China (Republic : 1949- )
    Document type Journal Article ; Review
    ISSN 2224-6614
    ISSN (online) 2224-6614
    DOI 10.1016/j.jfda.2015.10.009
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Cinnamophilin enhances temozolomide-induced cytotoxicity against malignant glioma: the roles of ROS and cell cycle arrest.

    Tai, Shih-Hang / Lin, Yu-Wen / Huang, Tung-Yi / Chang, Che-Chao / Chao, Liang-Chun / Wu, Tian-Shung / Lee, E-Jian

    Translational cancer research

    2022  Volume 10, Issue 9, Page(s) 3906–3920

    Abstract: Background: Temozolomide (TMZ) has been widely used to treat glioblastoma multiforme (GBM). However, many mechanisms are known to quickly adapt GBM cells to chemotherapy with TMZ, leading to drug resistance and expansion of tumor cell populations.: ... ...

    Abstract Background: Temozolomide (TMZ) has been widely used to treat glioblastoma multiforme (GBM). However, many mechanisms are known to quickly adapt GBM cells to chemotherapy with TMZ, leading to drug resistance and expansion of tumor cell populations.
    Methods: We subjected human glioblastoma cell lines and an animal model of glioblastoma xenografts with TMZ-based adjuvant treatments to evaluate the synergistic effect of cinnamophilin (CINN), a free radical scavenger.
    Results: Our results showed that the combined treatment of CINN and TMZ potentiated the anticancer effect and apoptotic cell death in glioma cell lines and enhanced antitumor action in glioma xenografts. TMZ induced reactive oxygen species (ROS) burst and elevated G2 arrest in glioma cells. The CINN-suppressed ROS burst in TMZ-treated glioma cells might be associated with increased apoptosis, as indicated by the upregulation of TUNEL-positive glioma cells. CINN-pretreated glioma cells exhibited increased cyclin B expression and reduced phosphorylation of Cdk1, suggesting reduced G2 arrest in the combined treatment group. Moreover, CINN lowered the protein level of LC3, a hallmark of autophagy, in TMZ-treated cells.
    Conclusions: These findings suggest that CINN may restore TMZ toxicity in glioma cancer by suppressing the ROS/G2 arrest pathway.
    Language English
    Publishing date 2022-01-15
    Publishing country China
    Document type Journal Article
    ZDB-ID 2901601-0
    ISSN 2219-6803 ; 2218-676X
    ISSN (online) 2219-6803
    ISSN 2218-676X
    DOI 10.21037/tcr-20-3426
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Novel application of rhein and its prodrug diacerein for reversing cancer-related multidrug resistance through the dual inhibition of P-glycoprotein efflux and STAT3-mediated P-glycoprotein expression.

    Teng, Yu-Ning / Kao, Ming-Chang / Huang, Shih-Ya / Wu, Tian-Shung / Lee, Tsui-Er / Kuo, Chan-Yen / Hung, Chin-Chuan

    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

    2022  Volume 150, Page(s) 112995

    Abstract: Multidrug resistance (MDR) is a multifactorial issue in cancer treatment. Drug efflux transporters, particularly P-glycoprotein (P-gp), are major contributors to such resistance. In the present study, we evaluated the P-gp-inhibiting and MDR-reversing ... ...

    Abstract Multidrug resistance (MDR) is a multifactorial issue in cancer treatment. Drug efflux transporters, particularly P-glycoprotein (P-gp), are major contributors to such resistance. In the present study, we evaluated the P-gp-inhibiting and MDR-reversing effects of two compounds, namely rhein, an anthraquinone, and diacerein, the acetylated prodrug of rhein. ABCB1/Flp-In-293 was used as a model for investigating the related molecular mechanisms, and the multi-drug-resistant cancer cell line KB/VIN was used as a platform for evaluating the reversal of MDR0. The results indicated that at a concentration of 2.5 μM, both diacerein and rhein significantly inhibited P-gp efflux function. They also downregulated P-gp expression by interacting with the signal transducer and activator of transcription 3. Further investigation of the inhibitory mechanism of these compounds revealed that both stimulated P-gp ATPase activity dose dependently and engaged in the noncompetitive inhibition of rhodamine 123 efflux. Furthermore, rhein was revealed to be a potent reverser of MDR in cancer, and the combination of 30 μM rhein and 1000 nM vincristine exerted a strong synergistic effect, achieving a high combination index (CI) of 0.092. Diacerein demonstrated potential applications as a selective cytotoxic agent against multi-drug-resistant cancer cells at a concentration of > 18.92 μM and as a mild MDR reverser at doses of < 10 μM. In conclusion, diacerein and rhein are potential candidates for P-gp inhibition and MDR reversal in cancer cells.
    MeSH term(s) ATP Binding Cassette Transporter, Subfamily B/metabolism ; ATP Binding Cassette Transporter, Subfamily B, Member 1/metabolism ; Anthraquinones/pharmacology ; Cell Line, Tumor ; Doxorubicin/pharmacology ; Drug Resistance, Multiple ; Drug Resistance, Neoplasm ; Neoplasms ; Prodrugs/pharmacology ; STAT3 Transcription Factor/metabolism
    Chemical Substances ATP Binding Cassette Transporter, Subfamily B ; ATP Binding Cassette Transporter, Subfamily B, Member 1 ; Anthraquinones ; Prodrugs ; STAT3 Transcription Factor ; diacerein (4HU6J11EL5) ; Doxorubicin (80168379AG) ; rhein (YM64C2P6UX)
    Language English
    Publishing date 2022-05-01
    Publishing country France
    Document type Journal Article
    ZDB-ID 392415-4
    ISSN 1950-6007 ; 0753-3322 ; 0300-0893
    ISSN (online) 1950-6007
    ISSN 0753-3322 ; 0300-0893
    DOI 10.1016/j.biopha.2022.112995
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Ud II Zs.198: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  7. Article: Chemoreversal Agents from Taiwanofungus Genus and Their More Potent Methyl Derivatives Targeting Signal Transducer and Activator of Transcription 3 (STAT3) Phosphorylation.

    Yu, Ko-Hua / Hung, Chin-Chuan / Wu, Tian-Shung / Chen, Chin-Fu / Wu, I-Ting / Kuo, Ping-Chung / Lam, Sio-Hong / Hung, Hsin-Yi

    Pharmaceuticals (Basel, Switzerland)

    2021  Volume 14, Issue 9

    Abstract: Multidrug resistance (MDR), for which the mechanisms are not yet fully clear, is one of the major obstacles to cancer treatment. In recent years, signal transducer and activator of transcription 3 (STAT3) were found to be one of the important MDR ... ...

    Abstract Multidrug resistance (MDR), for which the mechanisms are not yet fully clear, is one of the major obstacles to cancer treatment. In recent years, signal transducer and activator of transcription 3 (STAT3) were found to be one of the important MDR mechanism pathways. Based on the previous research, zhankuic acid A, B, and C were found to have collateral sensitivity effects on MDR cancer cells, and MDR inhibitory activity of zhankuic acid methyl ester was found to be better than that of its acid. Therefore, we executed a systematic examination of the structure-activity relationship of zhankuic acid methyl ester derivatives to collateral sensitivity in MDR cancer cells. The results showed that compound
    Language English
    Publishing date 2021-09-10
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2193542-7
    ISSN 1424-8247
    ISSN 1424-8247
    DOI 10.3390/ph14090916
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Chemical Constituents of Hedyotis diffusa and Their Anti-Inflammatory Bioactivities

    Hung, Hsin-Yi / Cheng, Kun-Ching / Kuo, Ping-Chung / Chen, I-Tsen / Li, Yue-Chiun / Hwang, Tsong-Long / Lam, Sio-Hong / Wu, Tian-Shung

    Antioxidants. 2022 Feb. 09, v. 11, no. 2

    2022  

    Abstract: Seven new anthraquinones with rare 2-isopropyldihydrofuran (1–3) and 2,2-dimethylpyrano (4–7) moieties together with thirty-four known compounds were isolated from the extracts of whole Hedyotis diffusa plants. Their structures were elucidated and ... ...

    Abstract Seven new anthraquinones with rare 2-isopropyldihydrofuran (1–3) and 2,2-dimethylpyrano (4–7) moieties together with thirty-four known compounds were isolated from the extracts of whole Hedyotis diffusa plants. Their structures were elucidated and established by various spectroscopic and spectrometric analytical methods. Among these isolates, selected compounds were examined for their anti-inflammatory activity. The results showed that rare substituted anthraquinones displayed potent inhibitory activity with IC₅₀ values ranging from 0.15 ± 0.01 to 5.52 ± 1.59 µM on the N-formyl-methionyl-leucyl-phenylalanine/cytochalasin B (fMLP/CB)-induced superoxide anion generation and elastase release cellular models. Meanwhile, the proposed drug target of the active anthraquinone was studied by computer modeling. The binding affinity between the anti-inflammatory anthraquinone and elastase was evaluated by molecular docking. These results provided the scientific insight into the medicinal values of Hedyotis diffusa and vision of development as lead compounds.
    Keywords Oldenlandia diffusa ; anthraquinones ; anti-inflammatory activity ; computers ; drugs ; elastase ; spectroscopy ; superoxide anion ; vision
    Language English
    Dates of publication 2022-0209
    Publishing place Multidisciplinary Digital Publishing Institute
    Document type Article
    ZDB-ID 2704216-9
    ISSN 2076-3921
    ISSN 2076-3921
    DOI 10.3390/antiox11020335
    Database NAL-Catalogue (AGRICOLA)

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  9. Article ; Online: Recent progress on the traditional Chinese medicines that regulate the blood

    Hsin-Yi Hung / Tian-Shung Wu

    Journal of Food and Drug Analysis, Vol 24, Iss 2, Pp 221-

    2016  Volume 238

    Abstract: In traditional Chinese medicine, the herbs that regulate blood play a vital role. Here, nine herbs including Typhae Pollen, Notoginseng Root, Common Bletilla Tuber, India Madder Root and Rhizome, Chinese Arborvitae Twig, Lignum Dalbergiae Oderiferae, ... ...

    Abstract In traditional Chinese medicine, the herbs that regulate blood play a vital role. Here, nine herbs including Typhae Pollen, Notoginseng Root, Common Bletilla Tuber, India Madder Root and Rhizome, Chinese Arborvitae Twig, Lignum Dalbergiae Oderiferae, Chuanxiong Rhizoma, Corydalis Tuber, and Motherwort Herb were selected and reviewed for their recent studies on anti-tumor, anti-inflammatory and cardiovascular effects. Besides, the analytical methods developed to qualify or quantify the active compounds of the herbs are also summarized.
    Keywords analytical methods ; traditional Chinese medicine ; Nutrition. Foods and food supply ; TX341-641 ; Therapeutics. Pharmacology ; RM1-950
    Language English
    Publishing date 2016-04-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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  10. Article ; Online: Application of Lanthanide Shift Reagent to the

    Lam, Sio-Hong / Hung, Hsin-Yi / Kuo, Ping-Chung / Kuo, Daih-Huang / Chen, Fu-An / Wu, Tian-Shung

    Molecules (Basel, Switzerland)

    2020  Volume 25, Issue 22

    Abstract: This study investigates the application of the paramagnetic shift reagent tris(dipivaloylmethanato)-europium(III) in NMR spectral studies of permethoxyacridone alkaloids ( ...

    Abstract This study investigates the application of the paramagnetic shift reagent tris(dipivaloylmethanato)-europium(III) in NMR spectral studies of permethoxyacridone alkaloids (
    MeSH term(s) Acridones/chemistry ; Alkaloids/chemistry ; Europium/chemistry ; Lanthanoid Series Elements/chemistry ; Proton Magnetic Resonance Spectroscopy
    Chemical Substances Acridones ; Alkaloids ; Lanthanoid Series Elements ; Europium (444W947O8O)
    Language English
    Publishing date 2020-11-17
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 1413402-0
    ISSN 1420-3049 ; 1431-5165 ; 1420-3049
    ISSN (online) 1420-3049
    ISSN 1431-5165 ; 1420-3049
    DOI 10.3390/molecules25225383
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.MO 81: Show issues

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