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Article ; Online: Predictive value of admission D-dimer levels in patient with acute ischaemic stroke and COVID-19: a second-wave prospective cohort study.

Rasyid, Al / Harris, Salim / Kurniawan, Mohammad / Mesiano, Taufik / Hidayat, Rakhmad / Wiyarta, Elvan

2024 Volume 14, Issue 4, Page(s) e077500

Abstract: Objectives: This study aimed to evaluate the predictive value of admission D-dimer levels for in-hospital mortality in patients with COVID-19 and acute ischaemic stroke.: Design: Cohort (prospective).: Setting: Tertiary referral hospital in the ... ...

Abstract	Objectives: This study aimed to evaluate the predictive value of admission D-dimer levels for in-hospital mortality in patients with COVID-19 and acute ischaemic stroke. Design: Cohort (prospective). Setting: Tertiary referral hospital in the capital city of Indonesia conducted from June to December 2021. Participants: 60 patients with acute ischaemic stroke and COVID-19 were included. Patients were classified into D-dimer groups (low and high) according to a 2 110 ng/mL cut-off value, determined via receiver operating characteristic analysis. Primary and secondary outcome measures: The primary outcome was in-hospital mortality, with admission D-dimer levels as the major predictor. Secondary outcomes included associations between other demographic and clinical variables and the admission D-dimer value. Kaplan-Meier method was used to carry out survival analysis, with univariable and multivariable Cox regression performed to assess the association of D-dimer levels and other confounding variables (including demographic, clinical and laboratory parameters) with in-hospital mortality. Results: The findings demonstrated an association between elevated admission D-dimer levels (≥2 110 ng/mL) and an increased likelihood of death during hospitalisation. The adjusted HR was 14.054 (95% CI 1.710 to 115.519; p=0.014), demonstrating an increase in mortality risk after accounting for confounders such as age and diabetes history. Other significant predictors of mortality included a history of diabetes and increased white blood cell count. Conclusions: Admission D-dimer levels may be a useful predictive indicator for the likelihood of death during hospitalisation in individuals with COVID-19 and acute ischaemic stroke.
MeSH term(s)	Humans ; COVID-19 ; Prognosis ; Prospective Studies ; Biomarkers ; Brain Ischemia ; Stroke ; Hospitalization ; Ischemic Stroke ; Diabetes Mellitus ; Retrospective Studies ; Fibrin Fibrinogen Degradation Products
Chemical Substances	fibrin fragment D ; Biomarkers ; Fibrin Fibrinogen Degradation Products
Language	English
Publishing date	2024-04-05
Publishing country	England
Document type	Journal Article
ZDB-ID	2599832-8
ISSN	2044-6055 ; 2044-6055
ISSN (online)	2044-6055
ISSN	2044-6055
DOI	10.1136/bmjopen-2023-077500
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: The Effect of Individual Characteristics and Entrepreneurship on Rice Farming Performance

Imelda Imelda / Rakhmad Hidayat / Marisi Aritonang

Agraris: Journal of Agribusiness and Rural Development Research, Vol 8, Iss 1, Pp 46-

2022 Volume 57

Abstract: Entrepreneurship in the agricultural sector produces creative, innovative, and independent farmers who can improve farm performance. Therefore, this research aimed to determine the impact of individual characteristics and entrepreneurship on rice farming ...

Abstract	Entrepreneurship in the agricultural sector produces creative, innovative, and independent farmers who can improve farm performance. Therefore, this research aimed to determine the impact of individual characteristics and entrepreneurship on rice farming performance. The method employed in this research was a descriptive method to provide a qualitative description of individual characteristics and entrepreneurship in the performance of rice farming. The research was executed in one of the rice-producing centers in Kubu Raya Regency, West Kalimantan. The simple random sampling method was used in selecting farmers with 150 respondents selected as the sample size. Furthermore, the research variables involved were individual characteristics, farmer’s entrepreneurship, and rice farming performance. Data were collected using questionnaires, interviews, and observations, and analysis was performed using Structural Equation Modeling (SEM) with SMART-PLS software. The results showed that individual characteristics and entrepreneurship had a significant and positive effect on rice farming performance. Consequently, it can be concluded to improve rice farming performance, farmers suggested strengthening their characteristics, particularly those related to farming motivation, and enhancing their entrepreneurial characteristics through their task and outcome-oriented behavior.
Keywords	individual characteristics ; farmer’s entrepreneurship ; rice farming performance ; Agriculture ; S ; Agriculture (General) ; S1-972 ; Business ; HF5001-6182
Subject code	650
Language	English
Publishing date	2022-06-01T00:00:00Z
Publisher	Universitas Muhammadiyah Yogyakarta
Document type	Article ; Online
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Article: Comprehensive Management of Acute Ischemic Stroke in Psoriatic Patient.

Rasyid, Al / Mesiano, Taufik / Kurniawan, Mohammad / Hidayat, Rakhmad / Eddy Yunus, Reyhan / Novianto, Endi / Ocktafiani, Ocktafiani / Wiyarta, Elvan / Harris, Salim

Case reports in dermatological medicine

2023 Volume 2023, Page(s) 6580971

Abstract: Background: Stroke is one of the top causes of death and disability in several nations. Patients with psoriasis are susceptible to multiple comorbidities, including stroke. In addition to acute ischemic stroke, psoriasis and chronic inflammation require ...

Abstract	Background: Stroke is one of the top causes of death and disability in several nations. Patients with psoriasis are susceptible to multiple comorbidities, including stroke. In addition to acute ischemic stroke, psoriasis and chronic inflammation require comprehensive treatment. Here, we present a comprehensive management case of a patient with an acute ischemic stroke and psoriasis. Conclusions: Cyclosporine should only be used for a maximum of 1 year for stroke management with psoriasis and be substituted for other systemic agents such as methotrexate. In addition, anticoagulants, antihypertensive, antihyperlipidemic, vitamin B6, vitamin 12, and folic acid regimens are highly recommended for comprehensive therapy of cardiovascular comorbidities.
Language	English
Publishing date	2023-03-08
Publishing country	United States
Document type	Case Reports
ZDB-ID	2684644-5
ISSN	2090-6471 ; 2090-6463
ISSN (online)	2090-6471
ISSN	2090-6463
DOI	10.1155/2023/6580971
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Article: Anaphylactic reaction as an etiology of ischemic stroke: A case report.

Hidayat, Rakhmad / Mesiano, Taufik / Kurniawan, Mohammad / Rasyid, Al / Harris, Salim / Zairinal, Ramdinal Aviesena / Mustika, Alyssa Putri / Fathi, Gemia Clarisa / Irfannadhira, Aruni Cahya

Radiology case reports

2023 Volume 18, Issue 12, Page(s) 4313–4317

Abstract: A 28-year-old man was brought to the emergency room (ER) with a history of decrease of consciousness 30 minutes before admission. In the previous 1 hour, the patient felt bitten or stabbed in the left temple area. Physical examination showed signs of N ... ...

Abstract	A 28-year-old man was brought to the emergency room (ER) with a history of decrease of consciousness 30 minutes before admission. In the previous 1 hour, the patient felt bitten or stabbed in the left temple area. Physical examination showed signs of N VII paresis, upper extremity motoric 3/2 (right/left) and lower extremity 3/2 (right/left), positive left extremity hypesthesia. Noncontrast MRI brain examination showed increased DWI signal intensity, suggesting diffusion restriction in bilateral centrum semiovale, bilateral posterior crus internal capsule, and bilateral corpus callosum leading to suspicion of acute-hyperacute ischemia. The therapy given while in the emergency room was IVFD asering, IV dexamethasone 5 mg, IV diphenhydramine 10 mg, oral paracetamol 500 mg, oral aspirin 80 mg, oral clopidogrel 75 mg, and oral atorvastatin 40 mg. We report a case of stroke due to an anaphylactic reaction in an effort to add to the point of view if the same case occurs.
Language	English
Publishing date	2023-09-26
Publishing country	Netherlands
Document type	Case Reports
ZDB-ID	2406300-9
ISSN	1930-0433
ISSN	1930-0433
DOI	10.1016/j.radcr.2023.08.110
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Article: Anal Swab in COVID-19 Patients.

Koesnoe, Sukamto / Hidayat, Rakhmad / Aini, Muhammad Hafiz / Fani, Devi Nurfadila / Widjaya, Nita

Acta medica Indonesiana

2022 Volume 54, Issue 3, Page(s) 451–455

Abstract: In 2020, a new type of coronavirus (SARS-CoV-2) whose disease is called Coronavirus disease 2019 (COVID-19) has been reported. This virus was first discovered in Wuhan, China and has infected 90,308 people per March 2, 2020. As of the end of October 2020, ...

Abstract	In 2020, a new type of coronavirus (SARS-CoV-2) whose disease is called Coronavirus disease 2019 (COVID-19) has been reported. This virus was first discovered in Wuhan, China and has infected 90,308 people per March 2, 2020. As of the end of October 2020, more than 40 million people have been infected, with the death toll reaching 1,150,000 worldwide. Apart from respiratory tract infections, patients infected with this virus may exhibit other symptoms, such as diarrhea, abdominal pain, nausea, or vomiting. This means that the virus can be found in feces and anus, hence the anal swab can be used as a diagnostic tool for COVID-19 infection. The results of the specimen test show that the sensitivity of the nasopharyngeal swab positive detection rate is the highest and remains the gold standard for diagnosis. This sensitivity can also be influenced by the course of the disease that can infect the gastrointestinal tract so that anal PCR is performed for the diagnosis to detect the COVID-19 virus in patients.
MeSH term(s)	COVID-19/diagnosis ; COVID-19 Testing ; Diarrhea ; Feces ; Humans ; SARS-CoV-2
Language	English
Publishing date	2022-09-09
Publishing country	Indonesia
Document type	Journal Article
ZDB-ID	2474707-5
ISSN	2338-2732 ; 0125-9326
ISSN (online)	2338-2732
ISSN	0125-9326
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Article ; Online: Guillain-Barré syndrome associated with COVID-19 infection

Muhammad Hafiz Aini / Rakhmad Hidayat / Nita Widjaya / Fhathia Avisha / Heydi Marizky Lisman / Devi Nurfadila Fani

Romanian Journal of Neurology, Vol 22, Iss 3, Pp 261-

A case report

2023 Volume 264

Abstract: Coronavirus 2 or SARS-CoV-2 is predominantly manifests as a respiratory infection; however, it has been linked to a spectrum of neurological disorders such as vertigo, cephalalgia, cognitive impairment, myalgia, and anosmia. Emerging reports indicate ... ...

Abstract	Coronavirus 2 or SARS-CoV-2 is predominantly manifests as a respiratory infection; however, it has been linked to a spectrum of neurological disorders such as vertigo, cephalalgia, cognitive impairment, myalgia, and anosmia. Emerging reports indicate several neurological illnesses that coincide with COVID-19, such as encephalitis and, notably, stroke. In this report, We present an instance of a patient infected with COVID-19 with Guillain-Barré Syndrome in this case report. Guillain-Barre Syndrome (GBS) is an inflammatory polyradiculoneuropathy linked to various viral infections. We present the case of a 76-year-old female patient hospitalized with acute progressive symmetric ascending quadriparesis. Seven days before hospitalization, the patient experienced fever and cough with RT-PCR testing confirmed a positive COVID-19 infection. Cerebrospinal fluid analysis revealed dissociation of cytoalbumin. Coronavirus stimulates inflammatory cells and produces various cytokines, leading to immune-mediated processes. GBS represents an immune-mediated disorder, with its pathogenesis intricately influenced by the pivotal role of molecular mimicry in its onset. Plasmapheresis was performed, resulting in an improved clinical outcome for the patient.
Keywords	guillain-barré syndrome ; covid-19 ; plasmapharesis ; neurology ; coronavirus ; intensive care ; Medicine ; R ; Neurology. Diseases of the nervous system ; RC346-429
Subject code	616
Language	English
Publishing date	2023-09-01T00:00:00Z
Publisher	Amaltea Medical Publishing House
Document type	Article ; Online
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Article: Endovascular embolization of Spetzler-Martin Grade I brain arteriovenous malformations: A case report on patient-centered neurointervention.

Rasyid, Al / Widjaya, Nita / Harris, Salim / Kurniawan, Mohammad / Mesiano, Taufik / Hidayat, Rakhmad / Harsono, Adrian Ridski / Nugroho, Setyo Widi / Yunus, Reyhan Eddy / Wiyarta, Elvan

Radiology case reports

2024 Volume 19, Issue 8, Page(s) 2905–2910

Abstract: Brain arteriovenous malformations (AVM) present complex treatment decisions, particularly for low-grade AVM where surgical resection is often considered the standard. This case report emphasizes the importance of patient preferences and cultural ... ...

Abstract	Brain arteriovenous malformations (AVM) present complex treatment decisions, particularly for low-grade AVM where surgical resection is often considered the standard. This case report emphasizes the importance of patient preferences and cultural considerations in selecting endovascular embolization over traditional surgical approaches for Spetzler-Martin Grade I AVM management, highlighting the evolving practice of patient-centered care in neurointervention. A 30-year-old male presented with recurrent seizures, characterized by a sudden onset of headache followed by speech arrest, without any preceding medical history of neurological deficits. Initial physical examination revealed no focal neurological deficits. Non-contrast computed tomography, magnetic resonance imaging, and magnetic resonance angiography suggested an AVM involving the cortical-subcortical regions of the left frontal lobe, measuring approximately 1.7 × 2.6 × 1.5 cm, fed by the left middle cerebral artery M3 segment, and draining into the superior sagittal sinus. Spetzler-Martin Grade I classification was confirmed via digital subtraction angiography. Given the patient's strong preference against invasive procedures, driven by personal and cultural beliefs, endovascular embolization was selected as the treatment strategy. Post-embolization, the patient showed marked symptomatic improvement with no evidence of residual AVM on follow-up imaging, and no postprocedure complications were reported. This case highlights the importance of considering patient preferences in AVM treatment planning, illustrating that endovascular embolization can be an effective and less invasive alternative to surgery in selected patients, reinforcing the need for personalized, patient-centered approaches in neurointerventional care.
Language	English
Publishing date	2024-05-03
Publishing country	Netherlands
Document type	Case Reports
ZDB-ID	2406300-9
ISSN	1930-0433
ISSN	1930-0433
DOI	10.1016/j.radcr.2024.03.078
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Article ; Online: Efficacy of endovascular therapy for stroke in developing country

Mohammad Kurniawan / Kevin Mulya Saputri / Taufik Mesiano / Reyhan E. Yunus / Affan P. Permana / Septo Sulistio / Eka Ginanjar / Rakhmad Hidayat / Al Rasyid / Salim Harris

Heliyon, Vol 10, Iss 1, Pp e23228- (2024)

A single-centre retrospective observational study in Indonesia from 2017 to 2021

1481

Abstract: Background: Indonesia as a developing nation faces a plethora of challenges in applying endovascular therapy (EVT), mostly due to the lack of physicians specialized in neuro-intervention, high operational cost, and time limitation. The efficacy of EVT in ...

Abstract	Background: Indonesia as a developing nation faces a plethora of challenges in applying endovascular therapy (EVT), mostly due to the lack of physicians specialized in neuro-intervention, high operational cost, and time limitation. The efficacy of EVT in improving functional outcomes of stroke in developing countries has not been previously studied. Methods: This retrospective cohort study was conducted at Dr. Cipto Mangunkusumo Hospital (Jakarta, Indonesia) from January 2017 to December 2021. Large vessel occlusion (LVO) diagnosis was established based on a combination of clinical and imaging characteristics. We assessed patients’ functional independence on day-90 based on modified Rankin Scale (mRS) between the endovascular treatment group and the conservative group (those receiving intravascular thrombolysis or medical treatment only). Functional independence was defined as mRS ≤2. Results: Among 111 stroke patients with LVO, we included 32 patients in the EVT group and 50 patients in the conservative group for this study. Patients with younger age (p = 0.004), lower hypertension rate (p < 0.001), higher intubation rate (p = 0.014), and earlier onset of stroke were observed in the EVT group. The proportion of mRS ≤2 at day-90 in the EVT group was higher than the conservative group (28.1 % vs. 18.0 %; p = 0.280). Patients within mRS ≤2 group had earlier onset-to-puncture time (p = 0.198), onset-to-recanalization time (p = 0.341), lower NIHSS (p = 0.026) and higher ASPECTS (p = 0.001) on admission. In multivariate analysis, ASPECTS (aOR 2.43; 95%CI 1.26–4.70; p = 0.008) defined functional independence in the EVT group. Conclusion: The endovascular therapy group had a higher proportion of mRS ≤2 at day-90 than the conservative group despite its statistical insignificance.
Keywords	Endovascular therapy ; Mechanical thrombectomy ; Ischemic stroke ; Indonesia ; Developing countries ; Science (General) ; Q1-390 ; Social sciences (General) ; H1-99
Subject code	610 ; 616
Language	English
Publishing date	2024-01-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Correlation P2Y12 Genetic Polymorphism As Risk Factor of Clopidogrel Resistance in Indonesian Stroke Patients.

Hidayat, Rakhmad / Rasyid, Al / Harris, Salim / Harahap, Alida / Herqutanto / Louisa, Melva / Listiyaningsih, Erlin / Rambe, Aldy Safruddin / Loho, Tonny

Vascular health and risk management

2023 Volume 19, Page(s) 53–61

Abstract: Background: Stroke is one of the highest causes of disability and mortality in several countries worldwide. Secondary prevention is important in the management of stroke. Clopidogrel is widely used in Asia as secondary prevention for ischemic stroke, ... ...

Abstract	Background: Stroke is one of the highest causes of disability and mortality in several countries worldwide. Secondary prevention is important in the management of stroke. Clopidogrel is widely used in Asia as secondary prevention for ischemic stroke, even though several studies in Western show limited data related to clopidogrel resistance in Asia. This study aims to determine the correlation between P2Y12 genetic polymorphism and clopidogrel resistance in Indonesia. Methods: This study was conducted on one-year duration, the subjects were chosen through the consecutive sampling method, all subjects were examined for genetics and resistance to clopidogrel. The data were analyzed through statistical analysis, a bivariate analysis was conducted to determine the correlation between several variables and the resistance variable. This study employed resistance diagnostic methods with VerifyNow. Polymorphism of receptor P2Y12 was tested with the Polymerase Chain Reaction method (PCR) and analysis of restriction fragment length polymorphism (RFLP). The genes tested in this study were G52T and C34T. Results: The number of participants in this study was 112. Examination of gene P2Y12 showed that the majority was homozygote, wild-type C34T allele (67%), and G52T (66.1%). There was no significant correlation between clopidogrel resistance and gene G52T and C34T of P2Y12 (p > 0.05). Hb levels significantly correlated with P2Y12 G52T (p = 0.024). Meanwhile, Fatty Liver significantly correlated with P2Y12 C34T (p = 0.037). Conclusion: Indonesia showed a low clopidogrel resistance rate and a very low C34T and G52T allele P2Y12 gene mutation, meaning that Indonesia had low mutations in the P2Y12. This is the cause of clopidogrel resistance in this study only 15%. Therefore, in a region with less clopidogrel resistance, examination of the P2Y12 gene would not give significant results.
MeSH term(s)	Humans ; Clopidogrel/therapeutic use ; Indonesia ; Platelet Aggregation Inhibitors/therapeutic use ; Polymorphism, Genetic ; Purinergic P2Y Receptor Antagonists/therapeutic use ; Receptors, Purinergic P2Y12/genetics ; Risk Factors ; Stroke/diagnosis ; Stroke/drug therapy ; Stroke/genetics ; Drug Resistance/genetics
Chemical Substances	Clopidogrel (A74586SNO7) ; Platelet Aggregation Inhibitors ; Purinergic P2Y Receptor Antagonists ; Receptors, Purinergic P2Y12
Language	English
Publishing date	2023-01-29
Publishing country	New Zealand
Document type	Journal Article
ZDB-ID	2186568-1
ISSN	1178-2048 ; 1176-6344
ISSN (online)	1178-2048
ISSN	1176-6344
DOI	10.2147/VHRM.S386107
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Article: The role of clopidogrel resistance-related genetic and epigenetic factors in major adverse cardiovascular events among patients with acute coronary syndrome after percutaneous coronary intervention.

Giantini, Astuti / Timan, Ina S / Dharma, Rahajuningsih / Sukmawan, Renan / Setiabudy, Rianto / Alwi, Idrus / Harahap, Alida R / Listiyaningsih, Erlin / Partakusuma, Lia G / Tansir, Arif R / Sahar, Windy / Hidayat, Rakhmad

Frontiers in cardiovascular medicine

2023 Volume 9, Page(s) 1027892

Abstract: Despite patients with acute coronary syndrome (ACS) undergoing percutaneous coronary intervention (PCI) and receiving clopidogrel therapy, some patients still experience major adverse cardiovascular events (MACEs). Clopidogrel resistance, which may be ... ...

Abstract	Despite patients with acute coronary syndrome (ACS) undergoing percutaneous coronary intervention (PCI) and receiving clopidogrel therapy, some patients still experience major adverse cardiovascular events (MACEs). Clopidogrel resistance, which may be regulated by genetic and epigenetic factors, may play a role in MACEs. This study aimed to determine the association between genetic (
Language	English
Publishing date	2023-02-08
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2781496-8
ISSN	2297-055X
ISSN	2297-055X
DOI	10.3389/fcvm.2022.1027892
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