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  1. Article ; Online: Transthyretin-related amyloid in a saphenous vein. Histological diagnosis in a patient undergoing coronary artery bypass surgery.

    Farci, Fabiola / De Martino, Andrea / Pratali, Stefano / Bortolotti, Uberto / Pucci, Angela

    Cardiovascular pathology : the official journal of the Society for Cardiovascular Pathology

    2019  Volume 41, Page(s) 21–23

    Abstract: Amyloidosis is an underdiagnosed and challenging disease with clinical and etiologic heterogenicity, requiring amyloid subtyping because of the distinctive prognostic and therapeutic impact. Transthyretin amyloidosis is more common in elderly patients, ... ...

    Abstract Amyloidosis is an underdiagnosed and challenging disease with clinical and etiologic heterogenicity, requiring amyloid subtyping because of the distinctive prognostic and therapeutic impact. Transthyretin amyloidosis is more common in elderly patients, and in such population undergoing cardiovascular surgery, it could be worthy to be investigated. We herein describe an unusual case of transthyretin-related vascular amyloidosis in an 81-year-old man undergoing coronary artery bypass surgery. Diagnosis done after histology showed an intimal eccentric thickening in a remnant segment of the right saphenous vein that was harvested for grafting. Transthyretin-related amyloidosis was demonstrated by histochemical Congo Red staining under polarized light and by immunohistochemistry, corresponding to the intimal thickening. The thorough histological analysis was crucial for the diagnosis of a previously unknown transthyretin-related vascular amyloidosis.
    MeSH term(s) Aged, 80 and over ; Amyloid/analysis ; Amyloid Neuropathies, Familial/diagnosis ; Amyloid Neuropathies, Familial/metabolism ; Amyloid Neuropathies, Familial/pathology ; Biomarkers/analysis ; Biopsy ; Coronary Artery Bypass ; Fatal Outcome ; Humans ; Immunohistochemistry ; Male ; Neointima ; Prealbumin/analysis ; Saphenous Vein/chemistry ; Saphenous Vein/pathology ; Saphenous Vein/transplantation ; Tissue and Organ Harvesting ; Treatment Outcome ; Vascular Diseases/diagnosis ; Vascular Diseases/metabolism ; Vascular Diseases/pathology
    Chemical Substances Amyloid ; Biomarkers ; Prealbumin ; TTR protein, human
    Language English
    Publishing date 2019-04-05
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 1134600-0
    ISSN 1879-1336 ; 1054-8807
    ISSN (online) 1879-1336
    ISSN 1054-8807
    DOI 10.1016/j.carpath.2019.03.004
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3572: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: Primary small cell carcinoma of the ureter: Case report and review of the literature.

    Farci, Fabiola / Manassero, Francesca / Baldesi, Ramona / Bartolucci, Annamaria / Boldrini, Laura / Selli, Cesare / Faviana, Pinuccia

    Medicine

    2018  Volume 97, Issue 24, Page(s) e11113

    Abstract: Rationale: Primitive small cell carcinoma of the ureter is extremely rare, in this case report is meticulously described its aggressive clinical course and the pathological clues that help with the diagnosis. Also, a detailed table with the clinico- ... ...

    Abstract Rationale: Primitive small cell carcinoma of the ureter is extremely rare, in this case report is meticulously described its aggressive clinical course and the pathological clues that help with the diagnosis. Also, a detailed table with the clinico-pathological features of analogous case reports in literature is provided.
    Patient concerns: A 79-year-old female presented with gross hematuria and flank pain.
    Diagnoses: Small cell carcinoma of the ureter. The surgical specimen showed a mixed histology of small cell carcinoma and transitional cell carcinoma; the common neuroendocrine markers (chromogranin A, synaptophysin, CD56) were positive, and vimentin and thyroid transcription factor 1 were negative. The patient had an advanced stage at presentation with regional nodes involvement (pT3N1).
    Interventions: Segmental ureterectomy was performed but it was only possible to administer 1 cycle of platinum-based adjuvant chemotherapy due to the rapid decline of her clinical parameters.
    Outcomes: The disease rapidly spread locally and metastasized.
    Lesson: The clinicians must be aware of this aggressive tumor with silent clinical course and advanced stages at presentation.
    MeSH term(s) Aged ; Carcinoma, Small Cell/pathology ; Carcinoma, Small Cell/surgery ; Chemotherapy, Adjuvant ; Female ; Humans ; Ureter/pathology ; Ureter/surgery ; Ureteral Neoplasms/pathology ; Ureteral Neoplasms/surgery ; Urologic Surgical Procedures/methods
    Language English
    Publishing date 2018-06-11
    Publishing country United States
    Document type Case Reports ; Journal Article ; Review
    ZDB-ID 80184-7
    ISSN 1536-5964 ; 0025-7974
    ISSN (online) 1536-5964
    ISSN 0025-7974
    DOI 10.1097/MD.0000000000011113
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Ua VI Zs.171: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  3. Article ; Online: EZH2 Expression in Intestinal Neuroendocrine Tumors.

    Faviana, Pinuccia / Marconcini, Riccardo / Ricci, Sergio / Galli, Luca / Lippolis, Piero / Farci, Fabiola / Castagna, Maura / Boldrini, Laura

    Applied immunohistochemistry & molecular morphology : AIMM

    2018  Volume 27, Issue 9, Page(s) 689–693

    Abstract: Neuroendocrine tumors (NETs) arise from the cells present throughout the diffuse endocrine system. These neoplasms were previously regarded as rare, but in fact are increasing in incidence (3.65/100 000 individuals/y). Enhancer of zeste homolog 2 (EZH2) ... ...

    Abstract Neuroendocrine tumors (NETs) arise from the cells present throughout the diffuse endocrine system. These neoplasms were previously regarded as rare, but in fact are increasing in incidence (3.65/100 000 individuals/y). Enhancer of zeste homolog 2 (EZH2) plays a crucial role in cell cycle regulation, and it was reported to be overexpressed in several tumors. The aim of the study was to investigate EZH2 expression, also related with proliferation rate, and p53 expression in NETs of the intestine encompassing a group of tumors primary to the stomach, appendix, small intestine, and colon. The specimens from 33 patients with neuroendrocrine tumors were investigated by immunohistochemistry for EZH2, p53, and Ki-67. Only 10 of 33 (30.3%) cases showed high EZH2 expression. High EZH2 levels significantly associated with elevated proliferation rates (P=0.0012) and with elevated percentage of positive cells for p53 (P=0.011). Our results suggest an association between p53 and the EZH2 pathway in NETs. EZH2 could represent a potential target antigen in cancer immunotherapy.
    MeSH term(s) Cell Line, Tumor ; Enhancer of Zeste Homolog 2 Protein/metabolism ; Female ; Humans ; Immunohistochemistry ; Intestinal Neoplasms/metabolism ; Intestinal Neoplasms/pathology ; Male ; Middle Aged ; Neuroendocrine Tumors/metabolism ; Neuroendocrine Tumors/pathology ; Tumor Suppressor Protein p53/metabolism
    Chemical Substances Tumor Suppressor Protein p53 ; EZH2 protein, human (EC 2.1.1.43) ; Enhancer of Zeste Homolog 2 Protein (EC 2.1.1.43)
    Language English
    Publishing date 2018-03-09
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1473273-7
    ISSN 1533-4058 ; 1062-3345 ; 1541-2016
    ISSN (online) 1533-4058
    ISSN 1062-3345 ; 1541-2016
    DOI 10.1097/PAI.0000000000000647
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3783: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

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