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  1. Article ; Online: Making HTLV-1 and those affected visible.

    Rosadas, Carolina

    Nature microbiology

    2024  Volume 9, Issue 4, Page(s) 880–881

    MeSH term(s) Human T-lymphotropic virus 1/genetics ; Humans ; HTLV-I Infections
    Language English
    Publishing date 2024-04-04
    Publishing country England
    Document type Journal Article
    ISSN 2058-5276
    ISSN (online) 2058-5276
    DOI 10.1038/s41564-024-01652-7
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: HTLV infection and cessation of breastfeeding: context and challenges in implementing universal prevention policies in Brazil.

    Rosadas, Carolina / Miranda, Angélica Espinosa

    Epidemiologia e servicos de saude : revista do Sistema Unico de Saude do Brasil

    2023  Volume 32, Issue 2, Page(s) e2023565

    MeSH term(s) Humans ; Female ; Brazil ; Breast Feeding ; Deltaretrovirus Infections
    Language Portuguese
    Publishing date 2023-09-18
    Publishing country Brazil
    Document type Journal Article
    ZDB-ID 2880588-4
    ISSN 2237-9622 ; 1679-4974
    ISSN (online) 2237-9622
    ISSN 1679-4974
    DOI 10.1590/S2237-96222023000200025
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  3. Article ; Online: Pre-analytical long-term stability of neopterin and neurofilament light in stored cerebrospinal fluid samples.

    Rosadas, Carolina / Taylor, Graham P

    Clinical chemistry and laboratory medicine

    2023  Volume 61, Issue 7, Page(s) 1230–1234

    Abstract: Objectives: The aim of this study was to evaluate the impact of long-term sample storage on the concentrations of neopterin and neurofilament light (Nfl) in cerebrospinal fluid (CSF) samples. These are useful markers of neuroinflammation and neuronal ... ...

    Abstract Objectives: The aim of this study was to evaluate the impact of long-term sample storage on the concentrations of neopterin and neurofilament light (Nfl) in cerebrospinal fluid (CSF) samples. These are useful markers of neuroinflammation and neuronal damage and have been applied as biomarkers for several neurological diseases. However, different pre-analytical variables have potential to influence results.
    Methods: Twenty-one CSF samples donated by patients with HTLV-1-associated myelopathy (HAM) and stored for up to 11 years at -80 °C were retested after three-years for neopterin (n=10) and Nfl (n=11) by ELISA.
    Results: There was a strong correlation between the paired results (r>0.98, p<0.0001). Neopterin concentrations (nmol/L) ranged from 12.4 to 64 initially and from 11.5 to 64.4 when retested, with means (SD) of 30 (18.4) 1st test and 33 (19.1) 2nd test. Nfl concentrations (pg/mL) ranged from 79.9 to 3,733 initially and from 86.3 to 3,332, when retested with means (SD) of 1,138 (1,272) 1st test and 1,009 (1,114) at re-test.
    Conclusions: Storing CSF samples at -80 °C appears not to impact the quantification of neopterin and Nfl allowing confidence in the reporting of archived samples.
    MeSH term(s) Humans ; Neopterin/cerebrospinal fluid ; Intermediate Filaments ; Enzyme-Linked Immunosorbent Assay ; Neurons ; Biomarkers/cerebrospinal fluid ; Neurofilament Proteins/analysis
    Chemical Substances Neopterin (670-65-5) ; Biomarkers ; Neurofilament Proteins
    Language English
    Publishing date 2023-01-25
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1418007-8
    ISSN 1437-4331 ; 1434-6621 ; 1437-8523
    ISSN (online) 1437-4331
    ISSN 1434-6621 ; 1437-8523
    DOI 10.1515/cclm-2022-0904
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    In stock of ZB MED Cologne/Königswinter

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    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
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  4. Article ; Online: Health inequities and HTLV-1.

    Rosadas, Carolina / Taylor, Graham P

    The Lancet. Microbe

    2022  Volume 3, Issue 3, Page(s) e164

    MeSH term(s) HTLV-I Infections/diagnosis ; Health Inequities ; Human T-lymphotropic virus 1 ; Humans
    Language English
    Publishing date 2022-01-05
    Publishing country England
    Document type Letter
    ISSN 2666-5247
    ISSN (online) 2666-5247
    DOI 10.1016/S2666-5247(21)00330-X
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  5. Article: HTLV-1 and Co-infections.

    Rosadas, Carolina / Taylor, Graham P

    Frontiers in medicine

    2022  Volume 9, Page(s) 812016

    Abstract: Human T lymphotropic virus type 1 (HTLV-1) is a retrovirus that causes lifelong T-cell infection in humans, impacting the host immune response. This virus causes a range of clinical manifestations, from inflammatory conditions, including neuronal damage ( ...

    Abstract Human T lymphotropic virus type 1 (HTLV-1) is a retrovirus that causes lifelong T-cell infection in humans, impacting the host immune response. This virus causes a range of clinical manifestations, from inflammatory conditions, including neuronal damage (HTLV-1 associated myelopathy, HAM) to life-threatening leukemia (adult T-cell leukemia, ATL). Human T lymphotropic virus type 1 is also associated with increased risk of all-cause mortality, but the mechanisms remain unclear. As a blood-borne and sexually transmitted infection (STI), HTLV-1 shares transmission routes to many other pathogens and although it has worldwide distribution, it affects mainly those in low- and middle-income tropical areas, where the prevalence of other infectious agents is high. These factors contribute to a high incidence of co-infections in people living with HTLV-1 (PLHTLV). This comprehensive review addresses the impact of HTLV-1 on several co-infections and vice-versa. There is evidence of higher rates of HTLV-1 infection in association with other blood borne (HCV, HBV) and sexually transmitted (Syphilis, Chlamydia, HPV, HSV) infections but whether this represents increased susceptibility or opportunity is unclear. Higher frequency of
    Language English
    Publishing date 2022-02-03
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2775999-4
    ISSN 2296-858X
    ISSN 2296-858X
    DOI 10.3389/fmed.2022.812016
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  6. Article: Current Interventions to Prevent HTLV-1 Mother-to-Child Transmission and Their Effectiveness: A Systematic Review and Meta-Analysis.

    Rosadas, Carolina / Taylor, Graham P

    Microorganisms

    2022  Volume 10, Issue 11

    Abstract: Human T lymphotropic virus 1 (HTLV-1) may be transmitted from mother to child and affects at least 5−10 million individuals worldwide, with severe consequences on health. Strategies to prevent transmission are important, as there is no treatment or ... ...

    Abstract Human T lymphotropic virus 1 (HTLV-1) may be transmitted from mother to child and affects at least 5−10 million individuals worldwide, with severe consequences on health. Strategies to prevent transmission are important, as there is no treatment or vaccine. This systematic review aimed to identify interventions to prevent HTLV-1 mother-to-child transmission and to determine their effectiveness. Exclusive formula feeding, short-term breastfeeding, use of freeze−thaw milk, milk pasteurization, maternal and infant antiretroviral drugs, caesarean section, early clamping of umbilical cord, screening of milk donors and avoidance of cross-breastfeeding were identified as possible strategies. Avoidance of breastfeeding is an intervention that prevents 85% of transmissions. This strategy is recommended in Japan, Brazil, Colombia, Canada, Chile, Uruguay, the USA and some regions of French Guyana. Whilst breastfeeding for <3 months does not increase the risk of transmission compared to exclusive formula-feeding, concerns remain regarding the limited number of studies outside Japan, and the lack of information on women having higher risk of HTLV-1 transmission and on the ability of women to discontinue breastfeeding. Additional interventions are plausible, but data on their effectiveness are limited. The acceptance of interventions is high. These findings may guide healthcare professionals and support policymakers in implementing policies to avoid HTLV-1 mother-to-child transmission.
    Language English
    Publishing date 2022-11-10
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2720891-6
    ISSN 2076-2607
    ISSN 2076-2607
    DOI 10.3390/microorganisms10112227
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  7. Article ; Online: How do socioeconomic determinants of health affect the likelihood of living with HTLV-1 globally? A systematic review with meta-analysis.

    Ramesh, Nydile / Cockbain, Beatrice / Taylor, Graham P / Rosadas, Carolina

    Frontiers in public health

    2024  Volume 12, Page(s) 1298308

    Abstract: Introduction: Human T Lymphotropic Virus type 1 (HTLV-1) is a neglected retrovirus associated with many clinical disorders, most notably Adult T-cell Leukemia/Lymphoma and HTLV-1-Associated Myelopathy (HAM). Found in endemic clusters across the world, ... ...

    Abstract Introduction: Human T Lymphotropic Virus type 1 (HTLV-1) is a neglected retrovirus associated with many clinical disorders, most notably Adult T-cell Leukemia/Lymphoma and HTLV-1-Associated Myelopathy (HAM). Found in endemic clusters across the world, high prevalence has been reported in minoritized groups who suffer from health inequities. This study investigates the association between HTLV-1 prevalence and the following socioeconomic determinants of health: education, income, and employment, which are markers of health inequity.
    Methods: A systematic review was conducted by searching the following databases: Ovid/Medline, Embase, Global Health Database, Web of Science, LILACS and SciELO. Primary studies in English, Spanish and Portuguese mentioning HTLV-1 and one of education, income and/or employment were included. A random-effects meta-analysis was performed, and odds ratios (OR) were calculated to determine the association between these socioeconomic determinants of health and HTLV-1 prevalence.
    Results: 42 studies were included. The likelihood of having HTLV-1 was higher in individuals with less than completed primary education compared to those who completed primary education (OR 1.86 [95% CI 1.34-2.57];
    Conclusion: Fewer years of schooling are associated with increased likelihood of contracting HTLV-1. Therefore, health promotion materials and public health policies regarding HTLV-1 must consider those with lower educational levels to effectively reduce disease transmission.
    Systematic review registration: https://www.crd.york.ac.uk/prospero/display_record.php?RecordID=335004, identifier (CRD42022335004).
    MeSH term(s) Humans ; Adult ; Human T-lymphotropic virus 1 ; HTLV-I Infections/epidemiology ; Paraparesis, Tropical Spastic/epidemiology ; Risk Factors ; Socioeconomic Factors
    Language English
    Publishing date 2024-01-24
    Publishing country Switzerland
    Document type Meta-Analysis ; Systematic Review
    ZDB-ID 2711781-9
    ISSN 2296-2565 ; 2296-2565
    ISSN (online) 2296-2565
    ISSN 2296-2565
    DOI 10.3389/fpubh.2024.1298308
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  8. Article ; Online: HTLV-1 as a contributing factor towards scabies and its systemic sequelae.

    Cockbain, Beatrice / Rosadas, Carolina / Taylor, Graham P

    Journal of global health

    2023  Volume 13, Page(s) 3057

    MeSH term(s) Humans ; Human T-lymphotropic virus 1 ; Scabies/complications
    Language English
    Publishing date 2023-11-03
    Publishing country Scotland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2741629-X
    ISSN 2047-2986 ; 2047-2986
    ISSN (online) 2047-2986
    ISSN 2047-2986
    DOI 10.7189/jogh.13.03057
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Health inequities and HTLV-1

    Carolina Rosadas / Graham P Taylor

    The Lancet Microbe, Vol 3, Iss 3, Pp e164- (2022)

    2022  

    Keywords Medicine (General) ; R5-920 ; Microbiology ; QR1-502
    Language English
    Publishing date 2022-03-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article ; Online: Current Interventions to Prevent HTLV-1 Mother-to-Child Transmission and Their Effectiveness

    Carolina Rosadas / Graham P. Taylor

    Microorganisms, Vol 10, Iss 2227, p

    A Systematic Review and Meta-Analysis

    2022  Volume 2227

    Abstract: Human T lymphotropic virus 1 (HTLV-1) may be transmitted from mother to child and affects at least 5–10 million individuals worldwide, with severe consequences on health. Strategies to prevent transmission are important, as there is no treatment or ... ...

    Abstract Human T lymphotropic virus 1 (HTLV-1) may be transmitted from mother to child and affects at least 5–10 million individuals worldwide, with severe consequences on health. Strategies to prevent transmission are important, as there is no treatment or vaccine. This systematic review aimed to identify interventions to prevent HTLV-1 mother-to-child transmission and to determine their effectiveness. Exclusive formula feeding, short-term breastfeeding, use of freeze–thaw milk, milk pasteurization, maternal and infant antiretroviral drugs, caesarean section, early clamping of umbilical cord, screening of milk donors and avoidance of cross-breastfeeding were identified as possible strategies. Avoidance of breastfeeding is an intervention that prevents 85% of transmissions. This strategy is recommended in Japan, Brazil, Colombia, Canada, Chile, Uruguay, the USA and some regions of French Guyana. Whilst breastfeeding for <3 months does not increase the risk of transmission compared to exclusive formula-feeding, concerns remain regarding the limited number of studies outside Japan, and the lack of information on women having higher risk of HTLV-1 transmission and on the ability of women to discontinue breastfeeding. Additional interventions are plausible, but data on their effectiveness are limited. The acceptance of interventions is high. These findings may guide healthcare professionals and support policymakers in implementing policies to avoid HTLV-1 mother-to-child transmission.
    Keywords HTLV ; mother-to-child transmission ; prevention ; public policies ; breastfeeding ; interventions ; Biology (General) ; QH301-705.5
    Subject code 360
    Language English
    Publishing date 2022-11-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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