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Article ; Online: METEOR Trial Reports on the Effect of Rosuvastatin on Progression of Carotid Intima-Media Thickness in Low-Risk Individuals with Subclinical Atherosclerosis.

Haddad, Rudy M / Ballantyne, Christie M

2010 Volume 38, Issue 2, Page(s) 180–182

Abstract: Practice pearl: The data from the METEOR trial show that asymptomatic low-risk patients treated with rosuvastatin have a reduction in progression of carotid intima-media thickness (CIMT) over 2 years versus placebo. ORIGINAL ARTICLE: Crouse JR 3rd, ... ...

Abstract	Practice pearl: The data from the METEOR trial show that asymptomatic low-risk patients treated with rosuvastatin have a reduction in progression of carotid intima-media thickness (CIMT) over 2 years versus placebo. ORIGINAL ARTICLE: Crouse JR 3rd, Raichlen JS, Riley WA, et al; METEOR Study Group. Effect of rosuvastatin on progression of carotid intima-media thickness in low-risk individuals with subclinical atherosclerosis: the METEOR Trial. JAMA. 2007;297(12):1344-1353.
MeSH term(s)	Atherosclerosis/drug therapy ; Carotid Arteries/drug effects ; Female ; Fluorobenzenes/therapeutic use ; Humans ; Hydroxymethylglutaryl-CoA Reductase Inhibitors/therapeutic use ; Male ; Pyrimidines/therapeutic use ; Sulfonamides/therapeutic use ; Tunica Intima/drug effects
Chemical Substances	Fluorobenzenes ; Hydroxymethylglutaryl-CoA Reductase Inhibitors ; Pyrimidines ; Sulfonamides
Language	English
Publishing date	2010-06-08
Publishing country	England
Document type	Journal Article ; Comment
ZDB-ID	753046-8
ISSN	2326-3660 ; 0091-3847
ISSN (online)	2326-3660
ISSN	0091-3847
DOI	10.3810/psm.2010.06.1797
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Article: Revision of the ant-eating spider genus Mallinus Simon, 1893 (Araneae, Zodariidae)

Haddad, Charles R / Henrard, Arnaud / Jocqué, Rudy

ZooKeys. 2019 Feb. 6, v. 822

2019

Abstract: The zodariine spider genus Mallinus Simon, 1893 is redescribed and diagnosed. The type species, M ... of both sexes of M. nitidiventris are described for the first time, based on recently collected material, and ... species, M. defectus Strand, 1906 from Tunisia, is considered a ‘species inquirenda’, as the type ...

Abstract	The zodariine spider genus Mallinus Simon, 1893 is redescribed and diagnosed. The type species, M. nitidiventris Simon, 1893 from South Africa, was originally described from subadult specimens. Adults of both sexes of M. nitidiventris are described for the first time, based on recently collected material, and the genus is rediagnosed, redescribed, and its relationships discussed. A single aberrant male specimen from Namibia is here described as a morphospecies, as it is presumed to only be superficially related. A second species, M. defectus Strand, 1906 from Tunisia, is considered a ‘species inquirenda’, as the type specimens could not be traced, but this species is in any case unlikely to be congeneric. The genus is one of 10 cases of a monotypic genus in the Zodariidae. Notes are provided on the biology of M. nitidiventris.
Keywords	Araneae ; males ; morphospecies ; spiders ; Namibia ; South Africa ; Tunisia
Language	English
Dates of publication	2019-0206
Size	p. 141-158.
Publishing place	Pensoft Publishers
Document type	Article
Note	NAL-light
ZDB-ID	2445640-8
ISSN	1313-2970 ; 1313-2989
ISSN (online)	1313-2970
ISSN	1313-2989
DOI	10.3897/zookeys.822.29835
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Article ; Online: Revision of the ant-eating spider genus Mallinus Simon, 1893 (Araneae, Zodariidae)

Charles R. Haddad / Arnaud Henrard / Rudy Jocqué

ZooKeys, Vol 822, Iss , Pp 141-

2019 Volume 158

Abstract	The zodariine spider genus Mallinus Simon, 1893 is redescribed and diagnosed. The type species, M. nitidiventris Simon, 1893 from South Africa, was originally described from subadult specimens. Adults of both sexes of M. nitidiventris are described for the first time, based on recently collected material, and the genus is rediagnosed, redescribed, and its relationships discussed. A single aberrant male specimen from Namibia is here described as a morphospecies, as it is presumed to only be superficially related. A second species, M. defectus Strand, 1906 from Tunisia, is considered a ‘species inquirenda’, as the type specimens could not be traced, but this species is in any case unlikely to be congeneric. The genus is one of 10 cases of a monotypic genus in the Zodariidae. Notes are provided on the biology of M. nitidiventris.
Keywords	Zoology ; QL1-991
Language	English
Publishing date	2019-02-01T00:00:00Z
Publisher	Pensoft Publishers
Document type	Article ; Online
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Article ; Online: Validation of a method to measure resident doctors' reflections on quality improvement.

Wittich, Christopher M / Beckman, Thomas J / Drefahl, Monica M / Mandrekar, Jayawant N / Reed, Darcy A / Krajicek, Bryan J / Haddad, Rudy M / McDonald, Furman S / Kolars, Joseph C / Thomas, Kris G

Medical education

2010 Volume 44, Issue 3, Page(s) 248–255

Abstract: Objectives: Resident reflection on the clinical learning environment is prerequisite to identifying quality improvement (QI) opportunities and demonstrating competence in practice-based learning. However, residents' abilities to reflect on QI ... ...

Abstract	Objectives: Resident reflection on the clinical learning environment is prerequisite to identifying quality improvement (QI) opportunities and demonstrating competence in practice-based learning. However, residents' abilities to reflect on QI opportunities are unknown. Therefore, we developed and determined the validity of the Mayo Evaluation of Reflection on Improvement Tool (MERIT) for assessing resident reflection on QI opportunities. Methods: The content of MERIT, which consists of 18 items structured on 4-point scales, was based on existing literature and input from national experts. Using MERIT, six faculty members rated 50 resident reflections. Factor analysis was used to examine the dimensionality of MERIT instrument scores. Inter-rater and internal consistency reliabilities were calculated. Results: Factor analysis revealed three factors (eigenvalue; number of items): Reflection on Personal Characteristics of QI (8.5; 7); Reflection on System Characteristics of QI (1.9; 6), and Problem of Merit (1.5; 5). Inter-rater reliability was very good (intraclass correlation coefficient range: 0.73-0.89). Internal consistency reliability was excellent (Cronbach's alpha 0.93 overall and 0.83-0.91 for factors). Item mean scores were highest for Problem of Merit (3.29) and lowest for Reflection on System Characteristics of QI (1.99). Conclusions: Validity evidence supports MERIT as a meaningful measure of resident reflection on QI opportunities. Our findings suggest that dimensions of resident reflection on QI opportunities may include personal, system and Problem of Merit factors. Additionally, residents may be more effective at reflecting on 'problems of merit' than personal and systems factors.
MeSH term(s)	Clinical Competence/standards ; Educational Measurement/methods ; Factor Analysis, Statistical ; Humans ; Internship and Residency/methods ; Internship and Residency/standards ; Quality Control ; Reproducibility of Results
Language	English
Publishing date	2010-03
Publishing country	England
Document type	Journal Article ; Validation Studies
ZDB-ID	195274-2
ISSN	1365-2923 ; 0308-0110
ISSN (online)	1365-2923
ISSN	0308-0110
DOI	10.1111/j.1365-2923.2009.03591.x
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Article: Testosterone use in men with sexual dysfunction: a systematic review and meta-analysis of randomized placebo-controlled trials.

Boloña, Enrique R / Uraga, Maria V / Haddad, Rudy M / Tracz, Michal J / Sideras, Kostandinos / Kennedy, Cassie C / Caples, Sean M / Erwin, Patricia J / Montori, Victor M

Mayo Clinic proceedings

2007 Volume 82, Issue 1, Page(s) 20–28

Abstract: Objective: To conduct a systematic review and meta-analysis of randomized placebo-controlled trials to measure the effect of testosterone use on sexual function in men with sexual dysfunction and varying testosterone levels.: Methods: Librarian- ... ...

Abstract	Objective: To conduct a systematic review and meta-analysis of randomized placebo-controlled trials to measure the effect of testosterone use on sexual function in men with sexual dysfunction and varying testosterone levels. Methods: Librarian-designed search strategies were used to search the MEDLINE (1966 to October 2004), EMBASE (1988 to October 2004), and Cochrane CENTRAL (inception to October 2004) databases. The MEDLINE search was rerun in March 2005. We also reviewed reference lists from included studies and content expert files. We selected randomized placebo-controlled trials of testosterone vs placebo that enrolled men with sexual dysfunction and measured satisfaction with erectile function and libido and overall sexual satisfaction. Results: We included 17 trials (N = 862 participants) in this review. Trials that enrolled participants with low testosterone levels showed (1) a moderate nonsignificant and inconsistent effect of testosterone use on satisfaction with erectile function (random-effects pooled effect size, 0.80; 95% confidence interval [CI], -0.10 to 1.60), (2) a large effect on libido (pooled effect size, 1.31; 95% CI, 0.40 to 2.25), and (3) no significant effect on overall sexual satisfaction. Trials that enrolled patients with low-normal and normal testosterone levels at baseline showed testosterone that caused (1) a small effect on satisfaction with erectile function (pooled effect size, 0.34; 95% CI, 0.03 to 0.65), (2) moderate nonsignificant effect on libido (pooled effect size, 0.41; 95% CI, -0.01 to 0.83), and (3) no significant effect on overall sexual satisfaction. Conclusion: Testosterone use in men is associated with small improvements in satisfaction with erectile function and moderate improvements in libido. Unexplained inconsistent results across trials, wide CIs, and possible reporting bias weaken these inferences.
MeSH term(s)	Androgens/therapeutic use ; Erectile Dysfunction/drug therapy ; Hormone Replacement Therapy ; Humans ; Libido/drug effects ; Male ; Randomized Controlled Trials as Topic ; Sexual Behavior/drug effects ; Testosterone/deficiency ; Testosterone/therapeutic use
Chemical Substances	Androgens ; Testosterone (3XMK78S47O)
Language	English
Publishing date	2007-01
Publishing country	England
Document type	Journal Article ; Meta-Analysis ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	124027-4
ISSN	1942-5546 ; 0025-6196
ISSN (online)	1942-5546
ISSN	0025-6196
DOI	10.4065/82.1.20
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Article: Testosterone and cardiovascular risk in men: a systematic review and meta-analysis of randomized placebo-controlled trials.

Haddad, Rudy M / Kennedy, Cassie C / Caples, Sean M / Tracz, Michal J / Boloña, Enrique R / Sideras, Kostandinos / Uraga, Maria V / Erwin, Patricia J / Montori, Victor M

Mayo Clinic proceedings

2007 Volume 82, Issue 1, Page(s) 29–39

Abstract: Objective: To conduct a systematic review and meta-analysis of randomized trials that assessed the effect of testosterone use on cardiovascular events and risk factors in men with different degrees of androgen deficiency.: Methods: Librarian-designed ...

Abstract	Objective: To conduct a systematic review and meta-analysis of randomized trials that assessed the effect of testosterone use on cardiovascular events and risk factors in men with different degrees of androgen deficiency. Methods: Librarian-designed search strategies were used to search the MEDLINE (1966 to October 2004), EMBASE (1988 to October 2004), and Cochrane CENTRAL (inception to October 2004) databases. The database search was performed again in March 2005. We also reviewed reference lists from included studies and content expert files. Eligible studies were randomized trials that compared any formulation of commercially available testosterone with placebo and that assessed cardiovascular risk factors (lipid fractions, blood pressure, blood glucose), cardiovascular events (cardiovascular death, nonfatal myocardial infarction, angina or claudication, revascularization, stroke), and cardiovascular surrogate end points (ie, laboratory tests indicative of cardiac or vascular disease). Using a standardized data extraction form, we collected data on participants, testosterone administration, and outcome measures. We assessed study quality with attention to allocation concealment, blinding, and loss to follow-up. Results: The 30 trials included 1642 men, 808 of whom were treated with testosterone. Overall, the trials had limited reporting of methodological features that prevent biased results (only 6 trials reported allocation concealment), enrolled few patients, and were of brief duration (only 4 trials followed up patients for > 1 year). The median loss to follow-up across all 30 trials was 9%. Testosterone use in men with low testosterone levels led to inconsequential changes in blood pressure and glycemia and in all lipid fractions (total cholesterol: odds ratio [OR], -0.22; 95% confidence interval [CI], -0.71 to 0.27; high-density lipoprotein cholesterol: OR, -0.04; 95% CI, -0.39 to 0.30; low-density lipoprotein cholesterol: OR, 0.06; 95% CI, -0.30 to 0.42; and triglycerides: OR, -0.27; 95% CI, -0.61 to 0.08); results were similar in patients with low-normal to normal testosterone levels. The OR between testosterone use and any cardiovascular event pooled across trials that reported these events (n = 6) was 1.82 (95% CI, 0.78 to 4.23). Several trials failed to report data on measured outcomes. For reasons we could not explain statistically, the results were inconsistent across trials. Conclusion: Currently available evidence weakly supports the inference that testosterone use in men is not associated with important cardiovascular effects. Patients and clinicians need large randomized trials of men at risk for cardiovascular disease to better inform the safety of long-term testosterone use.
MeSH term(s)	Androgens/adverse effects ; Androgens/therapeutic use ; Blood Glucose/drug effects ; Blood Pressure/drug effects ; Cardiovascular Diseases/epidemiology ; Cardiovascular Diseases/etiology ; Hormone Replacement Therapy/adverse effects ; Humans ; Lipids/blood ; Male ; Randomized Controlled Trials as Topic ; Testosterone/adverse effects ; Testosterone/deficiency ; Testosterone/therapeutic use
Chemical Substances	Androgens ; Blood Glucose ; Lipids ; Testosterone (3XMK78S47O)
Language	English
Publishing date	2007-01
Publishing country	England
Document type	Journal Article ; Meta-Analysis ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	124027-4
ISSN	1942-5546 ; 0025-6196
ISSN (online)	1942-5546
ISSN	0025-6196
DOI	10.4065/82.1.29
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Article: Testosterone use in men and its effects on bone health. A systematic review and meta-analysis of randomized placebo-controlled trials.

Tracz, Michal J / Sideras, Kostandinos / Boloña, Enrique R / Haddad, Rudy M / Kennedy, Cassie C / Uraga, Maria V / Caples, Sean M / Erwin, Patricia J / Montori, Victor M

The Journal of clinical endocrinology and metabolism

2006 Volume 91, Issue 6, Page(s) 2011–2016

Abstract: Context: Androgen-deficient men are at increased risk of osteoporosis. The extent to which testosterone can prevent and treat osteoporosis in men remains unclear.: Objective and design: We performed a systematic review and meta-analysis of randomized ...

Abstract	Context: Androgen-deficient men are at increased risk of osteoporosis. The extent to which testosterone can prevent and treat osteoporosis in men remains unclear. Objective and design: We performed a systematic review and meta-analysis of randomized placebo-controlled trials in men to estimate the effect of testosterone use on bone health outcomes. Data sources: The review encompassed librarian-designed search strategies using MEDLINE (1966 to March 2005), EMBASE (1988 to March 2005), and Cochrane CENTRAL (inception to March 2005); a review of reference lists from included studies; and content expert files. Data collection: Independently and in duplicate, we assessed the methodological quality of the eligible trials and collected data on bone mineral density and bone fractures at the longest point of complete follow-up. Data synthesis: We included eight trials enrolling 365 patients. Two trials followed patients for more than 1 yr. Meta-analysis of these trials showed that, compared with placebo, im testosterone was associated with an 8% (95% confidence interval, 4%, 13%) gain in lumbar bone mineral density and transdermal testosterone had no significant impact. Testosterone use was associated with a nonsignificant 4% (95% confidence interval, -2%, 9%) gain in femoral neck bone mineral density with unexplained differences in results across trials (26% of these differences were not explained by chance alone). No trials measured or reported the effect of testosterone on fractures. Conclusions: Intramuscular testosterone moderately increased lumbar bone density in men; the results on femoral neck bone density are inconclusive. Without bone fracture data, the available trials offer weak and indirect inferences about the clinical efficacy of testosterone on osteoporosis prevention and treatment in men.
MeSH term(s)	Bone Density/drug effects ; Glucocorticoids/adverse effects ; Humans ; Male ; Osteoporosis/prevention & control ; Randomized Controlled Trials as Topic ; Testosterone/administration & dosage ; Testosterone/blood ; Testosterone/therapeutic use
Chemical Substances	Glucocorticoids ; Testosterone (3XMK78S47O)
Language	English
Publishing date	2006-06
Publishing country	United States
Document type	Journal Article ; Meta-Analysis ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	3029-6
ISSN	1945-7197 ; 0021-972X
ISSN (online)	1945-7197
ISSN	0021-972X
DOI	10.1210/jc.2006-0036
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Article ; Online: The top 100 questions of importance to the future of global agriculture

Pretty, Jules N. / Sutherland, W.J. / Ashby, J.A. / Auburn, J. / Baulcombe, D.C. / Bell, M. / Bentley, J.W. / Bickersteth, S. / Brown, K. / Burke, J. / Campbell, H. / Chen, K. / Crowley, E.L. / Crute, I. / Dobbelaere, D.A.E. / Edwards-Jones, G. / Funes-Monzote, F. / Godfray, H.Charles J. / Griffon, M. /

Gypmantisiri, P. / Haddad, L. / Halavatau, S. / Herren, H. / Holderness, M. / Izac, A.M.N. / Jones, M. / Koohafkan, P. / Lal, R. / Lang, T. / McNeely, J. / Mueller, A. / Nisbett, N. / Noble, A.D. / Pingali, Prabhu L. / Pinto, Y. / Rabbinge, Rudy / Ravindranath, N.H. / Rola, A. / Roling, N. / Sage, C. / Settle, W. / Sha, J.M. / Shiming, L. / Simons, T. / Smith, Pete / Strzepek, K.M. / Swaine, H. / Terry, Eugene R. / Tomich, Thomas P. / Toulmin, C. / Trigo, Eduardo / Twomlow, Stephen / Vis, J.K. / Wilson, J. / Pilgrim, S.

2014

Abstract: Despite a significant growth in food production over the past half-century, one of the most important challenges facing society today is how to feed an expected population of some nine billion by the middle of the 20th century. To meet the expected ... ...

Abstract	Despite a significant growth in food production over the past half-century, one of the most important challenges facing society today is how to feed an expected population of some nine billion by the middle of the 20th century. To meet the expected demand for food without significant increases in prices, it has been estimated that we need to produce 70-100 per cent more food, in light of the growing impacts of climate change, concerns over energy security, regional dietary shifts and the Millennium Development target of halving world poverty and hunger by 2015. The goal for the agricultural sector is no longer simply to maximize productivity, but to optimize across a far more complex landscape of production, rural development, environmental, social justice and food consumption outcomes. However, there remain significant challenges to developing national and international policies that support the wide emergence of more sustainable forms of land use and efficient agricultural production. The lack of information flow between scientists, practitioners and policy makers is known to exacerbate the difficulties, despite increased emphasis upon evidence-based policy. In this paper, we seek to improve dialogue and understanding between agricultural research and policy by identifying the 100 most important questions for global agriculture. These have been compiled using a horizon-scanning approach with leading experts and representatives of major agricultural organizations worldwide. The aim is to use sound scientific evidence to inform decision making and guide policy makers in the future direction of agricultural research priorities and policy support. If addressed, we anticipate that these questions will have a significant impact on global agricultural practices worldwide, while improving the synergy between agricultural policy, practice and research. This research forms part of the UK Government's Foresight Global Food and Farming Futures project.
Keywords	farming ; food security ; agricultural policy ; agricultural research ; food consumption
Language	English
Publishing date	2014-06-13T14:47:52Z
Publisher	Informa UK Limited
Publishing country	fr
Document type	Article ; Online
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Article ; Online: Parkinson's disease mutations in PINK1 result in decreased Complex I activity and deficient synaptic function.

Morais, Vanessa A / Verstreken, Patrik / Roethig, Anne / Smet, Joél / Snellinx, An / Vanbrabant, Mieke / Haddad, Dominik / Frezza, Christian / Mandemakers, Wim / Vogt-Weisenhorn, Daniela / Van Coster, Rudy / Wurst, Wolfgang / Scorrano, Luca / De Strooper, Bart

EMBO molecular medicine

2010 Volume 1, Issue 2, Page(s) 99–111

Abstract: Mutations of the mitochondrial PTEN (phosphatase and tensin homologue)-induced kinase1 (PINK1) are important causes of recessive Parkinson disease (PD). Studies on loss of function and overexpression implicate PINK1 in apoptosis, abnormal mitochondrial ... ...

Abstract	Mutations of the mitochondrial PTEN (phosphatase and tensin homologue)-induced kinase1 (PINK1) are important causes of recessive Parkinson disease (PD). Studies on loss of function and overexpression implicate PINK1 in apoptosis, abnormal mitochondrial morphology, impaired dopamine release and motor deficits. However, the fundamental mechanism underlying these various phenotypes remains to be clarified. Using fruit fly and mouse models we show that PINK1 deficiency or clinical mutations impact on the function of Complex I of the mitochondrial respiratory chain, resulting in mitochondrial depolarization and increased sensitivity to apoptotic stress in mammalian cells and tissues. In Drosophila neurons, PINK1 deficiency affects synaptic function, as the reserve pool of synaptic vesicles is not mobilized during rapid stimulation. The fundamental importance of PINK1 for energy maintenance under increased demand is further corroborated as this deficit can be rescued by adding ATP to the synapse. The clinical relevance of our observations is demonstrated by the fact that human wild type PINK1, but not PINK1 containing clinical mutations, can rescue Complex 1 deficiency. Our work suggests that Complex I deficiency underlies, at least partially, the pathogenesis of this hereditary form of PD. As Complex I dysfunction is also implicated in sporadic PD, a convergence of genetic and environmental causes of PD on a similar mitochondrial molecular mechanism appears to emerge.
MeSH term(s)	Animals ; Apoptosis ; Drosophila Proteins/deficiency ; Drosophila Proteins/genetics ; Drosophila melanogaster/enzymology ; Electron Transport ; Electron Transport Complex I/metabolism ; Humans ; Membrane Potential, Mitochondrial/physiology ; Mice ; Mitochondria/enzymology ; Mitochondria/pathology ; Mitochondria/ultrastructure ; Mutation/genetics ; Parkinson Disease/enzymology ; Parkinson Disease/genetics ; Parkinson Disease/pathology ; Parkinson Disease/physiopathology ; Protein Kinases/deficiency ; Protein Kinases/genetics ; Protein-Serine-Threonine Kinases/deficiency ; Protein-Serine-Threonine Kinases/genetics ; Synapses/enzymology ; Synapses/pathology ; Synapses/ultrastructure ; Synaptic Transmission/physiology
Chemical Substances	Drosophila Proteins ; Protein Kinases (EC 2.7.-) ; PINK1 protein, Drosophila (EC 2.7.11.1) ; PTEN-induced putative kinase (EC 2.7.11.1) ; Protein-Serine-Threonine Kinases (EC 2.7.11.1) ; Electron Transport Complex I (EC 7.1.1.2)
Language	English
Publishing date	2010-01-05
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2467145-9
ISSN	1757-4684 ; 1757-4676
ISSN (online)	1757-4684
ISSN	1757-4676
DOI	10.1002/emmm.200900006
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