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Article: Training Physicians for the Next Decade: A new physician predicts the future.

Pellizzari, R

Canadian family physician Medecin de famille canadien

2011 Volume 36, Page(s) 1997–2001

Abstract: Growing evidence for the impact of social and economic determinants on the health of Canadians and on current mobidity and mortality trends indicates that graduating family medicine residents lack necessary skills. Current teaching practices and clinical ...

Abstract	Growing evidence for the impact of social and economic determinants on the health of Canadians and on current mobidity and mortality trends indicates that graduating family medicine residents lack necessary skills. Current teaching practices and clinical rotations are providing neither the context nor the critical tools that primary care providers in the 1990s will require to make a positive and lasting impact on health and disease prevention.
Language	English
Publishing date	2011-01-14
Publishing country	Canada
Document type	Journal Article
ZDB-ID	603565-6
ISSN	0008-350X
ISSN	0008-350X
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Article ; Online: Impact of Pregnancy on Papilledema and Vision Loss in Idiopathic Intracranial Hypertension Patients: A Chart Review and Case Series of 13 Patients.

Lambert-Cheatham, Nathan A / Nagia, Lina / Pasmanter, Nathaniel R / Pellizzari, Richard / Lee, Beom / Miller, Neysa J / Kaufman, David I

Journal of neuro-ophthalmology : the official journal of the North American Neuro-Ophthalmology Society

2023

Abstract: Background: Studies suggest that weight gain is a prominent risk factor for recurrence of papilledema in idiopathic intracranial hypertension (IIH). Given this information, the significant weight gain that occurs during pregnancy, and the fact that ... ...

Abstract	Background: Studies suggest that weight gain is a prominent risk factor for recurrence of papilledema in idiopathic intracranial hypertension (IIH). Given this information, the significant weight gain that occurs during pregnancy, and the fact that pharmacologic therapy is many times discontinued, raises concerns for worsening edema and vision loss. To examine the impact of pregnancy weight gain on IIH, a retrospective chart review of patients with IIH and pregnancy was performed. Compared with previous studies, we 1) quantified findings with optical coherence tomography (OCT) and Humphrey visual field (HVF) data, 2) Included baseline data before pregnancy, 3) determined excess pregnancy weight gain using body mass index-adjusted weight gain goals, and 4) correlated worsening in IIH symptoms with changes in papilledema. Methods: Charts were reviewed for patients with diagnoses of IIH who had at least 2 visits with neuro-ophthalmology during pregnancy. Thirteen patients met inclusion criteria. Data were compared from baseline visits before pregnancy, pregnancy visits, and postpregnancy visits. Results: Comparisons of HVF mean deviation (MD), OCT retinal nerve fiber layer (RNFL), and Max OCT RNFL during pregnancy were not significant compared with baseline ( P = 0.51, 0.41, and 0.25). Three patients were found to have increased papilledema during pregnancy (Max Avg OCT RNFL of 152.5, 129, and 123.5 μm) of which 2 developed new reproducible mild visual field defects (HVF ∆MD -1.78 and -4.49). All patients showed more than the 6% weight gain, typically observed in recurrent IIH. Eleven patients gained more than their weight from initial diagnosis. Eight patients had excess pregnancy weight gain. Six patients discontinued pharmacologic therapy for IIH. Conclusions: Weight gain seems to carry a lower risk in IIH patients when associated with pregnancy. This is suggested by the high rate of stable or even decreased disc edema in patients despite medication discontinuation and excess pregnancy weight gain. We postulate these findings may be related to changes in weight distribution or endocrine changes during pregnancy.
Language	English
Publishing date	2023-08-04
Publishing country	United States
Document type	Journal Article
ZDB-ID	1189901-3
ISSN	1536-5166 ; 1070-8022
ISSN (online)	1536-5166
ISSN	1070-8022
DOI	10.1097/WNO.0000000000001963
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Article ; Online: Appetite ratings and ghrelin concentrations in young adults after administration of a balanced meal. Does sex matter?

Leone, Alessandro / De Amicis, Ramona / Pellizzari, Marta / Bertoli, Simona / Ravella, Simone / Battezzati, Alberto

Biology of sex differences

2022 Volume 13, Issue 1, Page(s) 25

Abstract: Background: Sex-based differences in appetite ratings have been observed previously. Ghrelin is the only known orexigenic peptide hormone. Sex differences in postprandial ghrelin responses may underlie different perceptions of hunger and satiety, but ... ...

Abstract	Background: Sex-based differences in appetite ratings have been observed previously. Ghrelin is the only known orexigenic peptide hormone. Sex differences in postprandial ghrelin responses may underlie different perceptions of hunger and satiety, but results are conflicting. We conducted a parallel study to evaluate sex differences in postprandial appetite ratings and ghrelin concentration after administration of a physiological meal among students of University of Milan. Methods: Twenty-four healthy, normal weight volunteers (12 men and 12 women) aged 18-35 years were recruited. A balanced mixed meal meeting 40% of the estimated daily energy expenditure and providing 60% of calories from carbohydrates, 25% from lipids and 15% from protein was administrated. Sex differences in appetite ratings (satiety, hunger, fullness and desire to eat) and magnitude of ghrelin suppression during postprandial period (up to 180 min) were determined. Results: In the fasting state, men and women did not differ in appetite ratings and ghrelin concentrations. After feeding, women tended to reach peak of satiety earlier than men, who in turn reached the nadir of hunger later than women (median: 30 min, interquartile range (IQR): 1; 120 vs. 1 min, IQR 1; 1, p = 0.007). Ghrelin suppression was greater in women (median decremental AUC - 95, IQR - 122; - 66) than in men (median decremental AUC - 47, IQR - 87; - 31, p = 0.041). Conclusions: These findings suggest sex differences in the postprandial appetite regulation that might be important for nutritional strategy to prevent and treat obesity and eating disorders.
MeSH term(s)	Appetite ; Female ; Ghrelin ; Glucagon-Like Peptide 1 ; Humans ; Hunger ; Male ; Postprandial Period ; Young Adult
Chemical Substances	Ghrelin ; Glucagon-Like Peptide 1 (89750-14-1)
Language	English
Publishing date	2022-06-04
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2587352-0
ISSN	2042-6410 ; 2042-6410
ISSN (online)	2042-6410
ISSN	2042-6410
DOI	10.1186/s13293-022-00434-2
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Article ; Online: Ultra-Processed Food Consumption and Incidence of Obesity and Cardiometabolic Risk Factors in Adults: A Systematic Review of Prospective Studies.

Mambrini, Sara Paola / Menichetti, Francesca / Ravella, Simone / Pellizzari, Marta / De Amicis, Ramona / Foppiani, Andrea / Battezzati, Alberto / Bertoli, Simona / Leone, Alessandro

Nutrients

2023 Volume 15, Issue 11

Abstract: Ultra-processed foods (UPF) are energy-dense, nutritionally unbalanced products, low in fiber but high in saturated fat, salt, and sugar. Recently, UPF consumption has increased likewise the incidence of obesity and cardiometabolic diseases. To highlight ...

Abstract	Ultra-processed foods (UPF) are energy-dense, nutritionally unbalanced products, low in fiber but high in saturated fat, salt, and sugar. Recently, UPF consumption has increased likewise the incidence of obesity and cardiometabolic diseases. To highlight a possible relationship, we conducted a systematic review of prospective studies from PubMed and Web of Science investigating the association between UPF consumption and the incidence of obesity and cardiometabolic risk factors. Seventeen studies were selected. Eight evaluated the incidence of general and abdominal obesity, one the incidence of impaired fasting blood glucose, four the incidence of diabetes, two the incidence of dyslipidemia, and only one the incidence of metabolic syndrome. Studies' quality was assessed according to the Critical Appraisal Checklist for cohort studies proposed by the Joanna Briggs Institute. Substantial agreement emerged among the studies in defining UPF consumption as being associated with the incident risk of general and abdominal obesity. More limited was the evidence on cardiometabolic risk. Nevertheless, most studies reported that UPF consumption as being associated with an increased risk of hypertension, diabetes, and dyslipidemia. In conclusion, evidence supports the existence of a relationship between UPF consumption and the incidence of obesity and cardiometabolic risk. However, further longitudinal studies considering diet quality and changes over time are needed.
MeSH term(s)	Adult ; Humans ; Prospective Studies ; Food, Processed ; Obesity, Abdominal/complications ; Cardiometabolic Risk Factors ; Incidence ; Food Handling ; Fast Foods/adverse effects ; Obesity/epidemiology ; Obesity/etiology ; Diet/adverse effects ; Hypertension/complications
Language	English
Publishing date	2023-05-31
Publishing country	Switzerland
Document type	Systematic Review ; Journal Article ; Review
ZDB-ID	2518386-2
ISSN	2072-6643 ; 2072-6643
ISSN (online)	2072-6643
ISSN	2072-6643
DOI	10.3390/nu15112583
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Manufacturability of functionally graded porous β-Ti21S auxetic architected biomaterials produced by laser powder bed fusion: Comparison between 2D and 3D metrological characterization.

Emanuelli, Lorena / Jam, Alireza / du Plessis, Anton / Lora, Carlo / Biasi, Raffaele De / Benedetti, Matteo / Pellizzari, Massimo

International journal of bioprinting

2023 Volume 9, Issue 4, Page(s) 728

Abstract: Functionally graded porous structures (FGPSs) are attracting increasing interest in the manufacture of prostheses that benefit from lower stiffness and optimized pore size for osseointegration. In this work, we explore the possibility of employing FGPSs ... ...

Abstract	Functionally graded porous structures (FGPSs) are attracting increasing interest in the manufacture of prostheses that benefit from lower stiffness and optimized pore size for osseointegration. In this work, we explore the possibility of employing FGPSs with auxetic unit cells. Their negative Poisson's ratio was exploited to reduce the loss of connection between prosthesis and bone usually occurring in standard implant loaded under tension and therefore undergoing lateral shrinking. In addition, to further improve osseointegration and mitigate stress shielding effects, auxetic FGPSs were fabricated in this work using a novel β-Ti21S alloy characterized by a lower Young's modulus compared to traditional α + β Ti alloys. Specifically, two different auxetic FGPSs with aspect ratio equal to 1.5 and angle θ of 15° and 25° with a relative density (ρ
Language	English
Publishing date	2023-04-05
Publishing country	Singapore
Document type	Journal Article
ZDB-ID	2834694-4
ISSN	2424-8002 ; 2424-8002
ISSN (online)	2424-8002
ISSN	2424-8002
DOI	10.18063/ijb.728
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Article ; Online: Metrological characterization of porosity graded β-Ti21S triply periodic minimal surface cellular structure manufactured by laser powder bed fusion.

Emanuelli, Lorena / De Biasi, Raffaele / Fu, Huijuan / du Plessis, Anton / Lora, Carlo / Jam, Alireza / Benedetti, Matteo / Pellizzari, Massimo

International journal of bioprinting

2023 Volume 9, Issue 4, Page(s) 729

Abstract: The design of a functionally graded porous structure (FGPS) for use in prosthetic devices is crucial for meeting both mechanical and biological requirements. One of the most commonly used cellular structures in FGPS is the triply periodic minimal surface ...

Abstract	The design of a functionally graded porous structure (FGPS) for use in prosthetic devices is crucial for meeting both mechanical and biological requirements. One of the most commonly used cellular structures in FGPS is the triply periodic minimal surface (TPMS) structure due to its ability to be defined by implicit equations, which allows for smooth transitions between layers. This study evaluates the feasibility of using a novel β-Ti21S alloy to fabricate TPMS-based FGPS. This beta titanium alloy exhibits low elastic modulus (53 GPa) and good mechanical properties in as-built condition. Two TPMS FGPSs with relative density gradients of 0.17, 0.34, 0.50, 0.66, and 0.83 and unit cell sizes of 2.5 mm and 4 mm were designed and fabricated using laser powder bed fusion (LPBF). The as-manufactured structures were analyzed using scanning electron microscopy (SEM) and X-ray micro-computed tomography (μ-CT), and the results were compared to the design. The analysis revealed that the pore size and ligament thickness were undersized by less than 5%. Compression tests showed that the stabilized elastic modulus was 4.1 GPa for the TPMS with a 2.5 mm unit cell size and 10.7 GPa for the TPMS with a 4 mm unit cell size. A finite element simulation was performed to predict the specimen's elastic properties, and a lumped model based on lattice homogenized properties was proposed and its limitations were explored.
Language	English
Publishing date	2023-04-07
Publishing country	Singapore
Document type	Journal Article
ZDB-ID	2834694-4
ISSN	2424-8002 ; 2424-8002
ISSN (online)	2424-8002
ISSN	2424-8002
DOI	10.18063/ijb.729
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Article ; Online: A simple

Steiner, Katrina / Bermel, Wolfgang / Soong, Ronald / Lysak, Daniel H / Jenne, Amy / Downey, Katelyn / Wolff, William W / Costa, Peter M / Ronda, Kiera / Moxley-Paquette, Vincent / Pellizzari, Jacob / Simpson, Andre J

Journal of magnetic resonance (San Diego, Calif. : 1997)

2024 Volume 361, Page(s) 107653

Abstract: Nuclear magnetic resonance (NMR) ... ...

Abstract	Nuclear magnetic resonance (NMR) based
MeSH term(s)	Protons ; Magnetic Resonance Spectroscopy/methods ; Isotopes ; Complex Mixtures ; Lipids
Chemical Substances	Protons ; Isotopes ; Complex Mixtures ; Lipids
Language	English
Publishing date	2024-02-29
Publishing country	United States
Document type	Journal Article
ZDB-ID	1469665-4
ISSN	1096-0856 ; 1557-8968 ; 1090-7807 ; 0022-2364
ISSN (online)	1096-0856 ; 1557-8968
ISSN	1090-7807 ; 0022-2364
DOI	10.1016/j.jmr.2024.107653
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Article ; Online: Slice through the water-Exploring the fundamental challenge of water suppression for benchtop NMR systems.

Pellizzari, Jacob / Soong, Ronald / Downey, Katelyn / Biswas, Rajshree Ghosh / Kock, Flavio C / Steiner, Katrina / Goerling, Benjamin / Haber, Agnes / Decker, Venita / Busse, Falko / Simpson, Myrna / Simpson, Andre

Magnetic resonance in chemistry : MRC

2024 Volume 62, Issue 6, Page(s) 463–473

Abstract: Benchtop NMR provides improved accessibility in terms of cost, space, and technical expertise. In turn, this encourages new users into the field of NMR spectroscopy. Unfortunately, many interesting samples in education and research, from beer to whole ... ...

Abstract	Benchtop NMR provides improved accessibility in terms of cost, space, and technical expertise. In turn, this encourages new users into the field of NMR spectroscopy. Unfortunately, many interesting samples in education and research, from beer to whole blood, contain significant amounts of water that require suppression in
Language	English
Publishing date	2024-01-28
Publishing country	England
Document type	Journal Article
ZDB-ID	1475029-6
ISSN	1097-458X ; 0749-1581
ISSN (online)	1097-458X
ISSN	0749-1581
DOI	10.1002/mrc.5431
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Article ; Online: Stigma in Early-Stage Lung Cancer.

Bédard, Sarah / Sasewich, Hannah / Culling, Jessica / Turner, Simon R / Pellizzari, Janelle / Johnson, Scott / Bédard, Eric L R

Annals of behavioral medicine : a publication of the Society of Behavioral Medicine

2022 Volume 56, Issue 12, Page(s) 1272–1283

Abstract: Background: The phenomenon of lung cancer stigma has been firmly established in the literature. However, studies have predominantly focused on patients with advanced disease, whose experiences may differ from patients with earlier stage, surgically ... ...

Abstract	Background: The phenomenon of lung cancer stigma has been firmly established in the literature. However, studies have predominantly focused on patients with advanced disease, whose experiences may differ from patients with earlier stage, surgically resectable lung cancer and an improved prognosis. Purpose: The objective of the study was to examine the stigma experienced in a Canadian population with early-stage, resectable lung cancer. Methods: Patients with newly diagnosed lung cancer were enrolled at a tertiary thoracic surgery clinic. The 25-item Lung Cancer Stigma Inventory (LCSI) was self-administered by patients to quantitatively measure experiences of lung cancer stigma. LCSI results informed the development of a semi-structured focus group and individual interviews. Results: Of the 53 participants completing the survey, 38 (72%) met established LCSI score threshold, indicating a clinically meaningful level of stigma. No significant relationship was found between total LCSI scores and any demographic variable. Analysis of qualitative data revealed multiple themes related to experiences of lung cancer stigma. The major themes were classified into four categories: impact of the association between lung cancer and smoking, societal attitudes and assumptions, personal choices in relation to diagnosis, and experiences related to care. Conclusions: A surgical population of patients with predominantly early-stage lung cancer experienced lung cancer stigma at a high incidence and a level similar to previously studied populations with more advanced disease. The qualitative results support the quantitative findings that respondents experienced more internal stigma than either perceived stigma from others or constrained disclosure related to their diagnosis.
MeSH term(s)	Humans ; Canada ; Social Stigma ; Smoking ; Surveys and Questionnaires ; Lung Neoplasms
Language	English
Publishing date	2022-06-15
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	632630-4
ISSN	1532-4796 ; 0883-6612
ISSN (online)	1532-4796
ISSN	0883-6612
DOI	10.1093/abm/kaac021
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Article ; Online: Cancers of Unknown Primary Origin: Real-World Clinical Outcomes and Genomic Analysis at the European Institute of Oncology.

Boscolo Bielo, Luca / Belli, Carmen / Crimini, Edoardo / Repetto, Matteo / Ascione, Liliana / Pellizzari, Gloria / Santoro, Celeste / Fuorivia, Valeria / Barberis, Massimo / Fusco, Nicola / Rocco, Elena Guerini / Curigliano, Giuseppe

The oncologist

2024

Abstract: ... Statistical analyses were conducted with R Software 4.2.2.: Results: A total of 44 patients were included ...

Abstract	Background: Cancer of unknown primary origin (CUP) poses a significant challenge due to poor clinical outcomes and limited treatment options. As such, further definition of clinicopathological factors and genomic profile to better adapt treatment strategies is required. Methods: Medical records were interrogated to retrospectively include CUP with available clinical and genomics data at the European Institute of Oncology. Next-generation sequencing (NGS) included targeted panels. Statistical analyses were conducted with R Software 4.2.2. Results: A total of 44 patients were included. With a median follow-up of 39.46 months (interquartile range [IQR] 35.98-47.41 months), median PFS (mPFS) to first-line regimen was 3.98 months (95% CI 3.22-5.98), with a clinical benefit rate of 26% (95% CI 14%-49%), and disease control rate (DCR) limited to 48.28%. Most patients (26 of 31, 83.87%) received platinum-doublet chemotherapy, with no statistically significant difference between first-line treatment regimens. Median OS (mOS) was 18.8 months (95% CI 12.3-39.9), with a 12-month OS rate of 66% (95% CI 50%-85%). All patients received comprehensive genomic profiling (CGP). For 11 patients, NGS was unsuccessful due to low sample quantity and/or quality. For the remaining, TP53 (n = 16, 48%) and KRAS (n = 10, 30%) represented the most altered (alt) genes. No microsatellite instability was observed (0 of 28), while 6 of 28 (21.43%) tumors carried high TMB (≥10 mutation per megabase). Eight of 33 tumors (24.2%) displayed at least one actionable alteration with potential clinical benefit according to ESCAT. Only 2 of them received targeted therapy matched to genomic alterations, with a combined mPFS of 2.63 months (95% CI 1.84-not evaluable) as third-line regimens. Six patients received anti-PD1/PD-L1 therapy, showing a meaningful mPFS of 13 months (95% CI 2.04-not evaluable). Conclusion: CUP exhibits poor prognosis with limited benefits from standard treatment regimens. A significant proportion of CUPs carry actionable alterations, underscoring the importance of genomic profiling to gather additional treatment opportunities. In addition, immunotherapy might represent a valuable treatment option for a subset of CUP. Finally, accurate definition of sequencing methods and platforms is crucial to overcome NGS failures.
Language	English
Publishing date	2024-03-23
Publishing country	England
Document type	Journal Article
ZDB-ID	1409038-7
ISSN	1549-490X ; 1083-7159
ISSN (online)	1549-490X
ISSN	1083-7159
DOI	10.1093/oncolo/oyae038
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