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Artikel ; Online: Exploring colorant production by amazonian filamentous fungi: Stability and applications.

Oliveira, Luciana A / Sanches, Michele A / Segundo, Walter O P F / Santiago, Paulo A L / Lima, Rodrigo Q / Cortez, Ana C A / Souza, Érica S / Lima, Maria P / Lima, Emerson S / Koolen, Hector H F / Dufossé, Laurent / Souza, João V B

Journal of basic microbiology

2023 Band 64, Heft 2, Seite(n) e2300444

Abstract: The aim of this study was to investigate the production, stability and applicability of colorants produced by filamentous fungi isolated from soil samples from the Amazon. Initially, the isolates were evaluated in a screening for the production of ... ...

Abstract	The aim of this study was to investigate the production, stability and applicability of colorants produced by filamentous fungi isolated from soil samples from the Amazon. Initially, the isolates were evaluated in a screening for the production of colorants. The influences of cultivation and nutritional conditions on the production of colorants by fungal isolates were investigated. The colorants produced by selected fungal isolates were chemically characterized using the Liquid Chromatography-Mass Spectrometry technique. The antimicrobial and cytotoxic activities, stability evaluation and applicability of the colorants were investigated. As results, we observed that the isolates Penicillium sclerotiorum P3SO224, Clonostachys rosea P2SO329 and Penicillium gravinicasei P3SO332 stood out since they produced the most intense colorants. Compounds produced by Penicillium sclerotiorum P3SO224 and Clonostachys rosea P2SO329 were identified as sclerotiorin and penicillic acid. The colorant fraction (EtOAc) produced by these species has antimicrobial activity, stability at temperature and at different pHs, stability when exposure to light and UV, and when exposed to different concentrations of salts, as well as being nontoxic and having the ability to dye fabrics and be used as a pigment in creams and soap. Considering the results found in this study, it was concluded that fungi from the soil in the Amazon have the potential to produce colorants with applications in the textile and pharmaceutical industries.
Mesh-Begriff(e)	Pigments, Biological/chemistry ; Fungi/chemistry ; Hypocreales ; Anti-Infective Agents ; Soil ; Penicillium
Chemische Substanzen	Pigments, Biological ; Anti-Infective Agents ; Soil
Sprache	Englisch
Erscheinungsdatum	2023-12-05
Erscheinungsland	Germany
Dokumenttyp	Journal Article
ZDB-ID	632513-0
ISSN	1521-4028 ; 0233-111X
ISSN (online)	1521-4028
ISSN	0233-111X
DOI	10.1002/jobm.202300444
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel: Synthesis and Inhibition Evaluation of New Benzyltetrahydroprotoberberine Alkaloids Designed as Acetylcholinesterase Inhibitors.

de Lima, Bruna R / Lima, Juliana M / Maciel, Jéssica B / Valentim, Carolina Q / Nunomura, Rita de Cássia S / Lima, Emerson S / Koolen, Hector H F / de Souza, Afonso Duarte L / Pinheiro, Maria Lúcia B / Cass, Quezia B / da Silva, Felipe Moura A

Frontiers in chemistry

2019 Band 7, Seite(n) 629

Abstract: Secondary metabolites from natural products are a potential source of acetylcholinesterase inhibitors (AChEIs), which is a key enzyme in the treatment of many neurodegenerative diseases. Inspired by the reported activities of isoquinoline-derivative ... ...

Abstract	Secondary metabolites from natural products are a potential source of acetylcholinesterase inhibitors (AChEIs), which is a key enzyme in the treatment of many neurodegenerative diseases. Inspired by the reported activities of isoquinoline-derivative alkaloids herein we report the design, one step synthesis and evaluation by capillary enzyme reactor (ICER) of benzyl analogs (
Sprache	Englisch
Erscheinungsdatum	2019-09-18
Erscheinungsland	Switzerland
Dokumenttyp	Journal Article
ZDB-ID	2711776-5
ISSN	2296-2646
ISSN	2296-2646
DOI	10.3389/fchem.2019.00629
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel: Chalcogenylation of Naphthalene Derivatives Catalyzed by Iron(III) Chloride and Potassium Iodide

Seckler, Diego / da Luz, Eduardo Q. da / Silvério, Gabriel L. / Badshah, Gul / Lima, David B. / Abreu, Emerson A. / Albach, Breidi / Ribeiro, Ronny R. / Rampon, Daniel S.

Synlett

2021 Band 32, Heft 09, Seite(n) 940–946

Abstract: We have developed an efficient chalcogenylation of electron-rich naphthalene derivatives catalyzed by FeCl 3 and KI. The methodology provides access to several nonsymmetrical diorganoyl chalcogenides (S, Se) by selective C1 chalcogenylation of 2- ... ...

Abstract	We have developed an efficient chalcogenylation of electron-rich naphthalene derivatives catalyzed by FeCl 3 and KI. The methodology provides access to several nonsymmetrical diorganoyl chalcogenides (S, Se) by selective C1 chalcogenylation of 2-naphthols or 2-naphthylamines using simple and cheap catalysts. Several control experiments supported the hypothesis that a redox reaction between Fe(III) and KI produces I 2, which catalyzed the chalcogenylation.
Schlagwörter	iron catalysis ; potassium iodide catalysis ; sulfanylation ; selenylation ; naphthylamines ; naphthols
Sprache	Englisch
Erscheinungsdatum	2021-04-01
Verlag	Georg Thieme Verlag KG
Erscheinungsort	Stuttgart ; New York
Dokumenttyp	Artikel
ZDB-ID	2042012-2
ISSN	1437-2096 ; 0936-5214
ISSN (online)	1437-2096
ISSN	0936-5214
DOI	10.1055/s-0040-1706748
Datenquelle	Thieme Verlag

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Artikel: Viral hemorrhagic fever-induced acute kidney injury.

Lima, Emerson Q / Nogueira, Mauricio L

Seminars in nephrology

2008 Band 28, Heft 4, Seite(n) 409–415

Abstract: Viral hemorrhagic fevers (VHFs) are diseases caused by the RNA virus from 4 different families (Flaviridiae, Arenaviridae, Bunyaviridae, and Filoviridae) that are acquired through the bite of an infected arthropod or by the inhalation of particles of ... ...

Abstract	Viral hemorrhagic fevers (VHFs) are diseases caused by the RNA virus from 4 different families (Flaviridiae, Arenaviridae, Bunyaviridae, and Filoviridae) that are acquired through the bite of an infected arthropod or by the inhalation of particles of rodent excreta. Among the VHFs, dengue and yellow fever are the most prevalent in tropical regions worldwide. The clinical presentation is characterized by fever, malaise, increased vascular permeability, and coagulation defects that can result in bleeding. Acute kidney injury is an uncommon complication but renal dysfunction has been associated with various VHFs. In this article we review the renal manifestations of dengue and yellow fever infections.
Mesh-Begriff(e)	Acute Kidney Injury/etiology ; Acute Kidney Injury/physiopathology ; Hemorrhagic Fever with Renal Syndrome/physiopathology ; Humans ; Severe Dengue/physiopathology ; Yellow Fever/physiopathology
Sprache	Englisch
Erscheinungsdatum	2008-05-24
Erscheinungsland	United States
Dokumenttyp	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	604652-6
ISSN	1558-4488 ; 0270-9295
ISSN (online)	1558-4488
ISSN	0270-9295
DOI	10.1016/j.semnephrol.2008.04.009
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Renal biopsies in acute kidney injury: who are we missing?

Stillman, Isaac E / Lima, Emerson Q / Burdmann, Emmanuel A

Clinical journal of the American Society of Nephrology : CJASN

2008 Band 3, Heft 3, Seite(n) 647–648

Mesh-Begriff(e)	Acute Kidney Injury/epidemiology ; Acute Kidney Injury/etiology ; Acute Kidney Injury/pathology ; Age Distribution ; Biopsy ; Glomerulonephritis/complications ; Glomerulonephritis/pathology ; Humans ; Kidney/pathology ; Nephritis, Interstitial/complications ; Nephritis, Interstitial/pathology ; Prevalence ; Registries ; Spain/epidemiology ; Time Factors ; Vasculitis/complications ; Vasculitis/pathology
Sprache	Englisch
Erscheinungsdatum	2008-05
Erscheinungsland	United States
Dokumenttyp	Comment ; Editorial ; Research Support, Non-U.S. Gov't
ZDB-ID	2226665-3
ISSN	1555-905X ; 1555-9041
ISSN (online)	1555-905X
ISSN	1555-9041
DOI	10.2215/CJN.01110308
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Synthesis and Inhibition Evaluation of New Benzyltetrahydroprotoberberine Alkaloids Designed as Acetylcholinesterase Inhibitors

Bruna R. de Lima / Juliana M. Lima / Jéssica B. Maciel / Carolina Q. Valentim / Rita de Cássia S. Nunomura / Emerson S. Lima / Hector H. F. Koolen / Afonso Duarte L de Souza / Maria Lúcia B. Pinheiro / Quezia B. Cass / Felipe Moura A. da Silva

Frontiers in Chemistry, Vol

2019 Band 7

Abstract	Secondary metabolites from natural products are a potential source of acetylcholinesterase inhibitors (AChEIs), which is a key enzyme in the treatment of many neurodegenerative diseases. Inspired by the reported activities of isoquinoline-derivative alkaloids herein we report the design, one step synthesis and evaluation by capillary enzyme reactor (ICER) of benzyl analogs (1a–1e) of the tetrahydroprotoberberine alkaloid stepholidine, which is abundant in Onychopetalum amazonicum. Docking analysis based on the crystal structure of Torpedo californica AChE (TcAChE) indicated that π-π interactions were dominant in all planned derivatives and that the residues from esteratic, anionic and peripheral subsites of the enzyme played key interaction roles. Due to the similarities observed when compared with galantamine in the AChE complex, the results suggest that ligand-target interactions would increase, especially for the N-benzyl derivatives. From a series of synthesized compounds, the alkaloids (7R,13aS)-7-benzylstepholidine (1a), (7S,13aS)-7-benzylstepholidine (1b), and (S)-10-O-benzylstepholidine (1d) are reported here for the first time. The on flow bioaffinity chromatography inhibition assay, based on the quantification of choline, revealed the N-benzylated compound 1a and its epimer 1b to be the most active, with IC50 of 40.6 ± 1 and 51.9 ± 1 μM, respectively, and a non-competitive mechanism. The proposed approach, which is based on molecular docking and bioaffinity chromatography, demonstrated the usefulness of stepholidine as a template for the design of rational AChEIs and showed how the target-alkaloid derivatives interact with AChE.
Schlagwörter	bioaffinity chromatography ; molecular docking ; on-flow assay ; Onychopetalum amazonicum ; stepholidine derivatives ; Chemistry ; QD1-999
Thema/Rubrik (Code)	540
Sprache	Englisch
Erscheinungsdatum	2019-09-01T00:00:00Z
Verlag	Frontiers Media S.A.
Dokumenttyp	Artikel ; Online
Datenquelle	BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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Artikel ; Online: Prevention of intradialytic hypotension in patients with acute kidney injury submitted to sustained low-efficiency dialysis.

Lima, Emerson Q / Silva, Ricardo G / Donadi, Endrigo L S / Fernandes, Alex B / Zanon, Jeferson R / Pinto, Klinger R D / Burdmann, Emmanuel A

Renal failure

2012 Band 34, Heft 10, Seite(n) 1238–1243

Abstract: Objectives: This study evaluated the effects of a protocol aiming to reduce hypotension in acute kidney injury (AKI) patients submitted to sustained low-efficiency dialysis (SLED).: Methods: Patients were randomly assigned to two SLED prescriptions- ... ...

Abstract	Objectives: This study evaluated the effects of a protocol aiming to reduce hypotension in acute kidney injury (AKI) patients submitted to sustained low-efficiency dialysis (SLED). Methods: Patients were randomly assigned to two SLED prescriptions-control group, dialysate temperature was 37.0°C with a fixed sodium concentration [138 mEq/L] and ultrafiltration (UF) rate; and profiling group, dialysate temperature was 35.5°C with a variable sodium concentration [150-138 mEq/L] and UF rate. Results: Sixty-two SLED sessions were evaluated (34 in profiling and 28 in control). Patients (n = 31) were similar in terms of gender, age, and Sequential Organ Failure Assessment (SOFA) score. Dialysis time, dialysis dose, and post-dialysis serum sodium were similar in both groups. The profiling group had significantly less hypotension episodes (23% vs. 57% in control, p = 0.009) and achieved higher UF volume (2.23 ± 1.25 L vs. 1.59 ± 1.03 L in control, p = 0.04) when compared with control group. Conclusions: SLED protocol with modulation of dialysate temperature, sodium, and UF profiling showed similar efficacy but less intradialytic hypotension when compared with a standard SLED prescription.
Mesh-Begriff(e)	Acute Kidney Injury/therapy ; Female ; Humans ; Hypotension/etiology ; Hypotension/prevention & control ; Male ; Middle Aged ; Renal Dialysis/adverse effects ; Renal Dialysis/methods
Sprache	Englisch
Erscheinungsdatum	2012
Erscheinungsland	England
Dokumenttyp	Journal Article ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't
ZDB-ID	632949-4
ISSN	1525-6049 ; 0886-022X
ISSN (online)	1525-6049
ISSN	0886-022X
DOI	10.3109/0886022X.2012.723581
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel: Severe hypernatraemia (221 mEq/l), rhabdomyolysis and acute renal failure after cerebral aneurysm surgery.

Lima, Emerson Q / Aguiar, Filipe C / Barbosa, Daniela M / Burdmann, Emmanuel A

Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association

2004 Band 19, Heft 8, Seite(n) 2126–2129

Mesh-Begriff(e)	Acute Kidney Injury/etiology ; Comorbidity ; Diabetes Insipidus, Neurogenic/epidemiology ; Humans ; Hypernatremia/etiology ; Hypernatremia/therapy ; Intracranial Aneurysm/surgery ; Male ; Middle Aged ; Postoperative Complications/therapy ; Rhabdomyolysis/etiology ; Thirst
Sprache	Englisch
Erscheinungsdatum	2004-08
Erscheinungsland	England
Dokumenttyp	Case Reports ; Journal Article
ZDB-ID	90594-x
ISSN	1460-2385 ; 0931-0509
ISSN (online)	1460-2385
ISSN	0931-0509
DOI	10.1093/ndt/gfh324
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel: Tetanus-induced acute kidney injury in a renal transplant recipient.

Lima, Emerson Q / Silva, Ricardo G / Fernandes, Ida M M / Abbud-Filho, Mário / Burdmann, Emmanuel A

The American journal of tropical medicine and hygiene

2007 Band 77, Heft 2, Seite(n) 400–402

Abstract: A 48-year-old renal transplant recipient who developed tetanus 6 years after transplantation is described. His immunosuppressive protocol was mofetil mycophenolate, sirolimus, and prednisone. The patient presented symptoms of severe tetanus with ... ...

Abstract	A 48-year-old renal transplant recipient who developed tetanus 6 years after transplantation is described. His immunosuppressive protocol was mofetil mycophenolate, sirolimus, and prednisone. The patient presented symptoms of severe tetanus with autonomic dysfunction, requiring ICU care and mechanical ventilation. His clinical course was marked by development of tetanus-induced acute kidney injury and sepsis. He was discharged after 37 days of hospitalization with recovered renal function. Tetanus is a preventable disease associated with a high fatality rate. Its treatment is difficult and requires specialized and intensive care. This case highlights the crucial importance of following adequate immunization guidelines in transplant recipients.
Mesh-Begriff(e)	Acute Kidney Injury/microbiology ; Acute Kidney Injury/therapy ; Anti-Bacterial Agents/therapeutic use ; Clostridium tetani/growth & development ; Humans ; Kidney Transplantation ; Male ; Middle Aged ; Respiration, Artificial ; Tetanus/complications ; Tetanus/microbiology ; Tetanus/therapy ; Tetanus Toxoid/therapeutic use
Chemische Substanzen	Anti-Bacterial Agents ; Tetanus Toxoid
Sprache	Englisch
Erscheinungsdatum	2007-08
Erscheinungsland	United States
Dokumenttyp	Case Reports ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2942-7
ISSN	1476-1645 ; 0002-9637
ISSN (online)	1476-1645
ISSN	0002-9637
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Low insulin-like growth factor-1 and hypocholesterolemia as mortality predictors in acute kidney injury in the intensive care unit.

Guimarães, Sérgio M / Lima, Emerson Q / Cipullo, José P / Lobo, Suzana M / Burdmann, Emmanuel A

Critical care medicine

2008 Band 36, Heft 12, Seite(n) 3165–3170

Abstract: Objective: To assess the role of insulin-like growth factor-1 and cholesterol as predictors of acute kidney injury mortality in intensive care unit patients.: Design: Prospective cohort study.: Setting: Multidisciplinary adult intensive care unit ( ...

Abstract	Objective: To assess the role of insulin-like growth factor-1 and cholesterol as predictors of acute kidney injury mortality in intensive care unit patients. Design: Prospective cohort study. Setting: Multidisciplinary adult intensive care unit (24 beds). Patients: Adult patients with acute kidney injury at intensive care unit admission for an 11-month period were considered and a total of 56 patients were admitted in the study. Interventions: None. Measurements and main results: At intensive care unit admission serum insulin-like growth factor-1 (ng/mL), total cholesterol (mg/dL), albumin (g/dL), transferrin (mg/dL), total lymphocyte count, triceps skinfold thickness, arm muscle area, and Subjective Global Nutritional Assessment were evaluated. Insulin-like growth factor-1 was significantly lower in nonsurviving as compared with surviving patients (48.5 +/- 24.4 vs. 70.8 +/- 39.9; p = 0.044), as well as cholesterol (80.3 +/- 35.7 vs. 147.4 +/- 53.1; p < 0.001) and albumin (1.9 +/- 0.4 vs. 2.4 +/- 0.7; p = 0.018). Groups were similar regarding transferrin, lymphocyte, triceps skinfold thickness, arm muscle area, and subjective global nutritional assessment. A binary logistic regression model based on insulin-like growth factor-1 < or = median (50.6 ng/mL), presence of sepsis, oliguria, and cholesterol < or = median (96 mg/dL) identified insulin-like growth factor-1 (odds ratio = 7.73; 95% confidence interval 1.19-49.87; p = 0.032), sepsis (odds ratio = 7.28; 95% confidence interval 1.29-40.89; p = 0.024), oliguria (odds ratio = 8.7; 95% confidence interval 1.10-68.77; p = 0.040) and cholesterol (odds ratio = 10.94; 95% confidence interval 1.89-63.29; p = 0.008) as independent covariate for death. Conclusions: Decreased levels of insulin-like growth factor-1 and cholesterol were clearly related to higher mortality. The close correlation of insulin-like growth factor-1 with nutritional status, its serum stability, and short-half life makes it a suitable candidate for an early and sensitive marker for intensive care unit acute kidney injury mortality.
Mesh-Begriff(e)	Acute Kidney Injury/metabolism ; Acute Kidney Injury/mortality ; Adult ; Aged ; Aged, 80 and over ; Body Weights and Measures ; Cholesterol/blood ; Female ; Humans ; Insulin-Like Growth Factor I/analysis ; Intensive Care Units ; Male ; Middle Aged ; Nutrition Assessment ; Prospective Studies ; Risk Factors ; Survival Analysis ; Young Adult
Chemische Substanzen	Insulin-Like Growth Factor I (67763-96-6) ; Cholesterol (97C5T2UQ7J)
Sprache	Englisch
Erscheinungsdatum	2008-12
Erscheinungsland	United States
Dokumenttyp	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	197890-1
ISSN	1530-0293 ; 0090-3493
ISSN (online)	1530-0293
ISSN	0090-3493
DOI	10.1097/CCM.0b013e318186ab70
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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