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  1. Book ; Online: A personalized medicine approach to the diagnosis and management of autism spectrum disorder

    Frye, Richard Eugene / Boles, Richard G. / Rose, Shannon / Rossignol, Daniel

    2022  

    Author's details edited by Richard Eugene Frye, Richard G. Boles, Shannon Rose, Daniel Rossignol
    Language English
    Size 1 Online-Ressource (xi, 402 Seiten), Illustrationen, Diagramme
    Publisher MDPI
    Publishing place Basel
    Publishing country Switzerland
    Document type Book ; Online
    Note Printed edition of the special issue published in "Journal of personalized medicine" ; Open Access
    HBZ-ID HT021592982
    ISBN 978-3-0365-3220-2 ; 9783036532219 ; 3-0365-3220-X ; 3036532218
    DOI 10.3390/books978-3-0365-3220-2
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Book ; Online: A Personalized Medicine Approach to the Diagnosis and Management of Autism Spectrum Disorder

    Frye, Richard E / Boles, Richard / Rose, Shannon / Rossignol, Daniel / Boles, Richard

    2022  

    Keywords Medicine ; Neurosciences ; fecal metabolites ; ASD ; microbiome ; gastrointestinal symptoms ; Fisher Discriminant Analysis ; digital biomarkers ; wearables ; time series analysis ; autism ; social dyads ; socio-motor parameters ; network connectivity ; non-linear complex dynamics ; stochastic analysis ; autism spectrum disorders ; copy number variants ; females ; Array-Comparative Genomic Hybridization (Array-CGH) ; autism spectrum disorder ; Ehlers-Danlos syndrome ; hypermobility spectrum disorders ; autonomic disorder ; mast cell activation syndrome ; genetic testing ; chromosomal microarray analysis ; whole exome sequencing ; whole genome sequencing ; clinical utility ; polygenic risk scores ; Temple Grandin ; biomarker ; omics ; precision medicine ; proteomics ; transcriptomics ; epigenetics ; metabolomics ; patient stratification ; mitochondria ; oxidative stress ; prenatal environment ; immune dysfunction ; immunoglobulin G ; intravenous immunoglobulin ; energy metabolism ; fatty acid oxidation ; acyl-carnitines ; resveratrol ; integrative ; model ; concomitant ; condition ; disorder ; autism spectrum disorder (ASD) ; genomics ; personalized treatment strategy ; single nucleotide polymorphisms ; clinical decision support tool ; ADHD ; PANDAS ; OCD ; anxiety ; folate receptor alpha ; folates ; pregnancy ; brain development ; fetal development ; cobalamin ; glutathione ; methylation ; methylcobalamin ; redox metabolism ; locked-in network syndrome ; resting-state functional magnetic resonance imaging ; temporal lobe epilepsy ; amygdala ; brain ; COVID-19 ; children ; cytokines ; flavonoids ; inflammation ; luteolin ; mast cells ; microglia ; SARS-CoV-2 ; stress ; nutraceuticals ; survey ; vitamins ; minerals ; B12 ; folinic acid ; quality of life ; parents ; intervention ; systematic review ; medical claims ; logistic regression analysis ; retrospective analysis ; associated risk ; monoamine neurotransmitters ; neurotransmitter deficiency ; cerebral folate deficiency ; folate receptor alpha autoantibodies ; leucovorin ; α-amylase ; cortisol ; heart rate variability ; neuromodulation ; sleep anxiety ; transdermal electrical neuromodulation ; neurostimulation ; n/a
    Language English
    Size 1 electronic resource (416 pages)
    Publisher MDPI - Multidisciplinary Digital Publishing Institute
    Publishing place Basel
    Document type Book ; Online
    Note English
    HBZ-ID HT030378931
    ISBN 9783036532202 ; 303653220X
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  3. Book ; Online ; E-Book: The therapeutic use of N-Acetylcysteine (NAC) in medicine

    Frye, Richard Eugene / Berk, Michael

    2019  

    Author's details Richard Eugene Frye, Michael Berk editors
    Keywords Toxicology
    Subject code 615.1
    Language English
    Size 1 Online-Ressource (xii, 394 Seiten), Illustrationen
    Publisher Adis
    Publishing place Singapore
    Publishing country Singapore
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    HBZ-ID HT019860479
    ISBN 978-981-10-5311-5 ; 9789811053108 ; 981-10-5311-1 ; 9811053103
    DOI 10.1007/978-981-10-5311-5
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  4. Article ; Online: Succinic semialdehyde dehydrogenase deficiency: A model of neurocircuit imbalances in autism and potential insight into new biomarkers.

    Frye, Richard E

    Developmental medicine and child neurology

    2023  Volume 65, Issue 12, Page(s) 1544–1545

    MeSH term(s) Child ; Humans ; Autistic Disorder ; Succinate-Semialdehyde Dehydrogenase ; Developmental Disabilities/etiology ; Biomarkers
    Chemical Substances Succinate-Semialdehyde Dehydrogenase (EC 1.2.1.24) ; Biomarkers
    Language English
    Publishing date 2023-06-11
    Publishing country England
    Document type Journal Article ; Comment
    ZDB-ID 80369-8
    ISSN 1469-8749 ; 0012-1622
    ISSN (online) 1469-8749
    ISSN 0012-1622
    DOI 10.1111/dmcn.15671
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.B 5: Show issues Location:
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  5. Article ; Online: Editorial: Mitochondrial Gene Variations Increase Autism Risk: Uncovering the Complex Polygenetic Landscape of Autism.

    Frye, Richard E

    Journal of the American Academy of Child and Adolescent Psychiatry

    2023  

    Abstract: Autism spectrum disorder (ASD) is a behaviorally defined disorder with a complex, mostly unknown, etiology. Although many neurodevelopmental genetic disorders are associated with ASD, single gene mutations and copy number variations do not account for ... ...

    Abstract Autism spectrum disorder (ASD) is a behaviorally defined disorder with a complex, mostly unknown, etiology. Although many neurodevelopmental genetic disorders are associated with ASD, single gene mutations and copy number variations do not account for the majority of ASD cases. In fact, when found, genetic alterations are usually de novo rather than inherited.
    Language English
    Publishing date 2023-12-08
    Publishing country United States
    Document type Editorial
    ZDB-ID 392535-3
    ISSN 1527-5418 ; 0890-8567
    ISSN (online) 1527-5418
    ISSN 0890-8567
    DOI 10.1016/j.jaac.2023.12.002
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: A Personalized Multidisciplinary Approach to Evaluating and Treating Autism Spectrum Disorder.

    Frye, Richard E

    Journal of personalized medicine

    2022  Volume 12, Issue 3

    Abstract: Autism Spectrum Disorder (ASD) is a complex neurodevelopmental disorder without a known cure. Current standard-of-care treatments focus on addressing core symptoms directly but have provided limited benefits. In many cases, individuals with ASD have ... ...

    Abstract Autism Spectrum Disorder (ASD) is a complex neurodevelopmental disorder without a known cure. Current standard-of-care treatments focus on addressing core symptoms directly but have provided limited benefits. In many cases, individuals with ASD have abnormalities in multiple organs, including the brain, immune and gastrointestinal system, and multiple physiological systems including redox and metabolic systems. Additionally, multiple aspects of the environment can adversely affect children with ASD including the sensory environment, psychosocial stress, dietary limitations and exposures to allergens and toxicants. Although it is not clear whether these medical abnormalities and environmental factors are related to the etiology of ASD, there is evidence that many of these factors can modulate ASD symptoms, making them a potential treatment target for improving core and associated ASD-related symptoms and improving functional limitation. Additionally, addressing underlying biological disturbances that drive pathophysiology has the potential to be disease modifying. This article describes a systematic approach using clinical history and biomarkers to personalize medical treatment for children with ASD. This approach is medically comprehensive, making it attractive for a multidisciplinary approach. By concentrating on treatable conditions in ASD, it is possible to improve functional ability and quality of life, thus providing optimal outcomes.
    Language English
    Publishing date 2022-03-14
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2662248-8
    ISSN 2075-4426
    ISSN 2075-4426
    DOI 10.3390/jpm12030464
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Synchrony 2022: Catalyzing Research and Treatments to Benefit Individuals with Neurodevelopmental Disorders including Autism Spectrum Disorders.

    Nanda, Heer / Frye, Richard E

    Journal of personalized medicine

    2023  Volume 13, Issue 3

    Abstract: A unique translational medicine conference for research into treatments that can benefit individuals with neurodevelopmental disorders (NDD), including autism spectrum disorder (ASD), has been developed and hosted by The BRAIN Foundation (Pleasanton, CA, ...

    Abstract A unique translational medicine conference for research into treatments that can benefit individuals with neurodevelopmental disorders (NDD), including autism spectrum disorder (ASD), has been developed and hosted by The BRAIN Foundation (Pleasanton, CA, USA) since 2019 [...].
    Language English
    Publishing date 2023-03-09
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2662248-8
    ISSN 2075-4426
    ISSN 2075-4426
    DOI 10.3390/jpm13030490
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Synchrony 2022

    Heer Nanda / Richard E. Frye

    Journal of Personalized Medicine, Vol 13, Iss 490, p

    Catalyzing Research and Treatments to Benefit Individuals with Neurodevelopmental Disorders including Autism Spectrum Disorders

    2023  Volume 490

    Abstract: A unique translational medicine conference for research into treatments that can benefit individuals with neurodevelopmental disorders (NDD), including autism spectrum disorder (ASD), has been developed and hosted by The BRAIN Foundation (Pleasanton, CA, ...

    Abstract A unique translational medicine conference for research into treatments that can benefit individuals with neurodevelopmental disorders (NDD), including autism spectrum disorder (ASD), has been developed and hosted by The BRAIN Foundation (Pleasanton, CA, USA) since 2019 [.]
    Keywords n/a ; Medicine ; R
    Language English
    Publishing date 2023-03-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article ; Online: Introduction to Part 2.

    Frye, Richard E

    Seminars in pediatric neurology

    2020  Volume 35, Page(s) 100828

    Abstract: Autism spectrum disorder (ASD) is one of the most challenging neurodevelopmental disorders of our era. Currently the Centers for Disease Control and Prevention reports that the prevalence continues to rise with the current estimate at 1 in 54 children in ...

    Abstract Autism spectrum disorder (ASD) is one of the most challenging neurodevelopmental disorders of our era. Currently the Centers for Disease Control and Prevention reports that the prevalence continues to rise with the current estimate at 1 in 54 children in the United States. Over the last 2 decades research on ASD has increased, particularly in areas focusing on physiological disruptions such as mitochondrial and redox metabolism abnormalities, immune system dysfunction and environmental health, although research focusing on genetics and behavior still predominate the field. Drug treatment trials have provided few "home runs" and many failures. A series of 2 issues of Seminars in Pediatric Neurology provide articles representing the cutting edge of research and clinical care for children with ASD. The first issue contained 3 articles on Advances in Diagnostic Methodology and 3 articles on Cutting Edge Methods for Studying Outcomes. The second issue contains 2 articles on Advances in Early Screening and Diagnosis on the Front Lines and 7 articles on Novel and Cutting-Edge Therapies. The 2 issues will provide significant insight into new and exciting developments in the field as well as provide a framework for understanding the challenges ahead.
    MeSH term(s) Autism Spectrum Disorder/diagnosis ; Autism Spectrum Disorder/therapy ; Humans
    Language English
    Publishing date 2020-06-22
    Publishing country United States
    Document type Introductory Journal Article
    ZDB-ID 1290000-x
    ISSN 1558-0776 ; 1071-9091
    ISSN (online) 1558-0776
    ISSN 1071-9091
    DOI 10.1016/j.spen.2020.100828
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Introduction to Part 1.

    Frye, Richard E

    Seminars in pediatric neurology

    2020  Volume 34, Page(s) 100802

    Abstract: Autism spectrum disorder (ASD) is one of the most challenging neurodevelopmental disorders of our era that the Centers for Disease Control and Prevention estimates the prevalence to be about 1 in 59 children in the United States. Over the last two ... ...

    Abstract Autism spectrum disorder (ASD) is one of the most challenging neurodevelopmental disorders of our era that the Centers for Disease Control and Prevention estimates the prevalence to be about 1 in 59 children in the United States. Over the last two decades, research focusing on ASD has increased, particularly in areas focusing on physiological disruptions such as mitochondrial and redox metabolism abnormalities, immune system dysfunction and environmental health, although research focusing on genetics and behavior still predominate the field. Drug treatment trials have provided few "home runs" with many failures and some promising, but preliminary, results. A series of two issues of Seminars in Pediatric Neurology will provide articles representing the cutting edge of research and clinical care for children with ASD. The first issue will contain three articles on Advances in Diagnostic Methodology and three articles on Cutting Edge Method for Studying Outcomes. The second issue will contain articles on Advances in Early Screening and Diagnosis on the Front Lines and Novel and Cutting-Edge Therapies. I believe the two issues will provide significant insight into new and exciting developments in the field as well as provide a framework for understanding the challenges ahead.
    MeSH term(s) Autism Spectrum Disorder/diagnosis ; Autism Spectrum Disorder/physiopathology ; Autism Spectrum Disorder/therapy ; Humans
    Language English
    Publishing date 2020-03-07
    Publishing country United States
    Document type Introductory Journal Article
    ZDB-ID 1290000-x
    ISSN 1558-0776 ; 1071-9091
    ISSN (online) 1558-0776
    ISSN 1071-9091
    DOI 10.1016/j.spen.2020.100802
    Database MEDical Literature Analysis and Retrieval System OnLINE

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