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  1. Article ; Online: Body positioning-related laryngeal narrowing pattern and expiratory mechanical constraints in advanced chronic obstructive pulmonary disease: A case report.

    Nagata, Yuka / Miki, Keisuke / Kijima, Ryo / Mihashi, Yasuhiro / Miyamoto, Satoshi / Hashimoto, Hisako / Nii, Takuro / Matsuki, Takanori / Tsujino, Kazuyuki / Kida, Hiroshi

    Respiratory investigation

    2024  Volume 62, Issue 2, Page(s) 258–261

    Abstract: We previously reported that laryngeal widening led to improved exercise tolerance in COPD. However, it is not clear whether laryngeal narrowing occurs as a compensatory response to tracheal movement or is affected by posture. Here, we report the case of ... ...

    Abstract We previously reported that laryngeal widening led to improved exercise tolerance in COPD. However, it is not clear whether laryngeal narrowing occurs as a compensatory response to tracheal movement or is affected by posture. Here, we report the case of an advanced COPD patient whose more prolonged expiration in a head-forward leaning position compared with that in a neck-extended position occurred with an excessive duration of severe laryngeal narrowing without tracheal obstruction, which led to exercise intolerance with expiratory mechanical constraints. This case provided useful insights into the regulation of the upper airway with body positioning for improving exercise tolerance.
    MeSH term(s) Humans ; Patient Positioning ; Pulmonary Disease, Chronic Obstructive ; Exhalation/physiology ; Airway Obstruction/etiology ; Trachea
    Language English
    Publishing date 2024-01-18
    Publishing country Netherlands
    Document type Case Reports
    ZDB-ID 2660821-2
    ISSN 2212-5353 ; 2212-5345
    ISSN (online) 2212-5353
    ISSN 2212-5345
    DOI 10.1016/j.resinv.2024.01.004
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  2. Article ; Online: The diagnostic impact of fractional exhaled nitric oxide for asthmatic cough in nontuberculous mycobacterial pulmonary disease.

    Miki, Mari / Miki, Keisuke / Akiba, Eri / Kagawa, Hiroyuki / Oshitani, Yohei / Matsuki, Takanori / Tsujino, Kazuyuki / Kitada, Seigo / Maekura, Ryoji / Kida, Hiroshi

    BMC pulmonary medicine

    2024  Volume 24, Issue 1, Page(s) 210

    Abstract: Background: Measurement of exhaled nitric oxide (FeNO) is a potentially useful diagnostic test for asthma. However, no study has explored the relationship between FeNO and respiratory symptoms of nontuberculous mycobacterial pulmonary disease (NTM-PD) ... ...

    Abstract Background: Measurement of exhaled nitric oxide (FeNO) is a potentially useful diagnostic test for asthma. However, no study has explored the relationship between FeNO and respiratory symptoms of nontuberculous mycobacterial pulmonary disease (NTM-PD) complicated with asthma. The objective of this study was to assess the utility of measuring FeNO levels in patients with NTM-PD complicated by asthma.
    Methods: In this single-center retrospective cohort study, 140 NTM-PD patients with FeNO measured were enrolled. We selected NTM-PD patients who complicated with asthma as the NTM+BA group, defined using the following criteria: NTM patients with symptoms consistent with asthma, and NTM patients with symptomatic improvement after diagnostic therapy with ICS ± a long-acting beta 2-agonist (LABA). We then calculated a diagnostic cutoff point to distinguish between the NTM+BA groups and the NTM groups (all others). High-resolution computed tomography (HRCT) images were evaluated using the CT scoring system and their association with FeNO was examined.
    Results: A total of 89 patients were included in the study. (31 in the NTM+BA group and 58 in the NTM group). Compared with the NTM group, the NTM+BA group had higher rates of allergic disease (51.6% vs. 22.4%; p=0.0085) and higher FeNO values (median, 23 [interquartile range {IQR}, 15.0-43.0] ppb vs. median, 17 [IQR, 11.8-23.0] ppb; p=0.015). With diagnostic asthma care using mainly ICS/LABA with reference to the FeNO, most patients (91.0%, 20/22) in the NTM-preceding subgroup in the NTM+BA group demonstrated a prompt improvement of their symptoms and AFB culture findings did not worsen (Culture positive rate (%): Pre-treatment: 59.1% vs. Post-treatment: 40.9%, p=0.3660) at 6 months after starting diagnostic therapy. The optimal diagnostic cutoff point of FeNO to distinguish between the two groups was calculated as 21.5 ppb by the ROC curve (sensitivity 75%, specificity 71.93%, p<0.0001; area under the curve: 0.7989). No significant correlation was observed between FeNO and the severity of CT images in the patients.
    Conclusions: A certain number of patients with NTM-PD showed exacerbated respiratory symptoms due to asthmatic complications. Elevated FeNO levels suggest asthma complications, even in patients with NTM.
    MeSH term(s) Humans ; Female ; Male ; Mycobacterium Infections, Nontuberculous/diagnosis ; Mycobacterium Infections, Nontuberculous/complications ; Middle Aged ; Retrospective Studies ; Asthma/complications ; Asthma/diagnosis ; Aged ; Nitric Oxide/analysis ; Nitric Oxide/metabolism ; Cough/etiology ; Tomography, X-Ray Computed ; Fractional Exhaled Nitric Oxide Testing ; Breath Tests/methods ; ROC Curve
    Chemical Substances Nitric Oxide (31C4KY9ESH)
    Language English
    Publishing date 2024-04-29
    Publishing country England
    Document type Journal Article
    ZDB-ID 2059871-3
    ISSN 1471-2466 ; 1471-2466
    ISSN (online) 1471-2466
    ISSN 1471-2466
    DOI 10.1186/s12890-024-03028-3
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  3. Article ; Online: Natural Autoantibodies in Chronic Pulmonary Diseases.

    Fukushima, Kiyoharu / Tsujino, Kazuyuki / Futami, Shinji / Kida, Hiroshi

    International journal of molecular sciences

    2020  Volume 21, Issue 3

    Abstract: In autoantibody-mediated autoimmune diseases, pathogenic autoantibodies generated by a failure of central or peripheral tolerance, have different effects mediated by a variety of mechanisms. Interestingly, even non-autoimmune chronic diseases have a set ... ...

    Abstract In autoantibody-mediated autoimmune diseases, pathogenic autoantibodies generated by a failure of central or peripheral tolerance, have different effects mediated by a variety of mechanisms. Interestingly, even non-autoimmune chronic diseases have a set of disease-specific natural autoantibodies that are maintained for a long time. Because most of these natural autoantibodies target intracellular proteins or long non-coding RNAs, they are speculated to be non-pathological and have some important as yet unrecognized physiological functions such as debris clearance. Recently, we revealed a set of disease-specific natural autoantibodies of chronic pulmonary diseases with unknown etiology by protein arrays that enable detection of specific autoantibodies against >8000 targets. Surprisingly, some of the targeted antigens of disease-specific autoantibodies were subsequently reported by other laboratories as strongly associated with the disease, suggesting that these antigens reflect the pathology of each disease. Furthermore, some of these autoantibodies that target extracellular antigens might modify the original course of each disease. Here, we review the disease-specific natural autoantibodies of chronic pulmonary diseases, including chronic fibrosing idiopathic interstitial pneumonias, sarcoidosis, and autoimmune pulmonary alveolar proteinosis, and discuss their utility and effects.
    MeSH term(s) Autoantibodies ; Autoimmune Diseases/immunology ; Chronic Disease ; Humans ; Idiopathic Pulmonary Fibrosis/immunology ; Lung Diseases/immunology ; Pulmonary Alveolar Proteinosis/immunology ; Sarcoidosis/immunology
    Chemical Substances Autoantibodies
    Language English
    Publishing date 2020-02-08
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms21031138
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  4. Article: Diagnosis and Management of Drug-Induced Interstitial Lung Disease Associated with Amikacin Liposome Inhalation Suspension in Refractory

    Hashimoto, Kazuki / Nii, Takuro / Sumitani, Hitoshi / Yokoyama, Masashi / Miyamoto, Satoshi / Mihashi, Yasuhiro / Nagata, Yuka / Matsuki, Takanori / Tsujino, Kazuyuki / Miki, Keisuke / Kida, Hiroshi

    Infection and drug resistance

    2023  Volume 16, Page(s) 6629–6634

    Abstract: Amikacin liposome inhalation suspension (ALIS) is a key drug for the treatment of ... ...

    Abstract Amikacin liposome inhalation suspension (ALIS) is a key drug for the treatment of refractory
    Language English
    Publishing date 2023-10-10
    Publishing country New Zealand
    Document type Case Reports
    ZDB-ID 2494856-1
    ISSN 1178-6973
    ISSN 1178-6973
    DOI 10.2147/IDR.S427544
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  5. Article ; Online: Natural Autoantibodies in Chronic Pulmonary Diseases

    Kiyoharu Fukushima / Kazuyuki Tsujino / Shinji Futami / Hiroshi Kida

    International Journal of Molecular Sciences, Vol 21, Iss 3, p

    2020  Volume 1138

    Abstract: In autoantibody-mediated autoimmune diseases, pathogenic autoantibodies generated by a failure of central or peripheral tolerance, have different effects mediated by a variety of mechanisms. Interestingly, even non-autoimmune chronic diseases have a set ... ...

    Abstract In autoantibody-mediated autoimmune diseases, pathogenic autoantibodies generated by a failure of central or peripheral tolerance, have different effects mediated by a variety of mechanisms. Interestingly, even non-autoimmune chronic diseases have a set of disease-specific natural autoantibodies that are maintained for a long time. Because most of these natural autoantibodies target intracellular proteins or long non-coding RNAs, they are speculated to be non-pathological and have some important as yet unrecognized physiological functions such as debris clearance. Recently, we revealed a set of disease-specific natural autoantibodies of chronic pulmonary diseases with unknown etiology by protein arrays that enable detection of specific autoantibodies against >8000 targets. Surprisingly, some of the targeted antigens of disease-specific autoantibodies were subsequently reported by other laboratories as strongly associated with the disease, suggesting that these antigens reflect the pathology of each disease. Furthermore, some of these autoantibodies that target extracellular antigens might modify the original course of each disease. Here, we review the disease-specific natural autoantibodies of chronic pulmonary diseases, including chronic fibrosing idiopathic interstitial pneumonias, sarcoidosis, and autoimmune pulmonary alveolar proteinosis, and discuss their utility and effects.
    Keywords autoantibody ; protein array ; idiopathic interstitial pneumonias ; sarcoidosis ; autoimmune pulmonary alveolar proteinosis ; mx1 ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
    Subject code 610
    Language English
    Publishing date 2020-02-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
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  6. Article: Oxygen Extraction Based on Inspiratory and Expiratory Gas Analysis Identifies Ventilatory Inefficiency in Chronic Obstructive Pulmonary Disease.

    Miki, Keisuke / Tsujino, Kazuyuki / Maekura, Ryoji / Matsuki, Takanori / Miki, Mari / Hashimoto, Hisako / Kagawa, Hiroyuki / Kawasaki, Takahiro / Kuge, Tomoki / Kida, Hiroshi

    Frontiers in physiology

    2021  Volume 12, Page(s) 703977

    Abstract: Aims: ...

    Abstract Aims:
    Language English
    Publishing date 2021-07-28
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2564217-0
    ISSN 1664-042X
    ISSN 1664-042X
    DOI 10.3389/fphys.2021.703977
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  7. Article ; Online: Critical Appraisal of the Utility and Limitations of Animal Models of Scleroderma.

    Tsujino, Kazuyuki / Sheppard, Dean

    Current rheumatology reports

    2016  Volume 18, Issue 1, Page(s) 4

    Abstract: Scleroderma, also called systemic sclerosis (SSc), is an autoimmune connective tissue disease characterized by abnormality of the immune system, cardiovascular disorder, and fibrosis of the skin, lung, kidney, and other internal organs. Skin symptom and ... ...

    Abstract Scleroderma, also called systemic sclerosis (SSc), is an autoimmune connective tissue disease characterized by abnormality of the immune system, cardiovascular disorder, and fibrosis of the skin, lung, kidney, and other internal organs. Skin symptom and stiffness of the skin with accumulation of collagen cause severe disability, and cardiovascular and lung complications lead to high mortality. Despite recent progress, therapies for these complications in SSc are limited and the underlying mechanisms are poorly understood. Animal models are one strategy to identify molecular mechanisms and pathways underlying these complications of SSc and could provide a mechanistic basis for a design of clinical trials. However, although several animal models have been reported to reproduce some aspects of SSc, none of them recapitulates all of the pathological features of SSc. In this review, we describe previously reported animal models of scleroderma and discuss their utility and limitations in efforts to understand the mechanisms underlying scleroderma and develop new treatments for this disease.
    MeSH term(s) Angiotensin II ; Animals ; Bleomycin ; Disease Models, Animal ; Genetic Predisposition to Disease ; Graft vs Host Disease/complications ; Mice ; Mice, Transgenic ; Reactive Oxygen Species ; Scleroderma, Systemic/etiology
    Chemical Substances Reactive Oxygen Species ; Bleomycin (11056-06-7) ; Angiotensin II (11128-99-7)
    Language English
    Publishing date 2016-01
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2057357-1
    ISSN 1534-6307 ; 1523-3774
    ISSN (online) 1534-6307
    ISSN 1523-3774
    DOI 10.1007/s11926-015-0553-9
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    In stock of ZB MED Cologne/Königswinter

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  8. Article: Corrigendum: Oxygen Extraction Based on Inspiratory and Expiratory Gas Analysis Identifies Ventilatory Inefficiency in Chronic Obstructive Pulmonary Disease.

    Miki, Keisuke / Tsujino, Kazuyuki / Maekura, Ryoji / Matsuki, Takanori / Miki, Mari / Hashimoto, Hisako / Kagawa, Hiroyuki / Kawasaki, Takahiro / Kuge, Tomoki / Kida, Hiroshi

    Frontiers in physiology

    2021  Volume 12, Page(s) 770151

    Abstract: This corrects the article DOI: 10.3389/fphys.2021.703977.]. ...

    Abstract [This corrects the article DOI: 10.3389/fphys.2021.703977.].
    Language English
    Publishing date 2021-09-30
    Publishing country Switzerland
    Document type Published Erratum
    ZDB-ID 2564217-0
    ISSN 1664-042X
    ISSN 1664-042X
    DOI 10.3389/fphys.2021.770151
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  9. Article ; Online: Laryngeal widening and adequate ventilation by expiratory pressure load training improve aerobic capacity in COPD: a randomised controlled trial.

    Miki, Keisuke / Tsujino, Kazuyuki / Fukui, Motonari / Miki, Mari / Kitajima, Takamasa / Sumitani, Hitoshi / Hashimoto, Kazuki / Yokoyama, Masashi / Hashimoto, Hisako / Nii, Takuro / Matsuki, Takanori / Kida, Hiroshi

    Thorax

    2023  Volume 79, Issue 1, Page(s) 23–34

    Abstract: Rationale: Despite strategies acting on peripheral airway obstruction in chronic obstructive pulmonary disease (COPD), exercise intolerance remains inadequately improved. We hypothesised that laryngeal narrowing is a potential treatment target of ... ...

    Abstract Rationale: Despite strategies acting on peripheral airway obstruction in chronic obstructive pulmonary disease (COPD), exercise intolerance remains inadequately improved. We hypothesised that laryngeal narrowing is a potential treatment target of expiratory pressure load training (EPT) to improve exercise intolerance in COPD.
    Methods: The effect of 3-month EPT was assessed in 47 patients with COPD divided into Global Initiative for Chronic Obstructive Lung Disease (GOLD) mild-to-moderate (I-II) and severe-to-very severe (III-IV), randomly allocating 1:1 to EPT or control groups. The primary outcome was endurance time in the constant work rate exercise test in GOLD III-IV patients.
    Results: Compared with controls, EPT increased: (1) endurance time, with estimated treatment effect: +703 (95% CI: 379 to 1031) s, p=0.0008 (GOLD I-II); +390 (95% CI: 205 to 574) s, p=0.0006 (GOLD III-IV); (2) peak oxygen uptake (p=0.0086 in GOLD I-II; p=0.0004 in GOLD III-IV); (3) glottic dilatation ratio at maximum collapse on laryngoscopy in the submaximal exercise (p=0.0062 in GOLD I-II; p=0.0001 in GOLD III-IV); and (4) the inflection point of expiratory tidal volume relative to minute ventilation during the incremental exercise (p=0.0015 in GOLD I-II; p=0.0075 in GOLD III-IV). Across GOLD grades, the responses of glottic dilatation ratio at maximum collapse and the expiratory tidal volume at the inflection point were selected as more influential variables correlating with the improvement in peak oxygen uptake and endurance time, respectively.
    Conclusion: These results show that EPT improved aerobic capacity and endurance time with larger laryngeal widening and adequate ventilation despite advanced COPD.
    Trial registration number: UMIN000041250.
    MeSH term(s) Humans ; Lung ; Pulmonary Disease, Chronic Obstructive/therapy ; Exercise Tolerance ; Respiration ; Exercise Test ; Forced Expiratory Volume/physiology ; Oxygen
    Chemical Substances Oxygen (S88TT14065)
    Language English
    Publishing date 2023-12-15
    Publishing country England
    Document type Randomized Controlled Trial ; Journal Article
    ZDB-ID 204353-1
    ISSN 1468-3296 ; 0040-6376
    ISSN (online) 1468-3296
    ISSN 0040-6376
    DOI 10.1136/thorax-2022-219755
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    In stock of ZB MED Cologne/Königswinter

    Ui III Zs.83: Show issues Location:
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  10. Article: Increased Oxygen Extraction by Pulmonary Rehabilitation Improves Exercise Tolerance and Ventilatory Efficiency in Advanced Chronic Obstructive Pulmonary Disease.

    Miyazaki, Akito / Miki, Keisuke / Maekura, Ryoji / Tsujino, Kazuyuki / Hashimoto, Hisako / Miki, Mari / Yanagi, Hiromi / Koba, Taro / Nii, Takuro / Matsuki, Takanori / Kida, Hiroshi

    Journal of clinical medicine

    2022  Volume 11, Issue 4

    Abstract: Background: In cardiopulmonary exercise testing (CPET), oxygen uptake (: Methods: A total of 38 patients with severe and very severe COPD, whose PR responses were evaluated by CPET, were retrospectively analyzed.: Results: After PR, peak : ... ...

    Abstract Background: In cardiopulmonary exercise testing (CPET), oxygen uptake (
    Methods: A total of 38 patients with severe and very severe COPD, whose PR responses were evaluated by CPET, were retrospectively analyzed.
    Results: After PR, peak
    Conclusions: The increased O
    Language English
    Publishing date 2022-02-12
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm11040963
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