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Article ; Online: Th1, Th2 and Th17 inflammatory pathways synergistically predict cardiometabolic protein expression in serum of COVID-19 patients.

Michels, James R / Nazrul, Mohammad Shaheed / Adhikari, Sudeep / Wilkins, Dawn / Pavel, Ana B

Molecular omics

2022 Volume 18, Issue 5, Page(s) 408–416

Abstract: A predominant source of complication in SARS-CoV-2 patients arises from a severe systemic inflammation that can lead to tissue damage and organ failure. The high inflammatory burden of this viral infection often results in cardiovascular comorbidities. A ...

Abstract	A predominant source of complication in SARS-CoV-2 patients arises from a severe systemic inflammation that can lead to tissue damage and organ failure. The high inflammatory burden of this viral infection often results in cardiovascular comorbidities. A better understanding of the interaction between immune pathways and cardiovascular proteins might inform medical decisions and therapeutic approaches. In this study we hypothesized that helper T-cell inflammatory pathways (Th1, Th2 and Th17) synergistically correlate with cardiometabolic proteins in serum of COVID-19 patients. We found that Th1, Th2 and Th17 cytokines and chemokines are able to predict expression of 186 cardiometabolic proteins profiled by Olink proteomics.
MeSH term(s)	COVID-19 ; Cardiovascular Diseases/metabolism ; Humans ; Proteomics ; SARS-CoV-2 ; Th1 Cells/metabolism ; Th17 Cells/metabolism ; Th2 Cells/metabolism
Language	English
Publishing date	2022-06-13
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	2515-4184
ISSN (online)	2515-4184
DOI	10.1039/d2mo00055e
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Article ; Online: Failure to Complete Multidose Vaccine Series in Early Childhood.

Michels, Sarah Y / Niccolai, Linda M / Hadler, James L / Freeman, Rain E / Albers, Alexandria N / Glanz, Jason M / Daley, Matthew F / Newcomer, Sophia R

Pediatrics

2023 Volume 152, Issue 2

Abstract: Background: Most early childhood immunizations require 3 to 4 doses to achieve optimal protection. Our objective was to identify factors associated with starting but not completing multidose vaccine series.: Methods: Using 2019 National Immunization ... ...

Abstract	Background: Most early childhood immunizations require 3 to 4 doses to achieve optimal protection. Our objective was to identify factors associated with starting but not completing multidose vaccine series. Methods: Using 2019 National Immunization Survey-Child data, US children ages 19 to 35 months were classified in 1 of 3 vaccination patterns: (1) completed the combined 7-vaccine series, (2) did not initiate ≥1 of the 7 vaccine series, or (3) initiated all series, but did not complete ≥1 multidose series. Associations between sociodemographic factors and vaccination pattern were evaluated using multivariable log-linked binomial regression. Analyses accounted for the survey's stratified design and complex weighting. Results: Among 16 365 children, 72.9% completed the combined 7-vaccine series, 9.9% did not initiate ≥1 series, and 17.2% initiated, but did not complete ≥1 multidose series. Approximately 8.4% of children needed only 1 additional vaccine dose from 1 of the 5 multidose series to complete the combined 7-vaccine series. The strongest associations with starting but not completing multidose vaccine series were moving across state lines (adjusted prevalence ratio [aPR] = 1.45, 95% confidence interval [CI]: 1.18-1.79), number of children in the household (2 to 3: aPR = 1.29, 95% CI: 1.05-1.58; 4 or more: aPR = 1.68, 95% CI: 1.30-2.18), and lack of insurance coverage (aPR = 2.03, 95% CI: 1.42-2.91). Conclusions: More than 1 in 6 US children initiated but did not complete all doses in multidose vaccine series, suggesting children experienced structural barriers to vaccination. Increased focus on strategies to encourage multidose series completion is needed to optimize protection from preventable diseases and achieve vaccination coverage goals.
MeSH term(s)	Humans ; Child, Preschool ; Infant ; Vaccination ; Vaccines ; Vaccination Coverage ; Family Characteristics
Chemical Substances	Vaccines
Language	English
Publishing date	2023-07-25
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	207677-9
ISSN	1098-4275 ; 0031-4005
ISSN (online)	1098-4275
ISSN	0031-4005
DOI	10.1542/peds.2022-059844
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Article: Th2/Th1 Cytokine Imbalance Is Associated With Higher COVID-19 Risk Mortality.

Pavel, Ana B / Glickman, Jacob W / Michels, James R / Kim-Schulze, Seunghee / Miller, Rachel L / Guttman-Yassky, Emma

Frontiers in genetics

2021 Volume 12, Page(s) 706902

Abstract: A major component of COVID-19 severe respiratory syndrome is the patient's immune response to the SARS-CoV-2 virus and the consequential multi-organ inflammatory response. Several studies suggested a potential role of ... ...

Abstract	A major component of COVID-19 severe respiratory syndrome is the patient's immune response to the SARS-CoV-2 virus and the consequential multi-organ inflammatory response. Several studies suggested a potential role of CD4
Language	English
Publishing date	2021-07-16
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2606823-0
ISSN	1664-8021
ISSN	1664-8021
DOI	10.3389/fgene.2021.706902
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Article ; Online: Th1, Th2 and Th17 inflammatory pathways synergistically correlate with cardiometabolic processes. A case study in COVID-19.

Michels, James R / Nazrul, Mohammad Shaheed / Adhikari, Sudeep / Wilkins, Dawn / Pavel, Ana B

bioRxiv

Abstract: A predominant source of complication in SARS-CoV-2 patients arises from the cytokine storm, an elevated expression of inflammatory helper T-cell associated cytokines that can lead to tissue damage and organ failure. The high inflammatory burden of this ... ...

Abstract	A predominant source of complication in SARS-CoV-2 patients arises from the cytokine storm, an elevated expression of inflammatory helper T-cell associated cytokines that can lead to tissue damage and organ failure. The high inflammatory burden of this viral infection often results in cardiovascular comorbidities. A better understanding of the interaction between the cytokine storm and cardiovascular proteins might inform medical decisions and therapeutic approaches. We hypothesized that all major helper T-cell inflammatory pathways (Th1, Th2 and Th17) synergistically contribute to cardiometabolic modifications in serum of COVID-19 patients. We proved our hypothesis by integrating Th1, Th2 and Th17 cytokines to predict expression of cardiometabolic proteins profiled by OLINK proteomics.
Keywords	covid19
Language	English
Publishing date	2021-11-30
Publisher	Cold Spring Harbor Laboratory
Document type	Article ; Online
DOI	10.1101/2021.11.29.470414
Database	COVID19

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Article ; Online: A 10-Year Review of the Management of Ocular Mucous Membrane Pemphigoid: A Private Practice Experience.

Johnson, Kasey B / Rosenbaum, James T / Yarter, Jason T / Broadbent, Talmage / Michels, Kevin S

Cornea

2022 Volume 42, Issue 5, Page(s) 565–571

Abstract: ... episode were qualified at 3 months as complete response (CR), response (R), or failure (F). After 3 months ... In comparison to dapsone, mycophenolate was more likely to achieve sustained CR (50% vs. 0%, P = 0.022) and R ...

Abstract	Purpose: Ocular mucous membrane pemphigoid (OcMMP) is a rare and potentially blinding condition for which consensus treatment guidelines do not exist. The purpose of this study was to assess the effectiveness and safety of various immunomodulatory agents in the treatment of OcMMP in a private practice setting. Methods: We conducted a 10-year retrospective chart review of patients managed with OcMMP (n = 22). The median age at diagnosis was 73 (range: 35-91) years, and 59% (13/22) of patients were female. Visual acuity, Foster stage, and adverse effects (AEs) were documented. Treatment outcomes for each treatment episode were qualified at 3 months as complete response (CR), response (R), or failure (F). After 3 months, CR was then further subqualified as sustained CR, reactivation after initial CR, or AE after initial CR. The Fisher exact test P values were calculated for each outcome in comparison with mycophenolate. Results: Twenty patients were treated with an immunomodulatory agent for a total of 55 treatment episodes. In comparison to dapsone, mycophenolate was more likely to achieve sustained CR (50% vs. 0%, P = 0.022) and R (100% vs. 50%, P = 0.007), and less likely to fail (0% vs. 50%, P = 0.007). Dapsone was also more likely to be discontinued because of AEs than mycophenolate (40% vs. 6%, P = 0.041). Conclusions: Mycophenolate is a superior first-line agent to dapsone in the treatment of OcMMP. Although not statistically significant, mycophenolate trends toward superiority over methotrexate as well. Mycophenolate is very effective when used in combination with rituximab. Azathioprine remains a reasonable second-line agent.
MeSH term(s)	Humans ; Female ; Male ; Retrospective Studies ; Pemphigoid, Bullous/chemically induced ; Immunosuppressive Agents/therapeutic use ; Pemphigoid, Benign Mucous Membrane/diagnosis ; Pemphigoid, Benign Mucous Membrane/drug therapy ; Mucous Membrane ; Dapsone/therapeutic use
Chemical Substances	Immunosuppressive Agents ; Dapsone (8W5C518302)
Language	English
Publishing date	2022-06-13
Publishing country	United States
Document type	Journal Article
ZDB-ID	604826-2
ISSN	1536-4798 ; 0277-3740
ISSN (online)	1536-4798
ISSN	0277-3740
DOI	10.1097/ICO.0000000000003071
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Article ; Online: Evaluation of Antigens for Development of a Serological Test for Human African Trypanosomiasis

PLOS ONE

2023

Keywords	evaluation ; trypanosomiasis ; development ; antigens ; african trypanosomiasis
Publishing date	2023-03-10T14:36:27Z
Publisher	Public Library of Science
Publishing country	fr
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: General health and residential proximity to the coast in Belgium: Results from a cross-sectional health survey.

Hooyberg, Alexander / Roose, Henk / Grellier, James / Elliott, Lewis R / Lonneville, Britt / White, Mathew P / Michels, Nathalie / De Henauw, Stefaan / Vandegehuchte, Michiel / Everaert, Gert

Environmental research

2020 Volume 184, Page(s) 109225

Abstract: The health risks of coastal areas have long been researched, but the potential benefits for health are only recently being explored. The present study compared the general health of Belgian citizens a) according to the EU's definition of coastal (<50 km) ...

Abstract	The health risks of coastal areas have long been researched, but the potential benefits for health are only recently being explored. The present study compared the general health of Belgian citizens a) according to the EU's definition of coastal (<50 km) vs. inland (>50 km), and b) between eight more refined categories of residential proximity to the coast (<5 km to >250 km). Data was drawn from the Belgian Health Interview Survey (n = 60,939) and investigated using linear regression models and mediation analyses on several hypothesized mechanisms. Results indicated that populations living <5 km of the coast reported better general health than populations living at >50-100 km. Four commonly hypothesized mechanisms were considered but no indirect associations were found: scores for mental health, physical activity levels and social contacts were not higher at 0-5 km from the coast, and air pollution (PM
MeSH term(s)	Air Pollution ; Belgium ; Cross-Sectional Studies ; Health Surveys ; Humans ; Mental Health ; Oceans and Seas ; Residence Characteristics
Language	English
Publishing date	2020-02-04
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	205699-9
ISSN	1096-0953 ; 0013-9351
ISSN (online)	1096-0953
ISSN	0013-9351
DOI	10.1016/j.envres.2020.109225
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Article ; Online: Night shift work, sleep duration and endometrial cancer risk: A pooled analysis from the Epidemiology of Endometrial Cancer Consortium (E2C2).

Frias-Gomez, Jon / Alemany, Laia / Benavente, Yolanda / Clarke, Megan A / de Francisco, Javier / De Vivo, Immaculata / Du, Mengmeng / Goodman, Marc T / Lacey, James / Liao, Linda M / Lipworth, Loren / Lu, Lingeng / Merritt, Melissa A / Michels, Kara A / O'Connell, Kelli / Paytubi, Sonia / Pelegrina, Beatriz / Peremiquel-Trillas, Paula / Petruzella, Stacey /

Ponce, Jordi / Risch, Harvey / Setiawan, Veronica Wendy / Schouten, Leo J / Shu, Xiao-Ou / Trabert, Britton / Van den Brandt, Piet A / Wentzensen, Nicolas / Wilkens, Lynne R / Yu, Herbert / Costas, Laura

Sleep medicine reviews

2023 Volume 72, Page(s) 101848

Abstract: Data on the role of circadian related factors in the etiology of endometrial cancer are scarce. We collected individual data on night shift work or daily sleep duration from 7,207 cases and 22,027 controls participating in 11 studies from the ... ...

Abstract	Data on the role of circadian related factors in the etiology of endometrial cancer are scarce. We collected individual data on night shift work or daily sleep duration from 7,207 cases and 22,027 controls participating in 11 studies from the Epidemiology of Endometrial Cancer Consortium (E2C2). Main analyses were performed among postmenopausal women: 6,335 endometrial cancer cases and 18,453 controls. Using individual data, study-specific odd ratios (ORs) and their corresponding 95% confidence intervals (CIs) were estimated with logistic regression and pooled analyses were conducted using random-effects meta-analyses. A non-significant inverse association was observed between endometrial cancer and night shift work (OR=0.89, 95%CI=0.72-1.09; I
MeSH term(s)	Female ; Humans ; Endometrial Neoplasms/epidemiology ; Endometrial Neoplasms/etiology ; Risk Factors ; Shift Work Schedule/adverse effects ; Sleep ; Sleep Duration ; Work Schedule Tolerance
Language	English
Publishing date	2023-09-07
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	1414211-9
ISSN	1532-2955 ; 1087-0792
ISSN (online)	1532-2955
ISSN	1087-0792
DOI	10.1016/j.smrv.2023.101848
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Article: General health and residential proximity to the coast in Belgium: Results from a cross-sectional health survey

Hooyberg, Alexander / De Henauw, Stefaan / Elliott, Lewis R / Everaert, Gert / Grellier, James / Lonneville, Britt / Michels, Nathalie / Roose, Henk / Vandegehuchte, Michiel / White, Mathew P

Environmental research. 2020 May, v. 184

2020

Abstract	The health risks of coastal areas have long been researched, but the potential benefits for health are only recently being explored. The present study compared the general health of Belgian citizens a) according to the EU's definition of coastal (<50 km) vs. inland (>50 km), and b) between eight more refined categories of residential proximity to the coast (<5 km to >250 km). Data was drawn from the Belgian Health Interview Survey (n = 60,939) and investigated using linear regression models and mediation analyses on several hypothesized mechanisms. Results indicated that populations living <5 km of the coast reported better general health than populations living at >50–100 km. Four commonly hypothesized mechanisms were considered but no indirect associations were found: scores for mental health, physical activity levels and social contacts were not higher at 0–5 km from the coast, and air pollution (PM10 concentrations) was lower at 0–5 km from the coast but not statistically associated with better health. Results are controlled for typical variables such as age, sex, income, neighbourhood levels of green and freshwater blue space, etc. The spatial urban-rural-nature mosaic at the Belgian coast and alternative explanations are discussed. The positive associations between the ocean and human health observed in this study encourage policy makers to manage coastal areas sustainably to maintain associated public health benefits into the future.
Keywords	air pollution ; coasts ; freshwater ; health surveys ; income ; issues and policy ; mental health ; oceans ; particulates ; physical activity ; public health ; regression analysis ; risk ; Belgium
Language	English
Dates of publication	2020-05
Publishing place	Elsevier Inc.
Document type	Article
ZDB-ID	205699-9
ISSN	1096-0953 ; 0013-9351
ISSN (online)	1096-0953
ISSN	0013-9351
DOI	10.1016/j.envres.2020.109225
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Left Ventricular Systolic Dysfunction in Patients Diagnosed With Hypertrophic Cardiomyopathy During Childhood: Insights From the SHaRe Registry.

Abou Alaiwi, Sarah / Roston, Thomas M / Marstrand, Peter / Claggett, Brian Lee / Parikh, Victoria N / Helms, Adam S / Ingles, Jodie / Lampert, Rachel / Lakdawala, Neal K / Michels, Michelle / Owens, Anjali T / Rossano, Joseph W / Saberi, Sara / Abrams, Dominic J / Ashley, Euan A / Semsarian, Christopher / Stendahl, John C / Ware, James S / Miller, Erin /

Ryan, Thomas D / Russell, Mark W / Day, Sharlene M / Olivotto, Iacopo / Vissing, Christoffer R / Ho, Carolyn Y

Circulation

2023 Volume 148, Issue 5, Page(s) 394–404

Abstract: Background: The development of left ventricular systolic dysfunction (LVSD) in hypertrophic cardiomyopathy (HCM) is rare but serious and associated with poor outcomes in adults. Little is known about the prevalence, predictors, and prognosis of LVSD in ... ...

Abstract	Background: The development of left ventricular systolic dysfunction (LVSD) in hypertrophic cardiomyopathy (HCM) is rare but serious and associated with poor outcomes in adults. Little is known about the prevalence, predictors, and prognosis of LVSD in patients diagnosed with HCM as children. Methods: Data from patients with HCM in the international, multicenter SHaRe (Sarcomeric Human Cardiomyopathy Registry) were analyzed. LVSD was defined as left ventricular ejection fraction <50% on echocardiographic reports. Prognosis was assessed by a composite of death, cardiac transplantation, and left ventricular assist device implantation. Predictors of developing incident LVSD and subsequent prognosis with LVSD were assessed using Cox proportional hazards models. Results: We studied 1010 patients diagnosed with HCM during childhood (<18 years of age) and compared them with 6741 patients with HCM diagnosed as adults. In the pediatric HCM cohort, median age at HCM diagnosis was 12.7 years (interquartile range, 8.0-15.3), and 393 (36%) patients were female. At initial SHaRe site evaluation, 56 (5.5%) patients with childhood-diagnosed HCM had prevalent LVSD, and 92 (9.1%) developed incident LVSD during a median follow-up of 5.5 years. Overall LVSD prevalence was 14.7% compared with 8.7% in patients with adult-diagnosed HCM. Median age at incident LVSD was 32.6 years (interquartile range, 21.3-41.6) for the pediatric cohort and 57.2 years (interquartile range, 47.3-66.5) for the adult cohort. Predictors of developing incident LVSD in childhood-diagnosed HCM included age <12 years at HCM diagnosis (hazard ratio [HR], 1.72 [CI, 1.13-2.62), male sex (HR, 3.1 [CI, 1.88-5.2), carrying a pathogenic sarcomere variant (HR, 2.19 [CI, 1.08-4.4]), previous septal reduction therapy (HR, 2.34 [CI, 1.42-3.9]), and lower initial left ventricular ejection fraction (HR, 1.53 [CI, 1.38-1.69] per 5% decrease). Forty percent of patients with LVSD and HCM diagnosed during childhood met the composite outcome, with higher rates in female participants (HR, 2.60 [CI, 1.41-4.78]) and patients with a left ventricular ejection fraction <35% (HR, 3.76 [2.16-6.52]). Conclusions: Patients with childhood-diagnosed HCM have a significantly higher lifetime risk of developing LVSD, and LVSD emerges earlier than for patients with adult-diagnosed HCM. Regardless of age at diagnosis with HCM or LVSD, the prognosis with LVSD is poor, warranting careful surveillance for LVSD, especially as children with HCM transition to adult care.
MeSH term(s)	Adult ; Humans ; Male ; Female ; Child ; Ventricular Function, Left ; Stroke Volume ; Risk Factors ; Ventricular Dysfunction, Left/diagnostic imaging ; Ventricular Dysfunction, Left/epidemiology ; Ventricular Dysfunction, Left/complications ; Prognosis ; Cardiomyopathy, Hypertrophic/complications ; Cardiomyopathy, Hypertrophic/diagnosis ; Cardiomyopathy, Hypertrophic/epidemiology ; Registries
Language	English
Publishing date	2023-05-25
Publishing country	United States
Document type	Multicenter Study ; Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
ZDB-ID	80099-5
ISSN	1524-4539 ; 0009-7322 ; 0069-4193 ; 0065-8499
ISSN (online)	1524-4539
ISSN	0009-7322 ; 0069-4193 ; 0065-8499
DOI	10.1161/CIRCULATIONAHA.122.062517
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