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Article ; Online: Clinical Benefits of Targeting Treatable Traits in Asthma and Chronic Obstructive Pulmonary Disease.

Morishima, Yuko / Hizawa, Nobuyuki

2024

Abstract: Asthma and chronic obstructive pulmonary disease (COPD) have long been debated regarding their similarities and differences in clinical presentation and pathology. There has also been a discussion about how common therapeutics should be used differently ... ...

Abstract	Asthma and chronic obstructive pulmonary disease (COPD) have long been debated regarding their similarities and differences in clinical presentation and pathology. There has also been a discussion about how common therapeutics should be used differently for each disease. Traditionally, a "one size fits all" stepwise treatment has been chosen based on the severity of each case after categorizing the diseases, such as asthma or COPD. However, recently, the need for a precise approach for the treatment of individual patients beyond the disease category has been emphasized, especially in severe cases. To achieve precise personalized therapy, it has become necessary to focus on the individual phenotypes and underlying causal molecular mechanisms (endotypes) and to identify key therapeutic targets, which are called treatable traits. This review discusses the evidence for the importance of identifying treatable traits and therapeutic strategies based on the broader perspective of chronic obstructive airway disease rather than on individual diseases such as asthma or COPD.
Language	English
Publishing date	2024-03-04
Publishing country	Japan
Document type	Journal Article
ZDB-ID	32371-8
ISSN	1349-7235 ; 0021-5120 ; 0918-2918
ISSN (online)	1349-7235
ISSN	0021-5120 ; 0918-2918
DOI	10.2169/internalmedicine.3353-23
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Zs.A 240: Show issues

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Article ; Online: Body surface registration considering individual differences with non-rigid iterative closest point.

Tsumura, Ryosuke / Morishima, Yuko / Koseki, Yoshihiko / Yoshinaka, Kiyoshi

International journal of computer assisted radiology and surgery

2023 Volume 18, Issue 8, Page(s) 1511–1520

Abstract: Purpose: In telemedicine such as remote auscultation, patients themselves or non-medical people such as patient's parents need to place the stethoscope on their body surface in appropriate positions instead of the physicians. Meanwhile, as the position ... ...

Abstract	Purpose: In telemedicine such as remote auscultation, patients themselves or non-medical people such as patient's parents need to place the stethoscope on their body surface in appropriate positions instead of the physicians. Meanwhile, as the position depends on the individual difference of body shape, there is a demand for the efficient navigation to place the medical equipment. Methods: In this paper, we have proposed a non-rigid iterative closest point (ICP)-based registration method for localizing the auscultation area considering the individual difference of body surface. The proposed system provides the listening position by applying the body surface registration between the patient and reference model with the specified auscultation area. Our novelty is that selecting the utilized reference model similar to the patient body among several types of the prepared reference model increases the registration accuracy. Results: Simulation results showed that the registration error increases due to deviations of the body shape between the targeted models and reference model. Experimental results demonstrated that the proposed non-rigid ICP registration is capable of estimating the auscultation area with average error 5-19 mm when selecting the most similar reference model. The statistical analysis showed high correlation between the registration accuracy and similarity of the utilized models. Conclusion: The proposed non-rigid ICP registration is a promising new method that provides accurate auscultation area takes into account the individual difference of body shape. Our hypothesis that the registration accuracy depends on the similarity of both body surfaces is validated through simulation study and human trial.
MeSH term(s)	Humans ; Algorithms ; Individuality ; Computer Simulation
Language	English
Publishing date	2023-02-06
Publishing country	Germany
Document type	Journal Article
ZDB-ID	2365628-1
ISSN	1861-6429 ; 1861-6410
ISSN (online)	1861-6429
ISSN	1861-6410
DOI	10.1007/s11548-023-02842-0
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Zs.A 6615: Show issues

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Article ; Online: Suicide risk among patients with cancer by sex in Japan: A population-based study.

Kitagawa, Shinichi / Sobue, Tomotaka / Zha, Ling / Morishima, Toshitaka / Ohno, Yuko / Miyashiro, Isao

Journal of epidemiology

2024

Abstract: Background: In Japan, few studies have examined suicide risk for five-year relative survival rates for cancer sites. Since five-year relative survival rates differ by sex, we aim to examine suicide risk for patients with cancer separately for men and ... ...

Abstract	Background: In Japan, few studies have examined suicide risk for five-year relative survival rates for cancer sites. Since five-year relative survival rates differ by sex, we aim to examine suicide risk for patients with cancer separately for men and women. Methods: We estimated the risk of suicide among patients with cancer by sex in Japan compared to the general population, using standardized mortality ratios (SMRs). Patients with cancer diagnosed between January 1, 1985-December 31, 2013 and registered in the Osaka Cancer Registry were followed-up with for up to 10 years. The outcome was suicide death. In addition, cancer sites were classified into three prognosis groups based on five-year relative survival rates: good (> 70%), moderate (40-70%), poor (< 40%). Results: Among 623 995 patients with cancer observed for 2 349 432 person-years, 1210 patients died by suicide (867 men and 343 women). The SMRs were almost equal for men (1.66, 95% CI, 1.55-1.77) and women (1.65, 95% CI, 1.48-1.83). SMRs for cancer prognosis groups were 1.01 (95% CI, 0.84-1.22) for men and 1.47 (95% CI, 1.24-1.73) for women in the good group, 1.53 (95% CI, 1.39-1.68) for men and 1.74 (95% CI, 1.47-2.05) for women in the moderate group, and 2.54 (95% CI, 2.27-2.85) for men and 1.87 (95% CI, 1.43-2.46) for women in the poor group. Conclusions: In this population, both sexes had higher suicide risk with poor prognosis, but the difference in SMRs between the good and poor groups was smaller for women than men.
Language	English
Publishing date	2024-03-09
Publishing country	Japan
Document type	Journal Article
ZDB-ID	1442118-5
ISSN	1349-9092 ; 0917-5040
ISSN (online)	1349-9092
ISSN	0917-5040
DOI	10.2188/jea.JE20230280
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Zs.A 4931: Show issues

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Article ; Online: Abnormal saturated fatty acids and sphingolipids metabolism in asthma.

Yoshida, Kazufumi / Morishima, Yuko / Ishii, Yukio / Mastuzaka, Takashi / Shimano, Hitoshi / Hizawa, Nobuyuki

Respiratory investigation

2024 Volume 62, Issue 4, Page(s) 526–530

Abstract: Recent advances in fatty acid analysis have highlighted the links between lipid disruption and disease development. Lipid abnormalities are well-established risk factors for many of the most common chronic illnesses, and their involvement in asthma is ... ...

Abstract	Recent advances in fatty acid analysis have highlighted the links between lipid disruption and disease development. Lipid abnormalities are well-established risk factors for many of the most common chronic illnesses, and their involvement in asthma is also becoming clear. Here, we review research demonstrating the role of abnormal lipid metabolism in asthma, with a focus on saturated fatty acids and sphingolipids. High levels of palmitic acid, the most abundant saturated fatty acid in the human body, have been found in the airways of asthmatic patients with obesity, and were shown to worsen eosinophilic airway inflammation in asthma model mice on a high-fat diet. Aside from being a building block of longer-chain fatty acids, palmitic acid is also the starting point for de novo synthesis of ceramides, a class of sphingolipids. We outline the three main pathways for the synthesis of ceramides, which have been linked to the severity of asthma and act as precursors for the dynamic lipid mediator sphingosine 1-phosphate (S1P). S1P signaling is involved in allergen-induced eosinophilic inflammation, airway hyperresponsiveness, and immune-cell trafficking. A recent study of mice with mutations for the elongation of very long-chain fatty acid family member 6 (Elovl6), an enzyme that elongates fatty acid chains, has highlighted the potential role of palmitic acid composition, and thus lipid balance, in the pathophysiology of allergic airway inflammation. Elovl6 may be a potential therapeutic target in severe asthma.
Language	English
Publishing date	2024-04-18
Publishing country	Netherlands
Document type	Journal Article ; Review
ZDB-ID	2660821-2
ISSN	2212-5353 ; 2212-5345
ISSN (online)	2212-5353
ISSN	2212-5345
DOI	10.1016/j.resinv.2024.04.006
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Article ; Online: Corrigendum to "Risk of Parkinson's disease-related death in cancer survivors: A population-based study in Japan" [Park. Relat. Disord. 119 (2024) 105966].

Hayano, Eri / Gon, Yasufumi / Kimura, Yasuyoshi / Zha, Ling / Morishima, Toshitaka / Ohno, Yuko / Mochizuki, Hideki / Sobue, Tomotaka / Miyashiro, Isao

Parkinsonism & related disorders

2024 Volume 120, Page(s) 105990

Language	English
Publishing date	2024-01-10
Publishing country	England
Document type	Published Erratum
ZDB-ID	1311489-x
ISSN	1873-5126 ; 1353-8020
ISSN (online)	1873-5126
ISSN	1353-8020
DOI	10.1016/j.parkreldis.2024.105990
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Zs.A 4553: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 420: Show issues

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Article ; Online: Suppression of Clothing-Induced Acoustic Attenuation in Robotic Auscultation.

Tsumura, Ryosuke / Umezawa, Akihiro / Morishima, Yuko / Iwata, Hiroyasu / Yoshinaka, Kiyoshi

Sensors (Basel, Switzerland)

2023 Volume 23, Issue 4

Abstract: For patients who are often embarrassed and uncomfortable when exposing their breasts and having them touched by physicians of different genders during auscultation, we are developing a robotic system that performs auscultation over clothing. As the ... ...

Abstract	For patients who are often embarrassed and uncomfortable when exposing their breasts and having them touched by physicians of different genders during auscultation, we are developing a robotic system that performs auscultation over clothing. As the technical issue, the sound obtained through the clothing is often attenuated. This study aims to investigate clothing-induced acoustic attenuation and develop a suppression method for it. Because the attenuation is due to the loss of energy as sound propagates through a medium with viscosity, we hypothesized that the attenuation is improved by compressing clothing and shortening the sound propagation distance. Then, the amplitude spectrum of the heart sound was obtained over clothes of different thicknesses and materials in a phantom study and human trial at varying contact forces with a developed passive-actuated end-effector. Our results demonstrate the feasibility of the attenuation suppression method by applying an optimum contact force, which varied according to the clothing condition. In the phantom experiments, the attenuation rate was improved maximumly by 48% when applying the optimal contact force (1 N). In human trials, the attenuation rate was under the acceptable attenuation (40%) when applying the optimal contact force in all combinations in each subject. The proposed method promises the potential of robotic auscultation toward eliminating gender bias.
MeSH term(s)	Male ; Humans ; Female ; Robotic Surgical Procedures ; Sexism ; Acoustics ; Auscultation ; Clothing
Language	English
Publishing date	2023-02-17
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2052857-7
ISSN	1424-8220 ; 1424-8220
ISSN (online)	1424-8220
ISSN	1424-8220
DOI	10.3390/s23042260
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Article: Age-Dependent Causes of Death among Patients with Breast Cancer Based on Osaka Cancer Registry and Vital Statistics in Japan.

Nagayasu, Mayumi / Morishima, Toshitaka / Fujii, Makoto / Kudo, Haruka / Sobue, Tomotaka / Ohno, Yuko / Miyashiro, Isao

Healthcare (Basel, Switzerland)

2023 Volume 11, Issue 10

Abstract: We aimed to clarify the differences in causes of death among patients with breast cancer according to age at diagnosis and years elapsed since diagnosis. Using data from the Osaka Cancer Registry and Vital Statistics databases, 40,690 female patients ... ...

Abstract	We aimed to clarify the differences in causes of death among patients with breast cancer according to age at diagnosis and years elapsed since diagnosis. Using data from the Osaka Cancer Registry and Vital Statistics databases, 40,690 female patients diagnosed with primary breast cancer between 1985 and 2006 were included in this study. The statistics on all deaths between 1985 to 2016 were collected, and the observation period was 10 years (2006-2016). Mortality hazards according to age at diagnosis and years elapsed since diagnosis were estimated using a flexible parametric estimation. Of the 40,690 patients, 13,676 (34%) died from all-cause death, and the 10-year survival rate was 65.74% (95% confidence interval: 65.28-66.21). The proportions of deaths were 10,531 (77%) from breast cancer, 1048 (8%) from other cancers, and 2097 (15%) from non-cancer causes. The mortality hazard for deaths from breast cancer was initially high and then declined, whereas that for deaths from other cancers and non-cancer causes was initially low and then increased. The more likely causes of death 5 years after breast cancer diagnosis were other cancers or non-cancer causes among patients aged ≥70 years.
Language	English
Publishing date	2023-05-12
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2721009-1
ISSN	2227-9032
ISSN	2227-9032
DOI	10.3390/healthcare11101409
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Article: Cause of Death among Long-Term Cancer Survivors: The NANDE Study.

Fujii, Makoto / Morishima, Toshitaka / Nagayasu, Mayumi / Kudo, Haruka / Ohno, Yuko / Sobue, Tomotaka / Miyashiro, Isao

Healthcare (Basel, Switzerland)

2023 Volume 11, Issue 6

Abstract: Survival information for Japanese patients with cancer is based only on survival status and the cause of death among these patients remains unclear. In this study, Osaka Cancer Registry data (1985-2014) and vital statistics data (1985-2016) were linked ... ...

Abstract	Survival information for Japanese patients with cancer is based only on survival status and the cause of death among these patients remains unclear. In this study, Osaka Cancer Registry data (1985-2014) and vital statistics data (1985-2016) were linked to create a database, permitting the extraction of data on the causes of death. In total, 522,566 subjects diagnosed with cancer between 1995 and 2011 were analyzed. Follow-up for vital status was conducted 5 and 10 years after cancer diagnosis. To evaluate the three causes of death (index cancer, non-index cancer, and non-cancer death), cause-specific hazard and cumulative incidence functions were estimated using a life table and Gray's methods. The number of deaths owing to any of the causes in the observation period (median: 3.51 years, mean: 4.90 years) was 394,146. The 5- and 10-year cancer-specific survival rate was 48.56% and 39.92%, respectively. Immediately after cancer onset, the hazard of index cancer death was high. The proportion of non-index cancer deaths was high in patients with mouth and pharynx cancers. The hazard of index cancer death remained constant for breast and liver cancers. In prostate, breast, and laryngeal cancers with good prognosis, the hazard of non-index cancer and non-cancer death constantly increased.
Language	English
Publishing date	2023-03-13
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2721009-1
ISSN	2227-9032
ISSN	2227-9032
DOI	10.3390/healthcare11060835
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Article ; Online: Blood eosinophil phenotype during treatment with mepolizumab in patients with severe eosinophilic asthma.

Sakai, Chio / Matsuyama, Masashi / Nakajima, Masayuki / Matsumura, Sosuke / Nonaka, Mizu / Arai, Naoki / Kuramoto, Kenya / Yoshida, Kazufumi / Morishima, Yuko / Muratani, Masafumi / Hizawa, Nobuyuki

Allergology international : official journal of the Japanese Society of Allergology

2024

Language	English
Publishing date	2024-04-05
Publishing country	England
Document type	Letter
ZDB-ID	1336498-4
ISSN	1440-1592 ; 1323-8930
ISSN (online)	1440-1592
ISSN	1323-8930
DOI	10.1016/j.alit.2024.03.005
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Zs.A 5248: Show issues

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Article ; Online: Prolongation of clot lysis time by a direct thrombin inhibitor melagatran mediated by paradoxical enhancement of thrombin generation: comparison with a direct factor Xa inhibitor edoxaban.

Morishima, Yoshiyuki / Kamisato, Chikako / Honda, Yuko

Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis

2021 Volume 32, Issue 3, Page(s) 209–215

Abstract: Previously, we reported that a direct thrombin inhibitor melagatran paradoxically increased thrombin generation in human plasma in the presence of thrombomodulin. The aim of this study is to test the hypothesis that melagatran may exert a deleterious ... ...

Abstract	Previously, we reported that a direct thrombin inhibitor melagatran paradoxically increased thrombin generation in human plasma in the presence of thrombomodulin. The aim of this study is to test the hypothesis that melagatran may exert a deleterious effect on tissue-type plasminogen activator (t-PA)-induced fibrinolysis via enhancement of thrombin generation and subsequent activation of thrombin-activatable fibrinolysis inhibitor (TAFI) and factor XIII (FXIII). Clot formation in human plasma containing t-PA and thrombomodulin was induced by tissue factor. The absorbance at 405 nm was measured to obtain clot lysis time. Effects of melagatran and a factor Xa inhibitor edoxaban on clot lysis time were determined. In the presence of thrombomodulin, melagatran significantly prolonged clot lysis time, but edoxaban shortened it. In the absence of thrombomodulin, melagatran did not inhibit fibrinolysis. Prolongation of clot lysis time by melagatran was reversed by activated protein C (which suppressed thrombin generation increased by melagatran) and a TAFIa inhibitor. Melagatran significantly suppressed plasmin generation, while edoxaban significantly increased it. However, both melagatran and edoxaban suppressed FXIII activation. In the clot formed in the presence of melagatran and edoxaban, the fibrin fibre was thin compared with control, showing no clear difference in the clot structures between melagatran and edoxaban. These results indicated that melagatran, not edoxaban, prolonged clot lysis time through the paradoxical enhancement of thrombin generation, and subsequent TAFI activation and inhibition of plasmin generation. Neither FXIII activation nor change in fibrin clot structure contributed to the inhibition of fibrinolysis by melagatran.
MeSH term(s)	Antithrombins/pharmacology ; Azetidines/pharmacology ; Benzylamines/pharmacology ; Factor Xa Inhibitors/pharmacology ; Fibrin Clot Lysis Time ; Fibrinolysis/drug effects ; Humans ; Pyridines/pharmacology ; Thiazoles/pharmacology ; Thrombin/metabolism
Chemical Substances	Antithrombins ; Azetidines ; Benzylamines ; Factor Xa Inhibitors ; Pyridines ; Thiazoles ; melagatran (2A9QP32MD4) ; Thrombin (EC 3.4.21.5) ; edoxaban (NDU3J18APO)
Language	English
Publishing date	2021-02-09
Publishing country	England
Document type	Comparative Study ; Journal Article
ZDB-ID	1033551-1
ISSN	1473-5733 ; 0957-5235
ISSN (online)	1473-5733
ISSN	0957-5235
DOI	10.1097/MBC.0000000000001020
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