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  1. Article ; Online: Visualization software for radioactive contamination based on Compton camera: COMRIS.

    Sato, Yuki / Minemoto, Kojiro / Nemoto, Makoto

    Radiation protection dosimetry

    2023  Volume 199, Issue 8-9, Page(s) 1021–1028

    Abstract: Identifying and visualizing the radiation source location are important in reducing the radiation exposure of workers at the decommissioning site of the Fukushima Daiichi Nuclear Power Station and in improving the radiation protection functions in other ... ...

    Abstract Identifying and visualizing the radiation source location are important in reducing the radiation exposure of workers at the decommissioning site of the Fukushima Daiichi Nuclear Power Station and in improving the radiation protection functions in other sites where radiation sources are handled. In this paper, we developed the COMpton camera for Radiation Imaging System (COMRIS) to identify and visualize the radiation source location in 3D using output data from a Compton camera and a simultaneous localization and mapping (SLAM) device as input data. Here, we presented COMRIS to visualize a 137Cs-radiation source in a dark environment using data acquired by a commercial Compton camera and a LiDAR-based SLAM device mounted on a robot as input data. The radiation source image obtained using the Compton camera was drawn on the 3D work environment model acquired by the SLAM device, and the radiation source location was visible in 3D.
    MeSH term(s) Humans ; Cesium Radioisotopes ; Radiation Exposure ; Radiation Protection ; Software
    Chemical Substances Cesium-137 (4T2E65IAR7) ; Cesium Radioisotopes
    Language English
    Publishing date 2023-05-24
    Publishing country England
    Document type Journal Article
    ZDB-ID 225912-6
    ISSN 1742-3406 ; 0144-8420
    ISSN (online) 1742-3406
    ISSN 0144-8420
    DOI 10.1093/rpd/ncad106
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  2. Article: Potential role of type I interferon/IP-10 axis in the pathogenesis of anti-MDA5 antibody-positive dermatomyositis.

    Kokuzawa, Ayako / Nakamura, Jun / Kamata, Yasuyuki / Sato, Kojiro

    Clinical and experimental rheumatology

    2023  Volume 41, Issue 2, Page(s) 275–284

    Abstract: Objectives: Dermatomyositis (DM) patients with anti-melanoma differentiation-associated protein 5 (MDA5) antibodies are known for poor prognosis. This study was designed to identify humoral factors that are readily detectable in the disease and may ... ...

    Abstract Objectives: Dermatomyositis (DM) patients with anti-melanoma differentiation-associated protein 5 (MDA5) antibodies are known for poor prognosis. This study was designed to identify humoral factors that are readily detectable in the disease and may reflect its activity and pathophysiology.
    Methods: We first quantified the serum level expression of 28 cytokines in the serum of patients with collagen vascular diseases using bead-based multiplex immunoassays. We completed these evaluations at hospital admission and followed up with three DM patients with anti-MDA5 antibodies during hospitalisation. We also performed an immunohistochemical analysis of skin samples obtained from two patients.
    Results: The serum level of interferon gamma-induced protein 10 (IP-10) was significantly higher in DM patients with anti-MDA5 antibodies than in those without the antibody, decreasing drastically upon treatment. Interestingly, this time course paralleled not that of interferon (IFN)-γ, which was originally reported to be the inducer of IP-10, but that of IFN-α2. Immunohistochemical analysis revealed that most of the IP-10-positive cells were macrophages. Furthermore, monocytes stimulated with type I IFN in vitro produced IP-10 in a dose-dependent manner.
    Conclusions: IP-10 is a potentially useful disease activity marker of DM with anti-MDA5 antibodies, correlating more with IFN-α2 then IFN-γ. IP-10 released from macrophages might prompt the infiltration of macrophages themselves. Thus, the type I IFN/IP-10 axis may play a pivotal role in the pathogenesis of this intractable disease.
    MeSH term(s) Humans ; Autoantibodies ; Chemokine CXCL10/metabolism ; Connective Tissue Diseases/metabolism ; Connective Tissue Diseases/pathology ; Cytokines ; Dermatomyositis/metabolism ; Dermatomyositis/pathology ; Interferon Type I/metabolism ; Interferon-Induced Helicase, IFIH1/immunology ; Interferon-Induced Helicase, IFIH1/metabolism ; Prognosis ; Retrospective Studies
    Chemical Substances Autoantibodies ; Chemokine CXCL10 ; Cytokines ; Interferon Type I ; Interferon-Induced Helicase, IFIH1 (EC 3.6.4.13)
    Language English
    Publishing date 2023-01-09
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 605886-3
    ISSN 1593-098X ; 0392-856X
    ISSN (online) 1593-098X
    ISSN 0392-856X
    DOI 10.55563/clinexprheumatol/em67zx
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  3. Article ; Online: Oculomotor Palsy Caused by Aberrant Posterior Cerebral Artery.

    Sato, Sho / Takeuchi, Satoru / Ishihara, Shoichiro / Wada, Kojiro

    Internal medicine (Tokyo, Japan)

    2022  Volume 62, Issue 2, Page(s) 311–312

    MeSH term(s) Humans ; Posterior Cerebral Artery/diagnostic imaging ; Ophthalmoplegia/diagnosis ; Ophthalmoplegia/etiology ; Oculomotor Nerve Diseases/etiology ; Oculomotor Nerve Diseases/complications ; Intracranial Aneurysm/complications ; Oculomotor Nerve
    Language English
    Publishing date 2022-06-07
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 32371-8
    ISSN 1349-7235 ; 0021-5120 ; 0918-2918
    ISSN (online) 1349-7235
    ISSN 0021-5120 ; 0918-2918
    DOI 10.2169/internalmedicine.8706-21
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  4. Article: Effects of continuous supplementation of

    Sato, Takeru / Aoki, Takumi / Ito, Yuki / Oishi, Kan / Fujishima, Masaki / Okumura, Eri / Ishii, Kojiro

    Frontiers in cardiovascular medicine

    2024  Volume 11, Page(s) 1336676

    Abstract: Background: Cardiac autonomic function (CAF) decreases with aging, and : Methods: This double-blind, randomized controlled trial was conducted in the morning in a laboratory setting and was carried out between June 2017 and July 2017 at Kambaikan, ... ...

    Abstract Background: Cardiac autonomic function (CAF) decreases with aging, and
    Methods: This double-blind, randomized controlled trial was conducted in the morning in a laboratory setting and was carried out between June 2017 and July 2017 at Kambaikan, Doshisha University (Karasuma-higashi-iru, Imadegawa-dori, Kamigyo-ku, Kyoto 602-8580, Japan). In total, 28 community-dwelling elderly individuals (mean ± standard deviation = 72.5 ± 4.5 years) were included. Each subject was instructed to consume ASH or placebo supplements twice daily for 4 weeks. An autonomic reflex orthostatic tolerance recorder was used to measure CAF in pre- and post-intervention phases. Parameters were measured in a seated position and included coefficient of variation of R-R intervals (CVRR), low frequency (LF), high frequency (HF), LF/HF ratio, blood pressure, and heart rate (HR). Changes in each parameter were evaluated before and after standing. All parameters were defined as the difference between the mean value obtained in a standing position for 2 min and that obtained in a 2-min seated position.
    Results: A two-way analysis of variance revealed a significant group-time interaction effect on CVRR, HF, and ΔLF/HF ratio. Following the intervention, CVRR, HF, LF/HF ratio, systolic blood pressure (SBP), HR, ΔLF/HF ratio, ΔSBP, and ΔHR improved significantly in the ASH group only.
    Conclusions: Four-week supplementation of ASH improved CAF in community-dwelling elderly individuals during resting and standing tests.
    Clinical trial registration: https://center6.umin.ac.jp/cgi-open-bin/ctr/ctr_view.cgi?recptno=R000031218, UMIN Clinical Trials Registry (UMIN000027251).
    Language English
    Publishing date 2024-03-08
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2781496-8
    ISSN 2297-055X
    ISSN 2297-055X
    DOI 10.3389/fcvm.2024.1336676
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  5. Article ; Online: Essentiality of Nfatc1 short isoform in osteoclast differentiation and its self-regulation.

    Omata, Yasuhiro / Tachibana, Hideyuki / Aizaki, Yoshimi / Mimura, Toshihide / Sato, Kojiro

    Scientific reports

    2023  Volume 13, Issue 1, Page(s) 18797

    Abstract: During osteoclast differentiation, the expression of the transcription factor nuclear factor of activated T cell 1 (Nfatc1) increases in an autoproliferative manner. Nfatc1 isoforms are of three sizes, and only the short isoform increases during ... ...

    Abstract During osteoclast differentiation, the expression of the transcription factor nuclear factor of activated T cell 1 (Nfatc1) increases in an autoproliferative manner. Nfatc1 isoforms are of three sizes, and only the short isoform increases during osteoclast differentiation. Genetic ablation of the whole Nfatc1 gene demonstrated that it is essential for osteoclastogenesis; however, the specific role of the Nfatc1 short form (Nfatc1/αA) remains unknown. In this study, we engineered Nfatc1 short form-specific knockout mice and found that these mice died in utero by day 13.5. We developed a novel osteoclast culture system in which hematopoietic stem cells were cultured, proliferated, and then differentiated into osteoclasts in vitro. Using this system, we show that the Nfatc1/αA isoform is essential for osteoclastogenesis and is responsible for the expression of various osteoclast markers, the Nfatc1 short form itself, and Nfatc1 regulators.
    MeSH term(s) Mice ; Animals ; Osteoclasts/metabolism ; NFATC Transcription Factors/genetics ; NFATC Transcription Factors/metabolism ; T-Lymphocytes/metabolism ; Cell Differentiation/genetics ; Protein Isoforms/genetics ; Protein Isoforms/metabolism ; Self-Control ; RANK Ligand/metabolism
    Chemical Substances NFATC Transcription Factors ; Protein Isoforms ; RANK Ligand ; Nfatc1 protein, mouse
    Language English
    Publishing date 2023-11-01
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-023-45909-3
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  6. Article ; Online: Perihepatitis as an Initial Manifestation of Systemic Lupus Erythematosus.

    Nakamura, Jun / Nagashima, Takao / Yazawa, Hiroaki / Kokuzawa, Ayako / Sato, Kojiro

    Internal medicine (Tokyo, Japan)

    2023  Volume 63, Issue 5, Page(s) 739–741

    Abstract: A 25-year-old man presented with a fever and right upper quadrant abdominal pain. Computed tomography (CT) of the abdomen revealed diffuse perihepatic capsular enhancement, suggesting perihepatitis. Although the patient was a man, Fitz-Hugh-Curtis ... ...

    Abstract A 25-year-old man presented with a fever and right upper quadrant abdominal pain. Computed tomography (CT) of the abdomen revealed diffuse perihepatic capsular enhancement, suggesting perihepatitis. Although the patient was a man, Fitz-Hugh-Curtis syndrome was suspected based on the CT findings. Treatment with several antibiotics was ineffective. Urinary tract infection was ruled out due to negative urinary bacterial screening and careful history taking. He was finally diagnosed with systemic lupus erythematous (malar rash, pleuritis, positive antinuclear antibody, and positive anti-ds-DNA antibody). Perihepatitis resolved quickly with high-dose prednisolone. Perihepatitis may be the first manifestation of SLE.
    MeSH term(s) Adult ; Humans ; Male ; Hepatitis/etiology ; Lupus Erythematosus, Systemic/complications ; Lupus Erythematosus, Systemic/diagnosis ; Pelvic Inflammatory Disease/diagnostic imaging ; Peritonitis/etiology
    Language English
    Publishing date 2023-07-19
    Publishing country Japan
    Document type Case Reports ; Journal Article
    ZDB-ID 32371-8
    ISSN 1349-7235 ; 0021-5120 ; 0918-2918
    ISSN (online) 1349-7235
    ISSN 0021-5120 ; 0918-2918
    DOI 10.2169/internalmedicine.2165-23
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  7. Article ; Online: Essentiality of Nfatc1 short isoform in osteoclast differentiation and its self-regulation

    Yasuhiro Omata / Hideyuki Tachibana / Yoshimi Aizaki / Toshihide Mimura / Kojiro Sato

    Scientific Reports, Vol 13, Iss 1, Pp 1-

    2023  Volume 14

    Abstract: Abstract During osteoclast differentiation, the expression of the transcription factor nuclear factor of activated T cell 1 (Nfatc1) increases in an autoproliferative manner. Nfatc1 isoforms are of three sizes, and only the short isoform increases during ...

    Abstract Abstract During osteoclast differentiation, the expression of the transcription factor nuclear factor of activated T cell 1 (Nfatc1) increases in an autoproliferative manner. Nfatc1 isoforms are of three sizes, and only the short isoform increases during osteoclast differentiation. Genetic ablation of the whole Nfatc1 gene demonstrated that it is essential for osteoclastogenesis; however, the specific role of the Nfatc1 short form (Nfatc1/αA) remains unknown. In this study, we engineered Nfatc1 short form-specific knockout mice and found that these mice died in utero by day 13.5. We developed a novel osteoclast culture system in which hematopoietic stem cells were cultured, proliferated, and then differentiated into osteoclasts in vitro. Using this system, we show that the Nfatc1/αA isoform is essential for osteoclastogenesis and is responsible for the expression of various osteoclast markers, the Nfatc1 short form itself, and Nfatc1 regulators.
    Keywords Medicine ; R ; Science ; Q
    Subject code 570
    Language English
    Publishing date 2023-11-01T00:00:00Z
    Publisher Nature Portfolio
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article: Two cases of idiopathic pulmonary fibrosis evaluated by dynamic digital radiography for diaphragmatic motion and disease progression.

    Nikaido, Takefumi / Tanino, Yoshinori / Sato, Yuki / Togawa, Ryuichi / Kawamata, Takaya / Watanabe, Natsumi / Minemura, Hiroyuki / Ono, Kojiro / Sato, Katsumasa / Shibata, Yoko

    Respirology case reports

    2024  Volume 12, Issue 2, Page(s) e01301

    Abstract: Forced vital capacity has been utilized as a parameter of disease progression in idiopathic pulmonary fibrosis (IPF); however, its measurement is difficult when patients do not understand or cooperate. Dynamic digital radiography (DDR) enables sequential ...

    Abstract Forced vital capacity has been utilized as a parameter of disease progression in idiopathic pulmonary fibrosis (IPF); however, its measurement is difficult when patients do not understand or cooperate. Dynamic digital radiography (DDR) enables sequential chest X-ray imaging during breathing, with lower radiation doses compared to conventional fluoroscopy or computed tomography. There is accumulating evidence showing that parameters obtained from DDR, particularly those related to diaphragmatic dynamics, are correlated with pulmonary function parameters, and are useful for pathophysiological evaluation. We herein present two cases that suggest parameters obtained from DDR during supine normal tidal breathing may predict disease progression of IPF.
    Language English
    Publishing date 2024-02-21
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2750180-2
    ISSN 2051-3380
    ISSN 2051-3380
    DOI 10.1002/rcr2.1301
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  9. Article ; Online: Course of insight, depression and suicidality in inpatients with first-episode schizophrenia who received group psychoeducation.

    Sato, Kojiro / So, Ryuhei / Yoshimura, Bunta / Kitagawa, Kohei

    Early intervention in psychiatry

    2021  Volume 16, Issue 9, Page(s) 979–984

    Abstract: Aim: We aimed to investigate whether gaining insight through psychoeducation for first-episode schizophrenia is associated with increased suicidality.: Methods: We conducted a secondary analysis of a prospective cohort study that included inpatients ... ...

    Abstract Aim: We aimed to investigate whether gaining insight through psychoeducation for first-episode schizophrenia is associated with increased suicidality.
    Methods: We conducted a secondary analysis of a prospective cohort study that included inpatients with first-episode schizophrenia who attended a group psychoeducation program during their admission. The group psychoeducation program consisted of four weekly sessions provided by a multidisciplinary team. The primary outcome was the correlation between changes in insight and suicidality. We also examined whether change in insight was associated with changes in hopelessness and depression. We measured insight using the Birchwood Insight Scale. Suicidality, hopelessness and depression were measured using the Calgary Depression Rating Scale for Schizophrenia.
    Results: A total of 125 people participated in the educational program. The Spearman's correlation coefficient between changes in insight and suicidality was -0.14 (95% confidence interval, -0.31 to 0.04; p = .12). Similarly, gain in insight did not significantly correlate with change in depression (0.01, 95% confidence interval, -0.17 to 0.18; p = .93) and change in hopelessness (0.01, 95% confidence interval, -0.16 to 0.19; p = .88).
    Conclusions: We observed almost no association between gaining insight and suicidality after a group psychoeducation program in inpatients with first-episode schizophrenia.
    MeSH term(s) Depression ; Humans ; Inpatients ; Prospective Studies ; Psychiatric Status Rating Scales ; Schizophrenia/therapy ; Suicide
    Language English
    Publishing date 2021-11-02
    Publishing country Australia
    Document type Journal Article
    ZDB-ID 2272425-4
    ISSN 1751-7893 ; 1751-7885
    ISSN (online) 1751-7893
    ISSN 1751-7885
    DOI 10.1111/eip.13239
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  10. Article: Dual effects of interleukin-10 on natural killer cells and monocytes and the implications for adult-onset Still's disease.

    Aizaki, Yoshimi / Yazawa, Hiroaki / Sato, Kojiro / Mimura, Toshihide

    Clinical and experimental rheumatology

    2021  Volume 39 Suppl 132, Issue 5, Page(s) 22–29

    Abstract: Objectives: We compared the serum levels of multiple cytokines in patients with adult-onset Still's disease (AOSD) and healthy controls to assess the effects of humoral factors on natural killer (NK) cells and monocytes.: Methods: We quantified the ... ...

    Abstract Objectives: We compared the serum levels of multiple cytokines in patients with adult-onset Still's disease (AOSD) and healthy controls to assess the effects of humoral factors on natural killer (NK) cells and monocytes.
    Methods: We quantified the serum levels of 10 cytokines in the patients using bead-based multiplex immunoassays, along with interleukin (IL-)18 using ELISA. We then sorted NK cells and monocytes from the peripheral blood mononuclear cells (PBMCs) of healthy volunteers, cultured them in the presence or absence of cytokines that were detected in some or all of the serum samples from the AOSD patients and their combinations in vitro, and analysed the culture supernatant.
    Results: IL-6 and IL-18 were the main cytokines increased in the serum of AOSD patients. When NK cells were cultured with the cytokines and IL-10, the combination of IL-10 and IL-18 substantially induced interferon (IFN-)γ. IL-6 had little effect on NK cells, probably because they barely expressed the IL-6 receptor and glycoprotein 130 (gp130). IFN-γ induced monocytes to produce IL-1β, IL-6 and tumour necrosis factor (TNF-)α whereas IL-10 inhibited the induction of these proinflammatory cytokines.
    Conclusions: IL-10 evidently has dual effects on NK cells (stimulation) and on monocytes (inhibition). Better understanding the roles of the cytokine network would shed light on the pathogenesis of AOSD.
    MeSH term(s) Cytokines ; Humans ; Interleukin-10/blood ; Interleukin-10/metabolism ; Killer Cells, Natural ; Leukocytes, Mononuclear ; Monocytes ; Still's Disease, Adult-Onset/blood ; Still's Disease, Adult-Onset/diagnosis ; Still's Disease, Adult-Onset/drug therapy ; Still's Disease, Adult-Onset/metabolism
    Chemical Substances Cytokines ; IL10 protein, human ; Interleukin-10 (130068-27-8)
    Language English
    Publishing date 2021-05-17
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 605886-3
    ISSN 1593-098X ; 0392-856X
    ISSN (online) 1593-098X
    ISSN 0392-856X
    DOI 10.55563/clinexprheumatol/2vdem0
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