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  1. Article: Exploring post-SEPSIS and post-COVID-19 syndromes: crossovers from pathophysiology to therapeutic approach.

    Holmes, Darcy / Colaneri, Marta / Palomba, Emanuele / Gori, Andrea

    Frontiers in medicine

    2024  Volume 10, Page(s) 1280951

    Abstract: Sepsis, driven by several infections, including COVID-19, can lead to post-sepsis syndrome (PSS) and post-acute sequelae of COVID-19 (PASC). Both these conditions share clinical and pathophysiological similarities, as survivors face persistent multi- ... ...

    Abstract Sepsis, driven by several infections, including COVID-19, can lead to post-sepsis syndrome (PSS) and post-acute sequelae of COVID-19 (PASC). Both these conditions share clinical and pathophysiological similarities, as survivors face persistent multi-organ dysfunctions, including respiratory, cardiovascular, renal, and neurological issues. Moreover, dysregulated immune responses, immunosuppression, and hyperinflammation contribute to these conditions. The lack of clear definitions and diagnostic criteria hampers comprehensive treatment strategies, and a unified therapeutic approach is significantly needed. One potential target might be the renin-angiotensin system (RAS), which plays a significant role in immune modulation. In fact, RAS imbalance can exacerbate these responses. Potential interventions involving RAS include ACE inhibitors, ACE receptor blockers, and recombinant human ACE2 (rhACE2). To address the complexities of PSS and PASC, a multifaceted approach is required, considering shared immunological mechanisms and the role of RAS. Standardization, research funding, and clinical trials are essential for advancing treatment strategies for these conditions.
    Language English
    Publishing date 2024-01-05
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2775999-4
    ISSN 2296-858X
    ISSN 2296-858X
    DOI 10.3389/fmed.2023.1280951
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Post-exposure prophylaxis, STI testing and factors associated with follow-up attendance: a review of 4159 cases of acute post-sexual assault medical care.

    Kane, Daniel / Holmes, Andrea / Eogan, Maeve

    Sexually transmitted infections

    2024  Volume 100, Issue 1, Page(s) 39–44

    Abstract: Background: Sexual assault (SA) is a prevalent issue with enduring consequences. Post-SA medical care mainly focuses on injuries, sexually transmitted infection (STI) prevention and detection, as well as preventing unwanted pregnancies. Swift access to ... ...

    Abstract Background: Sexual assault (SA) is a prevalent issue with enduring consequences. Post-SA medical care mainly focuses on injuries, sexually transmitted infection (STI) prevention and detection, as well as preventing unwanted pregnancies. Swift access to post-SA medical care is vital with sexual assault treatment units (SATUs) streamlining this care. The primary aim of our study is to report on post-SA care provided at the national SATU network in Ireland with a secondary aim of analysing factors associated with follow-up attendance for STI testing.
    Methods: This is a retrospective cohort study of all acute attendances (<7 days from incident) at the national SATU network between 1 January 2017 to 31 December 2022.
    Results: A total of 4159 acute cases presented during the study period. Emergency contraception (EC) was administered to 53.8% (n=1899/3529) of cases, while postexposure prophylaxis (PEP) for chlamydia was given in 75.1% (n=3124/4159) and for HIV in 11.0% (n=304/3387). Hepatitis B vaccination was initiated in 53.7% (n=2233/4159) of cases. 1.4% (n=59/4159) of the attendees were referred to an emergency department for the treatment of injuries. Follow-up appointments were scheduled for 75.8% (3151/4159) of acute cases. 71.6% (n=2257/3151) attended follow-up.Certain factors were found to correlate with a higher likelihood of attending follow-up appointments: adolescents (p<0.0001), concern about drug-facilitated SA (DFSA) (p=0.01), no consumption of recreational drugs before the incident (p<0.0001), alcohol consumption prior to the incident (p=0.01), and not reporting the crime to the police (p<0.001). However, gender (p=0.06) and the presence of injury at time of primary attendance (p=0.97) were not predictive of likelihood of follow-up attendance.
    Conclusion: This study demonstrates that EC, chlamydia PEP, HIV PEP and hepatitis B vaccination were all administered at SATU. A small proportion of attenders required emergency injury care. Factors influencing attendance at follow-up include age, drug use, alcohol use and police involvement, highlighting the need for tailored patient-centred support.
    MeSH term(s) Pregnancy ; Female ; Adolescent ; Humans ; Retrospective Studies ; Follow-Up Studies ; Post-Exposure Prophylaxis ; Sexually Transmitted Diseases/diagnosis ; Sexually Transmitted Diseases/epidemiology ; Sexually Transmitted Diseases/prevention & control ; Sex Offenses ; HIV Infections/diagnosis ; HIV Infections/epidemiology ; HIV Infections/prevention & control ; Hepatitis B/diagnosis ; Hepatitis B/epidemiology ; Hepatitis B/prevention & control
    Language English
    Publishing date 2024-01-17
    Publishing country England
    Document type Review ; Journal Article
    ZDB-ID 1420303-0
    ISSN 1472-3263 ; 1368-4973
    ISSN (online) 1472-3263
    ISSN 1368-4973
    DOI 10.1136/sextrans-2023-055980
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Carbapenem or new β-lactam-β-lactamase inhibitors? An Italian survey supported by SITA, SIMIT and SIAARTI to identify the factors affecting empiric antimicrobial therapy choice in real-life clinical practice.

    Colaneri, Marta / Genovese, Camilla / Lombardi, Andrea / Holmes, Darcy / Bandera, Alessandra / Gori, Andrea

    European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology

    2024  

    Abstract: While a tailored antibiotic treatment plan is often straightforward, what we often observe in daily clinical practice is a highly variable approach when defining empirical therapy. Specifically, a debate exists on preference to spare the new β-lactams ... ...

    Abstract While a tailored antibiotic treatment plan is often straightforward, what we often observe in daily clinical practice is a highly variable approach when defining empirical therapy. Specifically, a debate exists on preference to spare the new β-lactams and β-lactamase inhibitors (BL-BLIs) or to apply a carbapenem-sparing strategy first. To investigate, we designed a web survey aimed at investigating the variables considered relevant to empirically choosing one antibiotic over the other. Submitted to Italian infectious diseases and intensive care physicians through the support of Società Italiana di Malattie Infettive e Tropicali (SIMIT), Società Italiana di Terapia Antinfettiva (SITA) and Società Italiana Anestesia, Analgesia, Rianimazione e Terapia Intensiva (SIAARTI). We found that demographic characteristics were irrelevant when deciding for empirical therapy. Clinical and anamnestic data were most meaningful. Significantly considered were underlying comorbidities and previous exposure to antimicrobial treatments. History of third-generation cephalosporin-resistant, carbapenem-resistant and/or metallo-β-lactamase-producing Enterobacterales rectal colonisation and/or infection were considered the most relevant by most physicians. Unexpectedly, clinicians considered less the source of infection. These results prompt the need of straightforward methods to retrieve medical histories and the magnitude of rectal colonisation data, often not routinely obtained.
    Language English
    Publishing date 2024-03-08
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 603155-9
    ISSN 1435-4373 ; 0934-9723 ; 0722-2211
    ISSN (online) 1435-4373
    ISSN 0934-9723 ; 0722-2211
    DOI 10.1007/s10096-024-04798-8
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Exploring post-SEPSIS and post-COVID-19 syndromes

    Darcy Holmes / Marta Colaneri / Emanuele Palomba / Andrea Gori

    Frontiers in Medicine, Vol

    crossovers from pathophysiology to therapeutic approach

    2024  Volume 10

    Abstract: Sepsis, driven by several infections, including COVID-19, can lead to post-sepsis syndrome (PSS) and post-acute sequelae of COVID-19 (PASC). Both these conditions share clinical and pathophysiological similarities, as survivors face persistent multi- ... ...

    Abstract Sepsis, driven by several infections, including COVID-19, can lead to post-sepsis syndrome (PSS) and post-acute sequelae of COVID-19 (PASC). Both these conditions share clinical and pathophysiological similarities, as survivors face persistent multi-organ dysfunctions, including respiratory, cardiovascular, renal, and neurological issues. Moreover, dysregulated immune responses, immunosuppression, and hyperinflammation contribute to these conditions. The lack of clear definitions and diagnostic criteria hampers comprehensive treatment strategies, and a unified therapeutic approach is significantly needed. One potential target might be the renin-angiotensin system (RAS), which plays a significant role in immune modulation. In fact, RAS imbalance can exacerbate these responses. Potential interventions involving RAS include ACE inhibitors, ACE receptor blockers, and recombinant human ACE2 (rhACE2). To address the complexities of PSS and PASC, a multifaceted approach is required, considering shared immunological mechanisms and the role of RAS. Standardization, research funding, and clinical trials are essential for advancing treatment strategies for these conditions.
    Keywords post-sepsis syndrome (PSS) ; post-acute sequelae of COVID-19 (PASC) ; immune dysfunction ; renin-angiotensin system (RAS) ; angiotensin-converting enzyme 2 (ACE2) ; Medicine (General) ; R5-920
    Subject code 610
    Language English
    Publishing date 2024-01-01T00:00:00Z
    Publisher Frontiers Media S.A.
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: Soil salinization and chemically mediated plant-insect interactions in a changing climate.

    Marroquin, Andrea / Holmes, Katherine / Salazar, Diego

    Current opinion in insect science

    2023  Volume 60, Page(s) 101130

    Abstract: Increase in soil salinization due to climate change is a global phenomenon that can induce significant changes in plant growth, physiology, and chemistry, exacerbating growing threats to insect biodiversity. Insects that rely on plants are likely to be ... ...

    Abstract Increase in soil salinization due to climate change is a global phenomenon that can induce significant changes in plant growth, physiology, and chemistry, exacerbating growing threats to insect biodiversity. Insects that rely on plants are likely to be indirectly impacted by changes in soil salt content through changes in plant chemistry, yet few studies link changes in plant metabolism to impacts on higher trophic levels. Some salinity-mediated changes in specialized metabolites may be predictable due to highly conserved metabolic pathways shared between herbivore defense and stress resistance, but recent studies also suggest substantial variation across plant species and habitats. To date, most of the research on salinity and chemically mediated plant-insect interactions has focused on herbivores, particularly in agricultural systems. Published effects of salinity on pollinators and parasitoids are scarce. Future research will need to focus more on the role of plant chemistry to bridge the divide between studies of plant and insect responses to salinization.
    MeSH term(s) Animals ; Soil ; Insecta/physiology ; Ecosystem ; Herbivory/physiology ; Plants/chemistry ; Climate Change
    Chemical Substances Soil
    Language English
    Publishing date 2023-10-13
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 2772833-X
    ISSN 2214-5753 ; 2214-5745
    ISSN (online) 2214-5753
    ISSN 2214-5745
    DOI 10.1016/j.cois.2023.101130
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Geospatial Management and Analysis of Microstructural Data from San Andreas Fault Observatory at Depth (SAFOD) Core Samples

    Holmes, Elliott M / Gaughan, Andrea E / Biddle, Donald J / Stevens, Forrest R / Hadizadeh, Jafar

    ISPRS international journal of geo-information. 2021 May 14, v. 10, no. 5

    2021  

    Abstract: ... remote sensing techniques to the data. Using 26 core billet samples from the San Andreas Fault Observatory ...

    Abstract Core samples obtained from scientific drilling could provide large volumes of direct microstructural and compositional data, but generating results via the traditional treatment of such data is often time-consuming and inefficient. Unifying microstructural data within a spatially referenced Geographic Information System (GIS) environment provides an opportunity to readily locate, visualize, correlate, and apply remote sensing techniques to the data. Using 26 core billet samples from the San Andreas Fault Observatory at Depth (SAFOD), this study developed GIS-based procedures for: 1. Spatially referenced visualization and storage of various microstructural data from core billets; 2. 3D modeling of billets and thin section positions within each billet, which serve as a digital record after irreversible fragmentation of the physical billets; and 3. Vector feature creation and unsupervised classification of a multi-generation calcite vein network from cathodluminescence (CL) imagery. Building on existing work which is predominantly limited to the 2D space of single thin sections, our results indicate that a GIS can facilitate spatial treatment of data even at centimeter to nanometer scales, but also revealed challenges involving intensive 3D representations and complex matrix transformations required to create geographically translated forms of the within-billet coordinate systems, which are suggested for consideration in future studies.
    Keywords calcite ; geographic information systems ; spatial data
    Language English
    Dates of publication 2021-0514
    Publishing place Multidisciplinary Digital Publishing Institute
    Document type Article
    Note NAL-AP-2-clean
    ZDB-ID 2655790-3
    ISSN 2220-9964
    ISSN 2220-9964
    DOI 10.3390/ijgi10050332
    Database NAL-Catalogue (AGRICOLA)

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  7. Article: Resistance Training Recommendations for Children and Adolescents With Cystic Fibrosis-Related Diabetes.

    Holmes, Clifton J / Granados, Andrea

    Strength and conditioning journal

    2021  Volume 44, Issue 1, Page(s) 111–118

    Abstract: Cystic fibrosis (CF) is the most prevalent hereditary life-threatening disease in the Caucasian population. With the improvement in clinical care, individuals with CF are living longer, and CF-related diabetes (CFRD) has emerged as a major complication. ... ...

    Abstract Cystic fibrosis (CF) is the most prevalent hereditary life-threatening disease in the Caucasian population. With the improvement in clinical care, individuals with CF are living longer, and CF-related diabetes (CFRD) has emerged as a major complication. The diagnosis of CFRD is associated with shortening survival, increasing morbidity, worsening physical capacity, and body composition. Engagement in exercise training has become a prominent nonpharmacologic intervention that aims to improve fitness and clinical outcomes in individuals with CF and CFRD. This column will specifically focus on the potential benefits of resistance training and provide recommendations for children and adolescents with CF and CFRD.
    Language English
    Publishing date 2021-04-27
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2095938-2
    ISSN 1533-4295 ; 1524-1602
    ISSN (online) 1533-4295
    ISSN 1524-1602
    DOI 10.1519/ssc.0000000000000641
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: The influence of jaw-muscle fibre-type phenotypes on estimating maximum muscle and bite forces in primates.

    Holmes, Megan / Taylor, Andrea B

    Interface focus

    2021  Volume 11, Issue 5, Page(s) 20210009

    Abstract: Numerous anthropological studies have been aimed at estimating jaw-adductor muscle forces, which, in turn, are used to estimate bite force. While primate jaw adductors show considerable intra- and intermuscular heterogeneity in fibre types, studies ... ...

    Abstract Numerous anthropological studies have been aimed at estimating jaw-adductor muscle forces, which, in turn, are used to estimate bite force. While primate jaw adductors show considerable intra- and intermuscular heterogeneity in fibre types, studies generally model jaw-muscle forces by treating the jaw adductors as either homogeneously slow or homogeneously fast muscles. Here, we provide a novel extension of such studies by integrating fibre architecture, fibre types and fibre-specific tensions to estimate maximum muscle forces in the masseter and temporalis of five anthropoid primates:
    Language English
    Publishing date 2021-08-13
    Publishing country England
    Document type Journal Article
    ISSN 2042-8898
    ISSN 2042-8898
    DOI 10.1098/rsfs.2021.0009
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Geospatial Management and Analysis of Microstructural Data from San Andreas Fault Observatory at Depth (SAFOD) Core Samples

    Elliott M. Holmes / Andrea E. Gaughan / Donald J. Biddle / Forrest R. Stevens / Jafar Hadizadeh

    ISPRS International Journal of Geo-Information, Vol 10, Iss 332, p

    2021  Volume 332

    Abstract: ... remote sensing techniques to the data. Using 26 core billet samples from the San Andreas Fault Observatory ...

    Abstract Core samples obtained from scientific drilling could provide large volumes of direct microstructural and compositional data, but generating results via the traditional treatment of such data is often time-consuming and inefficient. Unifying microstructural data within a spatially referenced Geographic Information System (GIS) environment provides an opportunity to readily locate, visualize, correlate, and apply remote sensing techniques to the data. Using 26 core billet samples from the San Andreas Fault Observatory at Depth (SAFOD), this study developed GIS-based procedures for: 1. Spatially referenced visualization and storage of various microstructural data from core billets; 2. 3D modeling of billets and thin section positions within each billet, which serve as a digital record after irreversible fragmentation of the physical billets; and 3. Vector feature creation and unsupervised classification of a multi-generation calcite vein network from cathodluminescence (CL) imagery. Building on existing work which is predominantly limited to the 2D space of single thin sections, our results indicate that a GIS can facilitate spatial treatment of data even at centimeter to nanometer scales, but also revealed challenges involving intensive 3D representations and complex matrix transformations required to create geographically translated forms of the within-billet coordinate systems, which are suggested for consideration in future studies.
    Keywords Geographic Information Systems (GIS) ; remote sensing ; structural geology ; 3D visualization ; spatial analyses ; Geography (General) ; G1-922
    Subject code 910
    Language English
    Publishing date 2021-05-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article ; Online: Letter by Natale et al Regarding Article, "Amplatzer Amulet Left Atrial Appendage Occluder Versus Watchman Device for Stroke Prophylaxis (Amulet IDE): A Randomized, Controlled Trial".

    Natale, Andrea / Kar, Saibal / Holmes, David

    Circulation

    2022  Volume 145, Issue 17, Page(s) e847–e848

    MeSH term(s) Atrial Appendage/surgery ; Atrial Fibrillation/drug therapy ; Humans ; Septal Occluder Device ; Stroke/etiology ; Stroke/prevention & control
    Language English
    Publishing date 2022-04-25
    Publishing country United States
    Document type Letter ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 80099-5
    ISSN 1524-4539 ; 0009-7322 ; 0069-4193 ; 0065-8499
    ISSN (online) 1524-4539
    ISSN 0009-7322 ; 0069-4193 ; 0065-8499
    DOI 10.1161/CIRCULATIONAHA.121.057567
    Database MEDical Literature Analysis and Retrieval System OnLINE

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