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Article: Taxonomic Reassessment of the Izumo Lineage of

Sugawara, Hirotaka / Iwata, Takayuki / Yamashita, Hitoshi / Nagano, Masahiro

Animals : an open access journal from MDPI

2021 Volume 11, Issue 8

Abstract: Here, we describe a new species of the ... ...

Abstract	Here, we describe a new species of the genus
Language	English
Publishing date	2021-07-23
Publishing country	Switzerland
Document type	Journal Article
ISSN	2076-2615
ISSN	2076-2615
DOI	10.3390/ani11082187
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Article: [Rupture of Artificial Blood Vessel by a Sternal Wire:Report of a Case].

Toyama, Masahiro / Higa, Shotaro / Ando, Mizuki / Maeda, Tatsuya / Kise, Yuya / Inafuku, Hitoshi / Nakaema, Moriyasu / Nagano, Takaaki / Furukawa, Kojiro

Kyobu geka. The Japanese journal of thoracic surgery

2024 Volume 77, Issue 3, Page(s) 213–216

Abstract: Formation of a pseudoaneurysm due to blood leakage from the anastomotic site of the vascular graft in large-diameter vessels is often seen, but formation of a pseudoaneurysm from the non-anastomotic site is extremely rare. A 68-year-old woman presented ... ...

Abstract	Formation of a pseudoaneurysm due to blood leakage from the anastomotic site of the vascular graft in large-diameter vessels is often seen, but formation of a pseudoaneurysm from the non-anastomotic site is extremely rare. A 68-year-old woman presented with a history of double valve replacement for combined valvular disease at 37 years old and hemiarch replacement for thoracic aortic dilatation at 65 years old. She visited the emergency room with a 2-week history of chest pain. Contrast-enhanced computed tomography (CT) revealed a 5-cm-diameter pseudoaneurysm and extravasation from the ascending aorta, so emergency surgery was performed. Around the ascending aorta area, we confirmed bleeding from a 5-mm dehiscence in the non-anastomotic part of the graft prosthesis, so hemostasis was performed with a cross-stitch mattress suture over a felt strip. Initially, the cause of the pseudoaneurysm was unknown, but re-examination of CT images from after the previous hemiarch replacement confirmed contact between the sternal wire and graft prosthesis. The wire was thus considered to have caused damage and bleeding. The patient was discharged from the hospital with a good postoperative course and is being followed-up in the outpatient department.
MeSH term(s)	Aged ; Female ; Humans ; Aneurysm, False/diagnostic imaging ; Aneurysm, False/etiology ; Aneurysm, False/surgery ; Aorta/surgery ; Blood Substitutes ; Blood Vessel Prosthesis Implantation/adverse effects
Chemical Substances	Blood Substitutes
Language	Japanese
Publishing date	2024-03-07
Publishing country	Japan
Document type	Case Reports ; English Abstract ; Journal Article
ZDB-ID	603899-2
ISSN	0021-5252
ISSN	0021-5252
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Zs.B 11: Show issues

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Article ; Online: Radiological Analysis of Cerebrospinal Fluid Dynamics at the Craniovertebral Junction Using Time-Spatial Labeling Inversion Pulse Magnetic Resonance Imaging in Patients with Cervical Spinal Canal Stenosis.

Yamahata, Hitoshi / Ijiri, Kosei / Tanabe, Fumito / Murasumi, Kyoichi / Nagano, Yushi / Makino, Ryutaro / Higa, Nayuta / Hanaya, Ryosuke

World neurosurgery

2024 Volume 184, Page(s) e731–e736

Abstract: Objective: Spondylotic changes in the cervical spine cause degeneration, leading to cervical spinal canal stenosis. This stenotic change can affect cerebrospinal fluid (CSF) dynamics by compressing the dural sac and reducing space in the subarachnoid ... ...

Abstract	Objective: Spondylotic changes in the cervical spine cause degeneration, leading to cervical spinal canal stenosis. This stenotic change can affect cerebrospinal fluid (CSF) dynamics by compressing the dural sac and reducing space in the subarachnoid space. We examined CSF dynamics at the craniovertebral junction (CVJ) using time-spatial labeling inversion pulse magnetic resonance imaging (Time-SLIP MRI) in patients with cervical spinal canal stenosis. Methods: The maximum longitudinal movement of the CSF at the CVJ was measured as length of motion (LOM) in the Time-SLIP MRI of 56 patients. The sum of ventral and dorsal LOM was defined as the total LOM. Patients were classified into 3 groups depending on their spinal sagittal magnetic resonance imaging findings: control (n = 27, Kang classification grades 0 and 1), stenosis (n = 14, Kang classification grade 2), and severe stenosis (n = 15, Kang classification grade 3). Results: Time-SLIP MRI revealed pulsatile movement of the CSF at the CVJ. The mean total, ventral, and dorsal LOM was 14.2 ± 9, 8.1 ± 5.7, and 3.8 ± 2.9 mm, respectively. The ventral LOM was significantly larger than the dorsal LOM. The total LOM was significantly smaller in the severe stenosis group (6.1 ± 3.4 mm) than in the control (16.0 ± 8.4 mm) or stenosis (11 ± 5.4 mm) groups (P < 0.001, Kruskal-Wallis H-test). In 5 patients, postoperative total LOM was improved after adequate decompression surgery. Conclusions: This study demonstrates that CSF dynamics at the CVJ are influenced by cervical spinal canal stenosis. Time-SLIP MRI is useful for evaluating CSF dynamics at the CVJ in patients with spinal canal stenosis.
MeSH term(s)	Humans ; Constriction, Pathologic/pathology ; Magnetic Resonance Imaging/methods ; Spinal Stenosis/diagnostic imaging ; Spinal Stenosis/surgery ; Spinal Stenosis/pathology ; Radiography ; Spinal Canal/diagnostic imaging ; Spinal Canal/pathology ; Cervical Vertebrae/surgery ; Cerebrospinal Fluid/diagnostic imaging
Language	English
Publishing date	2024-02-09
Publishing country	United States
Document type	Journal Article
ZDB-ID	2534351-8
ISSN	1878-8769 ; 1878-8750
ISSN (online)	1878-8769
ISSN	1878-8750
DOI	10.1016/j.wneu.2024.02.020
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Zs.A 1159: Show issues

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Article: Inter-layer magnetic tuning by gas adsorption in π-stacked pillared-layer framework magnets.

Kosaka, Wataru / Nemoto, Honoka / Nagano, Kohei / Kawaguchi, Shogo / Sugimoto, Kunihisa / Miyasaka, Hitoshi

Chemical science

2022 Volume 14, Issue 4, Page(s) 791–800

Abstract: Magnetism of layered magnets depends on the inter-layer through-space magnetic interactions ( ...

Abstract	Magnetism of layered magnets depends on the inter-layer through-space magnetic interactions (
Language	English
Publishing date	2022-12-26
Publishing country	England
Document type	Journal Article
ZDB-ID	2559110-1
ISSN	2041-6539 ; 2041-6520
ISSN (online)	2041-6539
ISSN	2041-6520
DOI	10.1039/d2sc06337a
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Article ; Online: Cellular immunity reflects the persistent symptoms among COVID-19 recovered patients in Japan.

Miyata, Yoshiharu / Suzuki, Kohjin / Nagano, Tatsuya / Iida, Keiji / Hasegawa, Takehiro / Uga, Hitoshi / Matsuoka, Hiroshi

Scientific reports

2023 Volume 13, Issue 1, Page(s) 11071

Abstract: Coronavirus disease (COVID-19) often causes persistent symptoms long after infection, referred to as "long COVID" or post-acute COVID-19 syndrome (PACS). This phenomenon has been studied primarily concerning B-cell immunity, while the involvement of T- ... ...

Abstract	Coronavirus disease (COVID-19) often causes persistent symptoms long after infection, referred to as "long COVID" or post-acute COVID-19 syndrome (PACS). This phenomenon has been studied primarily concerning B-cell immunity, while the involvement of T-cell immunity is still unclear. This retrospective study aimed to examine the relationship among the number of symptoms, cytokine levels, and the Enzyme-linked immunosorbent spot (ELISPOT) assay data in patients with COVID-19. To examine inflammatory conditions, plasma interleukin (IL)-6, IL-10, IL-18, chemokine ligand 9 (CXCL9), chemokine ligand 3 (CCL3), and vascular endothelial growth factor (VEGF) levels were analyzed using plasma obtained from COVID-19 recovery patients and healthy controls (HC). These levels were significantly higher in the COVID-19 group than those in the HC group. ELISPOT assays were performed to investigate the correlation between COVID-19 persistent symptoms and T-cell immunity. Cluster analysis of ELISPOT categorized COVID-19 recovery patients in the ELISPOT-high and -low groups, based on the values of S1, S2, and N. The number of persistent symptoms was significantly higher in the ELISPOT-low group than those in the ELISPOT-high group. Thus, T cell immunity is critical for the rapid elimination of COVID-19 persistent symptoms, and its measurement immediately after COVID-19 recovery might predict long-term COVID-19 or PACS.
MeSH term(s)	Humans ; Vascular Endothelial Growth Factor A ; Retrospective Studies ; Japan/epidemiology ; Ligands ; COVID-19 ; Immunity, Cellular ; Interleukin-6
Chemical Substances	Vascular Endothelial Growth Factor A ; Ligands ; Interleukin-6
Language	English
Publishing date	2023-07-08
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-023-35505-w
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Article ; Online: Survey of infants hospitalized for respiratory syncytial virus disease in Tokyo, 2018.

Seimiya, Ayako / Morioka, Ichiro / Okahashi, Aya / Nagano, Nobuhiko / Yoda, Hitoshi

Pediatrics international : official journal of the Japan Pediatric Society

2021 Volume 63, Issue 2, Page(s) 219–221

MeSH term(s)	Antiviral Agents/therapeutic use ; Hospitalization ; Humans ; Infant ; Palivizumab/therapeutic use ; Respiratory Syncytial Virus Infections/diagnosis ; Respiratory Syncytial Virus Infections/drug therapy ; Respiratory Syncytial Virus Infections/epidemiology ; Respiratory Syncytial Viruses ; Tokyo/epidemiology
Chemical Substances	Antiviral Agents ; Palivizumab (DQ448MW7KS)
Language	English
Publishing date	2021-02-13
Publishing country	Australia
Document type	Journal Article
ZDB-ID	1470376-2
ISSN	1442-200X ; 1328-8067
ISSN (online)	1442-200X
ISSN	1328-8067
DOI	10.1111/ped.14381
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Zs.A 848: Show issues

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ab Jg. 2022: Lesesaal (EG)

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Article ; Online: Synthesis of N-methylated unsymmetric porphyrinoids with restricted N-centered chirality from chlorophyll-a.

Kawamoto, Yuki / Nagano, Yasunobu / Kitagawa, Yuichi / Tamiaki, Hitoshi

Organic & biomolecular chemistry

2020 Volume 18, Issue 48, Page(s) 9800–9804

Abstract: Regioselectively N-methylated chlorophyll-a derivatives were prepared as their cationic and hydrophilic species. Both their epimerically pure samples at the chiral methylated nitrogen atom were obtained, and the stereochemistry was proposed by circular ... ...

Abstract	Regioselectively N-methylated chlorophyll-a derivatives were prepared as their cationic and hydrophilic species. Both their epimerically pure samples at the chiral methylated nitrogen atom were obtained, and the stereochemistry was proposed by circular dichroism spectral analysis. This is the first example for restricted N-centered chirality in an unsymmetric chlorin core.
MeSH term(s)	Chlorophyll A
Chemical Substances	Chlorophyll A (YF5Q9EJC8Y)
Language	English
Publishing date	2020-12-09
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2097583-1
ISSN	1477-0539 ; 1477-0520
ISSN (online)	1477-0539
ISSN	1477-0520
DOI	10.1039/d0ob02146f
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Article ; Online: Cellular immunity reflects the persistent symptoms among COVID-19 recovered patients in Japan

Yoshiharu Miyata / Kohjin Suzuki / Tatsuya Nagano / Keiji Iida / Takehiro Hasegawa / Hitoshi Uga / Hiroshi Matsuoka

Scientific Reports, Vol 13, Iss 1, Pp 1-

2023 Volume 11

Abstract: Abstract Coronavirus disease (COVID-19) often causes persistent symptoms long after infection, referred to as “long COVID” or post-acute COVID-19 syndrome (PACS). This phenomenon has been studied primarily concerning B-cell immunity, while the ... ...

Abstract	Abstract Coronavirus disease (COVID-19) often causes persistent symptoms long after infection, referred to as “long COVID” or post-acute COVID-19 syndrome (PACS). This phenomenon has been studied primarily concerning B-cell immunity, while the involvement of T-cell immunity is still unclear. This retrospective study aimed to examine the relationship among the number of symptoms, cytokine levels, and the Enzyme-linked immunosorbent spot (ELISPOT) assay data in patients with COVID-19. To examine inflammatory conditions, plasma interleukin (IL)-6, IL-10, IL-18, chemokine ligand 9 (CXCL9), chemokine ligand 3 (CCL3), and vascular endothelial growth factor (VEGF) levels were analyzed using plasma obtained from COVID-19 recovery patients and healthy controls (HC). These levels were significantly higher in the COVID-19 group than those in the HC group. ELISPOT assays were performed to investigate the correlation between COVID-19 persistent symptoms and T-cell immunity. Cluster analysis of ELISPOT categorized COVID-19 recovery patients in the ELISPOT-high and -low groups, based on the values of S1, S2, and N. The number of persistent symptoms was significantly higher in the ELISPOT-low group than those in the ELISPOT-high group. Thus, T cell immunity is critical for the rapid elimination of COVID-19 persistent symptoms, and its measurement immediately after COVID-19 recovery might predict long-term COVID-19 or PACS.
Keywords	Medicine ; R ; Science ; Q
Subject code	610
Language	English
Publishing date	2023-07-01T00:00:00Z
Publisher	Nature Portfolio
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Taxonomic Reassessment of the Izumo Lineage of Hynobius utsunomiyaorum

Hirotaka Sugawara / Takayuki Iwata / Hitoshi Yamashita / Masahiro Nagano

Animals, Vol 11, Iss 2187, p

Description of a New Species from Chugoku, Japan

2021 Volume 2187

Abstract: Here, we describe a new species of the genus Hynobius from Chugoku, Japan. In populations from central to eastern Shimane Prefecture, the Izumo Lineage of Hynobius utsunomiyaorum was clearly distinguished from the true Hynobius utsunomiyaorum based on ... ...

Abstract	Here, we describe a new species of the genus Hynobius from Chugoku, Japan. In populations from central to eastern Shimane Prefecture, the Izumo Lineage of Hynobius utsunomiyaorum was clearly distinguished from the true Hynobius utsunomiyaorum based on morphological and molecular evidence. Thus, we describe the former lineage as a new species, Hynobius kunibiki sp. nov. Morphological comparisons revealed that H. utsunomiyaorum lacks a distinct yellow line on the ventral side of its tail, whereas the new species possesses this yellow line; most H. utsunomiyaorum individuals have distinct white spots on the lateral sides of their body and lack a fifth toe, whereas the new species largely lacks these spots, and all examined individuals had a fifth toe. The two species also differed significantly by several other morphological characteristics. The lentic species Hynobius setoi is morphologically similar to H. kunibiki sp. nov., but they differ significantly by various morphological characteristics. Despite their partial morphological similarity, these two species differed substantially in terms of their genetics. Finally, we show, in a phylogenetic tree including all Japanese Hynobius species, that the subgenus Hynobius can be divided into four genetic clades. Overall, this information will help develop conservation management strategies and policies for these species.
Keywords	canonical discriminant analysis ; cytochrome b ; lentic salamander ; polyphyly ; San’in region ; Veterinary medicine ; SF600-1100 ; Zoology ; QL1-991
Subject code	590 ; 580
Language	English
Publishing date	2021-07-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: History of the terrestrial isopod genus Ligidium in Japan based on phylogeographic analysis.

Harigai, Wakana / Saito, Aya / Zemmoto, Chika / Karasawa, Shigenori / Yokoi, Touta / Nagano, Atsushi J / Suzuki, Hitoshi / Yamamoto, Masanobu

BMC ecology and evolution

2023 Volume 23, Issue 1, Page(s) 38

Abstract: Background: Phylogeographical approaches explain the genetic diversity of local organisms in the context of their geological and geographic environments. Thus, genetic diversity can be a proxy for geological history. Here we propose a genus of woodland ... ...

Abstract	Background: Phylogeographical approaches explain the genetic diversity of local organisms in the context of their geological and geographic environments. Thus, genetic diversity can be a proxy for geological history. Here we propose a genus of woodland isopod, Ligidium, as a marker of geological history in relation to orogeny and the Quaternary glacial cycle. Results: Mitochondrial analysis of 721 individuals from 97 sites across Japan revealed phylogenetic divergence between the northeastern and southwestern Japan arcs. It also showed repeated population expansions in northeastern Japan in response to Quaternary glacial and interglacial cycles. Genome-wide analysis of 83 selected individuals revealed multiple genetic nuclear clusters. The genomic groupings were consistent with the local geographic distribution, indicating that the Ligidium phylogeny reflects its regional history. Conclusion: Ligidium DNA sequence analysis can provide insight into the geological, geographical, and paleoenvironmental history of the studied region.
MeSH term(s)	Humans ; Animals ; Phylogeny ; Isopoda/genetics ; Japan ; Genetic Variation/genetics ; Phylogeography ; Forests
Language	English
Publishing date	2023-08-07
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	2730-7182
ISSN (online)	2730-7182
DOI	10.1186/s12862-023-02144-8
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