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  1. Article ; Online: What's New in Musculoskeletal Tumor Surgery.

    Gazendam, Aaron / Ghert, Michelle

    The Journal of bone and joint surgery. American volume

    2023  Volume 105, Issue 24, Page(s) 1929–1936

    MeSH term(s) Humans ; Musculoskeletal Diseases ; Neoplasms
    Language English
    Publishing date 2023-10-24
    Publishing country United States
    Document type Editorial
    ZDB-ID 220625-0
    ISSN 1535-1386 ; 0021-9355
    ISSN (online) 1535-1386
    ISSN 0021-9355
    DOI 10.2106/JBJS.23.00833
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  2. Article ; Online: ASO Author Reflections: Timing of Neoadjuvant Chemotherapy in Patients with Sarcoma.

    Gazendam, Aaron M / Ghert, Michelle

    Annals of surgical oncology

    2022  Volume 29, Issue 12, Page(s) 7318

    MeSH term(s) Humans ; Neoadjuvant Therapy ; Sarcoma/drug therapy ; Soft Tissue Neoplasms
    Language English
    Publishing date 2022-07-26
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 1200469-8
    ISSN 1534-4681 ; 1068-9265
    ISSN (online) 1534-4681
    ISSN 1068-9265
    DOI 10.1245/s10434-022-12276-8
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  3. Article ; Online: What's New in Musculoskeletal Tumor Surgery.

    Gazendam, Aaron / Ghert, Michelle

    The Journal of bone and joint surgery. American volume

    2022  Volume 104, Issue 24, Page(s) 2131–2144

    MeSH term(s) Humans ; Musculoskeletal Diseases ; Neoplasms
    Language English
    Publishing date 2022-11-08
    Publishing country United States
    Document type Editorial
    ZDB-ID 220625-0
    ISSN 1535-1386 ; 0021-9355
    ISSN (online) 1535-1386
    ISSN 0021-9355
    DOI 10.2106/JBJS.22.00811
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  4. Article: Chondrosarcoma: A Clinical Review.

    Gazendam, Aaron / Popovic, Snezana / Parasu, Naveen / Ghert, Michelle

    Journal of clinical medicine

    2023  Volume 12, Issue 7

    Abstract: Chondrosarcomas are a diverse group of malignant cartilaginous matrix-producing neoplasms. Conventional chondrosarcomas are a continuum of disease based on the biologic activity of the tumor. The tumors range from the relatively biologically benign low- ... ...

    Abstract Chondrosarcomas are a diverse group of malignant cartilaginous matrix-producing neoplasms. Conventional chondrosarcomas are a continuum of disease based on the biologic activity of the tumor. The tumors range from the relatively biologically benign low-grade tumors or intermediate atypical cartilaginous tumors (ACTs), to malignant, aggressive high-grade tumors. The clinical presentation, radiographic and pathologic findings, treatments and outcomes vary significantly based on the histologic grade of the tumor. Chondrosarcomas present a diagnostic dilemma, particularly in the differentiation between high- and intermediate-grade tumors and that of low-grade tumors from benign enchondromas. A multidisciplinary team at a tertiary sarcoma centre allows for optimal care of these patients.
    Language English
    Publishing date 2023-03-26
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm12072506
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  5. Article ; Online: Cochrane in CORR®: Tourniquet Use For Knee Replacement Surgery.

    Gazendam, Aaron / Wood, Thomas J

    Clinical orthopaedics and related research

    2021  Volume 479, Issue 3, Page(s) 445–451

    MeSH term(s) Arthroplasty, Replacement, Knee ; Humans ; Knee Joint/surgery ; Tourniquets
    Language English
    Publishing date 2021-01-27
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 80301-7
    ISSN 1528-1132 ; 0009-921X
    ISSN (online) 1528-1132
    ISSN 0009-921X
    DOI 10.1097/CORR.0000000000001668
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  6. Article ; Online: Marginalization Influences Access, Outcomes, and Discharge Destination Following Total Joint Arthroplasty in Canada's Universal Healthcare System.

    Rubinger, Luc / Gazendam, Aaron M / Wood, Thomas J

    The Journal of arthroplasty

    2023  Volume 38, Issue 11, Page(s) 2204–2209

    Abstract: Background: The influence of socioeconomic status on outcomes following total joint arthroplasty (TJA) in the Canadian single-payer healthcare system is yet to be elucidated. The objective of the present study was to evaluate the impact of socioeconomic ...

    Abstract Background: The influence of socioeconomic status on outcomes following total joint arthroplasty (TJA) in the Canadian single-payer healthcare system is yet to be elucidated. The objective of the present study was to evaluate the impact of socioeconomic status on TJA outcomes.
    Methods: This was a retrospective review of 7,304 consecutive TJA (4,456 knees and 2,848 hips) performed between January 1, 2001 and December 31, 2019. The primary independent variable was the average census marginalization index. The primary dependent variable was functional outcome scores.
    Results: The most marginalized patients in both the hip and knee cohorts had significantly worse preoperative and postoperative functional scores. Patients in the most marginalized quintile (V) showed a decreased odds of achieving a minimal important difference in functional scores at 1-year follow-up (odds ratio [OR] 0.44; 95% confidence interval [CI] [0.20, 0.97], P = .043). Patients in the knee cohort in the most marginalized quintiles (IV and V) had increased odds of being discharged to an inpatient facility with an OR of 2.07 (95% CI [1.06, 4.04], P = .033) and OR of 2.57 (95% CI [1.26, 5.22], P = .009), respectively. Patients in the hip cohort in V quintile (most marginalized) had increased odds of being discharged to an inpatient facility with an OR of 2.24 (95% CI [1.02, 4.96], P = .046).
    Conclusion: Despite being a part of the Canadian universal single-payer healthcare system, the most marginalized patients had worse preoperative and postoperative function, and had increased odds of being discharged to another inpatient facility.
    Level of evidence: IV.
    MeSH term(s) Humans ; Arthroplasty, Replacement, Knee ; Patient Discharge ; Arthroplasty, Replacement, Hip ; Universal Health Care ; Canada ; Retrospective Studies ; Risk Factors ; Postoperative Complications
    Language English
    Publishing date 2023-06-05
    Publishing country United States
    Document type Journal Article
    ZDB-ID 632770-9
    ISSN 1532-8406 ; 0883-5403
    ISSN (online) 1532-8406
    ISSN 0883-5403
    DOI 10.1016/j.arth.2023.05.075
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    Zs.A 2134: Show issues Location:
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  7. Article ; Online: Regarding "Arthroscopic Bankart Repair With and Without Curettage of the Glenoid Edge: A Prospective, Randomized, Controlled Study".

    Gazendam, Aaron / Khan, Moin

    Arthroscopy : the journal of arthroscopic & related surgery : official publication of the Arthroscopy Association of North America and the International Arthroscopy Association

    2021  Volume 37, Issue 4, Page(s) 1064–1065

    MeSH term(s) Arthroplasty ; Arthroscopy ; Curettage ; Humans ; Prospective Studies ; Scapula/surgery
    Language English
    Publishing date 2021-04-03
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 632528-2
    ISSN 1526-3231 ; 0749-8063
    ISSN (online) 1526-3231
    ISSN 0749-8063
    DOI 10.1016/j.arthro.2021.01.030
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  8. Article ; Online: Chondrosarcoma

    Aaron Gazendam / Snezana Popovic / Naveen Parasu / Michelle Ghert

    Journal of Clinical Medicine, Vol 12, Iss 2506, p

    A Clinical Review

    2023  Volume 2506

    Abstract: Chondrosarcomas are a diverse group of malignant cartilaginous matrix-producing neoplasms. Conventional chondrosarcomas are a continuum of disease based on the biologic activity of the tumor. The tumors range from the relatively biologically benign low- ... ...

    Abstract Chondrosarcomas are a diverse group of malignant cartilaginous matrix-producing neoplasms. Conventional chondrosarcomas are a continuum of disease based on the biologic activity of the tumor. The tumors range from the relatively biologically benign low-grade tumors or intermediate atypical cartilaginous tumors (ACTs), to malignant, aggressive high-grade tumors. The clinical presentation, radiographic and pathologic findings, treatments and outcomes vary significantly based on the histologic grade of the tumor. Chondrosarcomas present a diagnostic dilemma, particularly in the differentiation between high- and intermediate-grade tumors and that of low-grade tumors from benign enchondromas. A multidisciplinary team at a tertiary sarcoma centre allows for optimal care of these patients.
    Keywords chondrosarcoma ; review ; sarcoma ; Medicine ; R
    Language English
    Publishing date 2023-03-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article ; Online: The Impact of Implant Fixation Type on Reoperation Rates Following Endoprosthetic Reconstruction Surgery.

    Giglio, Victoria / Gazendam, Aaron / Schneider, Patricia / Ghert, Michelle / Wilson, David

    The Journal of bone and joint surgery. American volume

    2023  Volume 105, Issue Suppl 1, Page(s) 15–21

    Abstract: Background: Prospective evidence supporting the use of cemented or uncemented implants in endoprosthetic reconstruction is lacking. The present study aimed to determine the effect of cemented fixation compared with uncemented fixation on the rate of all- ...

    Abstract Background: Prospective evidence supporting the use of cemented or uncemented implants in endoprosthetic reconstruction is lacking. The present study aimed to determine the effect of cemented fixation compared with uncemented fixation on the rate of all-cause reoperation at 1 year postoperatively.
    Methods: This is a secondary analysis of the Prophylactic Antibiotic Regimens In Tumor Surgery (PARITY) trial. A total of 503 patients who underwent surgical excision and endoprosthetic reconstruction of a lower-extremity bone tumor were included in this analysis. A multivariate Cox proportional hazards model was utilized to assess the independent relationship between fixation group and implant survivorship, with all-cause reoperation as the end point.
    Results: There were 388 cemented implants and 115 uncemented implants. Participants had a mean age of 42.7 years (standard deviation, 22.0 years), and 59% were male. Overall, 131 reoperations were identified over the 1-year follow-up period. There were no significant differences found in all-cause reoperation (hazard ratio [HR], 1.05; 95% confidence interval [CI], 0.70 to 1.57; p = 0.761), septic reoperation, or aseptic reoperation between cemented and uncemented fixation at 1 year postoperatively. The Cox regression analysis demonstrated that total operative time (HR per hour, 1.10; 95% CI, 1.02 to 1.20; p = 0.019) was an independent predictor of reoperation. The risk of reoperation was lower in patients with benign aggressive disease (HR, 0.11; 95% CI, 0.02 to 0.80; p = 0.029) or metastatic bone disease (HR, 0.30; 95% CI, 0.11 to 0.85; p = 0.023). Patients who underwent cemented fixation showed clinically meaningful functional improvement at 1 year postoperatively.
    Conclusions: Cemented compared with uncemented fixation has no effect on 1-year all-cause reoperation rates in endoprosthetic reconstruction surgery. Further research is required to investigate the long-term survival of cemented versus uncemented implants.
    Level of evidence: Prognostic Level IV. See Instructions for Authors for a complete description of levels of evidence.
    MeSH term(s) Adult ; Female ; Humans ; Male ; Prospective Studies ; Prosthesis Design ; Prosthesis Failure ; Reoperation/adverse effects ; Treatment Outcome
    Language English
    Publishing date 2023-07-19
    Publishing country United States
    Document type Clinical Trial ; Comparative Study ; Journal Article
    ZDB-ID 220625-0
    ISSN 1535-1386 ; 0021-9355
    ISSN (online) 1535-1386
    ISSN 0021-9355
    DOI 10.2106/JBJS.22.00886
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  10. Article ; Online: Fixation of Distal Radius Fractures Under Wide-Awake Local Anesthesia: A Systematic Review.

    Gouveia, Kyle / Harbour, Eric / Gazendam, Aaron / Bhandari, Mohit

    Hand (New York, N.Y.)

    2022  Volume 19, Issue 1, Page(s) 58–67

    Abstract: Background: The purpose of this systematic review was to analyze the available literature on fixation of distal radius fractures (DRFs) under wide-awake local anesthesia no-tourniquet (WALANT), and to examine postoperative pain scores and functional ... ...

    Abstract Background: The purpose of this systematic review was to analyze the available literature on fixation of distal radius fractures (DRFs) under wide-awake local anesthesia no-tourniquet (WALANT), and to examine postoperative pain scores and functional outcomes, operative data including operative time and blood loss, and the frequency of adverse events.
    Methods: Embase, MEDLINE, Web of Science, and SCOPUS were searched from inception until May 2022 for relevant studies. Studies were screened in duplicate, and data on pain scores, functional outcomes, and adverse events were recorded. Due to methodological and statistical heterogeneity, the results are presented in a descriptive fashion.
    Results: Ten studies were included comprising 456 patients with closed, unilateral DRFs, of whom 226 underwent fixation under WALANT. These patients had a mean age of 52.8 ± 8.3 years, were 48% female, and had a mean follow-up time of 11.6 months (range: 6-24). Operative time for WALANT patients averaged 60.4 ± 6.5 minutes, with mean postoperative pain scores of 1.4 ± 0.6 on a 10-point scale. Studies that compared WALANT to general anesthesia found shorter hospital stays with most WALANT patients being sent home the same day, decreased postoperative pain scores, and decreased costs to the healthcare system. No adverse events were reported for WALANT patients.
    Conclusions: A growing body of literature reports that for closed, unilateral DRF, surgical fixation under WALANT is a safe and effective option. It allows patients to have surgery sooner, with improved pain scores and good functional outcomes, with a very low incidence of adverse events.
    MeSH term(s) Humans ; Female ; Adult ; Middle Aged ; Male ; Anesthesia, Local/methods ; Wrist Fractures ; Fracture Fixation, Internal/methods ; Wakefulness ; Pain, Postoperative
    Language English
    Publishing date 2022-07-26
    Publishing country United States
    Document type Systematic Review ; Journal Article
    ZDB-ID 2277325-3
    ISSN 1558-9455 ; 1558-9447
    ISSN (online) 1558-9455
    ISSN 1558-9447
    DOI 10.1177/15589447221109632
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