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Article ; Online: Role of device therapy in left ventricular noncompaction cardiomyopathy: is it different from other causes of heart failure?

Fung, Jeffrey W H

2010 Volume 7, Issue 11, Page(s) 1550–1551

MeSH term(s)	Cardiac Resynchronization Therapy ; Cardiomyopathies/therapy ; Humans ; Treatment Outcome
Language	English
Publishing date	2010-11
Publishing country	United States
Document type	Comment ; Editorial
ZDB-ID	2229357-7
ISSN	1556-3871 ; 1547-5271
ISSN (online)	1556-3871
ISSN	1547-5271
DOI	10.1016/j.hrthm.2010.07.024
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Article ; Online: Recurrence patterns among patients with sinonasal mucosal melanoma: A multi-institutional study.

Pandrangi, Vivek C / Mace, Jess C / Abiri, Arash / Adappa, Nithin D / Beswick, Daniel M / Chang, Eugene H / Eide, Jacob G / Fung, Nicholas / Hong, Michelle / Johnson, Brian J / Kohanski, Michael A / Kshirsagar, Rijul S / Kuan, Edward C / Le, Christopher H / Lee, Jivianne T / Nabavizadeh, Seyed A / Obermeyer, Isaac P / Palmer, James N / Pinheiro-Neto, Carlos D /

Smith, Timothy L / Snyderman, Carl H / Suh, Jeffrey D / Wang, Eric W / Wang, Marilene B / Choby, Garret / Geltzeiler, Mathew

International forum of allergy & rhinology

2023 Volume 13, Issue 12, Page(s) 2156–2164

Abstract: Objective: To evaluate recurrence patterns and survival after recurrence among patients with sinonasal mucosal melanoma (SNMM).: Methods: This was a multi-institutional retrospective review from seven U.S. institutions of patients with SNMM from 1991 ...

Abstract	Objective: To evaluate recurrence patterns and survival after recurrence among patients with sinonasal mucosal melanoma (SNMM). Methods: This was a multi-institutional retrospective review from seven U.S. institutions of patients with SNMM from 1991 to 2022. Recurrence was categorized as local, regional, distant, or multifocal. Kaplan-Meier tests were used to evaluate disease-free survival (DFS), overall survival (OS), and post-recurrence survival (PRS) reported with standard errors (SE) and log-rank testing used for comparison. Cox-regression was further used, with hazard ratios (HR) and 95% confidence intervals (CI) reported. Results: Among 196 patients with SNMM, there were 146 patients with recurrence (74.5%). Among all patients, 60-month DFS (SE) was 15.5% (2.9%), 60-month OS (SE) was 44.7% (3.7%), mean age ± standard deviation at diagnosis was 69.7 ± 12.5 years, and 54.6% were female. In 26 patients who underwent primary treatment of the neck, 60-month DFS did not differ from no treatment (p > 0.05). Isolated distant recurrence was most common (42.8%), followed by local (28.3%), multifocal (20.7%), and regional recurrence (8.3%). Among patients with regional recurrence in the neck, there was no 60-month PRS benefit for patients undergoing salvage neck dissection or radiation (p > 0.05). Among patients with distant recurrence, only immunotherapy was associated with improved 12-month PRS (HR = 0.32, 95% CI = 0.11-0.92, p = 0.034), and no treatment group was associated with improved 24- or 60-month PRS (p > 0.05). Conclusion: SNMM is associated with a high recurrence rate and poor survival. Primary treatment of the neck was not associated with reduced recurrence, and immunotherapy for treatment of distant recurrence was associated with increased 12-month PRS.
MeSH term(s)	Female ; Humans ; Male ; Disease-Free Survival ; Melanoma/therapy ; Nasal Mucosa ; Neoplasm Recurrence, Local/epidemiology ; Paranasal Sinus Neoplasms/surgery ; Retrospective Studies ; Survival Rate ; Middle Aged ; Aged ; Aged, 80 and over
Language	English
Publishing date	2023-06-15
Publishing country	United States
Document type	Multicenter Study ; Journal Article
ZDB-ID	2625826-2
ISSN	2042-6984 ; 2042-6976
ISSN (online)	2042-6984
ISSN	2042-6976
DOI	10.1002/alr.23204
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Zs.A 6927: Show issues

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Article ; Online: Regression of non-compaction in left ventricular non-compaction cardiomyopathy by cardiac contractility modulation.

Wong, Philip H C / Fung, Jeffrey W H

International journal of cardiology

2012 Volume 154, Issue 3, Page(s) e50–1

MeSH term(s)	Cardiac Pacing, Artificial ; Heart Failure/etiology ; Heart Failure/therapy ; Humans ; Isolated Noncompaction of the Ventricular Myocardium/complications ; Male ; Middle Aged ; Pacemaker, Artificial
Language	English
Publishing date	2012-02-09
Publishing country	Netherlands
Document type	Case Reports ; Letter
ZDB-ID	779519-1
ISSN	1874-1754 ; 0167-5273
ISSN (online)	1874-1754
ISSN	0167-5273
DOI	10.1016/j.ijcard.2011.06.040
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Zs.A 1673: Show issues

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Article ; Online: Seizure clustering during presurgical electroencephalographic monitoring in children.

Fung, France W / Libenson, Mark H / Bolton, Jeffrey / Pearl, Phillip L / Kapur, Kush / Marti, Candice / Paris, Ann / Bergin, Ann M / Harini, Chellamani

Epilepsy & behavior : E&B

2018 Volume 80, Page(s) 291–295

Abstract: Background: Presurgical evaluation with antiseizure medication tapering in patients with refractory epilepsy places them at risk for seizure clustering or prolonged seizures. We looked at the occurrence of seizure clustering (3 or more seizures within ... ...

Abstract	Background: Presurgical evaluation with antiseizure medication tapering in patients with refractory epilepsy places them at risk for seizure clustering or prolonged seizures. We looked at the occurrence of seizure clustering (3 or more seizures within 24h) and prolonged seizures and the factors that influence seizure clustering and affect length of stay (LOS) in pediatric patients during presurgical monitoring. Methods: We retrospectively reviewed the medical records of all consecutive admissions to the epilepsy monitoring unit (EMU) and included patients undergoing noninvasive presurgical evaluation. Data were extracted regarding demographics, seizure history, details of the EMU admission including occurrence of seizure clusters, prolonged seizures, status epilepticus, treatment, and LOS. Results: Sixty-nine patients met our inclusion criteria. Seizure clustering during monitoring was observed in 33 patients (48%). Prolonged seizures lasting >5min was observed in 14 (20%) patients including 2 with status epilepticus (3%). Seizure clusters necessitated rescue treatment in around 30%. History of seizure clustering at home was the only factor associated with the occurrence of seizure clustering during the EMU stay (p<0.0001). The LOS did not differ significantly between patients who had seizure clustering during monitoring versus those who did not (p=0.369). Conclusions: Seizure clustering was common in children undergoing presurgical monitoring and seen especially in those with a history of seizure clustering at home. Occurrence of seizure clustering did not prolong the LOS but necessitated the use of rescue medications in about a third of the patients with seizure clusters due to multiple seizures.
MeSH term(s)	Adolescent ; Child ; Electroencephalography/methods ; Electroencephalography/statistics & numerical data ; Epilepsy/diagnosis ; Epilepsy/drug therapy ; Epilepsy/pathology ; Epilepsy/surgery ; Female ; Hospital Units ; Hospitalization ; Humans ; Length of Stay ; Male ; Monitoring, Ambulatory ; Monitoring, Physiologic/methods ; Monitoring, Physiologic/statistics & numerical data ; Preoperative Care/methods ; Preoperative Care/statistics & numerical data ; Preoperative Period ; Retrospective Studies ; Seizures/diagnosis ; Seizures/epidemiology ; Seizures/surgery ; Status Epilepticus
Language	English
Publishing date	2018-02-03
Publishing country	United States
Document type	Journal Article
ZDB-ID	2010587-3
ISSN	1525-5069 ; 1525-5050
ISSN (online)	1525-5069
ISSN	1525-5050
DOI	10.1016/j.yebeh.2018.01.013
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Zs.A 5289: Show issues

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Article ; Online: Should we switch to RVOT pacing for all now? Not yet.

Fung, Jeffrey W H / Yu, Cheuk-Man

Journal of cardiovascular electrophysiology

2010 Volume 21, Issue 10, Page(s) 1127–1129

MeSH term(s)	Aged ; Cardiac Pacing, Artificial/adverse effects ; Female ; Heart Conduction System/physiopathology ; Heart Ventricles/physiopathology ; Humans ; Male ; Ventricular Dysfunction, Left/diagnosis ; Ventricular Dysfunction, Left/etiology ; Ventricular Dysfunction, Left/physiopathology
Language	English
Publishing date	2010-10
Publishing country	United States
Document type	Comment ; Editorial
ZDB-ID	1025989-2
ISSN	1540-8167 ; 1045-3873
ISSN (online)	1540-8167
ISSN	1045-3873
DOI	10.1111/j.1540-8167.2010.01821.x
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Zs.A 2863: Show issues

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Article ; Online: The 2010 update of the ESC guidelines for the management of atrial fibrillation. Beyond the rate or rhythm strategy debate.

Fung, Jeffrey W H / Yu, Cheuk-Man

Circulation journal : official journal of the Japanese Circulation Society

2010 Volume 74, Issue 12, Page(s) 2538–2541

MeSH term(s)	Atrial Fibrillation/epidemiology ; Atrial Fibrillation/physiopathology ; Atrial Fibrillation/therapy ; Humans ; Practice Guidelines as Topic
Language	English
Publishing date	2010-11-02
Publishing country	Japan
Document type	Journal Article ; Review
ZDB-ID	2068090-9
ISSN	1347-4820 ; 1346-9843
ISSN (online)	1347-4820
ISSN	1346-9843
DOI	10.1253/circj.cj-10-1042
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Article ; Online: Assessment of pharyngeal motor function using a novel velopharyngeal squeeze maneuver and a novel endoscopic pharyngeal contraction grade scale in patients with dysphagia after radiotherapy for nasopharyngeal carcinoma.

Head & neck

2021 Volume 43, Issue 11, Page(s) 3586–3597

Abstract: Background: To investigate a novel velopharyngeal squeeze maneuver (VPSM) and novel endoscopic pharyngeal contraction grade (EPCG) scale for the evaluation of pharyngeal motor function.: Methods: During endoscopic examination of 77 post-irradiated ... ...

Abstract	Background: To investigate a novel velopharyngeal squeeze maneuver (VPSM) and novel endoscopic pharyngeal contraction grade (EPCG) scale for the evaluation of pharyngeal motor function. Methods: During endoscopic examination of 77 post-irradiated nasopharyngeal carcinoma patients and control subjects, VPSM was rated and lateral pharyngeal wall movement graded with EPCG scale during swallowing. Pharyngeal constriction ratio (PCR) measured by videofluoroscopy was used for correlation. Results: VPSM and EPCG scale showed almost perfect intra-rater and inter-rater reliability (Kappa: >0.90). VPSM was present in 61% of patients suggesting good pharyngeal motor function. VPSM was predictive of EPCG scale (Wald statistic = 29.99, p < 0.001). EPCG scale also correlated strongly with PCR (r: 0.812) and was predictive for aspiration (odds ratio: 22.14 [95% CI 5.01-97.89, p < 0.001]). Conclusions: VPSM and EPCG scale are two novel tools to assess pharyngeal motor function, and both correlate well with pharyngeal contractility and aspiration.
MeSH term(s)	Deglutition ; Deglutition Disorders/diagnosis ; Deglutition Disorders/etiology ; Humans ; Nasopharyngeal Carcinoma/radiotherapy ; Nasopharyngeal Neoplasms/radiotherapy ; Pharynx/diagnostic imaging ; Reproducibility of Results
Language	English
Publishing date	2021-09-15
Publishing country	United States
Document type	Journal Article
ZDB-ID	645165-2
ISSN	1097-0347 ; 0148-6403 ; 1043-3074
ISSN (online)	1097-0347
ISSN	0148-6403 ; 1043-3074
DOI	10.1002/hed.26871
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Zs.A 1493: Show issues

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Article ; Online: Screening for Fabry Disease in patients with unexplained left ventricular hypertrophy.

Sadasivan, Chandu / Chow, Josie T Y / Sheng, Bun / Chan, David K H / Fan, Yiting / Choi, Paul C L / Wong, Jeffrey K T / Tong, Mabel M B / Chan, Tsz-Ngai / Fung, Erik / Kam, Kevin K H / Chan, Joseph Y S / Chi, Wai-Kin / Paterson, D Ian / Senaratne, Manohara / Brass, Neil / Oudit, Gavin Y / Lee, Alex P W

PloS one

2020 Volume 15, Issue 9, Page(s) e0239675

Abstract: Fabry Disease (FD) is a systemic disorder that can result in cardiovascular, renal, and neurovascular disease leading to reduced life expectancy. FD should be considered in the differential of all patients with unexplained left ventricular hypertrophy ( ... ...

Abstract	Fabry Disease (FD) is a systemic disorder that can result in cardiovascular, renal, and neurovascular disease leading to reduced life expectancy. FD should be considered in the differential of all patients with unexplained left ventricular hypertrophy (LVH). We therefore performed a prospective screening study in Edmonton and Hong Kong using Dried Blood Spot (DBS) testing on patients with undiagnosed LVH. Participants found to have unexplained LVH on echocardiography were invited to participate and subsequently subjected to DBS testing. DBS testing was used to measure α-galactosidase (α-GAL) enzyme activity and for mutation analysis of the α-galactosidase (GLA) gene, both of which are required to make a diagnosis of FD. DBS testing was performed as a screening tool on patients (n = 266) in Edmonton and Hong Kong, allowing for detection of five patients with FD (2% prevalence of FD) and one patient with hydroxychloroquine-induced phenocopy. Left ventricular mass index (LVMI) by GLA genotype showed a higher LVMI in patients with IVS4 + 919G > A mutations compared to those without the mutation. Two patients were initiated on ERT and hydroxychloroquine was discontinued in the patient with a phenocopy of FD. Overall, we detected FD in 2% of our screening cohort using DBS testing as an effective and easy to administer screening tool in patients with unexplained LVH. Utilizing DBS testing to screen for FD in patients with otherwise undiagnosed LVH is clinically important due to the availability of effective therapies and the value of cascade screening in extended families.
MeSH term(s)	Adult ; Aged ; Aged, 80 and over ; DNA Mutational Analysis ; Diagnosis, Differential ; Dried Blood Spot Testing ; Echocardiography ; Fabry Disease/diagnosis ; Fabry Disease/enzymology ; Fabry Disease/epidemiology ; Female ; Genotype ; Hong Kong/epidemiology ; Humans ; Hypertrophy, Left Ventricular/diagnosis ; Hypertrophy, Left Ventricular/enzymology ; Hypertrophy, Left Ventricular/epidemiology ; Male ; Mass Screening/methods ; Middle Aged ; Mutation ; Phenotype ; Prospective Studies ; alpha-Galactosidase/genetics
Chemical Substances	GLA protein, human (EC 3.2.1.22) ; alpha-Galactosidase (EC 3.2.1.22)
Keywords	covid19
Language	English
Publishing date	2020-09-28
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2267670-3
ISSN	1932-6203 ; 1932-6203
ISSN (online)	1932-6203
ISSN	1932-6203
DOI	10.1371/journal.pone.0239675
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Article ; Online: Real-World Assessment of Acute Left Ventricular Lead Implant Success and Complication Rates: Results from the Attain Success Clinical Trial.

Hummel, John D / Coppess, Mark A / Osborn, Jeffrey S / Yee, Raymond / Fung, Jeffrey W H / Augostini, Ralph / Li, Shelby / Hine, Douglas / Singh, Jagmeet P

Pacing and clinical electrophysiology : PACE

2016 Volume 39, Issue 11, Page(s) 1246–1253

Abstract: Background: Left ventricular lead (LVL) implant success rates have historically ranged between 70.5% and 95.5%. To date, there are few large studies that evaluate LVL implant success utilizing a single family of delivery catheters and leads. The Attain ... ...

Abstract	Background: Left ventricular lead (LVL) implant success rates have historically ranged between 70.5% and 95.5%. To date, there are few large studies that evaluate LVL implant success utilizing a single family of delivery catheters and leads. The Attain Success study was a prospective nonrandomized multicenter global study with the main objectives of assessing single-system LVL implant success and complication rates. Methods: Patients undergoing cardiac resynchronization therapy implantation were eligible for enrollment. There was no prespecified level of experience for investigator participation. LVL implant success and complication rates were assessed though 3 months of follow-up. Results: A total of 2,014 patients (69.1 ± 12.0 years, 71% male and 38% atrial fibrillation) were enrolled from 114 centers with a follow-up of 3.5 ± 2.1 months. Coronary sinus cannulation success rate was 96.4% with Attain Family delivery catheters. Implant success rate for Attain Family leads using Attain Family catheters was 94.0%; overall LVL implant success rate was 97.1%. Median procedure time was 4 minutes for cannulation and 9 minutes for LVL placement. Median fluoroscopy time was 17 minutes and median contrast used was 25 cc. There were 55 catheter or LVL-related complications in 53 subjects; the majority were LVL dislodgements (34, 1.7%) and extracardiac stimulation (11, 0.5%). The Kaplan-Meier estimate of the 3-month complication probability was 2.6%. Conclusion: This study represents the largest prospective evaluation of LVL implantation to date, revealing a high LVL implant success rate and low complication rate using a single family of leads and delivery catheters.
MeSH term(s)	Aged ; Cardiac Resynchronization Therapy ; Female ; Follow-Up Studies ; Heart Ventricles ; Humans ; Male ; Postoperative Complications ; Prospective Studies ; Prostheses and Implants ; Treatment Outcome
Language	English
Publishing date	2016-11
Publishing country	United States
Document type	Journal Article
ZDB-ID	424437-0
ISSN	1540-8159 ; 0147-8389
ISSN (online)	1540-8159
ISSN	0147-8389
DOI	10.1111/pace.12939
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Zs.A 1466: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Screening for Fabry Disease in patients with unexplained left ventricular hypertrophy.

Chandu Sadasivan / Josie T Y Chow / Bun Sheng / David K H Chan / Yiting Fan / Paul C L Choi / Jeffrey K T Wong / Mabel M B Tong / Tsz-Ngai Chan / Erik Fung / Kevin K H Kam / Joseph Y S Chan / Wai-Kin Chi / D Ian Paterson / Manohara Senaratne / Neil Brass / Gavin Y Oudit / Alex P W Lee

PLoS ONE, Vol 15, Iss 9, p e

2020 Volume 0239675

Abstract	Fabry Disease (FD) is a systemic disorder that can result in cardiovascular, renal, and neurovascular disease leading to reduced life expectancy. FD should be considered in the differential of all patients with unexplained left ventricular hypertrophy (LVH). We therefore performed a prospective screening study in Edmonton and Hong Kong using Dried Blood Spot (DBS) testing on patients with undiagnosed LVH. Participants found to have unexplained LVH on echocardiography were invited to participate and subsequently subjected to DBS testing. DBS testing was used to measure α-galactosidase (α-GAL) enzyme activity and for mutation analysis of the α-galactosidase (GLA) gene, both of which are required to make a diagnosis of FD. DBS testing was performed as a screening tool on patients (n = 266) in Edmonton and Hong Kong, allowing for detection of five patients with FD (2% prevalence of FD) and one patient with hydroxychloroquine-induced phenocopy. Left ventricular mass index (LVMI) by GLA genotype showed a higher LVMI in patients with IVS4 + 919G > A mutations compared to those without the mutation. Two patients were initiated on ERT and hydroxychloroquine was discontinued in the patient with a phenocopy of FD. Overall, we detected FD in 2% of our screening cohort using DBS testing as an effective and easy to administer screening tool in patients with unexplained LVH. Utilizing DBS testing to screen for FD in patients with otherwise undiagnosed LVH is clinically important due to the availability of effective therapies and the value of cascade screening in extended families.
Keywords	Medicine ; R ; Science ; Q
Subject code	610
Language	English
Publishing date	2020-01-01T00:00:00Z
Publisher	Public Library of Science (PLoS)
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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