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  1. Book ; Online: Next Generation Agriculture: Understanding Plant Life for Food, Health and Energy

    De Martinis, Domenico / Benvenuto, Eugenio / Colonna, Nicola / Llorente, Briardo / Rybicki, Edward / Benvenuto, Eugenio

    2020  

    Keywords Science: general issues ; Botany & plant sciences ; climate change ; agriculture ; bioproducts ; food ; biofuel ; bioeconomy ; artificial intelligence ; molecular farming
    Size 1 electronic resource (247 pages)
    Publisher Frontiers Media SA
    Document type Book ; Online
    Note English ; Open Access
    HBZ-ID HT021230872
    ISBN 9782889660629 ; 2889660621
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Book ; Online: Engineering the Plant Factory for the Production of Biologics and Small-Molecule Medicines

    Rybicki, Edward P. / Benvenuto, Eugenio / Franconi, Rosella / Martinis, Domenico De / Fujiyama, Kazuhito

    2017  

    Abstract: Plant gene transfer achieved in the early '80s paved the way for the exploitation of the potential of gene engineering to add novel agronomic traits and/or to design plants as factories for high added value molecules. For this latter area of research, ... ...

    Abstract Plant gene transfer achieved in the early '80s paved the way for the exploitation of the potential of gene engineering to add novel agronomic traits and/or to design plants as factories for high added value molecules. For this latter area of research, the term Molecular Farming was coined in reference to agricultural applications in that major crops like maize and tobacco were originally used basically for pharma applications. The concept of the "green biofactory" implies different advantages over the typical cell factories based on animal cell or microbial cultures already when considering the investment and managing costs of fermenters. Although yield, stability, and quality of the molecules may vary among different heterologous systems and plants are competitive on a case-to-case basis, still the "plant factory" attracts scientists and technologists for the challenging features of low production cost, product safety and easy scale up.-

    Once engineered, a plant is among the cheapest and easiest eukaryotic system to be bred with simple know-how, using nutrients, water and light. Molecules that are currently being produced in plants vary from industrial and pharmaceutical proteins, including medical diagnostics proteins and vaccine antigens, to nutritional supplements such as vitamins, carbohydrates and biopolymers. Convergence among disciplines as distant as plant physiology and pharmacology and, more recently, as omic sciences, bioinformatics and nanotechnology, increases the options of research on the plant cell factory. "Farming for Pharming" biologics and small-molecule medicines is a challenging area of plant biotechnology that may break the limits of current standard production technologies.-

    The recent success on Ebola fighting with plant-made antibodies put a spotlight on the enormous potential of next generation herbal medicines made especially in the name of the guiding principle of reduction of costs, hence reduction of disparities of health rights and as a tool to guarantee adequate health protection in developing countries.Plant gene transfer achieved in the early '80s paved the way for the exploitation of the potential of gene engineering to add novel agronomic traits and/or to design plants as factories for high added value molecules. For this latter area of research, the term Molecular Farming was coined in reference to agricultural applications in that major crops like maize and tobacco were originally used basically for pharma applications. The concept of the "green biofactory" implies different advantages over the typical cell factories based on animal cell or microbial cultures already when considering the investment and managing costs of fermenters.-
    Keywords Biotechnology ; Engineering (General). Civil engineering (General) ; Botany ; Science (General)
    Size 1 electronic resource (377 p.)
    Publisher Frontiers Media SA
    Document type Book ; Online
    Note English ; Open Access
    HBZ-ID HT020094975
    ISBN 9782889450510 ; 2889450511
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  3. Article ; Online: Rate of Vaginal Cuff Dehiscence When Using Vicryl (Poliglactyn 910) Compared to PDS (Polydioxanone) for Vaginal Cuff Closure in Laparoscopic Hysterectomy.

    Cannone, Francesco Giuseppe / Cormaci, Livia / Ettore, Carla / Gulino, Ferdinando Antonio / Incognito, Giosuè Giordano / Benvenuto, Domenico / Ettore, Giuseppe

    Medicina (Kaunas, Lithuania)

    2024  Volume 60, Issue 1

    Abstract: Objective: ...

    Abstract Objective:
    MeSH term(s) Pregnancy ; Female ; Humans ; Polydioxanone/therapeutic use ; Polyglactin 910/therapeutic use ; Prospective Studies ; Retrospective Studies ; Laparoscopy/adverse effects ; Hysterectomy/adverse effects
    Chemical Substances Polydioxanone (31621-87-1) ; Polyglactin 910 (34346-01-5)
    Language English
    Publishing date 2024-01-03
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2188113-3
    ISSN 1648-9144 ; 1010-660X
    ISSN (online) 1648-9144
    ISSN 1010-660X
    DOI 10.3390/medicina60010090
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Is Molecular Mimicry between hPF4 and SARS-CoV-2 Spike Protein a Potential Basis for Autoimmune Responses in Vaccinated and Naturally Infected Patients?

    Carnevale, Sergio / Giovanetti, Marta / Benvenuto, Domenico / Ciccozzi, Massimo / Broccolo, Francesco

    Seminars in thrombosis and hemostasis

    2022  Volume 49, Issue 1, Page(s) 103–104

    MeSH term(s) Humans ; Autoimmunity ; COVID-19 ; Molecular Mimicry ; SARS-CoV-2 ; Spike Glycoprotein, Coronavirus
    Chemical Substances Spike Glycoprotein, Coronavirus ; spike protein, SARS-CoV-2 ; ZNF85 protein, human
    Language English
    Publishing date 2022-01-12
    Publishing country United States
    Document type Journal Article
    ZDB-ID 196901-8
    ISSN 1098-9064 ; 0094-6176
    ISSN (online) 1098-9064
    ISSN 0094-6176
    DOI 10.1055/s-0041-1742092
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Molecular Mimicry between hPF4 and SARS-CoV-2 Spike Protein: Response to Comment.

    Benvenuto, Domenico / Carnevale, Sergio / Giovanetti, Marta / Ciccozzi, Massimo / Broccolo, Francesco

    Seminars in thrombosis and hemostasis

    2022  Volume 49, Issue 1, Page(s) 106–107

    MeSH term(s) Humans ; COVID-19/metabolism ; COVID-19/virology ; Molecular Mimicry ; Protein Binding ; SARS-CoV-2/chemistry ; Spike Glycoprotein, Coronavirus/chemistry ; Platelet Factor 4/chemistry
    Chemical Substances Spike Glycoprotein, Coronavirus ; spike protein, SARS-CoV-2 ; Platelet Factor 4 (37270-94-3)
    Language English
    Publishing date 2022-06-21
    Publishing country United States
    Document type Journal Article
    ZDB-ID 196901-8
    ISSN 1098-9064 ; 0094-6176
    ISSN (online) 1098-9064
    ISSN 0094-6176
    DOI 10.1055/s-0042-1744280
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Editorial: Engineering the Plant Biofactory for the Production of Biologics and Small-Molecule Medicines-Volume 2.

    De Martinis, Domenico / Hitzeroth, Inga Isabel / Matsuda, Ryo / Soto Pérez, Natacha / Benvenuto, Eugenio

    Frontiers in plant science

    2022  Volume 13, Page(s) 942746

    Language English
    Publishing date 2022-07-07
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2613694-6
    ISSN 1664-462X
    ISSN 1664-462X
    DOI 10.3389/fpls.2022.942746
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Preliminary Results on Tropospheric ZTD Estimation by Smartphone

    Benvenuto, Lorenzo / Dabove, Paolo / Ferrando, Ilaria / Sguerso, Domenico

    Remote Sensing. 2021 Nov. 13, v. 13, no. 22

    2021  

    Abstract: The Global Navigation Satellite System (GNSS) receiver is one of the many sensors embedded in smartphones. The early versions of the Android operating system could only access limited information from the GNSS, allowing the related Application Program ... ...

    Abstract The Global Navigation Satellite System (GNSS) receiver is one of the many sensors embedded in smartphones. The early versions of the Android operating system could only access limited information from the GNSS, allowing the related Application Program Interface (API) to obtain only the location. With the development of the Android 7.0 (Nougat) operating system in May 2016, raw measurements from the internal GNSS sensor installed in the smartphone could be accessed. This work aims to show an initial analysis regarding the feasibility of Zenith Total Delay (ZTD) estimation by GNSS measurements extracted from smartphones, evaluating the accuracy of estimation to open a new window on troposphere local monitoring. Two different test sites have been considered, and two different types of software for data processing have been used. ZTDs have been estimated from both a dual-frequency and a multi-constellation receiver embedded in the smartphone, and from a GNSS Continuously Operating Reference Station (CORS). The results have shown interesting performances in terms of ZTD estimation from the smartphone in respect of the estimations obtained with a geodetic receiver.
    Keywords application programming interface ; computer software ; geodesy ; global positioning systems ; mobile telephones ; troposphere
    Language English
    Dates of publication 2021-1113
    Publishing place Multidisciplinary Digital Publishing Institute
    Document type Article
    ZDB-ID 2513863-7
    ISSN 2072-4292
    ISSN 2072-4292
    DOI 10.3390/rs13224567
    Database NAL-Catalogue (AGRICOLA)

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  8. Article ; Online: The value of electrostatic potentials of the spike receptor binding and N-terminal domains in addressing transmissibility and infectivity of SARS-CoV-2 variants of concern.

    Pascarella, Stefano / Ciccozzi, Massimo / Bianchi, Martina / Benvenuto, Domenico / Cauda, Roberto / Cassone, Antonio

    The Journal of infection

    2022  Volume 84, Issue 5, Page(s) e62–e63

    MeSH term(s) COVID-19 ; Humans ; Mutation ; Protein Binding ; SARS-CoV-2/genetics ; Spike Glycoprotein, Coronavirus/genetics ; Spike Glycoprotein, Coronavirus/metabolism ; Static Electricity
    Chemical Substances Spike Glycoprotein, Coronavirus ; spike protein, SARS-CoV-2
    Language English
    Publishing date 2022-02-23
    Publishing country England
    Document type Letter
    ZDB-ID 424417-5
    ISSN 1532-2742 ; 0163-4453
    ISSN (online) 1532-2742
    ISSN 0163-4453
    DOI 10.1016/j.jinf.2022.02.023
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Peculiar Variations of the Electrostatic Potential of Spike Protein N-terminal Domain Associated with the Emergence of Successive SARS-CoV-2 Omicron Lineages.

    Pascarella, Stefano / Ciccozzi, Massimo / Benvenuto, Domenico / Borsetti, Alessandra / Cauda, Roberto / Cassone, Antonio

    The Journal of infection

    2022  Volume 86, Issue 1, Page(s) 66–117

    MeSH term(s) Humans ; COVID-19 ; SARS-CoV-2 ; Spike Glycoprotein, Coronavirus/genetics ; Static Electricity ; Mutation
    Chemical Substances spike protein, SARS-CoV-2 ; Spike Glycoprotein, Coronavirus
    Language English
    Publishing date 2022-07-29
    Publishing country England
    Document type Letter
    ZDB-ID 424417-5
    ISSN 1532-2742 ; 0163-4453
    ISSN (online) 1532-2742
    ISSN 0163-4453
    DOI 10.1016/j.jinf.2022.07.018
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Response to Carletti et al, "About the origin of the first two SARS-CoV-2 infections in Italy: Inference not supported by appropriate sequence analysis".

    Ciccozzi, Massimo / Giovanetti, Marta / Benvenuto, Domenico / Angeletti, Silvia

    Journal of medical virology

    2020  Volume 92, Issue 9, Page(s) 1406–1407

    MeSH term(s) COVID-19 ; Coronavirus Infections/epidemiology ; Humans ; Italy/epidemiology ; Pandemics ; Pneumonia, Viral/epidemiology ; SARS-CoV-2 ; Sequence Analysis
    Keywords covid19
    Language English
    Publishing date 2020-04-10
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 752392-0
    ISSN 1096-9071 ; 0146-6615
    ISSN (online) 1096-9071
    ISSN 0146-6615
    DOI 10.1002/jmv.25823
    Database MEDical Literature Analysis and Retrieval System OnLINE

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