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Article ; Online: Non-invasive, Real-time, Glucose Monitoring is in the Near Future.

Hirsch, Irl B / Navon, Ami / Tirosh, Amir

2024

Abstract: Objective: Since the introduction of continuous glucose monitoring technology, developers have rigorously researched the feasibility of creating a noninvasive glucose monitoring device. In a recent pilot study, investigators reported a strong ... ...

Abstract	Objective: Since the introduction of continuous glucose monitoring technology, developers have rigorously researched the feasibility of creating a noninvasive glucose monitoring device. In a recent pilot study, investigators reported a strong correlation between glucose values obtained from novel, noninvasive monitoring device (GWave) values to venous and capillary glucose measurements. Research design and methods: We investigated if the level of accuracy observed in the pilot study could be reproduced in a larger cohort, using a smaller third-generation, manufacturable device (Gen III GWave) containing a standardized sensor chip that can be mass produced for commercial use. The evaluation assessed concordance with capillary blood glucose, reproducibility between two gen III devices, and accuracy during insulin-induced hypoglycemia. Results: Assessment of samples from 75 subjects (T2D, n=6; T1D, n=28; nondiabetic pregnant subjects, n=10; and nondiabetic, n=31) showed that 97% of values were in Zone A with 3% in Zone B of the Clarke Error Grid, with a mean absolute relative difference (MARD) of 6.7% from reference blood glucose. Comparison between two independent Gen III GWave devices demonstrated reproducibility between the sensors (R2=0.95), with 100% of values within Zone A. In the hypoglycemia assessment, measurements from the Gen III sensor tightly followed the capillary glucose measurements down to 42 mg/dL (2.3 mmol/L), whereas the CGM measurements from two different CGM only converged with the GWave and capillary glucose readings after 90 minutes of decreasing glucose levels. Conclusion: Our results show promise as potentially the first noninvasive technology. Future studies will focus on larger numbers of people in all glucose ranges. Real-time noninvasive blood glucose monitoring is possible using GWave technology.
Language	English
Publishing date	2024-02-28
Publishing country	United States
Document type	Journal Article
ZDB-ID	1452816-2
ISSN	1557-8593 ; 1520-9156
ISSN (online)	1557-8593
ISSN	1520-9156
DOI	10.1089/dia.2024.0009
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Book ; Online: Antimicrobial Resistance in Horses

Steinman, Amir / Navon-Venezia, Shiri

2020

Keywords	Humanities ; Social interaction ; equine ; foal ; ESBL-E ; antibiotic resistance ; shedding ; umbilical infection ; risk factors ; healthy horses ; staphylococci ; MSSA ; ST1640 ; lukPQ ; ESBL ; Escherichia coli ; Enterobacteriaceae ; antimicrobial resistance ; CTX-M-1 ; SHV ; farm ; ESBL-E acquisition ; AmpC ; Klebsiella pneumoniae ; antibiotic-resistance ; β-lactamases ; horses ; extended-spectrum β-lactamase ; AmpC β-lactamase ; horse ; multidrug resistance ; beta-lactamase ; cephalosporinase ; microbiota ; North America ; horse pathogens ; epidemiology ; n/a
Size	1 electronic resource (124 pages)
Publisher	MDPI - Multidisciplinary Digital Publishing Institute
Publishing place	Basel, Switzerland
Document type	Book ; Online
Note	English ; Open Access
HBZ-ID	HT021044575
ISBN	9783039367139 ; 3039367137
Database	ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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Article ; Online: The role of RNF149 in the pre-emptive quality control substrate ubiquitination.

Legesse, Aster / Kaushansky, Nathali / Braunstein, Ilana / Saad, Haddas / Lederkremer, Gerardo / Navon, Ami / Stanhill, Ariel

Communications biology

2023 Volume 6, Issue 1, Page(s) 385

Abstract: Protein quality control is a process in which a protein's folding status is constantly monitored. Mislocalized proteins (MLP), are processed by the various quality control pathways, as they are often misfolded due to inappropriate cellular surroundings. ... ...

Abstract	Protein quality control is a process in which a protein's folding status is constantly monitored. Mislocalized proteins (MLP), are processed by the various quality control pathways, as they are often misfolded due to inappropriate cellular surroundings. Polypeptides that fail to translocate into the ER due to an inefficient signal peptide, mutations or ER stress are recognized by the pre-emptive ER associated quality control (pEQC) pathway and degraded by the 26 S proteasome. In this report we reveal the role of RNF149, a membrane bound E3 ligase in the ubiquitination of known pEQC substrates. We demonstrate its selective binding only to non-translocated proteins and its association with known pEQC components. Impairment in RNF149 function increases translocation flux into the ER and manifests in a myeloproliferative neoplasm (MPN) phenotype, a pathological condition associated with pEQC impairment. Finally, the dynamic localization of RNF149 may provide a molecular switch to regulate pEQC during ER stress.
MeSH term(s)	Ubiquitination ; Ubiquitin-Protein Ligases/genetics ; Ubiquitin-Protein Ligases/metabolism
Chemical Substances	Ubiquitin-Protein Ligases (EC 2.3.2.27)
Language	English
Publishing date	2023-04-08
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	2399-3642
ISSN (online)	2399-3642
DOI	10.1038/s42003-023-04763-9
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: The role of RNF149 in the pre-emptive quality control substrate ubiquitination

Aster Legesse / Nathali Kaushansky / Ilana Braunstein / Haddas Saad / Gerardo Lederkremer / Ami Navon / Ariel Stanhill

Communications Biology, Vol 6, Iss 1, Pp 1-

2023 Volume 10

Abstract: E3 ligase RNF149 contributes to the pre-emptive quality control (pQC) pathway & interacts with AIRAPL in a ubiquitin-dependent manner, with loss of RNF149 function appearing to increase the translocation flux of pQC substrates to the ER. ...

Abstract	E3 ligase RNF149 contributes to the pre-emptive quality control (pQC) pathway & interacts with AIRAPL in a ubiquitin-dependent manner, with loss of RNF149 function appearing to increase the translocation flux of pQC substrates to the ER.
Keywords	Biology (General) ; QH301-705.5
Language	English
Publishing date	2023-04-01T00:00:00Z
Publisher	Nature Portfolio
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Thimet Oligopeptidase Biochemical and Biological Significances: Past, Present, and Future Directions.

Ferro, Emer S / Gewehr, Mayara C F / Navon, Ami

Biomolecules

2020 Volume 10, Issue 9

Abstract: Thimet oligopeptidase (EC 3.4.24.15; EP24.15, THOP1) is a metallopeptidase ubiquitously distributed in mammalian tissues. Beyond its previously well characterized role in major histocompatibility class I (MHC-I) antigen presentation, the recent ... ...

Abstract	Thimet oligopeptidase (EC 3.4.24.15; EP24.15, THOP1) is a metallopeptidase ubiquitously distributed in mammalian tissues. Beyond its previously well characterized role in major histocompatibility class I (MHC-I) antigen presentation, the recent characterization of the THOP1 C57BL6/N null mice (THOP1
MeSH term(s)	Amino Acid Sequence ; Animals ; Antigen Presentation ; Catalytic Domain ; Encephalomyelitis, Autoimmune, Experimental/enzymology ; Encephalomyelitis, Autoimmune, Experimental/genetics ; Encephalomyelitis, Autoimmune, Experimental/immunology ; Energy Metabolism ; Female ; Genetic Association Studies ; Histocompatibility Antigens Class I/metabolism ; Humans ; Male ; Metalloendopeptidases/chemistry ; Metalloendopeptidases/genetics ; Metalloendopeptidases/metabolism ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Models, Biological ; Neuropeptides/metabolism ; Protease Inhibitors/pharmacology ; Proteasome Endopeptidase Complex/metabolism ; Proteolysis ; Substrate Specificity
Chemical Substances	Histocompatibility Antigens Class I ; Neuropeptides ; Protease Inhibitors ; Metalloendopeptidases (EC 3.4.24.-) ; thimet oligopeptidase (EC 3.4.24.15) ; Proteasome Endopeptidase Complex (EC 3.4.25.1)
Language	English
Publishing date	2020-08-24
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	2701262-1
ISSN	2218-273X ; 2218-273X
ISSN (online)	2218-273X
ISSN	2218-273X
DOI	10.3390/biom10091229
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Article ; Online: Peptidomic profiling of cerebrospinal fluid from patients with intracranial saccular aneurysms.

Sakaya, Gabriel R / Parada, Carolina A / Eichler, Rosangela A / Yamaki, Vitor N / Navon, Ami / Heimann, Andrea S / Figueiredo, Eberval G / Ferro, Emer S

Journal of proteomics

2021 Volume 240, Page(s) 104188

Abstract: Intracranial saccular aneurysms (ISA) represent 90%-95% of all intracranial aneurysm cases, characterizing abnormal pockets at arterial branch points. Ruptures lead to subarachnoid hemorrhages (SAH) and poor prognoses. We applied mass spectrometry-based ... ...

Abstract	Intracranial saccular aneurysms (ISA) represent 90%-95% of all intracranial aneurysm cases, characterizing abnormal pockets at arterial branch points. Ruptures lead to subarachnoid hemorrhages (SAH) and poor prognoses. We applied mass spectrometry-based peptidomics to investigate the peptidome of twelve cerebrospinal fluid (CSF) samples collected from eleven patients diagnosed with ISA. For peptide profile analyses, participants were classified into: 1) ruptured intracranial saccular aneurysms (RIA), 2) unruptured intracranial saccular aneurysms (UIA), and late-ruptured intracranial saccular aneurysms (LRIA). Altogether, a total of 2199 peptides were detected by both Mascot and Peaks software, from which 484 (22.0%) were unique peptides. All unique peptides presented conserved chains, domains, regions of protein modulation and/or post-translational modification sites related to human diseases. Gene Ontology (GO) analyses of peptide precursor proteins showed that 42% are involved in binding, 56% in cellular anatomical entities, and 39% in intercellular signaling molecules. Unique peptides identified in patients diagnosed with RIA have a larger molecular weight and a distinctive developmental process compared to UIA and LRIA (P ≤ 0.05). Continued investigations will allow the characterization of the biological and clinical significance of the peptides identified in the present study, as well as identify prototypes for peptide-based pharmacological therapies to treat ISA. SIGNIFICANCE.
MeSH term(s)	Aneurysm, Ruptured ; Humans ; Intracranial Aneurysm ; Stroke ; Subarachnoid Hemorrhage
Language	English
Publishing date	2021-03-26
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2400835-7
ISSN	1876-7737 ; 1874-3919
ISSN (online)	1876-7737
ISSN	1874-3919
DOI	10.1016/j.jprot.2021.104188
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Article ; Online: Germline genetic biomarkers to stratify patients for personalized radiation treatment.

Deichaite, Ida / Hopper, Austin / Krockenberger, Lena / Sears, Timothy J / Sutton, Leisa / Ray, Xenia / Sharabi, Andrew / Navon, Ami / Sanghvi, Parag / Carter, Hannah / Moiseenko, Vitali

Journal of translational medicine

2022 Volume 20, Issue 1, Page(s) 360

Abstract: Background: Precision medicine incorporating genetic profiling is becoming a standard of care in medical oncology. However, in the field of radiation oncology there is limited use of genetic profiling and the impact of germline genetic biomarkers on ... ...

Abstract	Background: Precision medicine incorporating genetic profiling is becoming a standard of care in medical oncology. However, in the field of radiation oncology there is limited use of genetic profiling and the impact of germline genetic biomarkers on radiosensitivity, radioresistance, or patient outcomes after radiation therapy is poorly understood. In HNSCC, the toxicity associated with treatment can cause delays or early cessation which has been associated with worse outcomes. Identifying potential biomarkers which can help predict toxicity, as well as response to treatment, is of significant interest. Methods: Patients with HNSCC who received RT and underwent next generation sequencing of somatic tumor samples, transcriptome RNA-seq with matched normal tissue samples were included. Patients were then grouped by propensity towards increased late vs. early toxicity (Group A) and those without (Group B), assessed by CTCAE v5.0. The groups were then analyzed for association of specific germline variants with toxicity and clinical outcomes. Results: In this study we analyzed 37 patients for correlation between germline variants and toxicity. We observed that TSC2, HLA-A, TET2, GEN1, NCOR2 and other germline variants were significantly associated with long term toxicities. 34 HNSCC patients treated with curative intent were evaluated for clinical outcomes. Group A had significantly improved overall survival as well as improved rates of locoregional recurrence and metastatic disease. Specific variants associated with improved clinical outcomes included TSC2, FANCD2, and PPP1R15A, while the HLA-A and GEN1 variants were not correlated with survival or recurrence. A group of five HLA-DMA/HLA-DMB variants was only found in Group B and was associated with a higher risk of locoregional recurrence. Conclusions: This study indicates that germline genetic biomarkers may have utility in predicting toxicity and outcomes after radiation therapy and deserve further investigation in precision radiation medicine approaches.
MeSH term(s)	Biomarkers, Tumor/genetics ; Carcinoma, Squamous Cell/pathology ; Germ Cells ; HLA-A Antigens ; Head and Neck Neoplasms/genetics ; Head and Neck Neoplasms/radiotherapy ; Humans ; Neoplasm Recurrence, Local/genetics ; Squamous Cell Carcinoma of Head and Neck
Chemical Substances	Biomarkers, Tumor ; HLA-A Antigens
Language	English
Publishing date	2022-08-12
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
ZDB-ID	2118570-0
ISSN	1479-5876 ; 1479-5876
ISSN (online)	1479-5876
ISSN	1479-5876
DOI	10.1186/s12967-022-03561-x
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Antimicrobial Resistance in Horses.

Steinman, Amir / Navon-Venezia, Shiri

Animals : an open access journal from MDPI

2020 Volume 10, Issue 7

Abstract: Antimicrobial resistance (AMR) is an increasingly recognized global public health threat to the modern health-care system that could hamper the control and treatment of infectious diseases [ ... ]. ...

Abstract	Antimicrobial resistance (AMR) is an increasingly recognized global public health threat to the modern health-care system that could hamper the control and treatment of infectious diseases [...].
Language	English
Publishing date	2020-07-09
Publishing country	Switzerland
Document type	Editorial
ISSN	2076-2615
ISSN	2076-2615
DOI	10.3390/ani10071161
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Germline genetic biomarkers to stratify patients for personalized radiation treatment

Ida Deichaite / Austin Hopper / Lena Krockenberger / Timothy J. Sears / Leisa Sutton / Xenia Ray / Andrew Sharabi / Ami Navon / Parag Sanghvi / Hannah Carter / Vitali Moiseenko

Journal of Translational Medicine, Vol 20, Iss 1, Pp 1-

2022 Volume 13

Abstract: Abstract Background Precision medicine incorporating genetic profiling is becoming a standard of care in medical oncology. However, in the field of radiation oncology there is limited use of genetic profiling and the impact of germline genetic biomarkers ...

Abstract	Abstract Background Precision medicine incorporating genetic profiling is becoming a standard of care in medical oncology. However, in the field of radiation oncology there is limited use of genetic profiling and the impact of germline genetic biomarkers on radiosensitivity, radioresistance, or patient outcomes after radiation therapy is poorly understood. In HNSCC, the toxicity associated with treatment can cause delays or early cessation which has been associated with worse outcomes. Identifying potential biomarkers which can help predict toxicity, as well as response to treatment, is of significant interest. Methods Patients with HNSCC who received RT and underwent next generation sequencing of somatic tumor samples, transcriptome RNA-seq with matched normal tissue samples were included. Patients were then grouped by propensity towards increased late vs. early toxicity (Group A) and those without (Group B), assessed by CTCAE v5.0. The groups were then analyzed for association of specific germline variants with toxicity and clinical outcomes. Results In this study we analyzed 37 patients for correlation between germline variants and toxicity. We observed that TSC2, HLA-A, TET2, GEN1, NCOR2 and other germline variants were significantly associated with long term toxicities. 34 HNSCC patients treated with curative intent were evaluated for clinical outcomes. Group A had significantly improved overall survival as well as improved rates of locoregional recurrence and metastatic disease. Specific variants associated with improved clinical outcomes included TSC2, FANCD2, and PPP1R15A, while the HLA-A and GEN1 variants were not correlated with survival or recurrence. A group of five HLA-DMA/HLA-DMB variants was only found in Group B and was associated with a higher risk of locoregional recurrence. Conclusions This study indicates that germline genetic biomarkers may have utility in predicting toxicity and outcomes after radiation therapy and deserve further investigation in precision radiation medicine approaches.
Keywords	Predictive biomarkers of radiation toxicity ; Head and neck squamous cell carcinoma ; Radiogenomics ; Germline variants ; TSC2 ; HLA-A ; Medicine ; R
Subject code	616 ; 610
Language	English
Publishing date	2022-08-01T00:00:00Z
Publisher	BMC
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Host test based on tumor necrosis factor-related apoptosis-inducing ligand, interferon gamma-induced protein-10 and C-reactive protein for differentiating bacterial and viral respiratory tract infections in adults: diagnostic accuracy study.

Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases

2023 Volume 29, Issue 9, Page(s) 1159–1165

Abstract: Objectives: To assess the performance of a test (called BV), integrating the blood levels of three immune proteins into a score, to differentiate bacterial from viral infection among adults with suspected lower respiratory tract infection (LRTI).: ... ...

Abstract	Objectives: To assess the performance of a test (called BV), integrating the blood levels of three immune proteins into a score, to differentiate bacterial from viral infection among adults with suspected lower respiratory tract infection (LRTI). Methods: Prospective diagnostic accuracy study, enrolling febrile adults >18 years with LRTI signs or symptoms for less than 7 days presenting to several hospitals' emergency departments in Israel. The main exclusion criterion was immunodeficiency. Reference standard diagnosis (bacterial/viral/indeterminate) was based on three experts independently reviewing comprehensive patient data including follow-up data. BV generated three results: viral infection or other nonbacterial condition (0 ≤ score < 35), equivocal (35 ≤ score ≤ 65) and bacterial infection including co-infection (65 < score ≤ 100). BV performance was assessed against the reference standard with indeterminate reference standard and equivocal BV cases removed. Results: Of 490 enrolled patients, 415 met eligibility criteria (median age 56 years, interquartile range 35). The reference standard classified 104 patients as bacterial, 210 as viral and 101 as indeterminate. BV was equivocal in 9.6% (30/314). Excluding indeterminate reference standard diagnoses and equivocal BV results, BV's sensitivity for bacterial infection was 98.1% (101/103; 95% confidence interval 95.4-100), specificity 88.4% (160/181; 83.7-93.1) and negative predictive value 98.8% (160/162; 97.1-100). Discussion: BV exhibited high diagnostic performance for febrile adults with suspected LRTI among patients with reference standard diagnoses of bacterial or viral LRTI.
MeSH term(s)	Humans ; Adult ; Middle Aged ; C-Reactive Protein/analysis ; Interferon-gamma ; Biomarkers ; Prospective Studies ; Ligands ; Sensitivity and Specificity ; Bacterial Infections/diagnosis ; Respiratory Tract Infections/diagnosis ; Respiratory Tract Infections/microbiology ; Virus Diseases/diagnosis ; Bacteria ; Fever ; Tumor Necrosis Factor-alpha
Chemical Substances	C-Reactive Protein (9007-41-4) ; Interferon-gamma (82115-62-6) ; Biomarkers ; Ligands ; Tumor Necrosis Factor-alpha
Language	English
Publishing date	2023-06-01
Publishing country	England
Document type	Journal Article
ZDB-ID	1328418-6
ISSN	1469-0691 ; 1470-9465 ; 1198-743X
ISSN (online)	1469-0691
ISSN	1470-9465 ; 1198-743X
DOI	10.1016/j.cmi.2023.05.033
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Zs.A 4541: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
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