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  1. Article ; Online: On the mucoadhesive properties of synthetic and natural polyampholytes.

    Fu, Manfei / Filippov, Sergey K / Williams, Adrian C / Khutoryanskiy, Vitaliy V

    Journal of colloid and interface science

    2024  Volume 659, Page(s) 849–858

    Abstract: Hypothesis: The mucoadhesive characteristics of amphoteric polymers (also known as polyampholytes) can vary and are influenced by factors such as the solution's pH and its relative position against their isoelectric point ( ... ...

    Abstract Hypothesis: The mucoadhesive characteristics of amphoteric polymers (also known as polyampholytes) can vary and are influenced by factors such as the solution's pH and its relative position against their isoelectric point (pH
    MeSH term(s) Swine ; Animals ; Polymers/chemistry ; Mucins/chemistry ; Gastric Mucins
    Chemical Substances Polymers ; Mucins ; Gastric Mucins
    Language English
    Publishing date 2024-01-05
    Publishing country United States
    Document type Journal Article
    ZDB-ID 241597-5
    ISSN 1095-7103 ; 0021-9797
    ISSN (online) 1095-7103
    ISSN 0021-9797
    DOI 10.1016/j.jcis.2023.12.176
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Bonn / Germany

    Z 71/707: Show issues

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  2. Book: Transdermal and topical drug delivery

    Williams, Adrian C.

    from theory to clinical practice

    2003  

    Author's details Adrian Williams
    Language English
    Size XII, 242 S. : Ill., graph. Darst.
    Edition 1. publ.
    Publisher PhP, Pharmaceutical Press ; Dt. Apotheker-Verl.
    Publishing place London u.a. ; Stuttgart
    Publishing country Great Britain
    Document type Book
    HBZ-ID HT015300049
    ISBN 978-3-7692-3251-6 ; 0-85369-489-3 ; 3-7692-3251-8 ; 978-0-85369-489-2
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2007 A 5834 order for loan Magazin

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  3. Article ; Online: The Companion Pandemic to COVID-19: The Use of Informal Practices to Access Public Healthcare Services in the European Union.

    Horodnic, Adrian V / Williams, Colin C / Drugă, Răzvan Ionuț

    International journal of public health

    2022  Volume 67, Page(s) 1604405

    Abstract: Objectives: ...

    Abstract Objectives:
    MeSH term(s) Humans ; Financing, Personal ; European Union ; Pandemics ; COVID-19/epidemiology ; Reproducibility of Results ; Delivery of Health Care ; Health Expenditures
    Language English
    Publishing date 2022-10-19
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2274130-6
    ISSN 1661-8564 ; 1661-8556
    ISSN (online) 1661-8564
    ISSN 1661-8556
    DOI 10.3389/ijph.2022.1604405
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 843: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  4. Book: Patient care in neurology

    Williams, Adrian C.

    1999  

    Author's details ed. by Adrian C. Williams
    Keywords Nervous System Diseases / diagnosis ; Nervous System Diseases / therapy ; Neurology
    Language English
    Size XII, 487 S. : Ill., graph. Darst.
    Publisher Oxford Univ. Press
    Publishing place Oxford
    Publishing country Great Britain
    Document type Book
    Note Includes bibliographical references and index
    HBZ-ID HT011102678
    ISBN 0-19-262857-7 ; 978-0-19-262857-2
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    1999 A 6093 order for loan Magazin

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  5. Article ; Online: Transdermal drug delivery in horses: An in vitro comparison of skin structure and permeation of two model drugs at various anatomical sites.

    Bizley, Samuel C / Dudhia, Jayesh / Smith, Roger K W / Williams, Adrian C

    Veterinary dermatology

    2023  

    Abstract: Background: Oral and parenteral drug delivery in horses can be difficult. Equine-specific transdermal drug formulations offer improved ease of treatment; development of such formulations requires a deeper understanding of the structural and chemical ... ...

    Abstract Background: Oral and parenteral drug delivery in horses can be difficult. Equine-specific transdermal drug formulations offer improved ease of treatment; development of such formulations requires a deeper understanding of the structural and chemical tissue barrier of horse skin.
    Hypothesis/objectives: To compare the structural composition and barrier properties of equine skin.
    Animals: Six warmblood horses (two males, four females) with no skin diseases.
    Materials and methods: Routine histological and microscopic analyses were carried out with image analysis for skin from six different anatomical locations. In vitro drug permeation was analysed using a standard Franz diffusion cell protocol coupled with reversed phase-high-performance liquid chromatography detailing flux, lag times and tissue partitioning ratios of two model drug compounds.
    Results: Epidermal and dermal thicknesses varied between sites. The dermal and epidermal thicknesses of the croup were 1764 ± 115 μm and 36 ± 3.6 μm, respectively, and were significantly different (p < 0.05) from the inner thigh thicknesses which were 824 ± 35 μm and 49 ± 3.6 μm. Follicular density and size also varied. The highest flux for the model hydrophilic molecule (caffeine) was for the flank (3.22 ± 0.36 μg/cm
    Conclusions and clinical relevance: Anatomical location differences in equine skin structure and small molecule permeability were demonstrated. These results can aid in the development of transdermal therapies for horses.
    Language English
    Publishing date 2023-04-26
    Publishing country England
    Document type Journal Article
    ZDB-ID 2011122-8
    ISSN 1365-3164 ; 0959-4493
    ISSN (online) 1365-3164
    ISSN 0959-4493
    DOI 10.1111/vde.13162
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Synthesis and Evaluation of Poly(3-hydroxypropyl Ethylene-imine) and Its Blends with Chitosan Forming Novel Elastic Films for Delivery of Haloperidol.

    Soradech, Sitthiphong / Kengkwasingh, Pattarawadee / Williams, Adrian C / Khutoryanskiy, Vitaliy V

    Pharmaceutics

    2022  Volume 14, Issue 12

    Abstract: This study aimed to develop novel elastic films based on chitosan and poly(3-hydroxypropyl ethyleneimine) or P3HPEI for the rapid delivery of haloperidol. P3HPEI was synthesized using a nucleophilic substitution reaction of linear polyethyleneimine (L- ... ...

    Abstract This study aimed to develop novel elastic films based on chitosan and poly(3-hydroxypropyl ethyleneimine) or P3HPEI for the rapid delivery of haloperidol. P3HPEI was synthesized using a nucleophilic substitution reaction of linear polyethyleneimine (L-PEI) with 3-bromo-1-propanol.
    Language English
    Publishing date 2022-11-30
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2527217-2
    ISSN 1999-4923
    ISSN 1999-4923
    DOI 10.3390/pharmaceutics14122671
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: The 4 D's of Pellagra and Progress.

    Williams, Adrian C / Hill, Lisa J

    International journal of tryptophan research : IJTR

    2020  Volume 13, Page(s) 1178646920910159

    Abstract: Nicotinamide homeostasis is a candidate common denominator to explain smooth transitions, whether demographic, epidemiological or economic. This 'NAD world', dependent on hydrogen-based energy, is not widely recognised as it is neither measured nor ... ...

    Abstract Nicotinamide homeostasis is a candidate common denominator to explain smooth transitions, whether demographic, epidemiological or economic. This 'NAD world', dependent on hydrogen-based energy, is not widely recognised as it is neither measured nor viewed from a sufficiently multi-genomic or historical perspective. Reviewing the importance of meat and nicotinamide balances during our co-evolution, recent history suggests that populations only modernise and age well with low fertility on a suitably balanced diet. Imbalances on the low meat side lead to an excess of infectious disease, short lives and boom-bust demographics. On the high side, meat has led to an excess of degenerative, allergic and metabolic disease and low fertility. A 'Goldilocks' diet derived from mixed and sustainable farming (preserving the topsoil) allows for high intellectual capital, height and good health with controlled population growth resulting in economic growth and prosperity. Implementing meat equity worldwide could lead to progress for future generations on 'spaceship' earth by establishing control over population quality, thermostat and biodiversity, if it is not already too late.
    Keywords covid19
    Language English
    Publishing date 2020-04-16
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2517435-6
    ISSN 1178-6469
    ISSN 1178-6469
    DOI 10.1177/1178646920910159
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  8. Article: Mutual Effects of Hydrogen Bonding and Polymer Hydrophobicity on Ibuprofen Crystal Inhibition in Solid Dispersions with Poly(

    Shan, Xiaoning / Moghul, Maryam A / Williams, Adrian C / Khutoryanskiy, Vitaliy V

    Pharmaceutics

    2021  Volume 13, Issue 5

    Abstract: Poly( ...

    Abstract Poly(
    Language English
    Publishing date 2021-05-04
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2527217-2
    ISSN 1999-4923
    ISSN 1999-4923
    DOI 10.3390/pharmaceutics13050659
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Cost-Effectiveness of Extracorporeal Photopheresis in Patients With Chronic Graft-vs-Host Disease.

    Peacock, Adrian / Dehle, Frances C / Mesa Zapata, Oscar A / Gennari, Francesca / Williams, Maro R I / Hamad, Nada / Larsen, Stephen / Harrison, Simon J / Taylor, Colman

    Journal of health economics and outcomes research

    2024  Volume 11, Issue 1, Page(s) 23–31

    Abstract: Background: ...

    Abstract Background:
    Language English
    Publishing date 2024-02-01
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2746906-2
    ISSN 2327-2236 ; 2327-2236
    ISSN (online) 2327-2236
    ISSN 2327-2236
    DOI 10.36469/001c.92028
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  10. Article: Nicotinamide as Independent Variable for Intelligence, Fertility, and Health: Origin of Human Creative Explosions?

    Williams, Adrian C / Hill, Lisa J

    International journal of tryptophan research : IJTR

    2019  Volume 12, Page(s) 1178646919855944

    Abstract: Meat and nicotinamide acquisition was a defining force during the 2-million-year evolution of the big brains necessary for, anatomically modern, ...

    Abstract Meat and nicotinamide acquisition was a defining force during the 2-million-year evolution of the big brains necessary for, anatomically modern,
    Language English
    Publishing date 2019-06-19
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2517435-6
    ISSN 1178-6469
    ISSN 1178-6469
    DOI 10.1177/1178646919855944
    Database MEDical Literature Analysis and Retrieval System OnLINE

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