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  1. Article ; Online: Response to David R. Crocker and Steven D. Langton "When is it Legitimate to Downplay Individual Differences?"

    Ludwigs, Jan-Dieter / Ebeling, Markus / Fredricks, Timothy B / Murfitt, Roger C / Kragten, Steven

    Environmental toxicology and chemistry

    2019  Volume 38, Issue 8, Page(s) 1604–1605

    Language English
    Publishing date 2019-07-30
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 46234-2
    ISSN 1552-8618 ; 0730-7268
    ISSN (online) 1552-8618
    ISSN 0730-7268
    DOI 10.1002/etc.4455
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2312: Show issues Location:
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  2. Book: The human microbiota

    Fredricks, David N.

    how microbial communities affect health and disease

    2013  

    Author's details ed. by David N. Fredricks
    Subject code 579
    Language English
    Size XIII, 362 S. : Ill., graph. Darst.
    Publisher Wiley Blackwell
    Publishing place Hoboken, NJ
    Publishing country United States
    Document type Book
    Note Includes bibliographical references and index ; The NIH human microbiome project -- Methods for characterizing microbial communities associated with the human body -- Phyloarrays -- Mathematical approaches for describing microbial populations : practice and theory for extrapolation of rich environments -- Tension at the border : how host genetics and the enteric microbiota conspire to promote Crohn's disease -- The human airway microbiome -- Microbiota of the mouth : a blessing or a curse? -- Microtiota of the genitourinary tract -- Functional structure of intestinal microbiota in health and disease -- From fly to human : understanding how commensal microorganisms influence host immunity and health -- Insights into the human microbiome from animal models -- To grow or not to grow : isolation and cultivation procedures in the genomic age -- New approaches to cultivation of human microbiota -- Manipulating the indigenous microbiota in humans : prebiotics, probiotics, and synbiotics
    HBZ-ID HT017766471
    ISBN 978-0-470-47989-6 ; 0-470-47989-2
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    2013 A 2483 available for loan (reading room) Lesesaal EG

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  3. Article ; Online: Evidence in Microbiome Science: Standards for the Field (and Laboratory).

    Fredricks, David N

    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

    2020  Volume 72, Issue 9, Page(s) 1514–1516

    MeSH term(s) Carbapenems ; Gram-Negative Bacterial Infections ; Humans ; Laboratories ; Leukemia, Myeloid, Acute ; Microbiota ; Stenotrophomonas maltophilia
    Chemical Substances Carbapenems
    Language English
    Publishing date 2020-06-12
    Publishing country United States
    Document type Editorial ; Research Support, N.I.H., Extramural ; Comment
    ZDB-ID 1099781-7
    ISSN 1537-6591 ; 1058-4838
    ISSN (online) 1537-6591
    ISSN 1058-4838
    DOI 10.1093/cid/ciaa766
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Effect of Metronidazole on Concentrations of Vaginal Bacteria Associated with Risk of HIV Acquisition.

    Valint, Daniel / Fiedler, Tina / Liu, Congzhou / Sriniva, Sujatha / Fredricks, David

    Research square

    2024  

    Abstract: Several bacterial vaginosis (BV)-associated bacteria have been associated with elevated risk of HIV acquisition, however susceptibility of these bacteria to antibiotics is poorly understood. Vaginal samples were collected from 22 persons daily for two ... ...

    Abstract Several bacterial vaginosis (BV)-associated bacteria have been associated with elevated risk of HIV acquisition, however susceptibility of these bacteria to antibiotics is poorly understood. Vaginal samples were collected from 22 persons daily for two weeks following BV diagnosis. Metronidazole treatment was prescribed for 5-7 days. Changes in bacterial concentrations were measured with taxon-specific 16S rRNA gene quantitative PCR (qPCR) assays. A culture-based antimicrobial assay confirmed presence of antibiotics in vaginal swab samples. Bacterial DNA concentrations decreased during antibiotic administration for all thirteen bacterial taxa tested. Comparison of bacterial DNA concentrations in samples before administration of antibiotics to samples taken on the last day of antimicrobial assay-confirmed antibiotic presence showed a 2.3-4.5 log10-fold decrease across all taxa. Concentrations were frequently reduced to the qPCR assay's limit of detection, suggesting eradication of bacteria. Mean clearance time varied across taxa (1.2-8.6 days), with several bacteria (e.g.,
    Language English
    Publishing date 2024-04-11
    Publishing country United States
    Document type Preprint
    DOI 10.21203/rs.3.rs-4219764/v1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: The gut microbiota and graft-versus-host disease.

    Fredricks, David N

    The Journal of clinical investigation

    2019  Volume 129, Issue 5, Page(s) 1808–1817

    Abstract: Graft-versus-host disease (GvHD) is a common complication of hematopoietic cell transplantation that negatively impacts quality of life in recipients and can be fatal. Animal experiments and human studies provide compelling evidence that the gut ... ...

    Abstract Graft-versus-host disease (GvHD) is a common complication of hematopoietic cell transplantation that negatively impacts quality of life in recipients and can be fatal. Animal experiments and human studies provide compelling evidence that the gut microbiota is associated with risk of GvHD, but the nature of this relationship remains unclear. If the gut microbiota is a driver of GvHD pathogenesis, then manipulation of the gut microbiota offers one promising avenue for preventing or treating this common condition, and antibiotic stewardship efforts in transplantation may help preserve the indigenous microbiota and modulate immune responses to benefit the host.
    MeSH term(s) Animals ; Antimicrobial Stewardship ; Gastrointestinal Microbiome/immunology ; Graft vs Host Disease/immunology ; Graft vs Host Disease/microbiology ; Graft vs Host Disease/therapy ; Hematopoietic Stem Cell Transplantation/adverse effects ; Humans ; Inflammation ; Lymphocyte Activation ; Mice ; Neoplasms/complications ; Neoplasms/therapy ; Quality of Life
    Language English
    Publishing date 2019-05-01
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Review
    ZDB-ID 3067-3
    ISSN 1558-8238 ; 0021-9738
    ISSN (online) 1558-8238
    ISSN 0021-9738
    DOI 10.1172/JCI125797
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Ua VI Zs.184: Show issues Location:
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  6. Article ; Online: Gardnerella Species and their Association with Bacterial Vaginosis.

    Munch, Matthew M / Strenk, Susan M / Srinivasan, Sujatha / Fiedler, Tina L / Proll, Sean / Fredricks, David N

    The Journal of infectious diseases

    2024  

    Abstract: Background: Bacterial vaginosis (BV) is a condition marked by high vaginal bacterial diversity. Gardnerella vaginalis has been implicated in BV but is also detected in healthy women. The Gardnerella genus has been expanded to encompass six validly named ...

    Abstract Background: Bacterial vaginosis (BV) is a condition marked by high vaginal bacterial diversity. Gardnerella vaginalis has been implicated in BV but is also detected in healthy women. The Gardnerella genus has been expanded to encompass six validly named species and several genomospecies. We hypothesized that particular Gardnerella species may be more associated with BV.
    Methods: Quantitative PCR assays were developed targeting the cpn60 gene of species groups including G. vaginalis, G. piotii/pickettii, G. swidsinskii/greenwoodii and G. leopoldii. These assays were applied to vaginal swabs from individuals with (n=101) and without BV (n=150) attending a sexual health clinic in Seattle, Washington. Weekly swabs were collected from 42 participants for up to 12 weeks.
    Results: Concentrations and prevalence of each Gardnerella species group were significantly higher in participants with BV. 91.1% of BV positive participants had three or more Gardnerella species groups detected compared to 32.0% of BV negative participants (p<0.0001). BV negative participants with three or more species groups detected were more likely to develop BV within 100 days versus those with fewer (60.5% vs 3.7%, p<0.0001).
    Conclusions: These results suggest that BV reflects a state of high Gardnerella species diversity. No Gardnerella species group was a specific marker for BV.
    Language English
    Publishing date 2024-01-24
    Publishing country United States
    Document type Journal Article
    ZDB-ID 3019-3
    ISSN 1537-6613 ; 0022-1899
    ISSN (online) 1537-6613
    ISSN 0022-1899
    DOI 10.1093/infdis/jiae026
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    Uh II Zs.50: Show issues Location:
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    Zs.MO 445: Show issues

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  7. Article ; Online: Viruses Associated With Unexplained Acute Liver Failure: Next Generation Reveals the Last Generation.

    Fredricks, David N

    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

    2017  Volume 65, Issue 9, Page(s) 1486–1488

    MeSH term(s) High-Throughput Nucleotide Sequencing ; Humans ; Liver Failure, Acute ; Metagenomics ; Viruses/genetics
    Language English
    Publishing date 2017-11-02
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 1099781-7
    ISSN 1537-6591 ; 1058-4838
    ISSN (online) 1537-6591
    ISSN 1058-4838
    DOI 10.1093/cid/cix597
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1505: Show issues Location:
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    Zs.MO 480: Show issues

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  8. Article ; Online: Economic Evaluation of a Point-of-Care Test for Bacterial Vaginosis Among Women With Vaginal Symptoms.

    Jiao, Boshen / Fredricks, David N / Srinivasan, Sujatha / Hansen, Ryan

    Sexually transmitted diseases

    2023  Volume 50, Issue 5, Page(s) 310–316

    Abstract: Background: There is an unmet need for a clinical diagnostic technology to detect bacterial vaginosis (BV) rapidly and accurately. Novel point-of-care (POC) tests have the potential to fulfill this gap. Our objective was to determine the cost- ... ...

    Abstract Background: There is an unmet need for a clinical diagnostic technology to detect bacterial vaginosis (BV) rapidly and accurately. Novel point-of-care (POC) tests have the potential to fulfill this gap. Our objective was to determine the cost-effectiveness of a hypothetical clinician-administered POC test for diagnosing BV in the United States.
    Methods: We developed a state-transition microsimulation model to evaluate the cost-effectiveness of using the POC test versus usual care among women of reproductive age with vaginal symptoms. We adopted a healthcare sector perspective that included relevant healthcare costs and a societal perspective that further incorporated productivity costs. Model parameters were empirically estimated based on commercial insurance claims data or derived from published literature. The primary model outcome was incremental cost-effectiveness ratio. We started with analyzing a hypothetical POC test with a sensitivity and specificity of 0.9 and a cost of $40, followed by extensive sensitivity analyses.
    Results: Using the hypothetical POC test to diagnose BV increased costs by $16 and quality-adjusted life-years by 0.0005 per person compared with the usual care, leading to an incremental cost-effectiveness ratio of $31,108 per quality-adjusted life-year gained. When also capturing the productivity costs, the POC test resulted in an average cost savings of $57. The sensitivity analyses showed that the POC test's sensitivity was more influential on its cost-effectiveness than specificity.
    Conclusions: Using the POC test to diagnose BV is likely to be cost-effective relative to usual care, especially with a high sensitivity or a substantial positive effect on productivity.
    MeSH term(s) Humans ; Female ; United States ; Cost-Benefit Analysis ; Vaginosis, Bacterial/diagnosis ; Point-of-Care Systems ; Point-of-Care Testing ; Health Care Costs ; Quality-Adjusted Life Years
    Language English
    Publishing date 2023-01-11
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 435191-5
    ISSN 1537-4521 ; 0148-5717
    ISSN (online) 1537-4521
    ISSN 0148-5717
    DOI 10.1097/OLQ.0000000000001766
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1217: Show issues Location:
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  9. Article ; Online: Identification of fallopian tube microbiota and its association with ovarian cancer.

    Yu, Bo / Liu, Congzhou / Proll, Sean C / Manhardt, Enna / Liang, Shuying / Srinivasan, Sujatha / Swisher, Elizabeth / Fredricks, David N

    eLife

    2024  Volume 12

    Abstract: Investigating the human fallopian tube (FT) microbiota has significant implications for understanding the pathogenesis of ovarian cancer (OC). In this large prospective study, we collected swabs intraoperatively from the FT and other surgical sites as ... ...

    Abstract Investigating the human fallopian tube (FT) microbiota has significant implications for understanding the pathogenesis of ovarian cancer (OC). In this large prospective study, we collected swabs intraoperatively from the FT and other surgical sites as controls to profile the microbiota in the FT and to assess its relationship with OC. Eighty-one OC and 106 non-cancer patients were enrolled and 1001 swabs were processed for 16S rRNA gene PCR and sequencing. We identified 84 bacterial species that may represent the FT microbiota and found a clear shift in the microbiota of the OC patients when compared to the non-cancer patients. Of the top 20 species that were most prevalent in the FT of OC patients, 60% were bacteria that predominantly reside in the gastrointestinal tract, while 30% normally reside in the mouth. Serous carcinoma had higher prevalence of almost all 84 FT bacterial species compared to the other OC subtypes. The clear shift in the FT microbiota in OC patients establishes the scientific foundation for future investigation into the role of these bacteria in the pathogenesis of OC.
    MeSH term(s) Female ; Humans ; Fallopian Tubes ; Prospective Studies ; RNA, Ribosomal, 16S/genetics ; Ovarian Neoplasms ; Microbiota ; Mouth
    Chemical Substances RNA, Ribosomal, 16S
    Language English
    Publishing date 2024-03-07
    Publishing country England
    Document type Journal Article
    ZDB-ID 2687154-3
    ISSN 2050-084X ; 2050-084X
    ISSN (online) 2050-084X
    ISSN 2050-084X
    DOI 10.7554/eLife.89830
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  10. Article ; Online: Diagnosis of infectious diseases in immunocompromised hosts using metagenomic next generation sequencing-based diagnostics.

    Casto, Amanda M / Fredricks, David N / Hill, Joshua A

    Blood reviews

    2021  Volume 53, Page(s) 100906

    Abstract: The diagnosis of infectious diseases in immunocompromised hosts presents unique challenges for the clinician. Metagenomic next generation sequencing (mNGS) based diagnostics that identify microbial nucleic acids in clinical samples (mNGS for pathogen ... ...

    Abstract The diagnosis of infectious diseases in immunocompromised hosts presents unique challenges for the clinician. Metagenomic next generation sequencing (mNGS) based diagnostics that identify microbial nucleic acids in clinical samples (mNGS for pathogen identification or mNGSpi) may be a useful tool in addressing some of these challenges. Studies of mNGSpi in immunocompromised hosts have demonstrated that these diagnostics are capable of identifying causative organisms in a subset of patients for whom conventional testing has been negative. While these studies provide proof of concept for mNGSpi utility, they have a number of limitations, which make it difficult to confidently assess test performance and clinical impact based on current data. Future studies will likely feature larger cohort sizes and controlled interventional study designs that assess the impact of mNGSpi on clinical endpoints. They will also likely include assessments of the clinical value of data generated by mNGS beyond pathogen identification.
    MeSH term(s) Communicable Diseases/diagnosis ; High-Throughput Nucleotide Sequencing ; Humans ; Immunocompromised Host ; Metagenomics ; Sensitivity and Specificity
    Language English
    Publishing date 2021-11-06
    Publishing country England
    Document type Journal Article ; Review ; Research Support, N.I.H., Extramural
    ZDB-ID 639015-8
    ISSN 1532-1681 ; 0268-960X
    ISSN (online) 1532-1681
    ISSN 0268-960X
    DOI 10.1016/j.blre.2021.100906
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