Result 1 - 10 of total 47
Can. J. Polit. Sci.
| Keywords | covid19 |
|---|---|
| Publisher | WHO |
| Document type | Article |
| Note | WHO #Covidence: #175180 |
| Database | COVID19 |
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Canadian Journal of Political Science
2020 Volume 53, Issue 2, Page(s) 305–309
Abstract: Legislatures are complex institutions that serve many purposes. While their overall roles vary in different political systems, they typically serve multiple functions, including representation, law making, scrutiny of government, public symbolism, and ... ...
| Abstract | Legislatures are complex institutions that serve many purposes. While their overall roles vary in different political systems, they typically serve multiple functions, including representation, law making, scrutiny of government, public symbolism, and others. These inevitably overlap and sometimes collide; similarly, individual legislators must balance party, constituency, and personal factors in their decision making. Now, in a time of sudden and unexpected disruption amid the COVID-19 pandemic, the Parliament of Canada has been forced to rethink its complex activities under urgent and unexpected new conditions. |
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| Keywords | Sociology and Political Science ; covid19 |
| Language | English |
| Publisher | Cambridge University Press (CUP) |
| Publishing country | uk |
| Document type | Article ; Online |
| ZDB-ID | 2066084-4 |
| ISSN | 1744-9324 ; 0008-4239 |
| ISSN (online) | 1744-9324 |
| ISSN | 0008-4239 |
| DOI | 10.1017/s0008423920000426 |
| Database | BASE - Bielefeld Academic Search Engine (life sciences selection) |
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2023 Volume 11, Page(s) 1168619
Abstract: Flecainide is a class IC antiarrhythmic utilized in prophylaxis of refractory paroxysmal supraventricular tachycardias in pediatric populations. Despite being a highly effective agent, its narrow therapeutic index increases the risk of toxicity and ... ...
| Abstract | Flecainide is a class IC antiarrhythmic utilized in prophylaxis of refractory paroxysmal supraventricular tachycardias in pediatric populations. Despite being a highly effective agent, its narrow therapeutic index increases the risk of toxicity and proarrhythmic events, including wide-complex tachycardia. In the absence of direct plasma sampling in the fetus to quantitate flecainide systemic concentrations, clinicians typically make drug dosing decisions from maternal plasma concentrations and QRS duration on maternal ECGs. There remains a paucity of standard guidelines and data to inform the timing and frequency of the aforementioned test in pregnancy and timing of flecainide discontinuation prior to childbirth. Flecainide primarily undergoes metabolism via cytochrome P450 (CYP). Given the variance of CYP-mediated metabolism at the level of the individual patient, pharmacogenomics can be considered in patients who present with flecainide toxicity to determine the maternal vs. fetal factors as an etiology for the event. Finally, pharmacogenetic testing can be utilized as an adjunct to guide flecainide dosing decisions, but must be done with caution in neonates <2 weeks of age. This case report highlights utilization of pharmacogenomic testing and therapeutic drug monitoring as adjuncts to guide therapy for a newborn with refractory supraventricular tachycardia, who experienced flecainide toxicity immediately post-partum and was trialed unsuccessfully on multiple alternative antiarrhythmics without rhythm control. |
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| Language | English |
| Publishing date | 2023-06-28 |
| Publishing country | Switzerland |
| Document type | Case Reports |
| ZDB-ID | 2711999-3 |
| ISSN | 2296-2360 |
| ISSN | 2296-2360 |
| DOI | 10.3389/fped.2023.1168619 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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Plastic and reconstructive surgery. Global open
2021 Volume 9, Issue 1, Page(s) e3333
Abstract: Graduate medical education (GME) programs are vital to developing future plastic surgeons. However, their cost-efficiency has yet to be contextualized. This cohort quality improvement (QI) project aimed to measure the indirect costs an institution ... ...
| Abstract | Graduate medical education (GME) programs are vital to developing future plastic surgeons. However, their cost-efficiency has yet to be contextualized. This cohort quality improvement (QI) project aimed to measure the indirect costs an institution assumes in training surgical residents, by comparing the differences in operative time and procedural charges between a resident and a physician assistant (PA) first-assisting during adolescent reduction mammaplasty. Methods: From 2013 to 2019, adolescent bilateral reduction mammaplasty procedures first-assisted by either a resident or physician assistant were considered for analysis. Financial data, including all hospital and physician expenditures and operation duration, patient demographics, and outcomes data were retrospectively collected. Results: A total of 49 reduction mammaplasty cases were included for analysis. Residents had an average of 5.9 ± 1.5 years of post-graduate surgical training, whereas the PA had 2 years of surgical experience. Procedures first-assisted by a surgical resident took a mean/median of 34 minutes longer and were $3750 more expensive, respectively, than cases first-assisted by a PA ( Conclusions: Reduction mammaplasty procedures were longer and accrued higher charges when first-assisted by a surgical resident than by a PA. Although Graduate Medical Education programs are necessary to train the next generation of surgeons, they may result in unintended opportunity costs for teaching hospitals. Federal support to academic medical centers aims to cushion the cost of residential training, but is insufficient to compensate for resident inefficiency. Hospitals may consider incorporating PAs into the Graduate Medical Education paradigm to alleviate administrative burden, lower operational charges, and enhance resident training curricula. |
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| Language | English |
| Publishing date | 2021-01-25 |
| Publishing country | United States |
| Document type | Journal Article |
| ZDB-ID | 2851682-5 |
| ISSN | 2169-7574 ; 2169-7574 |
| ISSN (online) | 2169-7574 |
| ISSN | 2169-7574 |
| DOI | 10.1097/GOX.0000000000003333 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
| Zs.A 7091: Show issues | Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG) |
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2021 Volume 186, Issue Suppl 1, Page(s) 76–81
Abstract: Background: Respiratory viruses are an important cause of nonbattle injury disease and contribute to the top seven reasons for medical encounters. In the absence of vaccines that provide complete protection against these viruses, viral surveillance can ... ...
| Abstract | Background: Respiratory viruses are an important cause of nonbattle injury disease and contribute to the top seven reasons for medical encounters. In the absence of vaccines that provide complete protection against these viruses, viral surveillance can identify disease burden and target virus-specific preventative measures. Influenza infection, in particular, has significant adverse effects on force readiness. Methods: We tracked the frequency of 16 respiratory viruses at Walter Reed National Military Medical Center tested for during routine patient care using multiplex polymerase chain reaction and rapid antigen testing. We collected data on the date and location of the testing, as well as the age of the individual tested from two consecutive respiratory viral seasons. Results: During the first year of data compilation (2017-2018), 2556 tests were performed; 342 (13.4%) were positive for influenza A and 119 (4.7%) were positive for influenza B. After influenza, the most common families of viruses identified were rhino/enterovirus (490 [19.2%]). During the second year (2018-2019), 4,458 tests were run; 564 (12.7%) were positive for influenza A and 35 (0.79%) were positive for influenza B, while rhino/enterovirus was identified in 690 (15.4%). Influenza peaked early during the 2017-2018 season and later during the 2018-2019 season. Importantly, during the 2017-2018 season, the vaccine was less effective for the H3N2 strain circulating that year and viral surveillance quickly identified a hospital-specific outbreak and a larger disease burden. This was in contrast to the 2018-2019 vaccine which exhibited higher effectiveness for circulating strains. Conclusion: Our data highlight the seasonality of respiratory viruses with a focus on influenza. By tracking respiratory viruses in Department of Defense communities, we may be able to predict when influenza may cause the greatest burden for distinct organizational regions and prescribe with greater precision preventative protocols by location, as well as rapidly determine vaccine efficacy. Our current data suggest that when vaccine strains are mismatched, rapid upfront targeting of antivirals may be warranted, but when the vaccine strains are better matched, late season peaks of disease may indicate waning immunity and should be monitored. |
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| MeSH term(s) | Cost of Illness ; Humans ; Influenza A Virus, H3N2 Subtype/immunology ; Influenza Vaccines/therapeutic use ; Influenza, Human/epidemiology ; Influenza, Human/prevention & control ; Public Health ; Seasons |
| Chemical Substances | Influenza Vaccines |
| Language | English |
| Publishing date | 2021-01-22 |
| Publishing country | England |
| Document type | Journal Article ; Research Support, U.S. Gov't, Non-P.H.S. |
| ZDB-ID | 391061-1 |
| ISSN | 1930-613X ; 0026-4075 |
| ISSN (online) | 1930-613X |
| ISSN | 0026-4075 |
| DOI | 10.1093/milmed/usaa238 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
| Un I Zs.546: Show issues | Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG) |
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Aerosol science and technology : the journal of the American Association for Aerosol Research
2022 Volume 52, Page(s) 957–970
Abstract: Accurate development and evaluation of inlets for representatively collecting ambient particulate matter typically involves use of monodisperse particles in aerosol wind tunnels. However, the resource requirements of using monodisperse aerosols for inlet ...
| Abstract | Accurate development and evaluation of inlets for representatively collecting ambient particulate matter typically involves use of monodisperse particles in aerosol wind tunnels. However, the resource requirements of using monodisperse aerosols for inlet evaluation creates the need for more rapid and less-expensive techniques to enable determination of size-selective performance in aerosol wind tunnels. The goal of recent wind tunnel research at the U.S. EPA was to develop and validate the use of polydisperse aerosols which provide more rapid, less resource-intensive test results which still meet data quality requirements necessary for developing and evaluating ambient aerosol inlets. This goal was successfully achieved through comprehensive efforts regarding polydisperse aerosol generation, dispersion, collection, extraction, and analysis over a wide range of aerodynamic particle sizes. Using proper experimental techniques, a sampler's complete size-selective efficiency curve can be estimated with polydisperse aerosols in a single test, as opposed to the use of monodisperse aerosols which require conducting multiple tests using several different particle sizes. While this polydisperse aerosol technique is not proposed as a regulatory substitute for use of monodisperse aerosols, the use of polydisperse aerosols is advantageous during an inlet's development where variables of sampling flow rate and inlet geometry are often iteratively evaluated before a final inlet design can be successfully achieved. Complete Standard Operating Procedures for the generation, collection, and analysis of polydisperse calibration aerosols are available from EPA as downloadable files. The described experimental methods will be of value to other researchers during development of ambient sampling inlets and size-selective evaluation of the inlets in aerosol wind tunnels. |
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| Language | English |
| Publishing date | 2022-02-11 |
| Publishing country | United States |
| Document type | Journal Article |
| ISSN | 0278-6826 |
| ISSN | 0278-6826 |
| DOI | 10.1080/02786826.2018.1469728 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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2023 Volume 63, Page(s) 102749
Abstract: Background: Glycerol is a substrate for gluconeogenesis and fatty acid esterification in the liver, processes which are upregulated in obesity and may contribute to excess fat accumulation. Glycine and glutamate, in addition to cysteine, are components ... ...
| Abstract | Background: Glycerol is a substrate for gluconeogenesis and fatty acid esterification in the liver, processes which are upregulated in obesity and may contribute to excess fat accumulation. Glycine and glutamate, in addition to cysteine, are components of glutathione, the major antioxidant in the liver. In principle, glycerol could be incorporated into glutathione via the TCA cycle or 3-phosphoglycerate, but it is unknown whether glycerol contributes to hepatic de novo glutathione biosynthesis. Methods: Glycerol metabolism to hepatic metabolic products including glutathione was examined in the liver from adolescents undergoing bariatric surgery. Participants received oral [U- Results: Data were collected from 8 participants (2 male, 6 female; age 17.1 years [range 14-19]; BMI 47.4 kg/m Conclusions: This is the first report of glycerol incorporation into glutathione through glycine or glutamate metabolism in human liver. This could represent a compensatory mechanism to increase glutathione in the setting of excess glycerol delivery to the liver. |
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| MeSH term(s) | Humans ; Liver/metabolism ; Glutathione/metabolism ; Glycerol/metabolism ; Male ; Female ; Adolescent ; Young Adult ; Magnetic Resonance Spectroscopy |
| Chemical Substances | Glutathione (GAN16C9B8O) ; Glycerol (PDC6A3C0OX) |
| Language | English |
| Publishing date | 2023-05-16 |
| Publishing country | Netherlands |
| Document type | Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't |
| ZDB-ID | 2701011-9 |
| ISSN | 2213-2317 ; 2213-2317 |
| ISSN (online) | 2213-2317 |
| ISSN | 2213-2317 |
| DOI | 10.1016/j.redox.2023.102749 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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Research on child and adolescent psychopathology
2023 Volume 52, Issue 2, Page(s) 253–266
Abstract: In the aftermath of discrete disasters, how families discuss the event has been linked with child well-being. There is less understanding, however, of how family communication affects adjustment to a protracted and ongoing public health crisis such as ... ...
| Abstract | In the aftermath of discrete disasters, how families discuss the event has been linked with child well-being. There is less understanding, however, of how family communication affects adjustment to a protracted and ongoing public health crisis such as the COVID-19 pandemic. The present research leveraged a large longitudinal sample of families (N = 1884) across the United States and Canada to investigate factors that predicted family communication styles (active versus avoidant communication) about the COVID-19 pandemic and examined the longitudinal sequelae of mental health outcomes for youth associated with different family communication styles. Parents of youth between 5 to 17 years old completed surveys about their own mental health, their child's mental health, and family communication about the COVID-19 pandemic at two time points 6 months apart. Overall, findings indicated that poorer parental mental health was related to greater use of avoidant communication, and avoidant communication styles were associated with poorer youth mental health over time. Findings suggest potential perils of avoidant family communication about ongoing threats and can help identify families at risk of negative mental health outcomes. |
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| MeSH term(s) | Humans ; Adolescent ; United States/epidemiology ; Child, Preschool ; Child ; Pandemics ; COVID-19 ; Parents/psychology ; Parent-Child Relations ; Communication |
| Language | English |
| Publishing date | 2023-10-06 |
| Publishing country | United States |
| Document type | Journal Article |
| ZDB-ID | 3041907-4 |
| ISSN | 2730-7174 ; 2730-7166 |
| ISSN (online) | 2730-7174 |
| ISSN | 2730-7166 |
| DOI | 10.1007/s10802-023-01133-1 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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Clinical cancer research : an official journal of the American Association for Cancer Research
2024
Abstract: Purpose: Locoregionally advanced HPV+ oropharyngeal squamous cell carcinoma (OPSCC) has excellent cure rates, although current treatment regimens are accompanied by acute and long-term toxicities. We designed a phase II de-escalation trial for patients ... ...
| Abstract | Purpose: Locoregionally advanced HPV+ oropharyngeal squamous cell carcinoma (OPSCC) has excellent cure rates, although current treatment regimens are accompanied by acute and long-term toxicities. We designed a phase II de-escalation trial for patients with HPV+OPSCC to evaluate the feasibility of an upfront neck dissection to individualize definitive treatment selection to improve quality of life without compromising survival. Methods: Patients with T1-3, N0-2 HPV+ OPSCC underwent an upfront neck dissection with primary tumor biopsy. Patients with a single lymph node less than six centimeters, with no extracapsular spread(ECS), and no primary site adverse features underwent transoral surgery (Arm A). Patients who had two or more positive lymph nodes with no ECS, or those with primary site adverse features were treated with radiation alone (Arm B). Patients who had ECS in any lymph node were treated with chemoradiation (Arm C). The primary endpoint was quality of life at 1 year compared to a matched historical control. Results: Thirty-four patients were enrolled and underwent selective neck dissection. Based on pathologic characteristics, 14 patients were assigned to arm A, 10 patients to arm B, and 9 to arm C. A significant improvement was observed in HNQOL compared to historical controls (-2.6 vs -11.9, p=0.034). With a median follow-up of 37 months, the 3-year overall survival was 100% and estimated 3-year estimated progression free survival was 96% (95% CI: 76-99%). Conclusion: A neck dissection driven treatment paradigm warrants further research as a de-intensification strategy. |
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| Language | English |
| Publishing date | 2024-03-22 |
| Publishing country | United States |
| Document type | Journal Article |
| ZDB-ID | 1225457-5 |
| ISSN | 1557-3265 ; 1078-0432 |
| ISSN (online) | 1557-3265 |
| ISSN | 1078-0432 |
| DOI | 10.1158/1078-0432.CCR-23-3247 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
| Zs.A 4223: Show issues | Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG) |
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Ecological engineering. 2014 Mar., v. 64
2014
Abstract: Peatlands abandoned after being exploited for horticultural materials can be characterized by soilâwater deficits that challenge the establishment of appropriate plant species, thus rewetting is an important step to restoring them to naturally ... ...
| Abstract | Peatlands abandoned after being exploited for horticultural materials can be characterized by soilâwater deficits that challenge the establishment of appropriate plant species, thus rewetting is an important step to restoring them to naturally functioning ecosystems. A bog section of Bic-Saint-Fabien peatland near Rimouski, QC was vacuum-harvested for peat production and abandoned in 2000. Harvesting activity left topographic elevation differences across the harvested area, creating wetness gradients. In general, the site interior had more available water than peripheral regions. Bic-Saint-Fabien was cut down to minerotrophic sedge peat; therefore it was restored as a fen. Research for this study lasted four years, 2008â2011. A water budget was created for every year of study to determine the importance of different hydrological parameters at Bic-Saint-Fabien.The main loss of water was through evapotranspiration and the principal input was precipitation. The main difference in the water budget between study years was that pre-rewetting was climatologically wetter than post-rewetting. Despite more available water before rewetting, before-after-control-impact design ANOVA indicated the water table was significantly higher at the cutover area after rewetting. In 2011 a wetness gradient remained evident within the cutover section of the peatland; however the mean seasonal water table was close (within 20cm) to the peat surface at all measured wells. An interior section of Bic-Saint-Fabien remained saturated for nearly all of 2011 and had mean seasonal water table of +2.4cm, and volumetric soil moisture content and soil water pressure, measured 5cm below the surface, of 86% and +4mbar, respectively, compared to â15.4cm, 67% and â13mbar, respectively, at a nearby (â¼100m) peripheral section. Systematic differences in wetness across the site suggest that a uniform prescription for vegetation re-establishment in the rewetted section may not be appropriate. |
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| Keywords | altitude ; analysis of variance ; ecosystems ; evapotranspiration ; harvesting ; horticulture ; peat ; peatlands ; soil water ; soil water content ; vegetation ; water balance ; water table ; wells ; Quebec |
| Language | English |
| Dates of publication | 2014-03 |
| Size | p. 151-160. |
| Publishing place | Elsevier B.V. |
| Document type | Article |
| ZDB-ID | 1127407-4 |
| ISSN | 0925-8574 |
| ISSN | 0925-8574 |
| DOI | 10.1016/j.ecoleng.2013.12.015 |
| Database | NAL-Catalogue (AGRICOLA) |
| Z 5865: Show issues |
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