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  1. Article: Interactive testbed for research in autism - the SARA project

    Arellano, Diana / Rauh, Reinhold / Krautheim, Benjamin / Spicker, Marc / Schaller, Ulrich Max / Helzle, Volker / Deussen, Oliver

    Universal Access in the Information Society

    2018  Volume 17, Issue 1, Page(s) 21–36

    Abstract: ... the relation between eye gaze behavior, ASD and alexithymia (i.e., difficulties in expressing ones emotions ... The project Stylized Animations for Research on Autism (SARA) aims to develop a better ...

    Title translation Interaktives Testbett für die Autismusforschung - das SARA-Projekt (DeepL)
    Abstract The project Stylized Animations for Research on Autism (SARA) aims to develop a better understanding of the cognitive processes behind emotional categorization in children and adolescents with high-functioning autism spectrum disorder (ASD), in comparison with neurotypically developed peers. To this end, we combine novel real-time non-photorealistic rendering (NPR) algorithms, emotional facial animations, and eye-tracking technologies in a framework that serves as an interactive testbed for empirical research. In this paper, we focus on three experiments that: (1) validate real-time facial animations of virtual characters, (2) evaluate the NPR algorithms to create abstracted facial expressions, and (3) elucidate the relation between eye gaze behavior, ASD and alexithymia (i.e., difficulties in expressing ones emotions). The results show that our animations can be used in the proposed experiments; however, more evaluation is needed regarding the NPR abstractions, especially with individuals with ASD. Finally, even though no correlation was found between gaze behavior, ASD and alexithymia, the study opened several questions that will be addressed in future work.
    Keywords Alexithymia ; Alexithymie ; Autism Spectrum Disorders ; Autismus-Spektrum-Störungen ; Emotion Recognition ; Emotionserkennung ; Face Perception ; Gesichterwahrnehmung ; Visual Tracking ; Visuelles Tracking
    Language English
    Document type Article
    ISSN 1615-5289
    ISSN 1615-5289
    DOI 10.1007/s10209-016-0521-9
    Database PSYNDEX

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  2. Article ; Online: Aerosol formation during processing of potentially infectious samples on Roche immunochemistry analyzers (cobas e analyzers) and in an end-to-end laboratory workflow to model SARS-CoV-2 infection risk for laboratory operators.

    Burghardt, Géza V / Eckl, Markus / Huether, Doris / Larbolette, Oliver H D / Lo Faso, Alessia / Ofenloch-Haehnle, Beatus R / Riesch, Marlene A / Herb, Rolf A

    Frontiers in public health

    2022  Volume 10, Page(s) 1034289

    Abstract: ... application to SARS-CoV-2, mean HBsAg uptake/hour was 1.9 viral particles across the cobas e analyzers and 0 ... aerosol formation when using cobas e analyzers only and in an end-to-end laboratory workflow. Recombinant ... Using the HBsAg model, air sampling was performed at different positions around the cobas e analyzers ...

    Abstract Objectives: To assess aerosol formation during processing of model samples in a simulated real-world laboratory setting, then apply these findings to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) to assess the risk of infection to laboratory operators.
    Design: This study assessed aerosol formation when using cobas e analyzers only and in an end-to-end laboratory workflow. Recombinant hepatitis B surface antigen (HBsAg) was used as a surrogate marker for infectious SARS-CoV-2 viral particles. Using the HBsAg model, air sampling was performed at different positions around the cobas e analyzers and in four scenarios reflecting critical handling and/or transport locations in an end-to-end laboratory workflow. Aerosol formation of HBsAg was quantified using the Elecsys
    Results: Following application to SARS-CoV-2, mean HBsAg uptake/hour was 1.9 viral particles across the cobas e analyzers and 0.87 viral particles across all tested scenarios in an end-to-end laboratory workflow, corresponding to a maximum inhalation rate of <16 viral particles during an 8-hour shift.
    Conclusion: Low production of marker-containing aerosol when using cobas e analyzers and in an end-to-end laboratory workflow is consistent with a remote risk of laboratory-acquired SARS-CoV-2 infection for laboratory operators.
    MeSH term(s) Humans ; COVID-19/diagnosis ; SARS-CoV-2 ; Workflow ; Immunochemistry ; Hepatitis B Surface Antigens ; Respiratory Aerosols and Droplets
    Chemical Substances Hepatitis B Surface Antigens
    Language English
    Publishing date 2022-11-16
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2711781-9
    ISSN 2296-2565 ; 2296-2565
    ISSN (online) 2296-2565
    ISSN 2296-2565
    DOI 10.3389/fpubh.2022.1034289
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Aerosol formation during processing of potentially infectious samples on Roche immunochemistry analyzers (cobas e analyzers) and in an end-to-end laboratory workflow to model SARS-CoV-2 infection risk for laboratory operators

    Géza V. Burghardt / Markus Eckl / Doris Huether / Oliver H. D. Larbolette / Alessia Lo Faso / Beatus R. Ofenloch-Haehnle / Marlene A. Riesch / Rolf A. Herb

    Frontiers in Public Health, Vol

    2022  Volume 10

    Abstract: ... when using cobas e analyzers only and in an end-to-end laboratory workflow. Recombinant hepatitis B ... model, air sampling was performed at different positions around the cobas e analyzers and in four ... viral particles across the cobas e analyzers and 0.87 viral particles across all tested scenarios in an end-to-end ...

    Abstract ObjectivesTo assess aerosol formation during processing of model samples in a simulated real-world laboratory setting, then apply these findings to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) to assess the risk of infection to laboratory operators.DesignThis study assessed aerosol formation when using cobas e analyzers only and in an end-to-end laboratory workflow. Recombinant hepatitis B surface antigen (HBsAg) was used as a surrogate marker for infectious SARS-CoV-2 viral particles. Using the HBsAg model, air sampling was performed at different positions around the cobas e analyzers and in four scenarios reflecting critical handling and/or transport locations in an end-to-end laboratory workflow. Aerosol formation of HBsAg was quantified using the Elecsys® HBsAg II quant II immunoassay. The model was then applied to SARS-CoV-2.ResultsFollowing application to SARS-CoV-2, mean HBsAg uptake/hour was 1.9 viral particles across the cobas e analyzers and 0.87 viral particles across all tested scenarios in an end-to-end laboratory workflow, corresponding to a maximum inhalation rate of <16 viral particles during an 8-hour shift.ConclusionLow production of marker-containing aerosol when using cobas e analyzers and in an end-to-end laboratory workflow is consistent with a remote risk of laboratory-acquired SARS-CoV-2 infection for laboratory operators.
    Keywords SARS-CoV-2 ; viral aerosol ; HBsAg ; laboratory operator ; laboratory workflow ; surrogate marker ; Public aspects of medicine ; RA1-1270
    Language English
    Publishing date 2022-11-01T00:00:00Z
    Publisher Frontiers Media S.A.
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article: SARA: a cognitive process model to simulate the anchoring effect and hindsight bias.

    Pohl, Rüdiger F / Eisenhauer, Markus / Hardt, Oliver

    Memory (Hove, England)

    2003  Volume 11, Issue 4-5, Page(s) 337–356

    Abstract: ... assumes that all processes, namely generating an estimate, encoding new information (i.e., the "anchor ... The cognitive process model "SARA" aims to explain the anchoring effect and hindsight bias ... implemented as a computer program. A series of simulations demonstrates the power of SARA to reproduce ...

    Abstract The cognitive process model "SARA" aims to explain the anchoring effect and hindsight bias by making detailed assumptions about the representation and alteration of item-specific knowledge. The model assumes that all processes, namely generating an estimate, encoding new information (i.e., the "anchor"), and reconstructing a previously generated estimate, are based on a probabilistic sampling process. Sampling probes long-term memory in order to retrieve information into working memory. Retrieval depends on the associative strength between this information and the currently active retrieval cues. Encoding the anchor may alter this associative pattern ("selective activation") or the anchor may serve as a retrieval cue, thus directing memory search ("biased reconstruction"). Both processes lead to systematically changed retrieval probabilities, thus causing the anchoring effect or hindsight bias. The model is completely formalised and implemented as a computer program. A series of simulations demonstrates the power of SARA to reproduce empirical findings and to predict new ones.
    MeSH term(s) Association ; Cognition ; Cues ; Humans ; Judgment ; Memory, Short-Term ; Mental Recall ; Models, Psychological ; Probability
    Language English
    Publishing date 2003-07
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1147478-6
    ISSN 1464-0686 ; 0965-8211
    ISSN (online) 1464-0686
    ISSN 0965-8211
    DOI 10.1080/09658210244000487
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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    Jg. 1995 - 2021: Lesesall (2.OG)
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  5. Article ; Online: Aerosol Formation During Processing of Potentially Infectious Samples on Roche Immunochemistry Analyzers (cobas e analyzers) and in an End-to-End Laboratory Workflow to Model SARS-CoV-2 Infection Risk for Laboratory Operators

    Burghardt, Géza V. / Eckl, Markus / Huether, Doris / Larbolette, Oliver H.D. / Lo Faso, Alessia / Ofenloch-Haehnle, Beatus R. / Riesch, Marlene A. / Herb, Rolf A.

    bioRxiv

    Abstract: ... cobas e analyzers only and in an end-to-end laboratory workflow. To estimate aerosol formation ... air sampling was performed at different positions around the cobas e analyzers and in four scenarios reflecting ... RNA copies was 1.9 viral RNA copies across the cobas e analyzers and 0.87 viral RNA copies across ...

    Abstract Background: This study assessed formation of potentially infectious aerosols during processing of infectious samples in a real-world laboratory setting, which could then be applied in the context of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Methods: This two-part study assessed aerosol formation when using cobas e analyzers only and in an end-to-end laboratory workflow. To estimate aerosol formation, recombinant hepatitis B surface antigen (HBsAg) was used as a surrogate marker for infectious virus particles to evaluate the potential risk of SARS-CoV-2 infection to laboratory operators. Using the HBsAg model, air sampling was performed at different positions around the cobas e analyzers and in four scenarios reflecting critical handling and/or transport locations in an end-to-end laboratory workflow. Aerosol formation of HBsAg was quantified using the Elecsys<sup>®</sup> HBsAg II quant II assay. The model was then applied to a SARS-CoV-2 context using SARS-CoV-2 infection-specific parameters to calculate viral RNA copies. Results: Following application to SARS-CoV-2, the mean HBsAg uptake per hour when recalculated into viral RNA copies was 1.9 viral RNA copies across the cobas e analyzers and 0.87 viral RNA copies across all tested scenarios in an end-to-end laboratory workflow. This corresponds to a maximum aspiration rate of <16 viral RNA copies during an 8-hour shift when using cobas e analyzers and/or in an end-to-end laboratory workflow. Conclusions: The low production of marker-containing aerosol when using cobas e analyzers and in an end-to-end laboratory workflow is consistent with a remote risk of laboratory-acquired SARS-CoV-2 infection for laboratory operators.
    Keywords covid19
    Language English
    Publishing date 2022-02-09
    Publisher Cold Spring Harbor Laboratory
    Document type Article ; Online
    DOI 10.1101/2022.02.08.479519
    Database COVID19

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  6. Article ; Online: Predicting SARA composition of crude oil by means of NMR

    Sanchez-Minero, Felipe / Ancheyta, Jorge / Silva-Oliver, Guadalupe / Flores-Valle, Sergio

    Fuel. 2013 Aug., v. 110 p.318-321

    2013  

    Abstract: ... resonance (¹H NMR and ¹³C NMR) and SARA (saturates, aromatics, resins, and asphaltenes) composition ... correlations to predict the SARA concentration of crude oils. The developed correlations showed good accuracy ...

    Abstract Five crude oils with a wide range of API gravities were characterized by means of nuclear magnetic resonance (¹H NMR and ¹³C NMR) and SARA (saturates, aromatics, resins, and asphaltenes) composition. From NMR analyses, the concentrations of aromatic-hydrogen (Hₐᵣ) and aromatic-carbon (Cₐᵣ) were obtained, with which the corresponding aromaticity factors FHA and FCA were calculated. Aromaticity factors were used to develop correlations to predict the SARA concentration of crude oils. The developed correlations showed good accuracy when comparing experimental and calculated values.
    Keywords aromatic compounds ; nuclear magnetic resonance spectroscopy ; petroleum ; prediction ; resins
    Language English
    Dates of publication 2013-08
    Size p. 318-321.
    Publishing place Elsevier Ltd
    Document type Article ; Online
    ISSN 0016-2361
    DOI 10.1016/j.fuel.2012.10.027
    Database NAL-Catalogue (AGRICOLA)

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  7. Book ; Online: SARA (Systems biology of PGI2 and ADP P2Y12 receptor signaling) - Teilprojekt F - Bioinformatik

    Kohlbacher, Oliver

    Schlussbericht ; Laufzeit des Vorhabens: 02.09.2009 - 31.12.2012

    2013  

    Author's details Oliver Kohlbacher
    Language German
    Size Online-Ressource (8 S., 1,48 MB), graph. Darst.
    Publisher Technische Informationsbibliothek u. Universitätsbibliothek ; Univ., Angewandte Bioinformatik
    Publishing place Hannover ; Tübingen
    Document type Book ; Online
    Note Förderkennzeichen BMBF 0315395F. - Verbund-Nr. 01067673 ; Unterschiede zwischen dem gedruckten Dokument und der elektronischen Ressource können nicht ausgeschlossen werden
    Database Library catalogue of the German National Library of Science and Technology (TIB), Hannover

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  8. Book: SARA (SYSTEMS BIOLOGY OF PGI2 AND ADP P2Y12 RECEPTOR SIGNALING) - Teilprojekt F - Bioinformatik

    Kohlbacher, Oliver

    Schlussbericht ; Laufzeit des Vorhabens: 02.09.2009 - 31.12.2012

    2013  

    Author's details Oliver Kohlbacher
    Language German
    Size [8] S., graph. Darst.
    Publisher Univ., Angewandte Bioinformatik
    Publishing place Tübingen
    Document type Book
    Note Förderkennzeichen BMBF 0315395F. - Verbund-Nr. 01067673
    Database Library catalogue of the German National Library of Science and Technology (TIB), Hannover

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  9. Book ; Online: eConsent - chances and challenges for a multi-stakeholder community

    Vanaken, Hilde / Demotes, Jacques / Cornely, Oliver Andreas

    2023  

    Abstract: ... participant and investigator. The ability to store and retrieve the document (e.g. by printing, downloading ...

    Title variant VACCELERATE Webinar JULY 05 2023: eConsent - Chances and Challenges for a Multistakeholder Community
    Institution VACCELERATE
    Author's details Presenter: Hilde Vanaken, PhD ; Moderator: Prof. Jacques Demotes ; Organizor: VACCELERATE (Coordinator: Prof. Oliver A. Cornely)
    Abstract The consent document is not only the input but also the output and final agreement between participant and investigator. The ability to store and retrieve the document (e.g. by printing, downloading) is a "must have" digital feature of each eConsent tool. eConsent tools should be simple, self-explanatory, and easy-to-use. If they multiply investigator’s workload or frustrate participants, it will not work. But there is no "one size fits all" eConsent model. Each disease, each study, each site, each participant might have different needs. Clearly the COVID-19 pandemic increased the awareness and openness for eConsent, but it also showed that the impact of in-person contacts should not be underestimated. Different aspects should be considered when selecting the eConsent digital features for a disease, study, sites and participants. Ultimately, eConsent tools should be flexible and become as easy to use and create as a paper consent. In this webinar, Hilde Vanaken will speak about eConsent terminologies, requirements, advantages, and hurdles, and share some insights in the harmonization activities ongoing in the multistakeholder EFGCP initiative.
    Keywords COVID-19
    Subject Coronavirus-Krankheit-2019 ; Corona virus disease 2019 ; Coronavirus disease 2019 ; 2019-nCoV acute respiratory disease ; Wuhan pneumonia ; COVID-19-Infektion ; Coronavirus-SARS-CoV-2-Infektion ; SARS-CoV-2-Infektion
    Subject code 610
    Language English
    Size 1 Online-Ressource (1 Videodatei, Lauflänge: 00:49:00)
    Publisher VACCELERATE_EU
    Publishing place Cologe
    Publishing country Germany
    Document type Book ; Online
    Note Open Access
    HBZ-ID HT030066769
    DOI 10.4126/FRL01-006441847
    Database Repository for Life Sciences

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  10. Article ; Online: Insight into the Structural Ambiguity of Actinide(IV) Oxalate Sheet Structures: A Case for Alternate Coordination Geometries.

    Sockwell, A Kirstin / Sweet, Teagan F M / Barth, Brodie / Isbill, Sara B / DiBlasi, Nicole A / Szymanowski, Jennifer E S / Sigmon, Ginger E / Oliver, Allen G / Miskowiec, Andrew J / Burns, Peter C / Hixon, Amy E

    Chemistry (Weinheim an der Bergstrasse, Germany)

    2023  Volume 29, Issue 47, Page(s) e202301164

    Abstract: Plutonium(IV) oxalate hexahydrate (Pu( ... ...

    Abstract Plutonium(IV) oxalate hexahydrate (Pu(C
    Language English
    Publishing date 2023-07-07
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1478547-X
    ISSN 1521-3765 ; 0947-6539
    ISSN (online) 1521-3765
    ISSN 0947-6539
    DOI 10.1002/chem.202301164
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