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Article ; Online: Understanding thiopurine methyltransferase polymorphisms for the targeted treatment of hematologic malignancies.

Franca, R / Braidotti, S / Stocco, G / Decorti, G

Expert opinion on drug metabolism & toxicology

2021 Volume 17, Issue 10, Page(s) 1187–1198

Abstract: Introduction: Thiopurine methyltransferase (TPMT) catalyzes the S-methylation of thiopurines (mercaptopurine (MP) and tioguanine (TG)), chemotherapeutic agents used in the treatment of acute lymphoblastic leukemia (ALL). Polymorphisms in : Areas ... ...

Abstract	Introduction: Thiopurine methyltransferase (TPMT) catalyzes the S-methylation of thiopurines (mercaptopurine (MP) and tioguanine (TG)), chemotherapeutic agents used in the treatment of acute lymphoblastic leukemia (ALL). Polymorphisms in Areas covered: This review gives an overview on Expert opinion: To titrate thiopurines safely and effectively, achieve the right degree of lymphotoxic effect and avoid excessive myelosuppression, the optimal management will combine a preemptive
MeSH term(s)	Animals ; Antimetabolites, Antineoplastic/administration & dosage ; Antimetabolites, Antineoplastic/adverse effects ; Antimetabolites, Antineoplastic/pharmacokinetics ; Genotype ; Humans ; Mercaptopurine/administration & dosage ; Mercaptopurine/adverse effects ; Mercaptopurine/pharmacokinetics ; Methyltransferases/genetics ; Methyltransferases/metabolism ; Molecular Targeted Therapy ; Polymorphism, Genetic ; Precursor Cell Lymphoblastic Leukemia-Lymphoma/drug therapy ; Precursor Cell Lymphoblastic Leukemia-Lymphoma/enzymology ; Thioguanine/administration & dosage ; Thioguanine/adverse effects ; Thioguanine/pharmacokinetics
Chemical Substances	Antimetabolites, Antineoplastic ; Mercaptopurine (E7WED276I5) ; Methyltransferases (EC 2.1.1.-) ; thiopurine methyltransferase (EC 2.1.1.67) ; Thioguanine (FTK8U1GZNX)
Language	English
Publishing date	2021-09-06
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	2214462-6
ISSN	1744-7607 ; 1742-5255
ISSN (online)	1744-7607
ISSN	1742-5255
DOI	10.1080/17425255.2021.1974398
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Article ; Online: Cytofluorimetric assay to investigate variability in blinatumomab

Braidotti, Stefania / Franca, Raffaella / Granzotto, Marilena / Piscianz, Elisa / Tommasini, Alberto / Rabusin, Marco / Stocco, Gabriele / Decorti, Giuliana

Frontiers in bioscience (Landmark edition)

2022 Volume 27, Issue 2, Page(s) 39

Abstract: Background: The T-cell engager antibody blinatumomab (BlincytoT⁢M) represents a promising rescue therapy for relapsed/refractory CD19+ acute lymphoblastic leukemia (B-ALL), although ~20-30% of patients still do not respond to treatment. Blinatumomab ... ...

Abstract	Background: The T-cell engager antibody blinatumomab (BlincytoT⁢M) represents a promising rescue therapy for relapsed/refractory CD19+ acute lymphoblastic leukemia (B-ALL), although ~20-30% of patients still do not respond to treatment. Blinatumomab creates a tight synapsis between CD3+ T-lymphocytes and leukemic CD19+ B-cells, resulting in a granzyme B (GzB)-mediated specific lysis of leukemic cells. Methods: Aim of the study was to provide evidence that variability in blinatumomab response could have a genetic basis in Results: In contrast to NALM6, REH cells do not express the full-length PAX5 protein and show less CD19 on the cell surface (fluorescence peak median intensity: 9155 versus 28895). Co-cultures of CD3+ T-lymphocytes from healthy donors and B-ALL cell lines were seeded at an effector-to-target cell ratio of 1:10 for simulating the condition existing in the bone marrow due to the malignant invasion of blast cells. Co-cultures were exposed Conclusions: In conclusion, cytofluorimetric analysis can highlight the different response induced by blinatumomab among co-cultures. Whether and how this difference is affected by
MeSH term(s)	Antibodies, Bispecific/metabolism ; Antibodies, Bispecific/pharmacology ; Antigens, CD19 ; Child ; Humans ; Male ; Precursor Cell Lymphoblastic Leukemia-Lymphoma/drug therapy ; Precursor Cell Lymphoblastic Leukemia-Lymphoma/genetics ; T-Lymphocytes
Chemical Substances	Antibodies, Bispecific ; Antigens, CD19 ; blinatumomab (4FR53SIF3A)
Language	English
Publishing date	2022-02-28
Publishing country	Singapore
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2704569-9
ISSN	2768-6698 ; 1093-9946
ISSN (online)	2768-6698
ISSN	1093-9946
DOI	10.31083/j.fbl2702039
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Article ; Online: Draft Genome Sequences of Eight Bacilli Isolated from an Ancient Roman Amphora.

Colautti, Andrea / Comi, Giuseppe / De Paoli, Emanuele / Peterlunger, Enrico / Novello, Marta / Braidotti, Elena / Pasini, Daniele / Iacumin, Lucilla

Microbiology resource announcements

2022 Volume 11, Issue 7, Page(s) e0028022

Abstract: Paleomicrobiology, the study of ancient microbiological material, allows us to understand different evolutionary phenomena in bacteria. In this study, eight bacilli isolated from an ancient Roman amphora, which dates to the IV to V sec. AD, were ... ...

Abstract	Paleomicrobiology, the study of ancient microbiological material, allows us to understand different evolutionary phenomena in bacteria. In this study, eight bacilli isolated from an ancient Roman amphora, which dates to the IV to V sec. AD, were sequenced and functionally annotated.
Language	English
Publishing date	2022-05-31
Publishing country	United States
Document type	Journal Article
ISSN	2576-098X
ISSN (online)	2576-098X
DOI	10.1128/mra.00280-22
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Article ; Online: Traumatic Sacral Fractures: Navigation Technique in Instrumented Stabilization.

Santoro, Giorgio / Braidotti, Piero / Gregori, Fabrizio / Santoro, Antonio / Domenicucci, Maurizio

World neurosurgery

2019 Volume 131, Page(s) 399–407

Abstract: Background: Sacral fractures are a challenge regarding treatment and classification. Surgical techniques using spinal navigation systems can improve treatment, especially if used in collaboration among different specialists.: Methods: Between 2015 ... ...

Abstract	Background: Sacral fractures are a challenge regarding treatment and classification. Surgical techniques using spinal navigation systems can improve treatment, especially if used in collaboration among different specialists. Methods: Between 2015 and 2017, we treated 25 consecutive cases of sacral fracture. Twelve patients (48%) underwent mechanical ventilation due to hypovolemic shock for severe thoracoabdominal trauma; bleeding was blocked with pelvic packing in 9 cases (36%) and transcatheter embolization in 2 cases (8%). External fixation was used in 7 cases (28%). In 20 cases (80%) spinal fractures were associated. All patients were operated on using spinal navigation by a team of neurosurgeons and orthopedic surgeons. Results: The mean time from first observation to surgery was 18 days (range 8-31). Surgical treatment consisted of iliosacral fixation in 19 cases (76%) and spinopelvic fixation in 6 cases (24%). The mean number of screws for spinopelvic fixation was 9.67 (range 6-17) with a mean operation time of 323.67 minutes (range 247-471); in iliosacral osteosynthesis the mean screw number was 1.37 (range 1-3) and mean surgical time was 78.93 minutes (range 61-130). Postoperative computed tomography showed the correct screw placement. Wound infection occurred in 2 cases (8%), managed with vacuum-assisted closure therapy; in 1 case (4%) a sacral screw was removed for decubitus. Conclusions: Navigation systems in instrumented spinopelvic and sacropelvic reconstruction provide greater safety, reducing learning times and malpositioning. Multidisciplinary management allows us to achieve optimal results, especially when the sacral fracture is combined with spinal and pelvic lesions. The use of navigation systems could represent an important advancement.
MeSH term(s)	Accidental Falls ; Accidents, Traffic ; Adolescent ; Adult ; Aged ; Bone Screws ; Female ; Humans ; Magnetic Resonance Imaging ; Male ; Middle Aged ; Neuronavigation/methods ; Preoperative Care/methods ; Retrospective Studies ; Sacrum/injuries ; Sacrum/surgery ; Spinal Fractures/surgery ; Surgical Instruments ; Tomography, X-Ray Computed ; Young Adult
Language	English
Publishing date	2019-10-28
Publishing country	United States
Document type	Case Reports ; Journal Article
ZDB-ID	2534351-8
ISSN	1878-8769 ; 1878-8750
ISSN (online)	1878-8769
ISSN	1878-8750
DOI	10.1016/j.wneu.2019.07.050
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Article ; Online: Zel'dovich Amplification in a Superconducting Circuit.

Braidotti, Maria Chiara / Vinante, Andrea / Gasbarri, Giulio / Faccio, Daniele / Ulbricht, Hendrik

Physical review letters

2020 Volume 125, Issue 14, Page(s) 140801

Abstract: Zel'dovich proposed that electromagnetic (EM) waves with angular momentum reflected from a rotating metallic, lossy cylinder will be amplified. However, we are still lacking a direct experimental EM-wave verification of this fifty-year-old prediction due ...

Abstract	Zel'dovich proposed that electromagnetic (EM) waves with angular momentum reflected from a rotating metallic, lossy cylinder will be amplified. However, we are still lacking a direct experimental EM-wave verification of this fifty-year-old prediction due to the challenging conditions in which the phenomenon manifests itself: the mechanical rotation frequency of the cylinder must be comparable with the EM oscillation frequency. Here, we propose an experimental approach that solves this issue and is predicted to lead to a measurable Zel'dovich amplification with existing superconducting circuit technology. We design a superconducting circuit with low frequency EM modes that couple through free space to a magnetically levitated and spinning microsphere placed at the center of the circuit. We theoretically estimate the circuit EM mode gain and show that rotation of the microsphere can lead to experimentally observable amplification, thus paving the way for the first EM-field experimental demonstration of Zel'dovich amplification.
Language	English
Publishing date	2020-10-08
Publishing country	United States
Document type	Journal Article
ZDB-ID	208853-8
ISSN	1079-7114 ; 0031-9007
ISSN (online)	1079-7114
ISSN	0031-9007
DOI	10.1103/PhysRevLett.125.140801
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Article ; Online: RNA-FISH to analyze allele-specific expression.

Braidotti, G

Methods in molecular biology (Clifton, N.J.)

2001 Volume 181, Page(s) 169–180

Abstract: One of the difficulties associated with the analysis of imprinted gene expression is the need to distinguish RNA synthesis occurring at the maternal vs the paternally inherited copy of the gene. Most of the techniques used to examine allele-specific ... ...

Abstract	One of the difficulties associated with the analysis of imprinted gene expression is the need to distinguish RNA synthesis occurring at the maternal vs the paternally inherited copy of the gene. Most of the techniques used to examine allele-specific expression exploit naturally occurring polymorphisms and measure steady-state levels of RNA isolated from a pool of cells. Hence, a restriction fragment length polymorphism (RFLP) an be exploited in a heterozygote, by a reverse transcriptase polymerase chain reaction (RT-PCR)- based procedure, to analyze maternal vs paternal gene expression. The human IGF2R gene was analyzed in this way. Smrzka et al. (1) were thus able to show that the IGF2R gene possesses a hemimethylated, intronic CpG island analogous to the mouse imprinting box. However, IGF2R mRNA was detected that possessed the RFLP from both the maternal and paternal alleles in all but one of the 70 lymphoblastoid samples. (The one monoallelic sample reactivated its paternal allele with continued cell culturing.) It was concluded that monoallelic expression of the human gene is a polymorphic trait occurring in a small minority of all tested samples (reviewed in refs. 2,3). Although this is a sound conclusion, the question remains: Is the human IGF2R gene imprinted?
MeSH term(s)	Alleles ; Animals ; Gene Expression Profiling/methods ; Genomic Imprinting ; Humans ; In Situ Hybridization, Fluorescence/methods ; Mice ; Polymorphism, Restriction Fragment Length/genetics ; RNA/genetics ; Reverse Transcriptase Polymerase Chain Reaction
Chemical Substances	RNA (63231-63-0)
Language	English
Publishing date	2001
Publishing country	United States
Document type	Journal Article
ISSN	1940-6029
ISSN (online)	1940-6029
DOI	10.1385/1-59259-211-2:169
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Article ; Online: Physiological characterization of Vitis hybrid cv Merlot Khorus under two different water regimes in northeastern Italy

Calderan, Alberto / Cogato, Alessia / Braidotti, Riccardo / Alberti, Giorgio / Lisjak, Klemen / Herrera, José Carlos / Peterlunger, E. / Sivilotti, Paolo A. G.

Scientia Horticulturae. 2023 Nov., v. 321 p.112318-

2023

Abstract: Fungus–resistant varieties are gathering attention all over viticultural areas owing to their contribution to sustainable management. Sustainable viticulture implies lower inputs in terms of pesticides and water. However, investigations on the ... ...

Abstract	Fungus–resistant varieties are gathering attention all over viticultural areas owing to their contribution to sustainable management. Sustainable viticulture implies lower inputs in terms of pesticides and water. However, investigations on the physiological behavior of fungus–resistant varieties under drought stress have been seldom conducted so far. Under climate change conditions, evaluating precise water use is particularly important to set up proper irrigation. In this study, a two-year experiment was imposed to characterize the physiological behavior of the fungus–resistant variety Merlot Khorus under two contrasting water regimes (full irrigation, WW; water deficit, WD). Berry weight and grape quality in the two treatments was also compared to evaluate the feasibility of adopting deficit irrigation strategies in the region. The study was conducted in the Friuli Venezia Giulia region (Italy). The measured values of stem water potential (Ψₛₜₑₘ) did not highlight any severe water stress (> -1.15 MPa) in WD. However, gₛ and AN decreased to values typical of drought–stressed vines. Concurrently, the experiment assessed that the calculated Kcb of Merlot Khorus in northeast Italy is far different from what has been suggested by standard methodologies and the literature. The grapes under deficit irrigation showed reduced berry weight, while basic maturation parameters and anthocyanins were improved. Overall, the study indicated that Merlot Khorus appears to be a genotype suitable for dry farming or deficit irrigation management in northeastern Italy. Therefore, the results may help winegrowers to improve irrigation strategies.
Keywords	Vitis ; anthocyanins ; climate change ; deficit irrigation ; genotype ; grapes ; hybrids ; irrigation rates ; viticulture ; water potential ; water stress ; Italy ; Water deficit ; Grapevine ; Fungus–resistant variety ; Transpiration ; PIWI
Language	English
Dates of publication	2023-11
Publishing place	Elsevier B.V.
Document type	Article ; Online
ZDB-ID	185557-8
ISSN	0304-4238
ISSN	0304-4238
DOI	10.1016/j.scienta.2023.112318
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Mercury and arsenic mobility in resuspended contaminated estuarine sediments (Asturias, Spain): A laboratory-based study.

García-Ordiales, Efren / Covelli, Stefano / Braidotti, Greta / Petranich, Elisa / Pavoni, Elena / Acquavita, Alessandro / Sanz-Prada, Lorena / Roqueñí, Nieves / Loredo, Jorge

The Science of the total environment

2020 Volume 744, Page(s) 140870

Abstract: Estuarine sediments must be dredged to allow for navigation, and where these sediments are placed after dredging depends upon guidelines based only on the total concentration of contaminants. However, resuspension events could seriously affect the ... ...

Abstract	Estuarine sediments must be dredged to allow for navigation, and where these sediments are placed after dredging depends upon guidelines based only on the total concentration of contaminants. However, resuspension events could seriously affect the mobility and speciation of contaminants, including potentially toxic trace elements stored in sediments. The effects of resuspension on the cycling of mercury (Hg) and arsenic (As) between the sediment and water column was investigated in a mesocosm study. Four experiments were conducted in three estuaries in northern Spain based on samples collected from sites which have been impacted by decommissioned Hg and As mines and periodically subjected to dredging activities. Designed to mimic the resuspension of particles, each of the experiments revealed that the release of Hg and As species does not only depend on the total concentration in the sediments (16.3-50.9 mg kg
Language	English
Publishing date	2020-07-15
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	121506-1
ISSN	1879-1026 ; 0048-9697
ISSN (online)	1879-1026
ISSN	0048-9697
DOI	10.1016/j.scitotenv.2020.140870
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Article: Response of merlot grapevine to drought is associated to adjustments of growth and nonstructural carbohydrates allocation in above and underground organs

Vuerich, M. / Braidotti, R. / Sivilotti, P. / Alberti, G. / Casolo, V. / Braidot, E. / Boscutti, F. / Calderan, A. / Petrussa, E.

Water

2021 Volume 13, Issue 17, Art. 2336, Page(s) 16 pp.

Abstract: Studying changes in partitioning of dry matter and nonstructural carbohydrates (NSC) content in both aboveground and underground perennial tissues in drought-affected grapevines could provide insights into plant response and carbon allocation strategies ... ...

Institution	Department of Agricultural Food, Animal and Environmental Sciences, University of Udine, Via delle Scienze 206, 33100 Udine, Italy
Abstract	Studying changes in partitioning of dry matter and nonstructural carbohydrates (NSC) content in both aboveground and underground perennial tissues in drought-affected grapevines could provide insights into plant response and carbon allocation strategies during stress periods. The analysis of soluble NSC and starch content in leaf petioles, due to their role in hydraulic segmentation, should also be considered. In the present research, these aspects have been investigated in Merlot grapevines grown in pots and subjected to progressive and increasing soil dehydration, and in well-irrigated vines. Drought conditions caused drastic reduction of shoot elongation and total plant leaf area development in favor of a greater biomass allocation and partitioning towards roots, where most of the NSC reserves were also conserved. Dry matter content of the perennial organs increased in stressed vines due to growth reduction, allocation of carbon reserves and possible anatomical modifications. Vines subjected to drought showed a higher NSC content in petioles, supporting the hypothesis that they are involved as compatible solutes in osmotic adjustment
Language	English
Document type	Article
ZDB-ID	2521238-2
ISSN	2073-4441
ISSN	2073-4441
Database	Viticulture and Oenology Abstracts

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Article: A Novel ELISA-Based Peptide Biosensor Assay for Screening ABL1 Activity

Montecchini, Oksana / Braidotti, Stefania / Franca, Raffaella / Zudeh, Giulia / Boni, Christian / Sorio, Claudio / Toffoletti, Eleonora / Rabusin, Marco / Tommasini, Alberto / Decorti, Giuliana / Stocco, Gabriele

Frontiers in pharmacology

2021 Volume 12, Page(s) 749361

Abstract: The pathogenic role of the overactivated ABL1 tyrosine kinase (TK) pathway is well recognized in some forms ... ...

Abstract	The pathogenic role of the overactivated ABL1 tyrosine kinase (TK) pathway is well recognized in some forms of
Language	English
Publishing date	2021-11-19
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2587355-6
ISSN	1663-9812
ISSN	1663-9812
DOI	10.3389/fphar.2021.749361
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