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  1. Article ; Online: Coma caused by Shigella toxin-producing

    Velding, Kristien / Mulder, Bert / Oeben, Jeroen / Suurmeijer, Annelies / Veneman, Thiemo F

    European journal of case reports in internal medicine

    2016  Volume 3, Issue 5, Page(s) 418

    Abstract: Shigella toxin-producing : Learning points: Shigella toxin ... ...

    Abstract Shigella toxin-producing
    Learning points: Shigella toxin producing
    Language English
    Publishing date 2016-06-08
    Publishing country Italy
    Document type Journal Article
    ISSN 2284-2594
    ISSN (online) 2284-2594
    DOI 10.12890/2016_000418
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: The Application of Modern Dressings to Buruli Ulcers: Results from a Pilot Implementation Project in Ghana.

    Velding, Kristien / Klis, Sandor-Adrian / Abass, K Mohammad / van der Werf, Tjip S / Stienstra, Ymkje

    The American journal of tropical medicine and hygiene

    2016  Volume 95, Issue 1, Page(s) 60–62

    Abstract: Buruli ulcer (BU) is a tropical, infectious skin disease. The resulting ulcer can take a long time to heal, and a high standard of wound care is essential. Currently, the only dressing used for BU wound care is gauze, and its removal causes pain and ... ...

    Abstract Buruli ulcer (BU) is a tropical, infectious skin disease. The resulting ulcer can take a long time to heal, and a high standard of wound care is essential. Currently, the only dressing used for BU wound care is gauze, and its removal causes pain and bleeding. We performed a pilot implementation project using HydroTac(®) (HARTMANN, Heidenheim, Germany), a modern dressing combining foam with a hydrogel component. For future BU treatment, we recommend to use a more absorbent dressing than the HydroTac dressing used in the current project. However, we show that modern dressings can be applied to BUs and that HydroTac dressings yield clean, healing wounds, and prevent the pain and bleeding associated with gauze dressings. Wound care is a vital but to date neglected aspect of BU management.
    MeSH term(s) Adolescent ; Bandages ; Buruli Ulcer/microbiology ; Buruli Ulcer/therapy ; Child ; Ghana ; Humans ; Hydrogels/chemistry ; Pilot Projects ; Wound Healing
    Chemical Substances Hydrogels
    Language English
    Publishing date 2016-07-06
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2942-7
    ISSN 1476-1645 ; 0002-9637
    ISSN (online) 1476-1645
    ISSN 0002-9637
    DOI 10.4269/ajtmh.15-0378
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Coma caused by Shigella toxin-producing Escherichia coli in the absence of haemorrhagic uraemic syndrome (HUS)

    Kristien Velding / Bert Mulder / Jeroen Oeben / Annelies Suurmeijer / Thiemo F Veneman

    European Journal of Case Reports in Internal Medicine, Vol 3, Iss

    2016  Volume 5

    Abstract: Shigella toxin-producing Escherichia coli (STEC) is well known for its complications such as haemolytic uraemic syndrome (HUS), but neurological symptoms have also been reported. While most cases of infection with STEC occur with concurrent HUS, we ... ...

    Abstract Shigella toxin-producing Escherichia coli (STEC) is well known for its complications such as haemolytic uraemic syndrome (HUS), but neurological symptoms have also been reported. While most cases of infection with STEC occur with concurrent HUS, we describe a patient with severe neurological symptoms in the absence of HUS.
    Keywords Hemolytic uraemic syndrome ; Shigella toxin ; Escherichia Coli ; Medicine ; R
    Language English
    Publishing date 2016-07-01T00:00:00Z
    Publisher SMC MEDIA SRL
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: Posttraumatic stress and depressive symptoms among people living with HIV in the Gambia.

    Klis, Sandor / Velding, Kristien / Gidron, Yori / Peterson, Kevin

    AIDS care

    2011  Volume 23, Issue 4, Page(s) 426–434

    Abstract: This study aimed to assess the prevalence and clinical and psychosocial correlates of psychiatric symptoms in a sample of HIV patients in the Gambia. Data from 44 HIV-positive outpatients were collected at a Genito-Urinary Medicine clinic in Fajara, the ... ...

    Abstract This study aimed to assess the prevalence and clinical and psychosocial correlates of psychiatric symptoms in a sample of HIV patients in the Gambia. Data from 44 HIV-positive outpatients were collected at a Genito-Urinary Medicine clinic in Fajara, the Gambia. Translated versions of the Impact of Event Scale Revised and the Centre for Epidemiologic Studies Short Depression Scale were used to assess posttraumatic stress disorder (PTSD) symptoms and depressive symptoms, respectively. The Pictorial Representation of Illness and Self Measure revised was used to assess illness perception (IP). All other data (e.g., CD4 counts) were retrieved from medical charts or through standardised questions. The prevalence of PTSD symptoms (43.2%) and depressive symptoms (40.9%) was high. Not having an independent income and having a CD4 count under 200 cells/µl were independent correlates of depressive symptoms. Only IP was an independent correlate of PTSD symptoms. Finally, IP tended to moderate the relationship between CD4 cell counts and depressive symptoms. These findings indicate that routine screening for psychiatric symptoms is both necessary and feasible among HIV patients in the Gambia. In addition, any intervention targeting these symptoms should take IP into account.
    MeSH term(s) Adolescent ; Adult ; CD4 Lymphocyte Count ; Depressive Disorder/epidemiology ; Depressive Disorder/psychology ; Female ; Gambia/epidemiology ; HIV Infections/psychology ; HIV Seropositivity ; Humans ; Male ; Middle Aged ; Prevalence ; Self-Assessment ; Socioeconomic Factors ; Stress Disorders, Post-Traumatic/epidemiology ; Stress Disorders, Post-Traumatic/psychology ; Young Adult
    Language English
    Publishing date 2011-04
    Publishing country England
    Document type Journal Article
    ZDB-ID 1012651-x
    ISSN 1360-0451 ; 0954-0121
    ISSN (online) 1360-0451
    ISSN 0954-0121
    DOI 10.1080/09540121.2010.507756
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Wound care in Buruli ulcer disease in Ghana and Benin.

    Velding, Kristien / Klis, Sandor-Adrian / Abass, Kabiru M / Tuah, Wilson / Stienstra, Ymkje / van der Werf, Tjip

    The American journal of tropical medicine and hygiene

    2014  Volume 91, Issue 2, Page(s) 313–318

    Abstract: Buruli ulcer (BU) is a disease affecting the skin, subcutaneous fat, and bone tissues. Wound care is important in the prevention of disabilities. Awareness of current wound care practices in BU-endemic regions is necessary for future wound care ... ...

    Abstract Buruli ulcer (BU) is a disease affecting the skin, subcutaneous fat, and bone tissues. Wound care is important in the prevention of disabilities. Awareness of current wound care practices in BU-endemic regions is necessary for future wound care interventions. Thirty-one health care workers in Ghana and Benin were interviewed with a semi-structured interview, complemented by structural observations. Quantitative data were analyzed through t tests and one-way analysis of variance, and qualitative data through descriptive statistics. There appeared to be a general understanding of wound assessment. A large variety of different topical antiseptics was reported to be used, pressure irrigation was never reported. Gauze was the main dressing type and a moist environment was preferred, but could not be maintained. Bleeding and pain were observed frequently. Standard of wound care differed importantly between health care personnel and between institutions and adherence to World Health Organization guidelines was low.
    MeSH term(s) Anti-Infective Agents, Local/therapeutic use ; Bandages ; Benin ; Buruli Ulcer/microbiology ; Buruli Ulcer/surgery ; Buruli Ulcer/therapy ; Female ; Ghana ; Guideline Adherence/standards ; Humans ; Male ; Mycobacterium ulcerans ; Neglected Diseases ; Skin/drug effects ; Skin/microbiology ; Standard of Care ; World Health Organization ; Wound Infection/microbiology ; Wound Infection/surgery ; Wound Infection/therapy
    Chemical Substances Anti-Infective Agents, Local
    Language English
    Publishing date 2014-06-09
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2942-7
    ISSN 1476-1645 ; 0002-9637
    ISSN (online) 1476-1645
    ISSN 0002-9637
    DOI 10.4269/ajtmh.13-0255
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Good quality of life in former Buruli ulcer patients with small lesions: long-term follow-up of the BURULICO trial.

    Klis, Sandor / Ranchor, Adelita / Phillips, Richard O / Abass, Kabiru M / Tuah, Wilson / Loth, Susanne / Velding, Kristien / van der Werf, Tjip S / Stienstra, Ymkje

    PLoS neglected tropical diseases

    2014  Volume 8, Issue 7, Page(s) e2964

    Abstract: Background: Buruli Ulcer is a tropical skin disease caused by Mycobacterium ulcerans, which, due to scarring and contractures can lead to stigma and functional limitations. However, recent advances in treatment, combined with increased public health ... ...

    Abstract Background: Buruli Ulcer is a tropical skin disease caused by Mycobacterium ulcerans, which, due to scarring and contractures can lead to stigma and functional limitations. However, recent advances in treatment, combined with increased public health efforts have the potential to significantly improve disease outcome.
    Objectives: To study the Quality of Life (QoL) of former Buruli Ulcer patients who, in the context of a randomized controlled trial, reported early with small lesions (cross-sectional diameter <10 cm), and received a full course of antibiotic treatment.
    Methods: 127 Participants of the BURULICO drug trial in Ghana were revisited. All former patients aged 16 or older completed the Dermatology Life Quality Index (DLQI) and the abbreviated World Health Organization Quality of Life scale (WHOQOL-BREF). The WHOQOL-BREF was also administered to 82 matched healthy controls. Those younger than 16 completed the Childrens' Dermatology Life Quality Index (CDLQI) only.
    Results: The median (Inter Quartile Range) score on the DLQI was 0 (0-4), indicating good QoL. 85% of former patients indicated no effect, or only a small effect of the disease on their current life. Former patients also indicated good QoL on the physical and psychological domains of the WHOQOL-BREF, and scored significantly higher than healthy controls on these domains. There was a weak correlation between the DLQI and scar size (ρ = 0.32; p<0.001).
    Conclusions: BU patients who report early with small lesions and receive 8 weeks of antimicrobial therapy have a good QoL at long-term follow-up. These findings contrast with the debilitating sequelae often reported in BU, and highlight the importance of early case detection.
    MeSH term(s) Adolescent ; Adult ; Anti-Bacterial Agents/administration & dosage ; Anti-Bacterial Agents/therapeutic use ; Buruli Ulcer/drug therapy ; Buruli Ulcer/epidemiology ; Buruli Ulcer/psychology ; Female ; Follow-Up Studies ; Humans ; Male ; Quality of Life ; Young Adult
    Chemical Substances Anti-Bacterial Agents
    Language English
    Publishing date 2014-07-10
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2429704-5
    ISSN 1935-2735 ; 1935-2735
    ISSN (online) 1935-2735
    ISSN 1935-2735
    DOI 10.1371/journal.pntd.0002964
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Good quality of life in former Buruli ulcer patients with small lesions

    Sandor Klis / Adelita Ranchor / Richard O Phillips / Kabiru M Abass / Wilson Tuah / Susanne Loth / Kristien Velding / Tjip S van der Werf / Ymkje Stienstra

    PLoS Neglected Tropical Diseases, Vol 8, Iss 7, p e

    long-term follow-up of the BURULICO trial.

    2014  Volume 2964

    Abstract: Buruli Ulcer is a tropical skin disease caused by Mycobacterium ulcerans, which, due to scarring and contractures can lead to stigma and functional limitations. However, recent advances in treatment, combined with increased public health efforts have the ...

    Abstract Buruli Ulcer is a tropical skin disease caused by Mycobacterium ulcerans, which, due to scarring and contractures can lead to stigma and functional limitations. However, recent advances in treatment, combined with increased public health efforts have the potential to significantly improve disease outcome.To study the Quality of Life (QoL) of former Buruli Ulcer patients who, in the context of a randomized controlled trial, reported early with small lesions (cross-sectional diameter <10 cm), and received a full course of antibiotic treatment.127 Participants of the BURULICO drug trial in Ghana were revisited. All former patients aged 16 or older completed the Dermatology Life Quality Index (DLQI) and the abbreviated World Health Organization Quality of Life scale (WHOQOL-BREF). The WHOQOL-BREF was also administered to 82 matched healthy controls. Those younger than 16 completed the Childrens' Dermatology Life Quality Index (CDLQI) only.The median (Inter Quartile Range) score on the DLQI was 0 (0-4), indicating good QoL. 85% of former patients indicated no effect, or only a small effect of the disease on their current life. Former patients also indicated good QoL on the physical and psychological domains of the WHOQOL-BREF, and scored significantly higher than healthy controls on these domains. There was a weak correlation between the DLQI and scar size (ρ = 0.32; p<0.001).BU patients who report early with small lesions and receive 8 weeks of antimicrobial therapy have a good QoL at long-term follow-up. These findings contrast with the debilitating sequelae often reported in BU, and highlight the importance of early case detection.
    Keywords Arctic medicine. Tropical medicine ; RC955-962 ; Public aspects of medicine ; RA1-1270
    Subject code 610
    Language English
    Publishing date 2014-07-01T00:00:00Z
    Publisher Public Library of Science (PLoS)
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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