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Article: Holographic Focused Ultrasound Hyperthermia System for Uniform Simultaneous Thermal Exposure of Multiple Tumor Spheroids.

Andrés, Diana / Rivens, Ian / Mouratidis, Petros / Jiménez, Noé / Camarena, Francisco / Ter Haar, Gail

2023 Volume 15, Issue 9

Abstract: Hyperthermia is currently used to treat cancer due to its ability to radio- and chemo-sensitize and to stimulate the immune response. While ultrasound is non-ionizing and can induce hyperthermia deep within the body non-invasively, achieving uniform and ... ...

Abstract	Hyperthermia is currently used to treat cancer due to its ability to radio- and chemo-sensitize and to stimulate the immune response. While ultrasound is non-ionizing and can induce hyperthermia deep within the body non-invasively, achieving uniform and volumetric hyperthermia is challenging. This work presents a novel focused ultrasound hyperthermia system based on 3D-printed acoustic holograms combined with a high-intensity focused ultrasound (HIFU) transducer to produce a uniform iso-thermal dose in multiple targets. The system is designed with the aim of treating several 3D cell aggregates contained in an International Electrotechnical Commission (IEC) tissue-mimicking phantom with multiple wells, each holding a single tumor spheroid, with real-time temperature and thermal dose monitoring. System performance was validated using acoustic and thermal methods, ultimately yielding thermal doses in three wells that differed by less than 4%. The system was tested in vitro for delivery of thermal doses of 0-120 cumulative equivalent minutes at 43 °C (CEM
Language	English
Publishing date	2023-04-28
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2527080-1
ISSN	2072-6694
ISSN	2072-6694
DOI	10.3390/cancers15092540
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Numerical Study of Acoustic Holograms for Deep-Brain Targeting through the Temporal Bone Window.

Andrés, Diana / Jiménez, Noé / Benlloch, José M / Camarena, Francisco

Ultrasound in medicine & biology

2022 Volume 48, Issue 5, Page(s) 872–886

Abstract: Acoustic holograms can encode complex wavefronts to compensate the aberrations of a therapeutical ultrasound beam propagating through heterogeneous tissues such as the skull, and simultaneously, they can generate diffraction-limited acoustic images, that ...

Abstract	Acoustic holograms can encode complex wavefronts to compensate the aberrations of a therapeutical ultrasound beam propagating through heterogeneous tissues such as the skull, and simultaneously, they can generate diffraction-limited acoustic images, that is, arbitrary shaped focal spots. In this work, we numerically study the performance of acoustic holograms focusing at the thalamic nuclei when the source is located at the temporal bone window. The temporal window is the thinnest area of the lateral skull and it is mainly hairless, so it is a desirable area through which to transmit ultrasonic waves to the deep brain. However, in targeting from this area the bilateral thalamic nuclei are not aligned with the elongated focal spots of conventional focused transducers, and in addition, skull aberrations can distort the focal spot. We found that by using patient-specific holographic lenses coupled to a single-element 650-kHz-frequency 65-mm-aperture source, the focal spot can be sharply adapted to the thalamic nuclei in a bilateral way while skull aberrations are mitigated. Furthermore, the performance of these holograms was studied under misalignment errors between the source and the skull, concluding that for misalignments up to 5°, acoustic images are correctly restored. This work paves the way to designing clinical applications of transcranial ultrasound such as blood-brain barrier opening for drug delivery or deep-brain neuromodulation using this low-cost and personalized technology, presenting desirable aspects for long-term treatments because the patient's head does not need to be shaved completely and skull heating is low.
MeSH term(s)	Acoustics ; Brain/diagnostic imaging ; Head ; Humans ; Skull/diagnostic imaging ; Temporal Bone ; Transducers ; Ultrasonic Therapy/methods
Language	English
Publishing date	2022-02-25
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	186150-5
ISSN	1879-291X ; 0301-5629
ISSN (online)	1879-291X
ISSN	0301-5629
DOI	10.1016/j.ultrasmedbio.2022.01.010
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Article ; Online: El Estado de compromiso nacional-popular de la Cuarta Transformación en México

Noé Hernández Cortez

Cuestiones de Sociología, Iss 28, Pp e154-e

2023 Volume 154

Abstract: ... Pensión para el Bienestar de las Personas Adultas Mayores (PBAM), que el presidente Andrés Manuel López ...

Abstract	El triunfo de la coalición electoral “Juntos Haremos Historia” en la elección presidencial del 1º de julio de 2018 en México significó la constitución de un proyecto político popular de izquierda articulado en torno al reciente partido político Movimiento Regeneración Nacional (MORENA). Con base en la noción del “Estado de compromiso nacional-popular” de Juan Carlos Portantiero, se analiza el Programa Pensión para el Bienestar de las Personas Adultas Mayores (PBAM), que el presidente Andrés Manuel López Obrador ha implementado como un eje central de la política social de su proyecto político, denominado la Cuarta Transformación. En este sentido, mostramos cómo la política social de la pensión a los adultos mayores es una política que estructura el “Estado de compromiso nacional-popular” que había entrado en una profunda crisis en la etapa del neoliberalismo en México a partir de la década de los ochenta. Se argumenta que la Cuarta Transformación es un cambio hacia la vocación social del Estado al institucionalizar las demandas populares de las clases subalternas del México contemporáneo.
Keywords	estado nacional-popular ; cuarta transformación ; morena ; política social ; méxico ; Sociology (General) ; HM401-1281 ; Social sciences (General) ; H1-99
Language	English
Publishing date	2023-07-01T00:00:00Z
Publisher	Universidad Nacional de La Plata
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Thermal acclimation and habitat-dependent differences in temperature robustness of a crustacean motor circuit.

Stein, Wolfgang / Torres, Gabriela / Giménez, Luis / Espinosa-Novo, Noé / Geißel, Jan Phillipp / Vidal-Gadea, Andrés / Harzsch, Steffen

Frontiers in cellular neuroscience

2023 Volume 17, Page(s) 1263591

Abstract: Introduction: At the cellular level, acute temperature changes alter ionic conductances, ion channel kinetics, and the activity of entire neuronal circuits. This can result in severe consequences for neural function, animal behavior and survival. In ... ...

Abstract	Introduction: At the cellular level, acute temperature changes alter ionic conductances, ion channel kinetics, and the activity of entire neuronal circuits. This can result in severe consequences for neural function, animal behavior and survival. In poikilothermic animals, and particularly in aquatic species whose core temperature equals the surrounding water temperature, neurons experience rather rapid and wide-ranging temperature fluctuations. Recent work on pattern generating neural circuits in the crustacean stomatogastric nervous system have demonstrated that neuronal circuits can exhibit an intrinsic robustness to temperature fluctuations. However, considering the increased warming of the oceans and recurring heatwaves due to climate change, the question arises whether this intrinsic robustness can acclimate to changing environmental conditions, and whether it differs between species and ocean habitats. Methods: We address these questions using the pyloric pattern generating circuits in the stomatogastric nervous system of two crab species, Results and discussion: Consistent with their history as invasive species, we find that pyloric activity showed a broad temperature robustness (>30°C). Moreover, the temperature-robust range was dependent on habitat temperature in both species. Warm-acclimating animals shifted the critical temperature at which circuit activity breaks down to higher temperatures. This came at the cost of robustness against cold stimuli in
Language	English
Publishing date	2023-10-18
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2452963-1
ISSN	1662-5102
ISSN	1662-5102
DOI	10.3389/fncel.2023.1263591
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Article ; Online: BNT162b2 COVID-19 vaccination in children alters cytokine responses to heterologous pathogens and Toll-like receptor agonists.

Noé, Andrés / Dang, Thanh D / Axelrad, Christine / Burrell, Emma / Germano, Susie / Elia, Sonja / Burgner, David / Perrett, Kirsten P / Curtis, Nigel / Messina, Nicole L

Frontiers in immunology

2023 Volume 14, Page(s) 1242380

Abstract: Background: Vaccines can have beneficial off-target (heterologous) effects that alter immune responses to, and protect against, unrelated infections. The heterologous effects of COVID-19 vaccines have not been investigated in children.: Aim: To ... ...

Abstract	Background: Vaccines can have beneficial off-target (heterologous) effects that alter immune responses to, and protect against, unrelated infections. The heterologous effects of COVID-19 vaccines have not been investigated in children. Aim: To investigate heterologous and specific immunological effects of BNT162b2 COVID-19 vaccination in children. Methods: A whole blood stimulation assay was used to investigate Results: At V2 + 28, interferon-γ and monocyte chemoattractant protein-1 responses to Conclusions: BNT162b2 vaccination in children alters cytokine responses to heterologous stimulants, particularly one month after vaccination. This study is the first to report the immunological heterologous effects of COVID-19 vaccination in children.
MeSH term(s)	Humans ; Child ; Cytokines ; BNT162 Vaccine ; COVID-19 Vaccines ; Escherichia coli ; Staphylococcus aureus ; COVID-19/prevention & control ; SARS-CoV-2 ; Adjuvants, Immunologic ; Vaccination ; Central Nervous System Stimulants
Chemical Substances	Cytokines ; BNT162 Vaccine ; COVID-19 Vaccines ; Adjuvants, Immunologic ; Central Nervous System Stimulants
Language	English
Publishing date	2023-08-25
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2606827-8
ISSN	1664-3224 ; 1664-3224
ISSN (online)	1664-3224
ISSN	1664-3224
DOI	10.3389/fimmu.2023.1242380
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: The Application of Single-Cell RNA Sequencing in Vaccinology.

Noé, Andrés / Cargill, Tamsin N / Nielsen, Carolyn M / Russell, Andrew J C / Barnes, Eleanor

Journal of immunology research

2020 Volume 2020, Page(s) 8624963

Abstract: Single-cell RNA sequencing allows highly detailed profiling of cellular immune responses from limited-volume samples, advancing prospects of a new era of systems immunology. The power of single-cell RNA sequencing offers various opportunities to decipher ...

Abstract	Single-cell RNA sequencing allows highly detailed profiling of cellular immune responses from limited-volume samples, advancing prospects of a new era of systems immunology. The power of single-cell RNA sequencing offers various opportunities to decipher the immune response to infectious diseases and vaccines. Here, we describe the potential uses of single-cell RNA sequencing methods in prophylactic vaccine development, concentrating on infectious diseases including COVID-19. Using examples from several diseases, we review how single-cell RNA sequencing has been used to evaluate the immunological response to different vaccine platforms and regimens. By highlighting published and unpublished single-cell RNA sequencing studies relevant to vaccinology, we discuss some general considerations how the field could be enriched with the widespread adoption of this technology.
MeSH term(s)	Animals ; Betacoronavirus/immunology ; COVID-19 ; Cell Line ; Clinical Trials as Topic ; Coronavirus Infections/epidemiology ; Coronavirus Infections/immunology ; Coronavirus Infections/prevention & control ; Coronavirus Infections/virology ; Disease Models, Animal ; Drug Evaluation, Preclinical ; Host-Pathogen Interactions/genetics ; Host-Pathogen Interactions/immunology ; Humans ; Immunity, Cellular/genetics ; Immunity, Innate/genetics ; Immunogenicity, Vaccine ; Pandemics/prevention & control ; Pneumonia, Viral/epidemiology ; Pneumonia, Viral/immunology ; Pneumonia, Viral/prevention & control ; Pneumonia, Viral/virology ; RNA, Viral/isolation & purification ; RNA-Seq/methods ; SARS-CoV-2 ; Single-Cell Analysis ; Vaccinology/methods ; Viral Vaccines/administration & dosage ; Viral Vaccines/immunology
Chemical Substances	RNA, Viral ; Viral Vaccines
Keywords	covid19
Language	English
Publishing date	2020-08-06
Publishing country	Egypt
Document type	Journal Article ; Review
ZDB-ID	2817541-4
ISSN	2314-7156 ; 2314-7156
ISSN (online)	2314-7156
ISSN	2314-7156
DOI	10.1155/2020/8624963
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Article ; Online: Frame navigation guided percutaneous balloon compression for intractable trigeminal neuralgia secondary to multiple sclerosis.

Valerio Pascua, Jose E / Mantilla Farfan, Penelope / Fernandez, Maria Paula / Santiago Rea, Noe / Borro, Matteo / Alvarez-Pinzon, Andres M

Brain & spine

2024 Volume 4, Page(s) 102798

Abstract: Background: Patients with multiple sclerosis (MS) are more likely to develop trigeminal neuralgia (TN) compared to the regular population, due to scarring of the nerve and development of a demyelination plaque. Despite treatment, approximately 10% of MS ...

Abstract	Background: Patients with multiple sclerosis (MS) are more likely to develop trigeminal neuralgia (TN) compared to the regular population, due to scarring of the nerve and development of a demyelination plaque. Despite treatment, approximately 10% of MS patients treated for TN experience symptom recurrence, including the development of MS-like symptoms such as optic neuritis and bilateral facial pain. Methods: A computed tomography (CT) scan was performed preoperatively on two patients diagnosed with multiple sclerosis (MS) who experienced secondary trigeminal neuralgia (TN). A precise reference frame was strapped firmly to the patient's forehead during the intraoperative procedure. Preliminary CT images were registered using the navigation system and the bony landmarks were set. Case description: Two patients diagnosed with multiple sclerosis (MS) who experienced refractory trigeminal neuralgia (TN) underwent percutaneous balloon compression. Initial conservative treatment and one dosage of Gamma Knife Radiosurgery (GKR) resulted in symptom control for a few weeks. Both patients had an acute recurrence of pain; thus, percutaneous retrogasserian balloon compression was performed. During follow-up, the patients reported a 70% decrease in pain after the procedure, with minimal recurrence of shooting episodes. Conclusion: Management of trigeminal neuralgia secondary to drug-resistant multiple sclerosis presents a persistent challenge. The percutaneous technique for retrogasserian balloon compression may offer a solution for some patients, but it presents unique challenges for neurosurgeons. Given the complexity of the pathogenesis, target identification, and the potential absence of neurovascular conflict, microvascular decompression remains a debated approach for this patient population. While stereotactic radiosurgery may be a promising alternative.
Language	English
Publishing date	2024-04-01
Publishing country	Netherlands
Document type	Journal Article
ISSN	2772-5294
ISSN (online)	2772-5294
DOI	10.1016/j.bas.2024.102798
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Book ; Article ; Online: The Application of Single-Cell RNA Sequencing in Vaccinology

Andrés Noé / Tamsin N. Cargill / Carolyn M. Nielsen / Andrew J. C. Russell / Eleanor Barnes

2020

Abstract	Single-cell RNA sequencing allows highly detailed profiling of cellular immune responses from limited-volume samples, advancing prospects of a new era of systems immunology. The power of single-cell RNA sequencing offers various opportunities to decipher the immune response to infectious diseases and vaccines. Here, we describe the potential uses of single-cell RNA sequencing methods in prophylactic vaccine development, concentrating on infectious diseases including COVID-19. Using examples from several diseases, we review how single-cell RNA sequencing has been used to evaluate the immunological response to different vaccine platforms and regimens. By highlighting published and unpublished single-cell RNA sequencing studies relevant to vaccinology, we discuss some general considerations how the field could be enriched with the widespread adoption of this technology.
Keywords	covid19
Language	English
Publisher	Journal of Immunology Research
Publishing country	eg
Document type	Book ; Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: The Application of Single-Cell RNA Sequencing in Vaccinology

Andrés Noé / Tamsin N. Cargill / Carolyn M. Nielsen / Andrew J. C. Russell / Eleanor Barnes

Journal of Immunology Research, Vol

2020 Volume 2020

Abstract	Single-cell RNA sequencing allows highly detailed profiling of cellular immune responses from limited-volume samples, advancing prospects of a new era of systems immunology. The power of single-cell RNA sequencing offers various opportunities to decipher the immune response to infectious diseases and vaccines. Here, we describe the potential uses of single-cell RNA sequencing methods in prophylactic vaccine development, concentrating on infectious diseases including COVID-19. Using examples from several diseases, we review how single-cell RNA sequencing has been used to evaluate the immunological response to different vaccine platforms and regimens. By highlighting published and unpublished single-cell RNA sequencing studies relevant to vaccinology, we discuss some general considerations how the field could be enriched with the widespread adoption of this technology.
Keywords	Immunologic diseases. Allergy ; RC581-607 ; covid19
Language	English
Publishing date	2020-01-01T00:00:00Z
Publisher	Hindawi Limited
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Hybridization and polyploidization effects on LTR-retrotransposon activation in potato genome

Gantuz, Magdalena / Morales, Andrés / Bertoldi, María Victoria / Ibañez, Verónica Noé / Duarte, Paola Fernanda / Marfil, Carlos Federico / Masuelli, Ricardo Williams

Journal of plant research. 2022 Jan., v. 135, no. 1

2022

Abstract: Hybridization and polyploidization are major forces in plant evolution and potatoes are not an exception. It is proposed that the proliferation of Long Terminal Repeat-retrotransposons (LTR-RT) is related to genome reorganization caused by hybridization ... ...

Abstract	Hybridization and polyploidization are major forces in plant evolution and potatoes are not an exception. It is proposed that the proliferation of Long Terminal Repeat-retrotransposons (LTR-RT) is related to genome reorganization caused by hybridization and/or polyploidization. The main purpose of the present work was to evaluate the effect of interspecific hybridization and polyploidization on the activation of LTR-RT. We evaluated the proliferation of putative active LTR-RT in a diploid hybrid between the cultivated potato Solanum tuberosum and the wild diploid potato species S. kurtzianum, allotetraploid lines derived from this interspecific hybrid and S. kurtzianum autotetraploid lines (ktz-autotetraploid) using the S-SAP (sequence-specific amplified polymorphism) technique and normalized copy number determination by qPCR. Twenty-nine LTR-RT copies were activated in the hybrid and present in the allotetraploid lines. Major LTR-RT activity was detected in Copia-27, Copia-12, Copia-14 and, Gypsy-22. According to our results, LTR-RT copies were activated principally in the hybrid, there was no activation in allotetraploid lines and only one copy was activated in the autotetraploid.
Keywords	Solanum tuberosum ; allotetraploidy ; autotetraploidy ; diploidy ; evolution ; genome ; hybrids ; interspecific hybridization ; potatoes ; research
Language	English
Dates of publication	2022-01
Size	p. 81-92.
Publishing place	Springer Singapore
Document type	Article
ZDB-ID	2077362-6
ISSN	1618-0860 ; 0918-9440
ISSN (online)	1618-0860
ISSN	0918-9440
DOI	10.1007/s10265-021-01354-9
Database	NAL-Catalogue (AGRICOLA)

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