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Article ; Online: Body plethysmography - additional information on exercise capacity in patients with congenital heart disease?

Hock, Julia / Bessar, Mohammed / Ewert, Peter / Hager, Alfred

Clinical research in cardiology : official journal of the German Cardiac Society

2024

Abstract: Aims: In each cardiopulmonary exercise test (CPET), resting spirometry is performed in advance. In patients with a congenital heart defect (CHD), lung volumes are often impaired. This study investigates correlations between lung volumes and CPET ... ...

Abstract	Aims: In each cardiopulmonary exercise test (CPET), resting spirometry is performed in advance. In patients with a congenital heart defect (CHD), lung volumes are often impaired. This study investigates correlations between lung volumes and CPET parameters and determines, whether body plethysmography provides substantial additional information for these patients. Methods: Data from 102 patients (23.8 ± 10.4 years of age, 39 female) with various forms of CHD were examined from April 2018 to October 2022. All patients underwent spirometry (measuring forced vital capacity, FVC and forced expiratory volume in 1 s, FEV1), body plethysmography (measuring total lung capacity, TLC) and an exhausting CPET. Data is presented as the median and interquartile range (z-scores) and correlated with Spearman's rho. Results: Fifty-five% of all patients had normal results in lung function and 45% had normal peak oxygen uptake (≥ 80% predicted in peak VO Conclusion: Spirometry and exercise capacity positively correlate, also in CHD patients. However, body plethysmography does not provide additional or improved prediction and is therefore only recommended in noteworthy results in spirometry to exclude further lung co-morbidities.
Language	English
Publishing date	2024-02-05
Publishing country	Germany
Document type	Journal Article
ZDB-ID	2213295-8
ISSN	1861-0692 ; 1861-0684
ISSN (online)	1861-0692
ISSN	1861-0684
DOI	10.1007/s00392-024-02385-7
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Potent Apoptosis Induction by a Novel Trispecific B7-H3xCD16xTIGIT 2+1 Common Light Chain Natural Killer Cell Engager.

Ulitzka, Michael / Harwardt, Julia / Lipinski, Britta / Tran, Hue / Hock, Björn / Kolmar, Harald

Molecules (Basel, Switzerland)

2024 Volume 29, Issue 5

Abstract: Valued for their ability to rapidly kill multiple tumor cells in succession as well as their favorable safety profile, NK cells are of increasing interest in the field of immunotherapy. As their cytotoxic activity is controlled by a complex network of ... ...

Abstract	Valued for their ability to rapidly kill multiple tumor cells in succession as well as their favorable safety profile, NK cells are of increasing interest in the field of immunotherapy. As their cytotoxic activity is controlled by a complex network of activating and inhibiting receptors, they offer a wide range of possible antigens to modulate their function by antibodies. In this work, we utilized our established common light chain (cLC)-based yeast surface display (YSD) screening procedure to isolate novel B7-H3 and TIGIT binding monoclonal antibodies. The chicken-derived antibodies showed single- to low-double-digit nanomolar affinities and were combined with a previously published CD16-binding Fab in a 2+1 format to generate a potent NK engaging molecule. In a straightforward, easily adjustable apoptosis assay, the construct B7-H3xCD16xTIGIT showed potent apoptosis induction in cancer cells. These results showcase the potential of the TIGIT NK checkpoint in combination with activating receptors to achieve increased cytotoxic activity.
MeSH term(s)	Killer Cells, Natural ; Immunotherapy ; Antibodies, Monoclonal ; Receptors, Immunologic ; Apoptosis
Chemical Substances	Antibodies, Monoclonal ; Receptors, Immunologic
Language	English
Publishing date	2024-03-04
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	1413402-0
ISSN	1420-3049 ; 1431-5165 ; 1420-3049
ISSN (online)	1420-3049
ISSN	1431-5165 ; 1420-3049
DOI	10.3390/molecules29051140
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Book ; Online ; Thesis: Lung function in patients with a congenital heart defect

Hock, Julia [Verfasser] / Dalla Pozza, Robert [Akademischer Betreuer]

2023

Author's details	Julia Hock ; Betreuer: Robert Dalla Pozza
Keywords	Medizin, Gesundheit ; Medicine, Health
Subject code	sg610
Language	English
Publisher	Universitätsbibliothek der Ludwig-Maximilians-Universität
Publishing place	München
Document type	Book ; Online ; Thesis
Database	Digital theses on the web

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Article ; Online: Abnormalities in pulmonary function and volumes in patients with CHD: a systematic review - ERRATUM.

Hock, Julia / Willinger, Laura / Pozza, Robert Dalla / Ewert, Peter / Hager, Alfred

Cardiology in the young

2023 Volume 33, Issue 2, Page(s) 182

MeSH term(s)	Humans ; Lung/diagnostic imaging ; Heart Defects, Congenital/complications
Language	English
Publishing date	2023-01-23
Publishing country	England
Document type	Systematic Review ; Journal Article ; Published Erratum
ZDB-ID	1078466-4
ISSN	1467-1107 ; 1047-9511
ISSN (online)	1467-1107
ISSN	1047-9511
DOI	10.1017/S1047951123000082
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Article ; Online: Breathing training improves exercise capacity in patients with tetralogy of Fallot: a randomised trial.

Hock, Julia / Remmele, Julia / Oberhoffer, Renate / Ewert, Peter / Hager, Alfred

Heart (British Cardiac Society)

2021 Volume 108, Issue 2, Page(s) 111–116

Abstract: Objective: Patients with tetralogy of Fallot (ToF) have limited pulmonary blood flow before corrective surgery and ongoing dysfunction of the pulmonary valve and right ventricle throughout life leading to lower exercise capacity and lung volumes in many ...

Abstract	Objective: Patients with tetralogy of Fallot (ToF) have limited pulmonary blood flow before corrective surgery and ongoing dysfunction of the pulmonary valve and right ventricle throughout life leading to lower exercise capacity and lung volumes in many patients. Inhalation training can increase lung volumes, improve pulmonary blood flow and consequently exercise capacity. This study tests whether home-based daily breathing training improves exercise capacity and lung volumes. Methods: From February 2017 to November 2018, 60 patients (14.7±4.8 years, 39% female) underwent spirometry (forced vital capacity (FVC); forced expiratory volume in 1 s (FEV Results: In the first 6 months (intention to treat analysis), the training group showed a more favourable change in peak [Formula: see text]O Conclusions: Daily inspiratory volume-oriented breathing training increases dynamic lung volumes and slows down deconditioning in peak [Formula: see text]O
MeSH term(s)	Exercise Test/methods ; Exercise Tolerance/physiology ; Female ; Forced Expiratory Volume ; Humans ; Lung ; Male ; Tetralogy of Fallot/surgery
Language	English
Publishing date	2021-03-18
Publishing country	England
Document type	Journal Article ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't
ZDB-ID	1303417-0
ISSN	1468-201X ; 1355-6037
ISSN (online)	1468-201X
ISSN	1355-6037
DOI	10.1136/heartjnl-2020-318574
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Article ; Online: Abnormalities in pulmonary function and volumes in patients with CHD: a systematic review.

Hock, Julia / Willinger, Laura / Pozza, Robert Dalla / Ewert, Peter / Hager, Alfred

Cardiology in the young

2023 Volume 33, Issue 2, Page(s) 169–181

Abstract: Background: Lung function and cardiac function are naturally correlated by sharing the thoracic cage and handling the whole cardiac output sequentially. However, lung function studies are rare in patients with CHD, although results worthy of ... ...

Abstract	Background: Lung function and cardiac function are naturally correlated by sharing the thoracic cage and handling the whole cardiac output sequentially. However, lung function studies are rare in patients with CHD, although results worthy of investigation could be expected. This review summarises existing studies with the lung function parameters (spirometry and body plethysmography) in CHD patients during the last decade. Methods: A systematic review was performed in the relevant database (PubMed, Cochrane, and Scopus) in studies including paediatric and adult patients with CHD where lung parameters (spirometry, body plethysmography) were investigated from January 2010 to December 2020. Two independent reviewers evaluated the studies according to the Study Quality Assessment Tool for Observational Cohort and Cross-Sectional Studies of the National Heart, Lung, and Blood Institute. Results: Eight studies investigated patients with Fontan palliation including 704 patients (306 female). Four studies included patients after repaired tetralogy of Fallot examining 219 patients (103 female), with one study using double. Further six studies included 3208 (1324 female) children and adults with various CHDs. Overall, four studies were categorised as "good", ten as "fair", and four as "poor". While the measurements were consistently standardised, references to calculate %predicted differed substantially across all studies. All evaluated studies showed reduced forced vital capacity in the majority of CHD patients. Conclusions: Many CHD patients have a reduced forced vital capacity independent of their underlying defect. Spirometry should not only follow a standardised measure according to ATS (update 2019) but also stick to the 2012 GLI reference values.
MeSH term(s)	Adult ; Humans ; Female ; Child ; Cross-Sectional Studies ; Lung ; Spirometry
Language	English
Publishing date	2023-01-05
Publishing country	England
Document type	Systematic Review ; Journal Article ; Review
ZDB-ID	1078466-4
ISSN	1467-1107 ; 1047-9511
ISSN (online)	1467-1107
ISSN	1047-9511
DOI	10.1017/S1047951122004103
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Book ; Online: The Anthology of Babel

Zille, Tom / Speese, James / Sarfan, Austin / Newcomb, Matthew / Neira, Raul / Mendez, Maria-Josee / McLoone, Katherine / Marnane, Ryan / Ligo, Seth / Lehman, Eric D. / Krajewski, Bruce / Johnson, Reed / Hock, Stephen / Falk, Em K. / Daigle, Claire / Engel, Stephen David / Coursey, Julia / Ben-Merre, David / Simon, Ed

2020

Abstract: Why should there only be literary scholarship about authors who actually lived, and texts which exist? Where are the articles on Enoch Campion, Linus Withold, Redondo Panza, Darshan Singh, or Heidi B. Morton? That none of these are real authors should be ...

Abstract	Why should there only be literary scholarship about authors who actually lived, and texts which exist? Where are the articles on Enoch Campion, Linus Withold, Redondo Panza, Darshan Singh, or Heidi B. Morton? That none of these are real authors should be no impediment to interpreting their invented writings. In the first collection of its kind, The Anthology of Babel publishes academic articles by scholars on authors, books, and movements that are completely invented. Blurring the lines between scholarship and creative writing, The Anthology of Babel inaugurates a completely new literary genre perfectly attuned to the era we live in, a project evocative of Jorge-Louis Borges, Umberto Eco, and Italo Calvino
Keywords	Literature (General)
Size	1 electronic resource (398 pages)
Publisher	punctum books
Document type	Book ; Online
Note	English ; Open Access
HBZ-ID	HT020395144
ISBN	9781950192472 ; 9781950192489 ; 1950192474 ; 1950192482
DOI	10.21983/P3.0254.1.00
Database	ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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Article: Sportmedizinische Aspekte bei EMAH-Patienten

Hock, Julia / Hager, Alfred

Aktuelle Kardiologie

2021 Volume 10, Issue 05, Page(s) 441–448

Abstract: Immer mehr Patienten mit angeborenem Herzfehler erreichen das Erwachsenenalter. Neben der allgemeinen medizinischen Untersuchung (Elektrokardiogramm, Echokardiografie, Laborparameter etc.) findet auch die Funktionsdiagnostik immer mehr an ... ...

Abstract	Immer mehr Patienten mit angeborenem Herzfehler erreichen das Erwachsenenalter. Neben der allgemeinen medizinischen Untersuchung (Elektrokardiogramm, Echokardiografie, Laborparameter etc.) findet auch die Funktionsdiagnostik immer mehr an Bedeutung. Zu dieser zählen sowohl die Lungenfunktion (Spirometrie, Bodyplethysmografie) als auch die Bestimmung der Leistungsfähigkeit (6-Minuten-Gehtest, Spiroergometrie). Wann jedoch eine solche Untersuchung sinnvoll ist, scheint oftmals unklar. Dieser Artikel soll sowohl das standardisierte Vorgehen dieser Untersuchungen aufzeigen als auch die Vor- und Nachteile unterschiedlicher Untersuchungen je nach Fragestellung aufzeigen. Wichtig hierbei ist, dass eine vollständige sportmedizinische Untersuchung bei Patienten mit angeborenem Herzfehler immer zusammen mit einer kardiologischen Untersuchung stattfinden muss. Nur dann kann eine sichere Untersuchung durch das geschulte Personal gewährleistet werden.
Keywords	angeborener Herzfehler ; Leistungsfähigkeit ; Spiroergometrie ; sportmedizinische Untersuchung ; congenital heart disease ; exercise capacity ; cardiopulmonary exercise test
Language	German
Publishing date	2021-10-01
Publisher	Georg Thieme Verlag KG
Publishing place	Stuttgart ; New York
Document type	Article
ZDB-ID	2654127-0
ISSN	2193-5211 ; 2193-5203
ISSN (online)	2193-5211
ISSN	2193-5203
DOI	10.1055/a-1579-9384
Database	Thieme publisher's database

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Article ; Online: Generation of a symmetrical trispecific NK cell engager based on a two-in-one antibody.

Harwardt, Julia / Carrara, Stefania C / Bogen, Jan P / Schoenfeld, Katrin / Grzeschik, Julius / Hock, Björn / Kolmar, Harald

Frontiers in immunology

2023 Volume 14, Page(s) 1170042

Abstract: To construct a trispecific IgG-like antibody at least three different binding moieties need to be combined, which results in a complex architecture and challenging production of these molecules. Here we report for the first time the construction of ... ...

Abstract	To construct a trispecific IgG-like antibody at least three different binding moieties need to be combined, which results in a complex architecture and challenging production of these molecules. Here we report for the first time the construction of trispecific natural killer cell engagers based on a previously reported two-in-one antibody combined with a novel anti-CD16a common light chain module identified by yeast surface display (YSD) screening of chicken-derived immune libraries. The resulting antibodies simultaneously target epidermal growth factor receptor (EGFR), programmed death-ligand 1 (PD-L1) and CD16a with two Fab fragments, resulting in specific cellular binding properties on EGFR/PD-L1 double positive tumor cells and a potent ADCC effect. This study paves the way for further development of multispecific therapeutic antibodies derived from avian immunization with desired target combinations, valencies, molecular symmetries and architectures.
MeSH term(s)	B7-H1 Antigen/metabolism ; Killer Cells, Natural ; Antibodies/metabolism ; ErbB Receptors/metabolism
Chemical Substances	B7-H1 Antigen ; Antibodies ; ErbB Receptors (EC 2.7.10.1)
Language	English
Publishing date	2023-04-04
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2606827-8
ISSN	1664-3224 ; 1664-3224
ISSN (online)	1664-3224
ISSN	1664-3224
DOI	10.3389/fimmu.2023.1170042
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: TriTECM: A tetrafunctional T-cell engaging antibody with built-in risk mitigation of cytokine release syndrome.

Carrara, Stefania C / Harwardt, Julia / Grzeschik, Julius / Hock, Björn / Kolmar, Harald

Frontiers in immunology

2022 Volume 13, Page(s) 1051875

Abstract: Harnessing the innate power of T cells for therapeutic benefit has seen many shortcomings due to cytotoxicity in the past, but still remains a very attractive mechanism of action for immune-modulating biotherapeutics. With the intent of expanding the ... ...

Abstract	Harnessing the innate power of T cells for therapeutic benefit has seen many shortcomings due to cytotoxicity in the past, but still remains a very attractive mechanism of action for immune-modulating biotherapeutics. With the intent of expanding the therapeutic window for T-cell targeting biotherapeutics, we present an attenuated trispecific T-cell engager (TCE) combined with an anti- interleukin 6 receptor (IL-6R) binding moiety in order to modulate cytokine activity (TriTECM). Overshooting cytokine release, culminating in cytokine release syndrome (CRS), is one of the severest adverse effects observed with T-cell immunotherapies, where the IL-6/IL-6R axis is known to play a pivotal role. By targeting two tumour-associated antigens, epidermal growth factor receptor (EGFR) and programmed death ligand 1 (PD-L1), simultaneously with a bispecific two-in-one antibody, high tumour selectivity together with checkpoint inhibition was achieved. We generated tetrafunctional molecules that contained additional CD3- and IL-6R-binding modules. Ligand competition for both PD-L1 and IL-6R as well as inhibition of both EGF- and IL-6-mediated signalling pathways was observed. Furthermore, TriTECM molecules were able to activate T cells and trigger T-cell-mediated cytotoxicity through CD3-binding in an attenuated fashion. A decrease in pro-inflammatory cytokine interferon γ (IFNγ) after T-cell activation was observed for the TriTECM molecules compared to their respective controls lacking IL-6R binding, hinting at a successful attenuation and potential modulation
MeSH term(s)	Humans ; Cytokine Release Syndrome/etiology ; B7-H1 Antigen ; Interleukin-6/metabolism ; T-Lymphocytes ; Antilymphocyte Serum ; Cytokines
Chemical Substances	B7-H1 Antigen ; Interleukin-6 ; Antilymphocyte Serum ; Cytokines
Language	English
Publishing date	2022-11-10
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2606827-8
ISSN	1664-3224 ; 1664-3224
ISSN (online)	1664-3224
ISSN	1664-3224
DOI	10.3389/fimmu.2022.1051875
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