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  1. Article ; Online: Knowledge and attitude of rural diabetic population in the twenty-first century: Are we doing enough to spread public awareness?

    Kohli, Chander M / Gupta, Preeti / Kohli, Gaurav M

    Indian journal of ophthalmology

    2022  Volume 70, Issue 12, Page(s) 4468–4469

    MeSH term(s) Humans ; Rural Population ; Diabetes Mellitus/epidemiology
    Language English
    Publishing date 2022-12-19
    Publishing country India
    Document type Letter
    ZDB-ID 187392-1
    ISSN 1998-3689 ; 0301-4738
    ISSN (online) 1998-3689
    ISSN 0301-4738
    DOI 10.4103/ijo.IJO_2072_22
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  2. Article ; Online: Olfactory cleft computed tomography analysis and olfaction in chronic rhinosinusitis.

    Kohli, Preeti / Schlosser, Rodney J / Storck, Kristina / Soler, Zachary M

    American journal of rhinology & allergy

    2017  Volume 30, Issue 6, Page(s) 402–406

    Abstract: Background: Volumetric analysis of the olfactory cleft by using computed tomography has been associated with olfaction in patients with chronic rhinosinusitis (CRS). However, existing studies have not comprehensively measured olfaction, and it thus ... ...

    Abstract Background: Volumetric analysis of the olfactory cleft by using computed tomography has been associated with olfaction in patients with chronic rhinosinusitis (CRS). However, existing studies have not comprehensively measured olfaction, and it thus remains unknown whether correlations differ across specific dimensions of odor perception.
    Objective: To use comprehensive measures of patient-reported and objective olfaction to evaluate the relationship between volumetric olfactory cleft opacification and olfaction.
    Methods: Olfaction in patients with CRS was evaluated by using "Sniffin' Sticks" tests and a modified version of the Questionnaire of Olfactory Disorders. Olfactory cleft opacification was quantified by using two- and three-dimensional, computerized volumetric analysis. Correlations between olfactory metrics and olfactory cleft opacification were then calculated.
    Results: The overall CRS cohort included 26 patients without nasal polyposis (CRSsNP) (68.4%) and 12 patients with nasal polyposis (CRSwNP) (31.6%). Across the entire cohort, total olfactory cleft opacification was 82.8%, with greater opacification in the CRSwNP subgroup compared with CRSsNP (92.3 versus 78.4%, p < 0.001). The percent total volume opacification correlated with the total Sniffin' Sticks score (r = -0.568, p < 0.001) as well as individual threshold, discrimination, and identification scores (p < 0.001 for all). Within the CRSwNP subgroup, threshold (r = -0.616, p = 0.033) and identification (r = -0.647, p = 0.023) remained highly correlated with total volume opacification. In patients with CRSsNP, the threshold correlated with total volume scores (r = -0.457, p = 0.019), with weaker and nonsignificant correlations for discrimination and identification. Correlations between total volume opacification and the Questionnaire of Olfactory Disorders were qualitatively similar to objective olfactory findings in both CRSwNP (r = -0.566, p = 0.070) and CRSsNP (r = -0.310, p = 0.141) subgroups, although neither reached significance. When examined by two-dimensional planes, the percent opacification of the anterior plane had the strongest correlations with objective olfaction.
    Conclusion: Olfactory cleft opacification correlated with objective measures of olfaction in patients with CRS, which correlated with threshold values in patients with CRSsNP and all dimensions of olfaction in those with CRSwNP.
    MeSH term(s) Adult ; Aged ; Chronic Disease ; Disease Progression ; Female ; Humans ; Male ; Middle Aged ; Nasal Cavity/diagnostic imaging ; Nasal Cavity/pathology ; Nasal Polyps/diagnostic imaging ; Olfactory Bulb ; Rhinitis/complications ; Rhinitis/diagnostic imaging ; Sinusitis/complications ; Sinusitis/diagnostic imaging ; Smell ; Tomography, X-Ray Computed
    Language English
    Publishing date 2017-01-19
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2482804-X
    ISSN 1945-8932 ; 1945-8924
    ISSN (online) 1945-8932
    ISSN 1945-8924
    DOI 10.2500/ajra.2016.30.4365
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  3. Article ; Online: Olfactory Impairment in Chronic Rhinosinusitis Using Threshold, Discrimination, and Identification Scores.

    Soler, Zachary M / Kohli, Preeti / Storck, Kristina A / Schlosser, Rodney J

    Chemical senses

    2016  Volume 41, Issue 9, Page(s) 713–719

    Abstract: Differences in testing modalities and cut-points used to define olfactory dysfunction contribute to the wide variability in estimating the prevalence of olfactory dysfunction in chronic rhinosinusitis (CRS). The aim of this study is to report the ... ...

    Abstract Differences in testing modalities and cut-points used to define olfactory dysfunction contribute to the wide variability in estimating the prevalence of olfactory dysfunction in chronic rhinosinusitis (CRS). The aim of this study is to report the prevalence of olfactory impairment using each component of the Sniffin' Sticks test (threshold, discrimination, identification, and total score) with age-adjusted and ideal cut-points from normative populations. Patients meeting diagnostic criteria for CRS were enrolled from rhinology clinics at a tertiary academic center. Olfaction was assessed using the Sniffin' Sticks test. The study population consisted of 110 patients. The prevalence of normosmia, hyposmia, and anosmia using total Sniffin' Sticks score was 41.8%, 20.0%, and 38.2% using age-appropriate cut-points and 20.9%, 40.9%, and 38.2% using ideal cut-points. Olfactory impairment estimates for each dimension mirrored these findings, with threshold yielding the highest values. Threshold, discrimination, and identification were also found to be significantly correlated to each other ( P < 0.001). In addition, computed tomography scores, asthma, allergy, and diabetes were found to be associated with olfactory dysfunction. In conclusion, the prevalence of olfactory dysfunction is dependent upon olfactory dimension and if age-adjusted cut-points are used. The method of olfactory testing should be chosen based upon specific clinical and research goals.
    Language English
    Publishing date 2016-07-21
    Publishing country England
    Document type Journal Article
    ZDB-ID 754122-3
    ISSN 1464-3553 ; 0379-864X
    ISSN (online) 1464-3553
    ISSN 0379-864X
    DOI 10.1093/chemse/bjw080
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  4. Article ; Online: Burden of illness: A systematic review of depression in chronic rhinosinusitis.

    Schlosser, Rodney J / Gage, Selby E / Kohli, Preeti / Soler, Zachary M

    American journal of rhinology & allergy

    2016  Volume 30, Issue 4, Page(s) 250–256

    Abstract: Background: Depression has been reported in patients with chronic rhinosinusitis (CRS), but its prevalence varies across studies, and uncertainty remains regarding the association with baseline disease severity and treatment outcomes.: Objective: To ... ...

    Abstract Background: Depression has been reported in patients with chronic rhinosinusitis (CRS), but its prevalence varies across studies, and uncertainty remains regarding the association with baseline disease severity and treatment outcomes.
    Objective: To systematically assess the prevalence of depression in CRS and to review its relationship to baseline disease severity and outcomes after treatment.
    Methods: A systematic review of the prevalence of possible depression was performed by using the available methods to diagnose depression, and the results were pooled. Studies that examined the relationship of depression on baseline disease severity and treatment outcomes were organized and reported individually.
    Results: Thirteen studies met inclusion criteria for prevalence analysis. The prevalence of possible or likely depression in patients with CRS ranged from 11.0 to 40.0%, depending on the method of diagnosis and sensitivity of various depression instruments. Positive depression screening was consistently associated with worse CRS-specific quality of life (QOL), medication usage, and health care utilization, but there were no reliable CRS-specific factors to predict the presence of depression. Patients with possible depression who underwent medical or surgical treatment for CRS tended to have improvements in CRS-specific QOL but did not achieve the same degree of QOL as patients who were not depressed. Depression-specific QOL seemed to improve after treatment for CRS.
    Conclusion: Positive depression screening was common in patients with CRS and had a negative association on the entire spectrum of QOL, health care utilization, and productivity. CRS-specific treatments were still beneficial in patients who seemed to be depressed and improved both depression-specific and CRS-specific QOL.
    MeSH term(s) Chronic Disease ; Cost of Illness ; Depression/epidemiology ; Humans ; Prevalence ; Quality of Life ; Rhinitis/psychology ; Rhinitis/therapy ; Sinusitis/psychology ; Sinusitis/therapy
    Language English
    Publishing date 2016-07
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2482804-X
    ISSN 1945-8932 ; 1945-8924
    ISSN (online) 1945-8932
    ISSN 1945-8924
    DOI 10.2500/ajra.2016.30.4343
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  5. Article ; Online: Assisted living facility use by the program of all-inclusive care for the elderly.

    Kohli, Preeti / Arbaje, Alicia I / Leff, Bruce / Statom, Deborah / McNabney, Matthew

    Journal of the American Geriatrics Society

    2015  Volume 63, Issue 3, Page(s) 594–596

    MeSH term(s) Aged ; Aged, 80 and over ; Assisted Living Facilities/utilization ; Female ; Health Services for the Aged ; Humans ; Male
    Language English
    Publishing date 2015-03
    Publishing country United States
    Document type Letter
    ZDB-ID 80363-7
    ISSN 1532-5415 ; 0002-8614
    ISSN (online) 1532-5415
    ISSN 0002-8614
    DOI 10.1111/jgs.13289
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  6. Article ; Online: Response to: Can patients with chronic rhinosinusitis recover normal sleep after endoscopic sinus surgery?

    Alt, Jeremiah A / Ramakrishnan, Vijay R / Platt, Michael P / Kohli, Preeti / Storck, Kristina A / Schlosser, Rodney J / Soler, Zachary M

    International forum of allergy & rhinology

    2017  Volume 7, Issue 9, Page(s) 927

    MeSH term(s) Chronic Disease ; Endoscopy ; Humans ; Paranasal Sinuses ; Rhinitis ; Sinusitis
    Language English
    Publishing date 2017-07-13
    Publishing country United States
    Document type Letter ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 2625826-2
    ISSN 2042-6984 ; 2042-6976
    ISSN (online) 2042-6984
    ISSN 2042-6976
    DOI 10.1002/alr.21974
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  7. Article ; Online: Adjuvant radiation compares favorably to chemotherapy in patients with carcinoma penis and nodal positivity restricted to groin.

    Jaipuria, Jiten / Kohli, Tarun / Venkatasubramaniyan, Manikandan / Singh, Amitabh / Gupta, Shashikant / Pathak, Preeti / Sharma, Girish / Mitra, Swarupa / Talwar, Vineet / Rawal, Sudhir Kumar

    Urologic oncology

    2020  Volume 38, Issue 7, Page(s) 641.e9–641.e18

    Abstract: Objectives: To compare overall survival (OS) between adjuvant radiation, chemotherapy and chemoradiation (CCRT) postsurgery for node-positive patients with carcinoma penis.: Methods: Prospectively maintained registry for 45 patients receiving ... ...

    Abstract Objectives: To compare overall survival (OS) between adjuvant radiation, chemotherapy and chemoradiation (CCRT) postsurgery for node-positive patients with carcinoma penis.
    Methods: Prospectively maintained registry for 45 patients receiving adjuvant treatment following lymph node dissection from 2011 to 2017, having minimum 6 months follow-up and more than 2 positive inguinal nodes was analyzed. Patients without pelvic nodal positivity (n= 32) were treated by radiotherapy (RT) (n = 25) or chemotherapy (n = 7); CCRT (n = 6) or chemotherapy (n = 7) was used in patients with positive pelvic nodes (n = 13). Data was collected for age, comorbidities, body mass index, tobacco exposure, treatment modality, tumor grade, pathological T and N stage, and extra-nodal extension. OS was compared between different treatment modalities stratifying patients with and without pelvic nodal positivity. Multivariate cox proportional hazard analysis was used to narrow down remaining variables and Inverse Probability Treatment Weights modeling was used to determine average treatment effect.
    Results: About 12 of 14 patients in the chemotherapy group received both cisplatin and paclitaxel. Pathological T stage, N stage and extra-nodal extension had significant association with OS on multivariate analysis. Among patients with nodal positivity restricted to groin the estimated average OS when all patients received adjuvant RT was 1,438 days (95% confidence interval [CI] 1,256-1,619 days, Pvalue <0.0001). The estimated average OS if all patients received chemotherapy was lower by 1,007 days (95% CI 810-1,202 days, P value <0.0001). Among patients with positive pelvic nodes the estimated average OS when all patients received adjuvant CCRT was 467 days (95% CI 368-566 days, P value <0.0001). The estimated average OS difference if all patients received chemotherapy was 17 days (95% CI -144 to 178 days, Pvalue 0.21).
    Conclusion: In patients with nodal positivity limited to groin, adjuvant RT proved superior to chemotherapy. Among patients with pelvic nodal positivity, CCRT offers no significant OS advantage over combination chemotherapy.
    MeSH term(s) Groin/pathology ; Humans ; Male ; Middle Aged ; Penile Neoplasms/drug therapy ; Penile Neoplasms/mortality ; Penile Neoplasms/radiotherapy ; Prospective Studies ; Survival Analysis
    Language English
    Publishing date 2020-04-22
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1336505-8
    ISSN 1873-2496 ; 1078-1439
    ISSN (online) 1873-2496
    ISSN 1078-1439
    DOI 10.1016/j.urolonc.2020.03.026
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  8. Article ; Online: The Association Between Olfaction and Depression: A Systematic Review.

    Kohli, Preeti / Soler, Zachary M / Nguyen, Shaun A / Muus, John S / Schlosser, Rodney J

    Chemical senses

    2016  Volume 41, Issue 6, Page(s) 479–486

    Abstract: Previous studies on the relationship between olfaction and depression have revealed mixed results. In addition, few have focused on the reciprocity of this association. The aim of this study is to combine depression and olfactory data in two separate ... ...

    Abstract Previous studies on the relationship between olfaction and depression have revealed mixed results. In addition, few have focused on the reciprocity of this association. The aim of this study is to combine depression and olfactory data in two separate patient populations to further understand their association. A systematic literature review was conducted using 3 online databases to identify studies correlating olfaction and depression in patients presenting with either primary depression or primary olfactory dysfunction. For the depressed population, weighted means and standard deviations for the Sniffin' Sticks Test and the 40-item Smell Identification Test were combined using 10 studies. For the olfactory dysfunction population, weighted means of Beck's Depression Inventory were combined using 3 studies. Independent t-tests were used to compare differences between groups. Comparing primary depressed patients with controls, depressed patients showed decreased scores in olfactory threshold (6.31±1.38 vs. 6.78±0.88, P = 0.0005), discrimination (12.05±1.44 vs. 12.66±1.36, P = 0.0073), identification (12.57±0.74 vs. 12.98±0.90, P < 0.0001), and 40-Item Smell Identification Test (35.31±1.91 vs. 37.41±1.45, P < 0.0001). In patients with primary olfactory dysfunction, Beck's Depression Inventory scores were significantly different between patients classified as normosmics, hyposmics and anosmics (5.21±4.73 vs. 10.93±9.25 vs. 14.15±5.39, P ≤ 0.0274 for all 3 comparisons). In conclusion, patients with depression have reduced olfactory performance when compared with the healthy controls and conversely, patients with olfactory dysfunction, have symptoms of depression that worsen with severity of smell loss.
    MeSH term(s) Depressive Disorder/complications ; Depressive Disorder/physiopathology ; Depressive Disorder/psychology ; Humans ; Olfaction Disorders/complications ; Olfaction Disorders/physiopathology ; Olfaction Disorders/psychology ; Sensory Thresholds ; Smell
    Language English
    Publishing date 2016-07
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 754122-3
    ISSN 1464-3553 ; 0379-864X
    ISSN (online) 1464-3553
    ISSN 0379-864X
    DOI 10.1093/chemse/bjw061
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  9. Article ; Online: Sleep quality outcomes after medical and surgical management of chronic rhinosinusitis.

    Alt, Jeremiah A / Ramakrishnan, Vijay R / Platt, Michael P / Kohli, Preeti / Storck, Kristina A / Schlosser, Rodney J / Soler, Zachary M

    International forum of allergy & rhinology

    2017  Volume 7, Issue 2, Page(s) 113–118

    Abstract: Background: Endoscopic sinus surgery (ESS) has been shown to improve sleep in patients with chronic rhinosinusitis (CRS). However, it is unknown how this improvement compares with non-CRS control subjects' sleep, and medically treated CRS patients.: ... ...

    Abstract Background: Endoscopic sinus surgery (ESS) has been shown to improve sleep in patients with chronic rhinosinusitis (CRS). However, it is unknown how this improvement compares with non-CRS control subjects' sleep, and medically treated CRS patients.
    Methods: Patients meeting diagnostic criteria for CRS and controls from the same reference population were recruited from 4 academic centers. Patients chose either medical or surgical treatment. The Pittsburgh Sleep Quality Index (PSQI) was administered to patients before treatment and after 6 months, whereas controls received the PSQI at enrollment.
    Results: The study population consisted of 187 cases (64 medical and 123 surgical) and 101 controls. Baseline PSQI scores for CRS patients (9.27 ± 4.76) were worse than for controls (5.78 ± 3.25), even after controlling for potential confounding factors such as asthma and allergy (p < 0.001). There was no significant difference in baseline PSQI between patients choosing medical vs surgical treatment. The PSQI score in surgical patients improved from 8.36 ± 5.05 to 7.44 ± 5.09 (p = 0.020). The PSQI score in medical patients demonstrated a nonsignificant increase with treatment from 8.71 ± 4.48 to 9.06 ± 4.80 (p = 0.640). After controlling for allergy and asthma, 6-month PSQI scores in medical patients remained significantly higher than in controls (p = 0.001), whereas a significant difference could not be demonstrated between surgical patients and controls (p > 0.05). PSQI subdomain analysis mirrored the overall findings.
    Conclusion: Patients with CRS report worse sleep compared with controls. Surgically treated CRS patients show significant improvement in PSQI scores, whereas those continuing with medical management fail to improve and remain worse than controls.
    Language English
    Publishing date 2017-02
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2625826-2
    ISSN 2042-6984 ; 2042-6976
    ISSN (online) 2042-6984
    ISSN 2042-6976
    DOI 10.1002/alr.21860
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  10. Article ; Online: Myopericarditis after messenger RNA Coronavirus Disease 2019 Vaccination in Adolescents 12 to 18 Years of Age.

    Das, Bibhuti B / Kohli, Utkarsh / Ramachandran, Preeti / Nguyen, Hoang H / Greil, Gerald / Hussain, Tarique / Tandon, Animesh / Kane, Colin / Avula, Sravani / Duru, Chioma / Hede, Sannya / Sharma, Kavita / Chowdhury, Devyani / Patel, Sunil / Mercer, Christopher / Chaudhuri, Nita Ray / Patel, Bhavi / Ang, Jocelyn Y / Asmar, Basim /
    Sanchez, Joselito / Khan, Danyal

    The Journal of pediatrics

    2021  Volume 238, Page(s) 26–32.e1

    Abstract: Objectives: To characterize the clinical course and outcomes of children 12-18 years of age who developed probable myopericarditis after vaccination with the Pfizer-BioNTech (BNT162b2) coronavirus disease 2019 (COVID-19) messenger RNA (mRNA) vaccine.: ...

    Abstract Objectives: To characterize the clinical course and outcomes of children 12-18 years of age who developed probable myopericarditis after vaccination with the Pfizer-BioNTech (BNT162b2) coronavirus disease 2019 (COVID-19) messenger RNA (mRNA) vaccine.
    Study design: A cross-sectional study of 25 children, aged 12-18 years, diagnosed with probable myopericarditis after COVID-19 mRNA vaccination as per the Centers for Disease Control and Prevention criteria for myopericarditis at 8 US centers between May 10, 2021, and June 20, 2021. We retrospectively collected the following data: demographics, severe acute respiratory syndrome coronavirus 2 virus detection or serologic testing, clinical manifestations, laboratory test results, imaging study results, treatment, and time to resolutions of symptoms.
    Results: Most (88%) cases followed the second dose of vaccine, and chest pain (100%) was the most common presenting symptom. Patients came to medical attention a median of 2 days (range, <1-20 days) after receipt of Pfizer mRNA COVID-19 vaccination. All adolescents had an elevated plasma troponin concentration. Echocardiographic abnormalities were infrequent, and 92% showed normal cardiac function at presentation. However, cardiac magnetic resonance imaging, obtained in 16 patients (64%), revealed that 15 (94%) had late gadolinium enhancement consistent with myopericarditis. Most were treated with ibuprofen or an equivalent nonsteroidal anti-inflammatory drug for symptomatic relief. One patient was given a corticosteroid orally after the initial administration of ibuprofen or an nonsteroidal anti-inflammatory drug; 2 patients also received intravenous immune globulin. Symptom resolution was observed within 7 days in all patients.
    Conclusions: Our data suggest that symptoms owing to myopericarditis after the mRNA COVID-19 vaccination tend to be mild and transient. Approximately two-thirds of patients underwent cardiac magnetic resonance imaging, which revealed evidence of myocardial inflammation despite a lack of echocardiographic abnormalities.
    MeSH term(s) Adolescent ; COVID-19/epidemiology ; COVID-19/genetics ; COVID-19/prevention & control ; COVID-19 Vaccines/adverse effects ; COVID-19 Vaccines/genetics ; Child ; Cross-Sectional Studies ; Female ; Humans ; Incidence ; Magnetic Resonance Imaging, Cine/methods ; Male ; Myocarditis/diagnosis ; Myocarditis/epidemiology ; Myocarditis/etiology ; Pandemics ; Retrospective Studies ; SARS-CoV-2/immunology ; United States/epidemiology ; Vaccination/adverse effects ; Vaccines, Synthetic/adverse effects ; mRNA Vaccines
    Chemical Substances COVID-19 Vaccines ; Vaccines, Synthetic
    Language English
    Publishing date 2021-07-30
    Publishing country United States
    Document type Journal Article ; Multicenter Study
    ZDB-ID 3102-1
    ISSN 1097-6833 ; 0022-3476
    ISSN (online) 1097-6833
    ISSN 0022-3476
    DOI 10.1016/j.jpeds.2021.07.044
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