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Article: MiR-4492, a New Potential MicroRNA for Cancer Diagnosis and Treatment: A Mini Review.

Alizamir, Aida / Amini, Mohammad Amin / Karbasi, Ashkan / Beyrami, Mehdi

2024 Volume 60, Issue 1, Page(s) 21–26

Abstract: There is no doubt that the incidence of cancer sufferers is rising in the world, and it is estimated that in the next several decades, the number of people suffering from malignancies or the cancer rate will double. Diagnostic and therapeutic targeting ... ...

Abstract	There is no doubt that the incidence of cancer sufferers is rising in the world, and it is estimated that in the next several decades, the number of people suffering from malignancies or the cancer rate will double. Diagnostic and therapeutic targeting of noncoding RNAs (ncRNAs), especially microRNAs (miRNAs) and long noncoding RNAs (lncRNAs), represent an excellent approach for cancer diagnosis and treatment, as well as many other diseases. One of the latest miRNAs is miR-4492, upregulating some genes in tumor tissues including ROMO1, HLA-G, NKIRAS2, FOXK1, and UBE2C. It represents an attractant example of a miRNA acting at multiple levels to affect the same malignancy hallmark. Based on the studies, miR-4492 plays a key role in several cancers such as, breast cancer, bladder cancer, osteosarcoma, glioblastoma multiforme, hepatocellular carcinoma, colorectal cancer, and ovarian cancer. Putting it all together, identifying the precise mechanisms of miR-4492 in the pathogenesis of cancer, could pave the way to find better diagnostic and therapeutic strategies for cancer sufferers. For this reason, it might be a novel potential diagnostic biomarker and therapeutic target for neoplasms.
Language	English
Publishing date	2024-01-25
Publishing country	Korea (South)
Document type	Journal Article ; Review
ZDB-ID	2536217-3
ISSN	2233-7393 ; 2233-7385 ; 0377-9564
ISSN (online)	2233-7393
ISSN	2233-7385 ; 0377-9564
DOI	10.4068/cmj.2024.60.1.21
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Design and Fabrication of a High Performance Microfluidic Chip for Blood Plasma Separation: Modelling and Prediction of System Behaviour via CFD Method.

Amini, Hossein / Sokhansanj, Amin / Akrami, Mohammad / Haririan, Ismaeil

International journal of analytical chemistry

2023 Volume 2023, Page(s) 3648247

Abstract: This paper presents a single-step microfluidic system designed for passive separation of human fresh blood plasma using direct capillary forces. Our microfluidic system is composed of a cylindrical well between upper and lower channel pairs produced by ... ...

Abstract	This paper presents a single-step microfluidic system designed for passive separation of human fresh blood plasma using direct capillary forces. Our microfluidic system is composed of a cylindrical well between upper and lower channel pairs produced by soft photolithography. The microchip was fabricated based on hydrophobicity differences upon suitable cylindrical surfaces using gravitational and capillary forces and lateral migration of plasma and red blood cells. The plasma radiation was applied to attach the polymeric segment (polydimethylsiloxane (PDMS)) to the glass. Meanwhile, Tween 80 was used as a surfactant to increase the hydrophobicity of the lateral channel surfaces. This led to the higher movement of whole blood, including plasma. Fick's law of diffusion was validated for this diffusion transfer, the Navier-Stokes equation was used for the momentum balance, and the Laplace equation was utilized for the dynamics of the mesh. A model with high accuracy using the COMSOL Multiphysics software was created to predict the capillary forces and chip model validation. RBCs (red blood cells) were measured by the H3 cell counter instrument, by which 99% plasma purity was achieved. Practically, 58.3% of the plasma was separated from the blood within 12 min. Correlation between plasma separation results obtained from software and experimental data showed a coefficient of determination equal to 0.9732. This simple, rapid, stable, and reliable microchip can be considered as a promising candidate for providing plasma in point-of-care diagnostics.
Language	English
Publishing date	2023-06-26
Publishing country	Egypt
Document type	Journal Article
ZDB-ID	2494714-3
ISSN	1687-8779 ; 1687-8760
ISSN (online)	1687-8779
ISSN	1687-8760
DOI	10.1155/2023/3648247
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Article ; Online: Comparing the effect of individual and group cognitive-motor training on reconstructing subjective well-being and quality of life in older males, recovered from the COVID-19.

Amini, Amin / Vaezmousavi, Mohammad / Shirvani, Hossein

Cognitive processing

2023 Volume 24, Issue 3, Page(s) 361–374

Abstract: While the message emanating from physiological and psychological research has extolled the general advantages of exercise in physical and cognitive health, the social distancing and the impossibility of group exercises have revealed more complex ... ...

Abstract	While the message emanating from physiological and psychological research has extolled the general advantages of exercise in physical and cognitive health, the social distancing and the impossibility of group exercises have revealed more complex conditions. Therefore, we performed an experimental study comparing the effect of individual and group cognitive-motor training on reconstructing subjective well-being (SWB) and quality of life (QOL) in older males who recovered from COVID-19. The study's design is a single-blind, randomized controlled trial (RCT). The participants, 36 older men (65-80 yrs.) recovering from COVID-19, were randomly divided into (1) Group A (cognitive-motor training, G-CMT); (2) Group B (individual cognitive-motor training, I-CMT); and (3) Group C (control). Both training interventions involved performing a training protocol (cognitive-motor training) twice a week for four weeks. The outcomes included an assessment of the SWB and QOL of participants by SWB scale and world health organization QOL scale at baseline and two weeks after interventions. Except for the effect of age and number of children variables on QOL, other demographic variables had no significant effect on the results of SWB or WHOQOL of participants (P > 0.05). The SWB results in G-CMT were better than I-CMT and control groups in emotional and social well-being domains. Also, WHOQOL test results in G-CMT were better than control groups in domains of psychological and social relationships, whereas I-CMT performed better than G-CMT and control groups in domains of cognitive well-being, physical health, and environment. The results revealed that the mean test scores of SWB and WHOQOL in G-CMT and I-CMT were better than the control group (P ≤ 0.001). The positive effects of cognitive-motor training on reconstructing SWB and QOL are associated with the synchronicity of cognitive and motor components in these exercises. We suggest that the emotional, social, and psychological benefits of cognitive-motor training override cognitive, physical, and environmental changes. The future line of the present study will include pathophysiology and further clinical aspect of recovering from COVID-19.
MeSH term(s)	Male ; Child ; Humans ; Aged ; COVID-19 ; Quality of Life ; Exercise Therapy/methods ; Exercise ; Cognition/physiology
Language	English
Publishing date	2023-04-10
Publishing country	Germany
Document type	Randomized Controlled Trial ; Journal Article
ZDB-ID	2075054-7
ISSN	1612-4790 ; 1612-4782
ISSN (online)	1612-4790
ISSN	1612-4782
DOI	10.1007/s10339-023-01136-2
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Article ; Online: Design and Fabrication of a High Performance Microfluidic Chip for Blood Plasma Separation

Hossein Amini / Amin Sokhansanj / Mohammad Akrami / Ismaeil Haririan

International Journal of Analytical Chemistry, Vol

Modelling and Prediction of System Behaviour via CFD Method

2023 Volume 2023

Abstract	This paper presents a single-step microfluidic system designed for passive separation of human fresh blood plasma using direct capillary forces. Our microfluidic system is composed of a cylindrical well between upper and lower channel pairs produced by soft photolithography. The microchip was fabricated based on hydrophobicity differences upon suitable cylindrical surfaces using gravitational and capillary forces and lateral migration of plasma and red blood cells. The plasma radiation was applied to attach the polymeric segment (polydimethylsiloxane (PDMS)) to the glass. Meanwhile, Tween 80 was used as a surfactant to increase the hydrophobicity of the lateral channel surfaces. This led to the higher movement of whole blood, including plasma. Fick’s law of diffusion was validated for this diffusion transfer, the Navier–Stokes equation was used for the momentum balance, and the Laplace equation was utilized for the dynamics of the mesh. A model with high accuracy using the COMSOL Multiphysics software was created to predict the capillary forces and chip model validation. RBCs (red blood cells) were measured by the H3 cell counter instrument, by which 99% plasma purity was achieved. Practically, 58.3% of the plasma was separated from the blood within 12 min. Correlation between plasma separation results obtained from software and experimental data showed a coefficient of determination equal to 0.9732. This simple, rapid, stable, and reliable microchip can be considered as a promising candidate for providing plasma in point-of-care diagnostics.
Keywords	Analytical chemistry ; QD71-142
Subject code	600
Language	English
Publishing date	2023-01-01T00:00:00Z
Publisher	Hindawi Limited
Document type	Article ; Online
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Article ; Online: Effect of cannabis use on blood levels of brain-derived neurotrophic factor (BDNF) and nerve growth factor (NGF): A systematic review and meta-analysis.

Shafiee, Arman / Rafiei, Mohammad Ali / Jafarabady, Kyana / Eskandari, Alireza / Abhari, Faeze Soltani / Sattari, Mohammad Amin / Amini, Mohammad Javad / Bakhtiyari, Mahmood

Brain and behavior

2024 Volume 14, Issue 1, Page(s) e3340

Abstract: Background: The impact of cannabis uses on blood levels of brain-derived neurotrophic factor (BDNF) and nerve growth factor (NGF) remains uncertain, with conflicting findings reported in the literature. BDNF and NGF both are essential proteins for ... ...

Abstract	Background: The impact of cannabis uses on blood levels of brain-derived neurotrophic factor (BDNF) and nerve growth factor (NGF) remains uncertain, with conflicting findings reported in the literature. BDNF and NGF both are essential proteins for neuron's growth, and their dysregulation is seen in various mental disorders. This study aims to evaluate the relationship between cannabis usage and BDNF and NGF levels due to their potential implications for mental health. Methods: A comprehensive search of electronic databases was performed using appropriate MeSH terms and keywords. Inclusion criteria comprised human studies investigating the relationship between cannabis use and BDNF and NGF levels. Results: A total of 11 studies met the inclusion criteria and were included. The pooled analysis revealed a nonsignificant association between cannabis use and dysregulated blood levels of BDNF (random-effects model, standardized mean differences [SMD] = .26, 95% CI -.34 to .76, p = .40). The results of our subgroup analysis based on BDNF source showed a nonsignificant between-group difference. For NGF levels, four studies were included, the pooled analysis revealed a nonsignificant association between cannabis use and dysregulated blood levels of NGF (random-effects model, SMD = -.60, 95% CI -1.43 to -.23, p = .16). In both analyses, high heterogeneity was observed among the included studies which is a notable limitation to current meta-analysis. Conclusion: This systematic review highlights the need for further research to elucidate the relationship between cannabis use and these neurotrophic factors. A better understanding of these associations can contribute to our knowledge of the neurobiological effects of cannabis and inform potential implications for mental health, cognitive function, and neurodegenerative disorders.
MeSH term(s)	Humans ; Brain-Derived Neurotrophic Factor/metabolism ; Nerve Growth Factor/analysis ; Nerve Growth Factor/metabolism ; Cannabis ; Substance-Related Disorders
Chemical Substances	Brain-Derived Neurotrophic Factor ; Nerve Growth Factor (9061-61-4)
Language	English
Publishing date	2024-02-20
Publishing country	United States
Document type	Meta-Analysis ; Systematic Review ; Journal Article ; Review
ZDB-ID	2623587-0
ISSN	2162-3279 ; 2162-3279
ISSN (online)	2162-3279
ISSN	2162-3279
DOI	10.1002/brb3.3340
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Article: Simultaneous suppression of miR-21 and restoration of miR-145 in gastric cancer cells; a promising strategy for inhibition of cell proliferation and migration.

Bilan, Farzaneh / Amini, Mohammad / Doustvandi, Mohammad Amin / Tohidast, Maryam / Baghbanzadeh, Amir / Hosseini, Seyed Samad / Mokhtarzadeh, Ahad / Baradaran, Behzad

BioImpacts : BI

2023 Volume 14, Issue 2, Page(s) 27764

Language	English
Publishing date	2023-08-27
Publishing country	Iran
Document type	Journal Article
ZDB-ID	2604624-6
ISSN	2228-5660 ; 2228-5652
ISSN (online)	2228-5660
ISSN	2228-5652
DOI	10.34172/bi.2023.27764
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Article: Overexpression of miR-146a and miR-155 are Potentially Biomarkers and Predict Unfavorable Relationship between Gastric Cancer and Helicobacter pylori Infection.

Karimi, Masoud / Mohammadnia, Abdolreza / Amini, Mohammad Amin / Shamekh, Azar Ghavimi / Derakhshanfar, Elahe / Hosseini, Farzaneh

Chonnam medical journal

2023 Volume 59, Issue 3, Page(s) 167–173

Abstract: Gastric Cancer (GC) is one of the most dangerous malignancies in the world. This study aims to evaluate the relationship between miR-146a and miR-155 in patients ... ...

Abstract	Gastric Cancer (GC) is one of the most dangerous malignancies in the world. This study aims to evaluate the relationship between miR-146a and miR-155 in patients with
Language	English
Publishing date	2023-09-25
Publishing country	Korea (South)
Document type	Journal Article
ZDB-ID	2536217-3
ISSN	2233-7393 ; 2233-7385 ; 0377-9564
ISSN (online)	2233-7393
ISSN	2233-7385 ; 0377-9564
DOI	10.4068/cmj.2023.59.3.167
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Article: Mechanistic Insight into Age-Related Macular Degeneration (AMD): Anatomy, Epidemiology, Genetics, Pathogenesis, Prevention, Implications, and Treatment Strategies to Pace AMD Management.

Amini, Mohammad Amin / Karbasi, Ashkan / Vahabirad, Mohammad / Khanaghaei, Masoud / Alizamir, Aida

Chonnam medical journal

2023 Volume 59, Issue 3, Page(s) 143–159

Abstract: One of the most complicated eye disorders is age-related macular degeneration (AMD) which is the leading cause of irremediable blindness all over the world in the elderly. AMD is classified as early stage to late stage (advanced AMD), in which this stage ...

Abstract	One of the most complicated eye disorders is age-related macular degeneration (AMD) which is the leading cause of irremediable blindness all over the world in the elderly. AMD is classified as early stage to late stage (advanced AMD), in which this stage is divided into the exudative or neovascular form (wet AMD) and the nonexudative or atrophic form (dry AMD). Clinically, AMD primarily influences the central area of retina known as the macula. Importantly, the wet form is generally associated with more severe vision loss. AMD has a systemic component, where many factors, like aging, genetic, environment, autoimmune and non-autoimmune disorders are associated with this disease. Additionally, healthy lifestyles, regular exercise, maintaining a normal lipid profile and weight are crucial to decreasing the risk of AMD. Furthermore, therapeutic strategies for limiting AMD should encompass a variety of factors to avoid and improve drug interventions, and also need to take into account personalized genetic information. In conclusion, with the development of technology and research progress, visual impairment and legal blindness from AMD have been substantially reduced in incidence. This review article is focused on identifying and developing the knowledge about the association between genetics, and etiology with AMD. We hope that this review will encourage researchers and lecturers, open new discussions, and contribute to a better understanding of AMD that improves patients' visual acuity, and upgrades the quality of life of AMD patients.
Language	English
Publishing date	2023-09-25
Publishing country	Korea (South)
Document type	Journal Article ; Review
ZDB-ID	2536217-3
ISSN	2233-7393 ; 2233-7385 ; 0377-9564
ISSN (online)	2233-7393
ISSN	2233-7385 ; 0377-9564
DOI	10.4068/cmj.2023.59.3.143
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Article ; Online: The Effect of Differential Attentional Focus Strategies on the Performance of Military Elite Shooters.

Amini, Amin / Vaezmousavi, Mohammad

Behavioural neurology

2020 Volume 2020, Page(s) 1067610

Abstract: Methods: This study is semiexperimental with an intragroup design. A number of 10 military marksmen (30-42 years old) with at least 10 years of experience in shooting performed under four attentional focus strategies in a counterbalanced design. In each ...

Abstract	Methods: This study is semiexperimental with an intragroup design. A number of 10 military marksmen (30-42 years old) with at least 10 years of experience in shooting performed under four attentional focus strategies in a counterbalanced design. In each strategy, two blocks (each consisting of 20 trials) were conducted. Shooters' performance was recorded using SCATT device and analyzed using the factorial variance analysis with repeated measure. Results: Results showed that the interactional effects of internal-external/relevant-irrelevant focuses of attention were significant on shooting record, shooting accumulation, and stability on the target center. Results suggest that the external-relevant attentional focus strategies were more effective than other focus strategies. Conclusion: The results of the study support the hypothesis that external-relevant attentional focus produced better scores, better accumulation, more stability at the target center, and less average fluctuation. Therefore, this attentional focus strategy improves performance precision of military elite shooters.
MeSH term(s)	Adult ; Analysis of Variance ; Attention ; Firearms ; Humans ; Military Personnel ; Sports
Language	English
Publishing date	2020-11-25
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	1001896-7
ISSN	1875-8584 ; 0953-4180
ISSN (online)	1875-8584
ISSN	0953-4180
DOI	10.1155/2020/1067610
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Article ; Online: Angiotensin-converting enzyme I/D gene polymorphism and risk of type 2 diabetes mellitus in Iranian individuals.

Momeni-Moghaddam, Mohammad Amin / Chahkandi, Hanieh / Amini Beidokhti, Narges / Rahmani, Marziye / Salarbashi, Davoud / Khorasani, Milad

Nucleosides, nucleotides & nucleic acids

2024 , Page(s) 1–10

Abstract: This study aimed to examine the relationship between type 2 diabetes mellitus (T2DM) and renin-angiotensin system gene polymorphisms in the Iranian population. Additionally, we performed a straightforward meta-analysis of the present articles to better ... ...

Abstract	This study aimed to examine the relationship between type 2 diabetes mellitus (T2DM) and renin-angiotensin system gene polymorphisms in the Iranian population. Additionally, we performed a straightforward meta-analysis of the present articles to better understand this role. A total of 100 Iranian individuals, 50 patients with T2DM, and 50 age-matched healthy individuals were included in this study. DNA was extracted using the salting-out approach, polymerase chain reaction was used to amplify the angiotensin-converting enzyme (ACE) gene, electrophoresis techniques were used, and genotyping was performed. We also searched PubMed, Web of Science, Scopus, and Google Scholar databases for papers published in 2023. We found a significantly higher frequency of I/D genotype in the patient group than in the control group, and the risk of T2DM was 10 times higher in individuals with the I/D genotype (OR, 10 [95% CI, 3.7 to 27];
Language	English
Publishing date	2024-04-23
Publishing country	United States
Document type	Journal Article
ZDB-ID	2008956-9
ISSN	1532-2335 ; 1525-7770
ISSN (online)	1532-2335
ISSN	1525-7770
DOI	10.1080/15257770.2024.2343904
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