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  1. Article ; Online: Novel, Emerging Risk Factors for Colorectal Cancer Remain Understudied.

    Burnett-Hartman, Andrea N / Murphy, Caitlin C / Lee, Jeffrey K

    Gastroenterology

    2022  Volume 163, Issue 3, Page(s) 574–576

    MeSH term(s) Colorectal Neoplasms/diagnosis ; Colorectal Neoplasms/epidemiology ; Colorectal Neoplasms/etiology ; Humans ; Risk Factors
    Language English
    Publishing date 2022-07-07
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 80112-4
    ISSN 1528-0012 ; 0016-5085
    ISSN (online) 1528-0012
    ISSN 0016-5085
    DOI 10.1053/j.gastro.2022.06.085
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  2. Article ; Online: Depression, anxiety, & loneliness among cancer survivors during the COVID-19 pandemic.

    White, Larissa Lee / Goldberg, Shauna R / Spencer Feigelson, Heather / Burnett-Hartman, Andrea N

    Journal of psychosocial oncology

    2023  Volume 42, Issue 2, Page(s) 242–255

    Abstract: Purpose: To assess the impact of the COVID-19 pandemic on depression, anxiety, and loneliness between those with and without a history of cancer.: Design: This prospective observational study used a quantitative approach.: Participants: Adult ... ...

    Abstract Purpose: To assess the impact of the COVID-19 pandemic on depression, anxiety, and loneliness between those with and without a history of cancer.
    Design: This prospective observational study used a quantitative approach.
    Participants: Adult members of the Kaiser Permanente Research Bank (
    Methods: Participants completed a series of surveys from May to December 2020. The difference in score of depression, anxiety, and loneliness were estimated using linear mixed regression.
    Findings: Among cancer survivors, 21% and 19% met the thresholds for increased risk of depression and anxiety. Among cancer survivors, younger age groups and females reported increased depression, anxiety, and loneliness scores.
    Conclusions: This study highlights the continued necessity of addressing mental health needs and social support in cancer survivors during and after a public health emergency.
    Implications for psychosocial providers: Cancer survivors may need particular resources after cancer treatment to strengthen resilience and improve quality of life.
    MeSH term(s) Adult ; Female ; Humans ; Loneliness/psychology ; COVID-19 ; Depression/epidemiology ; Depression/psychology ; Cancer Survivors/psychology ; Quality of Life ; Pandemics ; Anxiety/epidemiology ; Anxiety/psychology ; Neoplasms/therapy
    Language English
    Publishing date 2023-07-24
    Publishing country United States
    Document type Observational Study ; Journal Article
    ZDB-ID 605892-9
    ISSN 1540-7586 ; 0734-7332
    ISSN (online) 1540-7586
    ISSN 0734-7332
    DOI 10.1080/07347332.2023.2238192
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  3. Article ; Online: Dietary Factors Differ Between Young-Onset and Older-Onset Colorectal Cancer Patients.

    Burnett-Hartman, Andrea N / Ton, Mimi / He, Qianchuan / Malen, Rachel C / Potter, John D / Reedy, Adriana M / Phipps, Amanda I / Newcomb, Polly A

    Nutrition and cancer

    2024  Volume 76, Issue 4, Page(s) 352–355

    Abstract: We aimed to evaluate differences in dietary factors between young-onset (diagnosed at ages <50) and older-onset colorectal cancer (CRC). CRC patients diagnosed from 1998 to 2018 reported to the Puget Sound Surveillance, Epidemiology, and End Results ... ...

    Abstract We aimed to evaluate differences in dietary factors between young-onset (diagnosed at ages <50) and older-onset colorectal cancer (CRC). CRC patients diagnosed from 1998 to 2018 reported to the Puget Sound Surveillance, Epidemiology, and End Results registry were recruited using mail and telephone. Consented patients completed questionnaires assessing demographics, medical history, and CRC risk factors, including dietary factors. We used multi-variable logistic regression to calculate adjusted odds ratios (ORs) and 95% confidence intervals (CIs) comparing dietary intake in young-onset vs. older-onset CRC. Analyses included 1,087 young- and 2,554 older-onset CRC patients. Compared to older-onset CRC, young-onset CRC patients had lower intake of vegetables (OR for highest intake vs. lowest = 0.59 CI: 0.55, 0.64) and fruit (OR for highest intake vs. lowest = 0.94 CI: 0.88, 0.99) and higher intake of processed meat (OR for highest intake vs. lowest = 1.82 CI: 1.11, 2.99) and spicy food (OR for highest intake vs. lowest = 1.69 CI: 1.09, 2.61). There was no statistically significant difference between young- and older-onset CRC patients for red meat consumption. Dietary patterns differed between young- and older-onset CRC; young-onset CRC patients had lower intake of vegetables and fruit and higher intakes of processed meat and spicy food.
    MeSH term(s) Humans ; Dietary Patterns ; Fruit ; Meat ; Odds Ratio ; Vegetables ; Colorectal Neoplasms/epidemiology ; Colorectal Neoplasms/etiology
    Language English
    Publishing date 2024-02-12
    Publishing country United States
    Document type Journal Article
    ZDB-ID 424433-3
    ISSN 1532-7914 ; 0163-5581
    ISSN (online) 1532-7914
    ISSN 0163-5581
    DOI 10.1080/01635581.2024.2316934
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  4. Article ; Online: Lessons Learned to Promote Lung Cancer Screening and Preempt Worsening Lung Cancer Disparities.

    Burnett-Hartman, Andrea N / Wiener, Renda Soylemez

    American journal of respiratory and critical care medicine

    2020  Volume 201, Issue 8, Page(s) 892–893

    MeSH term(s) Delivery of Health Care ; Early Detection of Cancer ; Humans ; Lung Neoplasms ; Mass Screening
    Language English
    Publishing date 2020-01-06
    Publishing country United States
    Document type Editorial ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 1180953-x
    ISSN 1535-4970 ; 0003-0805 ; 1073-449X
    ISSN (online) 1535-4970
    ISSN 0003-0805 ; 1073-449X
    DOI 10.1164/rccm.201912-2398ED
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: An Update on the Epidemiology, Molecular Characterization, Diagnosis, and Screening Strategies for Early-Onset Colorectal Cancer.

    Burnett-Hartman, Andrea N / Lee, Jeffrey K / Demb, Joshua / Gupta, Samir

    Gastroenterology

    2021  Volume 160, Issue 4, Page(s) 1041–1049

    Abstract: Rising trends in the incidence and mortality of early-onset colorectal cancer (CRC) in those who are younger than 50 years have been well established. These trends have spurred intense investigation focused on elucidating the epidemiology and ... ...

    Abstract Rising trends in the incidence and mortality of early-onset colorectal cancer (CRC) in those who are younger than 50 years have been well established. These trends have spurred intense investigation focused on elucidating the epidemiology and characteristics of early-onset CRC, as well as on identifying strategies for early detection and prevention. In this review, we provide a contemporary update on early-onset CRC with a particular focus on epidemiology, molecular characterization, red flag signs and symptoms, and screening for early-onset CRC.
    MeSH term(s) Age of Onset ; Biomarkers, Tumor/genetics ; Colorectal Neoplasms/diagnosis ; Colorectal Neoplasms/epidemiology ; Colorectal Neoplasms/genetics ; Colorectal Neoplasms/prevention & control ; Early Detection of Cancer/methods ; Early Detection of Cancer/standards ; Humans ; Mass Screening/methods ; Mass Screening/standards ; Microsatellite Instability ; Practice Guidelines as Topic ; Precision Medicine/methods ; Precision Medicine/standards ; Risk Factors ; Triage/standards
    Chemical Substances Biomarkers, Tumor
    Language English
    Publishing date 2021-01-05
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Review
    ZDB-ID 80112-4
    ISSN 1528-0012 ; 0016-5085
    ISSN (online) 1528-0012
    ISSN 0016-5085
    DOI 10.1053/j.gastro.2020.12.068
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Social risk factors among individuals with a history of cancer during the COVID-19 pandemic.

    Kelly, Cheryl / White, Larissa Lee / Scott, Shauna Goldberg / Feigelson, Heather Spencer / Burnett-Hartman, Andrea N

    Journal of cancer survivorship : research and practice

    2022  Volume 17, Issue 2, Page(s) 309–317

    Abstract: ... of cancer were estimated using multinomial logistic regression.: Results: Cancer survivors (n = 16,231 ... history of cancer (n = 88,409). Non-Hispanic (NH) Black and Hispanic cancer survivors had higher odds ...

    Abstract Purpose: The coronavirus disease (COVID-19) pandemic and its economic consequences may disproportionately impact cancer survivors and their overall health-related quality of life. The objective of this study was to examine whether cancer survivors experienced higher levels of financial strain or food insecurity compared to those without a history of cancer.
    Methods: Kaiser Permanente Research Bank (KPRB) study participants were invited to complete a series of electronic surveys starting April 2020 to assess the impact of the COVID-19 pandemic. Participants who completed the initial survey and one follow-up survey were included. The odds of financial strain and food insecurity in those with and without a history of cancer were estimated using multinomial logistic regression.
    Results: Cancer survivors (n = 16,231) had lower odds of reporting "somewhat hard" (AOR = 0.77) and "very hard" (AOR = 0.67) financial strain, and food insecurity "sometimes" (AOR = 0.70) and "often" (AOR = 0.55) compared to those with no history of cancer (n = 88,409). Non-Hispanic (NH) Black and Hispanic cancer survivors had higher odds compared to NH Whites of reporting financial strain and food insecurity. Smokers and those with multiple comorbidities had higher odds of reporting financial strain and food insecurity among cancer survivors.
    Conclusions: While cancer survivors overall did not report greater financial strain or food insecurity than individuals without a history of cancer, subsets of cancer survivors are experiencing greater social risks during the pandemic and should be prioritized for screening for social risk factors.
    Implications for cancer survivors: Incorporating screening for social risk factors into care coordination workflows for subsets of cancer survivors should be a priority.
    MeSH term(s) Humans ; Pandemics ; Quality of Life ; Food Supply ; COVID-19/epidemiology ; Cancer Survivors ; Risk Factors ; Neoplasms/epidemiology
    Language English
    Publishing date 2022-08-03
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2388888-X
    ISSN 1932-2267 ; 1932-2259
    ISSN (online) 1932-2267
    ISSN 1932-2259
    DOI 10.1007/s11764-022-01235-7
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: SARS-CoV-2 Infection and Related Hospitalization among Cancer Survivors.

    White, Larissa L / Burnett-Hartman, Andrea N / Ichikawa, Laura E / Goldberg, Shauna R / Chubak, Jessica / Spencer Feigelson, Heather / Kamineni, Aruna

    Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology

    2023  Volume 33, Issue 3, Page(s) 442–444

    Abstract: Background: Little is known about SARS-CoV-2 infection and COVID-19 severity among a growing population of cancer survivors. We describe the association of infection and related hospitalization by recency of cancer diagnosis in a large U.S. cohort.: ... ...

    Abstract Background: Little is known about SARS-CoV-2 infection and COVID-19 severity among a growing population of cancer survivors. We describe the association of infection and related hospitalization by recency of cancer diagnosis in a large U.S. cohort.
    Methods: Participants were sent electronic surveys between April 2020 and January 2021 to collect information on SARS-CoV-2 infection and potential COVID-19-related risk factors. SARS-CoV-2 infections were identified using survey report of a COVID-19-positive test and electronic health record data. Cumulative incidence of SARS-CoV-2 infection was estimated up to 365 days from baseline survey and stratified by recency of cancer diagnosis. Among those with SARS-CoV-2 infection, we used logistic regression to estimate the association between recency of cancer diagnosis and hospitalization within 30 days of infection.
    Results: Cumulative incidence of SARS-CoV-2 infection at 365 days was 3.3% [95% confidence interval (CI), 3.2%-3.5%] among those without cancer history and ranged from 2.8% (95% CI, 2.3%-3.5%) to 3.7% (95% CI, 2.9%-4.7%) among those with a history of cancer depending on recency. There was no statistically significant difference in odds of hospitalization within 30 days following SARS-CoV-2 infection by cancer diagnosis recency.
    Conclusions: Our null findings are consistent with other studies on COVID-19 infection risk in cancer survivors, where COVID-19 severity and sequelae were independent of cancer history and were likely associated with factors such as intensive care unit admission, noncancer comorbid conditions, and long-term care residency.
    Impact: This study can inform COVID-19 risk-counseling of cancer survivors and their caregivers as we continue to contend with COVID-19.
    MeSH term(s) Humans ; Cancer Survivors ; COVID-19/epidemiology ; SARS-CoV-2 ; Hospitalization ; Disease Progression ; Neoplasms/epidemiology
    Language English
    Publishing date 2023-12-20
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1153420-5
    ISSN 1538-7755 ; 1055-9965
    ISSN (online) 1538-7755
    ISSN 1055-9965
    DOI 10.1158/1055-9965.EPI-23-1303
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  8. Article ; Online: Challenges With Colorectal Cancer Family History Assessment-Motivation to Translate Polygenic Risk Scores Into Practice.

    Burnett-Hartman, Andrea N / Newcomb, Polly A / Peters, Ulrike

    Gastroenterology

    2019  Volume 158, Issue 2, Page(s) 433–435

    MeSH term(s) Colorectal Neoplasms/genetics ; Genetic Testing ; Humans ; Medical History Taking ; Motivation ; Multifactorial Inheritance
    Language English
    Publishing date 2019-11-01
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 80112-4
    ISSN 1528-0012 ; 0016-5085
    ISSN (online) 1528-0012
    ISSN 0016-5085
    DOI 10.1053/j.gastro.2019.10.030
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  9. Article: Sex hormones and risk of lung and colorectal cancers in women: a Mendelian randomization study.

    Denos, Marion / Sun, Yi-Qian / Brumpton, Ben / Li, Yafang / Albanes, Demetrius / Burnett-Hartman, Andrea / Campbell, Peter T / Küry, Sébastien / Li, Christopher I / White, Emily / Samadder, Jewel N / Jenkins, Mark / Mai, Xiao-Mei

    Research square

    2024  

    Abstract: The roles of sex hormones such as estradiol, testosterone, and sex hormone-binding globulin (SHBG) in the etiology of lung and colorectal cancers in women, among the most common cancers after breast cancer, are unclear. This Mendelian randomization (MR) ... ...

    Abstract The roles of sex hormones such as estradiol, testosterone, and sex hormone-binding globulin (SHBG) in the etiology of lung and colorectal cancers in women, among the most common cancers after breast cancer, are unclear. This Mendelian randomization (MR) study evaluated such potential causal associations in women of European ancestry. We used summary statistics data from genome-wide association studies (GWASs) on sex hormones and from the Trøndelag Health (HUNT) Study and large consortia on cancers. There was suggestive evidence of genetically predicted 1-standard deviation increase in total testosterone levels being associated with a lower risk of lung non-adenocarcinoma (hazard ratio (HR) 0.60, 95% CI 0.37-0.98) in the HUNT Study. However, this was not confirmed by using data from a larger consortium. In general, we did not find convincing evidence to support a causal role of sex hormones on risk of lung and colorectal cancers in women of European ancestry.
    Language English
    Publishing date 2024-04-10
    Publishing country United States
    Document type Preprint
    DOI 10.21203/rs.3.rs-4083598/v1
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  10. Article ; Online: Colorectal cancer pre-diagnostic symptoms are associated with anatomic cancer site.

    Briggs, Nicole L / Ton, Mimi / Malen, Rachel C / Reedy, Adriana M / Cohen, Stacey A / Phipps, Amanda I / Burnett-Hartman, Andrea N / Newcomb, Polly A

    BMC gastroenterology

    2024  Volume 24, Issue 1, Page(s) 65

    Abstract: ... through a SEER cancer registry (N = 626). We used logistic regression to estimate odds ratios and 95 ...

    Abstract Background: Signs and red flag symptoms in colorectal cancer (CRC) patients who are below the recommended screening age are often overlooked, leading to delayed diagnosis and worse prognosis. This study investigates how patient pre-diagnostic symptoms are associated with anatomic site of their cancer and whether the association varies by age at CRC diagnosis.
    Methods: We ascertained CRC patients' experienced symptoms and screening through medical abstractions from an ongoing population-based study of CRC patients identified through a SEER cancer registry (N = 626). We used logistic regression to estimate odds ratios and 95% confidence intervals for the association between symptoms and CRC anatomic site. Additional analyses were stratified by age at diagnosis. Early-onset was defined as less than 50 years of age at CRC diagnosis.
    Results: Participants who experienced blood in stool were more likely (odds ratio (95% confidence interval)) to have rectal (vs. colon) cancer (4.37 (3.02, 6.33)), as were patients who experienced changes to stool (1.78 (1.21, 2.60)). Patients diagnosed with colon cancer were more likely to present with abdominal pain (0.30 (0.19, 0.47)), anemia (0.40 (0.21, 0.75)), other symptoms (0.33 (0.19, 0.55)) and no symptoms (0.68 (0.44, 1.04)). When stratifying by age at diagnosis, we found that the association between blood in stool and rectal tumor location was particularly pronounced for patients with early-onset CRC (6.48 (2.73, 15.41)).
    Conclusions: Common pre-diagnostic red flag symptoms are associated with CRC anatomic site. These findings can inform best practices for gastroenterologist triage of care and early evaluation of CRC and are of key importance given the rise of early-onset (pre-screening age) CRC.
    Trial registration: Not applicable to this study and analysis.
    MeSH term(s) Humans ; Colorectal Neoplasms/diagnosis ; Colorectal Neoplasms/pathology ; Colonic Neoplasms ; Prognosis ; Registries ; Rectal Neoplasms ; Early Detection of Cancer
    Language English
    Publishing date 2024-02-06
    Publishing country England
    Document type Journal Article
    ZDB-ID 2041351-8
    ISSN 1471-230X ; 1471-230X
    ISSN (online) 1471-230X
    ISSN 1471-230X
    DOI 10.1186/s12876-024-03152-8
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