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  1. Article ; Online: Impact of lipopolysaccharide-induced acute lung injury in aged mice.

    Bae, Sukjin / Kim, In Kyoung / Im, Jeonghyeon / Lee, Heayon / Lee, Sang Haak / Kim, Sei Won

    Experimental lung research

    2023  Volume 49, Issue 1, Page(s) 193–204

    Abstract: Study Aim: ...

    Abstract Study Aim:
    MeSH term(s) Aged ; Humans ; Female ; Animals ; Mice ; Lipopolysaccharides/pharmacology ; Mice, Inbred C57BL ; Acute Lung Injury/pathology ; Lung ; Bronchoalveolar Lavage Fluid
    Chemical Substances Lipopolysaccharides
    Language English
    Publishing date 2023-11-25
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 603791-4
    ISSN 1521-0499 ; 0190-2148
    ISSN (online) 1521-0499
    ISSN 0190-2148
    DOI 10.1080/01902148.2023.2285061
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    In stock of ZB MED Cologne/Königswinter

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  2. Article ; Online: Air Pollutants and Frailty in Older Adults: A Geriatrician's Perspective.

    Lee, Heayon / Lee, Eunju / Jang, Il-Young

    Annals of geriatric medicine and research

    2019  Volume 23, Issue 4, Page(s) 212–213

    Language English
    Publishing date 2019-12-30
    Publishing country Korea (South)
    Document type Journal Article
    ZDB-ID 3035056-6
    ISSN 2508-4909 ; 2508-4798
    ISSN (online) 2508-4909
    ISSN 2508-4798
    DOI 10.4235/agmr.19.0049
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Air Pollutants and Frailty in Older Adults

    Heayon Lee / Eunju Lee / Il-Young Jang

    Annals of Geriatric Medicine and Research, Vol 23, Iss 4, Pp 212-

    A Geriatrician’s Perspective

    2019  Volume 213

    Keywords Medicine ; R ; Geriatrics ; RC952-954.6
    Language English
    Publishing date 2019-12-01T00:00:00Z
    Publisher Korea Geriatrics Society
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: Frailty and Comprehensive Geriatric Assessment.

    Lee, Heayon / Lee, Eunju / Jang, Il Young

    Journal of Korean medical science

    2020  Volume 35, Issue 3, Page(s) e16

    Abstract: Frailty is defined as a reduced physiologic reserve vulnerable to external stressors. For older individuals, frailty plays a decisive role in increasing adverse health outcomes in most clinical situations. Many tools or criteria have been introduced to ... ...

    Abstract Frailty is defined as a reduced physiologic reserve vulnerable to external stressors. For older individuals, frailty plays a decisive role in increasing adverse health outcomes in most clinical situations. Many tools or criteria have been introduced to define frailty in recent years, and the definition of frailty has gradually converged into several consensuses. Frail older adults often have multi-domain risk factors in terms of physical, psychological, and social health. Comprehensive geriatric assessment (CGA) is the process of identifying and quantifying frailty by examining various risky domains and body functions, which is the basis for geriatric medicine and research. CGA provides physicians with information on the reversible area of frailty and the leading cause of deterioration in frail older adults. Therefore frailty assessment based on understanding CGA and its relationship with frailty, can help establish treatment strategies and intervention in frail older adults. This review article summarizes the recent consensus and evidence of frailty and CGA.
    MeSH term(s) Aged, 80 and over ; Cardiovascular Diseases/pathology ; Frail Elderly ; Frailty/pathology ; Geriatric Assessment ; Humans ; Postoperative Complications
    Language English
    Publishing date 2020-01-20
    Publishing country Korea (South)
    Document type Journal Article ; Review
    ZDB-ID 639262-3
    ISSN 1598-6357 ; 1011-8934
    ISSN (online) 1598-6357
    ISSN 1011-8934
    DOI 10.3346/jkms.2020.35.e16
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Effects of aging on accompanying intermittent hypoxia in a bleomycin-induced pulmonary fibrosis mouse model.

    Lee, Heayon / Kim, In Kyoung / Im, Jeonghyeon / Jin, Bae Suk / Kim, Hwan Hee / Kim, Sei Won / Yeo, Chang Dong / Lee, Sang Haak

    The Korean journal of internal medicine

    2023  Volume 38, Issue 6, Page(s) 934–944

    Abstract: Background/aims: Obstructive sleep apnea (OSA) is prevalent in older patients with idiopathic pulmonary fibrosis (IPF); however, it is underrecognized. OSA is characterized by intermittent hypoxia (IH) and sleep fragmentation. In this study, we ... ...

    Abstract Background/aims: Obstructive sleep apnea (OSA) is prevalent in older patients with idiopathic pulmonary fibrosis (IPF); however, it is underrecognized. OSA is characterized by intermittent hypoxia (IH) and sleep fragmentation. In this study, we evaluated the effects of IH in an older mouse model of bleomycin-induced lung fibrosis.
    Methods: Bleomycin-induced mice (C57BL/6, female) were randomly divided into four groups of young vs. old and room air (RA)-exposed vs. IH-exposed. Mice were exposed to RA or IH (20 cycles/h, FiO2 nadir 7 ± 0.5%, 8 h/day) for four weeks. The mice were sacrificed on day 28, and blood, bronchoalveolar lavage (BAL) fluid, and lung tissue samples were obtained.
    Results: The bleomycin-induced IH-exposed (EBI) older group showed more severe inflammation, fibrosis, and oxidative stress than the other groups. The levels of inflammatory cytokines in the serum and BAL fluid increased in the EBI group. Hydroxyproline levels in the lung tissue increased markedly in the EBI group.
    Conclusion: This study demonstrates the possible harmful impact of OSA in an elderly mouse model of lung fibrosis. This study further suggests that older patients with IPF and OSA may be more of a concern than younger patients with IPF. Further research is required in this area.
    MeSH term(s) Humans ; Female ; Animals ; Mice ; Aged ; Bleomycin/toxicity ; Mice, Inbred C57BL ; Hypoxia ; Aging ; Idiopathic Pulmonary Fibrosis/chemically induced ; Sleep Apnea, Obstructive ; Disease Models, Animal
    Chemical Substances Bleomycin (11056-06-7)
    Language English
    Publishing date 2023-10-05
    Publishing country Korea (South)
    Document type Journal Article
    ZDB-ID 639023-7
    ISSN 2005-6648 ; 1226-3303
    ISSN (online) 2005-6648
    ISSN 1226-3303
    DOI 10.3904/kjim.2023.090
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Usefulness of monocyte distribution width and presepsin for early assessment of disease severity in COVID-19 patients.

    Kim, Sei Won / Lee, Heayon / Lee, Sang Haak / Jo, Sung Jin / Lee, Jehoon / Lim, Jihyang

    Medicine

    2022  Volume 101, Issue 27, Page(s) e29592

    Abstract: Early predictors of severe coronavirus disease 2019 (COVID-19) would identify patients requiring intensive care. Recently, the monocyte distribution width (MDW) and presepsin level have been used for the early diagnosis of sepsis. Here, we assessed the ... ...

    Abstract Early predictors of severe coronavirus disease 2019 (COVID-19) would identify patients requiring intensive care. Recently, the monocyte distribution width (MDW) and presepsin level have been used for the early diagnosis of sepsis. Here, we assessed the utility of MDW and presepsin for the early assessment of COVID-19 severity. Eighty-seven inpatients with confirmed COVID-19 were enrolled and divided into 3 groups by the type of respiratory support: (1) mechanical ventilation or high-flow nasal cannula oxygen therapy (MVHF-OT), (2) conventional oxygen therapy, and (3) no oxygen therapy. We measured the complete blood count; MDW; erythrocyte sedimentation rate; and the levels of presepsin, C-reactive protein, procalcitonin, lactate dehydrogenase, ferritin, Krebs von den Lungen-6 (KL-6), and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) neutralizing antibody. Thirteen (14.9%) patients on MVHF-OT exhibited a significantly higher mortality and a longer hospital stay than did the others. The MDW and presepsin levels were significantly elevated on admission, and correlated with COVID-19 severity (both P < .001). Notably, only the MDW correlated significantly with symptoms in the no oxygen therapy group (P < .012). In the first week after admission, the MDW fell and no longer differed among the groups. The KL-6 level did not differ by disease severity at any time. Neutralizing antibodies were detected in 74 patients (91.4%) and the level of neutralization correlated significantly with COVID-19 severity (P < .001). The MDW and presepsin are useful indicators for early assessment of disease severity in COVID-19 patients.
    MeSH term(s) Biomarkers ; COVID-19/diagnosis ; Critical Care ; Humans ; Lipopolysaccharide Receptors/analysis ; Monocytes ; Peptide Fragments/analysis ; SARS-CoV-2 ; Severity of Illness Index
    Chemical Substances Biomarkers ; Lipopolysaccharide Receptors ; Peptide Fragments ; presepsin protein, human
    Language English
    Publishing date 2022-07-08
    Publishing country United States
    Document type Journal Article
    ZDB-ID 80184-7
    ISSN 1536-5964 ; 0025-7974
    ISSN (online) 1536-5964
    ISSN 0025-7974
    DOI 10.1097/MD.0000000000029592
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Development of a population pharmacokinetic model of pyrazinamide to guide personalized therapy: impacts of geriatric and diabetes mellitus on clearance.

    Kim, Ryunha / Jayanti, Rannissa Puspita / Lee, Hongyeul / Kim, Hyun-Kuk / Kang, Jiyeon / Park, I-Nae / Kim, Jehun / Oh, Jee Youn / Kim, Hyung Woo / Lee, Heayon / Ghim, Jong-Lyul / Ahn, Sangzin / Long, Nguyen Phuoc / Cho, Yong-Soon / Shin, Jae-Gook / On Behalf Of The cPMTb

    Frontiers in pharmacology

    2023  Volume 14, Page(s) 1116226

    Abstract: Objectives: ...

    Abstract Objectives:
    Language English
    Publishing date 2023-05-26
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2587355-6
    ISSN 1663-9812
    ISSN 1663-9812
    DOI 10.3389/fphar.2023.1116226
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  8. Article ; Online: The Author's Response: A Lesson from Temporary Closing of a Single University-affiliated Hospital owing to In-Hospital Transmission of Coronavirus Disease 2019.

    Lee, Heayon / Heo, Jung Won / Kim, Sei Won / Lee, Jehoon / Choi, Jung Hyun

    Journal of Korean medical science

    2020  Volume 35, Issue 16, Page(s) e160

    MeSH term(s) Betacoronavirus ; COVID-19 ; Coronavirus ; Coronavirus Infections ; Humans ; Pandemics ; Pneumonia, Viral ; Republic of Korea ; SARS-CoV-2 ; Universities
    Keywords covid19
    Language English
    Publishing date 2020-04-27
    Publishing country Korea (South)
    Document type Letter ; Comment
    ZDB-ID 639262-3
    ISSN 1598-6357 ; 1011-8934
    ISSN (online) 1598-6357
    ISSN 1011-8934
    DOI 10.3346/jkms.2020.35.e160
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  9. Article ; Online: Association of the FRAIL Scale with Geriatric Syndromes and Health-Related Outcomes in Korean Older Adults.

    Lee, Heayon / Chong, Junyong / Jung, Hee-Won / Baek, Ji Yeon / Lee, Eunju / Jang, Il-Young

    Annals of geriatric medicine and research

    2021  Volume 25, Issue 2, Page(s) 79–85

    Abstract: Background: Owing to the growing older population, appropriate tools are needed for frailty screening in community-dwelling older people. We investigated the association between geriatric conditions and health-related outcomes using the five-item ... ...

    Abstract Background: Owing to the growing older population, appropriate tools are needed for frailty screening in community-dwelling older people. We investigated the association between geriatric conditions and health-related outcomes using the five-item Fatigue, Resistance, Ambulation, Illnesses, & Loss of Weight (FRAIL) scale in a Korean rural community setting.
    Methods: We performed comprehensive geriatric assessments, including the FRAIL scale, in 1,292 community-dwelling people (mean age, 74.6 years) in the Aging Study of Pyeongchang Rural Area. These populations were prospectively followed up for 3 years to analyze the outcomes of death, institutionalization, disability, and quality of life. We investigated the association between frailty status and outcomes using the FRAIL scale.
    Results: According to the FRAIL scale, 524 (36.5%) participants were prefrail and 297 (23.0%) were frail. According to the adjusted model, the degree of frailty status was significantly associated with concurrent geriatric syndromes and 3-year incidences of mortality, institutionalization, and disability; Kaplan-Meier analysis showed significant differences in 3-year survival based on frailty status (92.6% for robust, 85.7% for prefrail, and 74.2% for frail; log-rank p<0.001).
    Conclusion: The five-item FRAIL scale can be used to screen for accompanying geriatric syndromes and is associated with the 3-year health-related outcomes in community-dwelling Korean older adults. From the public health perspective, this simple screening tool for frailty assessment might be applicable to older populations in Korea.
    Language English
    Publishing date 2021-06-09
    Publishing country Korea (South)
    Document type Journal Article
    ZDB-ID 3035056-6
    ISSN 2508-4909 ; 2508-4798
    ISSN (online) 2508-4909
    ISSN 2508-4798
    DOI 10.4235/agmr.20.0095
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Effects of aging on accompanying intermittent hypoxia in a bleomycin-induced pulmonary fibrosis mouse model

    Heayon Lee / In Kyoung Kim / Jeonghyeon Im / Bae Suk Jin / Hwan Hee Kim / Sei Won Kim / Chang Dong Yeo / Sang Haak Lee

    The Korean Journal of Internal Medicine, Vol 38, Iss 6, Pp 934-

    2023  Volume 944

    Abstract: Background/Aims Obstructive sleep apnea (OSA) is prevalent in older patients with idiopathic pulmonary fibrosis (IPF); however, it is underrecognized. OSA is characterized by intermittent hypoxia (IH) and sleep fragmentation. In this study, we evaluated ... ...

    Abstract Background/Aims Obstructive sleep apnea (OSA) is prevalent in older patients with idiopathic pulmonary fibrosis (IPF); however, it is underrecognized. OSA is characterized by intermittent hypoxia (IH) and sleep fragmentation. In this study, we evaluated the effects of IH in an older mouse model of bleomycin-induced lung fibrosis. Methods Bleomycin-induced mice (C57BL/6, female) were randomly divided into four groups of young vs. old and room air (RA)-exposed vs. IH-exposed. Mice were exposed to RA or IH (20 cycles/h, FiO2 nadir 7 ± 0.5%, 8 h/day) for four weeks. The mice were sacrificed on day 28, and blood, bronchoalveolar lavage (BAL) fluid, and lung tissue samples were obtained. Results The bleomycin-induced IH-exposed (EBI) older group showed more severe inflammation, fibrosis, and oxidative stress than the other groups. The levels of inflammatory cytokines in the serum and BAL fluid increased in the EBI group. Hydroxyproline levels in the lung tissue increased markedly in the EBI group. Conclusions This study demonstrates the possible harmful impact of OSA in an elderly mouse model of lung fibrosis. This study further suggests that older patients with IPF and OSA may be more of a concern than younger patients with IPF. Further research is required in this area.
    Keywords elderly ; fibrosis ; hypoxia ; inflammation ; mice ; model ; Medicine ; R
    Subject code 610
    Language English
    Publishing date 2023-11-01T00:00:00Z
    Publisher The Korean Association of Internal Medicine
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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