LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 10 of total 6321

Search options

  1. Article ; Online: Revision of Chondrocyclus s.l. (Mollusca

    Mary L. Cole

    European Journal of Taxonomy, Iss

    Cyclophoridae), with description of a new genus and twelve new species

    2019  Volume 569

    Abstract: ... A comprehensive revision of Chondrocyclus s.l. is provided here based on comparative morphological examinations ... cytochrome c oxidase subunit I and 16S rRNA. Two genus-level lineages are recognised, Chondrocyclus s.s. and Afrocyclus ... widespread group. Such evidence is urgently needed for conservation of South Africa’s threatened forest biome. ...

    Abstract Chondrocyclus Ancey, 1898 is a genus of nine species of African operculate land snails restricted to indigenous forest and mesic thicket. Worn specimens (i.e., without a periostracum or operculum), on which some species descriptions and records were based, appear to be indistinguishable morphologically. A comprehensive revision of Chondrocyclus s.l. is provided here based on comparative morphological examinations of the shell, protoconch, periostracum, operculum, radula and penis, and on mitochondrial genes cytochrome c oxidase subunit I and 16S rRNA. Two genus-level lineages are recognised, Chondrocyclus s.s. and Afrocyclus gen. nov. Revised species descriptions are given for seven species. Two species, C. meredithae Bruggen, 1983 and C. chirindae Bruggen, 1986 both from north of South Africa, are removed from Chondrocyclus. Twelve new species are described: C. herberti sp. nov., C. silvicolus sp. nov., C. amathole sp. nov., C. pondoensis sp. nov., C. devilliersi sp. nov., C. pulcherrimus sp. nov., C. cooperae sp. nov., C. langebergensis sp. nov., C. kevincolei sp. nov., A. oxygala gen. et sp. nov., A. potteri gen. et sp. nov. and A. bhaca gen. et sp. nov. This is the first detailed systematic revision of an Afrotropical cyclophorid group to include morphological and molecular data. This study complements research on other taxa of low-vagility forest-dwelling habitat specialists by providing comparative distribution data for an independent, widespread group. Such evidence is urgently needed for conservation of South Africa’s threatened forest biome.
    Keywords Cyclophoroidea ; new genus ; systematics ; South African distribution ; forests ; Zoology ; QL1-991 ; Botany ; QK1-989
    Language English
    Publishing date 2019-10-01T00:00:00Z
    Publisher Consortium of European Natural History Museums
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

    More links

    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  2. Article ; Online: A fragment-based approach to identifying S-adenosyl-l-methionine -competitive inhibitors of catechol O-methyl transferase (COMT).

    Lanier, Marion / Ambrus, Geza / Cole, Derek C / Davenport, Richard / Ellery, Jonathan / Fosbeary, Richard / Jennings, Andy J / Kadotani, Akito / Kamada, Yusuke / Kamran, Ruhi / Matsumoto, Shin-Ichi / Mizukami, Atsushi / Okubo, Shoichi / Okada, Kengo / Saikatendu, Kumar / Walsh, Louise / Wu, Haihong / Hixon, Mark S

    Journal of medicinal chemistry

    2014  Volume 57, Issue 12, Page(s) 5459–5463

    Abstract: Catechol O-methyl transferase belongs to the diverse family of S-adenosyl-l-methionine transferases ...

    Abstract Catechol O-methyl transferase belongs to the diverse family of S-adenosyl-l-methionine transferases. It is a target involved in the treatment of Parkinson's disease. Here we present a fragment-based screening approach to discover noncatechol derived COMT inhibitors which bind at the SAM binding pocket. We describe the identification and characterization of a series of highly ligand efficient SAM competitive bisaryl fragments (LE = 0.33-0.58). We also present the first SAM-competitive small-molecule COMT co-complex crystal structure.
    MeSH term(s) Animals ; Binding Sites ; Catechol O-Methyltransferase/chemistry ; Catechol O-Methyltransferase Inhibitors ; Humans ; Kinetics ; Mice ; Models, Molecular ; Protein Conformation ; Pyrazoles/chemistry ; Rats ; S-Adenosylmethionine/chemistry ; S-Adenosylmethionine/metabolism ; Structure-Activity Relationship ; Thiazoles/chemistry ; Triazoles/chemistry
    Chemical Substances Catechol O-Methyltransferase Inhibitors ; Pyrazoles ; Thiazoles ; Triazoles ; S-Adenosylmethionine (7LP2MPO46S) ; Catechol O-Methyltransferase (EC 2.1.1.6)
    Language English
    Publishing date 2014-06-26
    Publishing country United States
    Document type Journal Article
    ZDB-ID 218133-2
    ISSN 1520-4804 ; 0022-2623
    ISSN (online) 1520-4804
    ISSN 0022-2623
    DOI 10.1021/jm500475k
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.B 151: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)
    Zs.MB 1: Show issues

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  3. Article ; Online: Using S-adenosyl-L-homocysteine capture compounds to characterize S-adenosyl-L-methionine and S-adenosyl-L-homocysteine binding proteins.

    Brown, Lindsey J / Baranowski, Matthias / Wang, Yun / Schrey, Anna K / Lenz, Thomas / Taverna, Sean D / Cole, Philip A / Sefkow, Michael

    Analytical biochemistry

    2014  Volume 467, Page(s) 14–21

    Abstract: S-Adenosyl-l-methionine (SAM) is recognized as an important cofactor in a variety ... a method to quickly identify and characterize SAM binding proteins. The affinity of S-adenosyl-l ...

    Abstract S-Adenosyl-l-methionine (SAM) is recognized as an important cofactor in a variety of biochemical reactions. As more proteins and pathways that require SAM are discovered, it is important to establish a method to quickly identify and characterize SAM binding proteins. The affinity of S-adenosyl-l-homocysteine (SAH) for SAM binding proteins was used to design two SAH-derived capture compounds (CCs). We demonstrate interactions of the proteins COMT and SAHH with SAH-CC with biotin used in conjunction with streptavidin-horseradish peroxidase. After demonstrating SAH-dependent photo-crosslinking of the CC to these proteins, we used a CC labeled with a fluorescein tag to measure binding affinity via fluorescence anisotropy. We then used this approach to show and characterize binding of SAM to the PR domain of PRDM2, a lysine methyltransferase with putative tumor suppressor activity. We calculated the Kd values for COMT, SAHH, and PRDM2 (24.1 ± 2.2 μM, 6.0 ± 2.9 μM, and 10.06 ± 2.87 μM, respectively) and found them to be close to previously established Kd values of other SAM binding proteins. Here, we present new methods to discover and characterize SAM and SAH binding proteins using fluorescent CCs.
    MeSH term(s) Catechol O-Methyltransferase/analysis ; Catechol O-Methyltransferase/metabolism ; DNA-Binding Proteins/analysis ; DNA-Binding Proteins/metabolism ; Fluorescence Polarization/methods ; Histone-Lysine N-Methyltransferase/analysis ; Histone-Lysine N-Methyltransferase/metabolism ; Humans ; Hydrolases/analysis ; Hydrolases/metabolism ; Nuclear Proteins/analysis ; Nuclear Proteins/metabolism ; S-Adenosylhomocysteine/metabolism ; S-Adenosylmethionine/metabolism ; Transcription Factors/analysis ; Transcription Factors/metabolism
    Chemical Substances DNA-Binding Proteins ; Nuclear Proteins ; Transcription Factors ; S-Adenosylmethionine (7LP2MPO46S) ; S-Adenosylhomocysteine (979-92-0) ; Histone-Lysine N-Methyltransferase (EC 2.1.1.43) ; PRDM2 protein, human (EC 2.1.1.43) ; COMT protein, human (EC 2.1.1.6) ; Catechol O-Methyltransferase (EC 2.1.1.6) ; Hydrolases (EC 3.-) ; adenosylmethionine hydrolase (EC 3.3.1.2)
    Language English
    Publishing date 2014-08-27
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1110-1
    ISSN 1096-0309 ; 0003-2697
    ISSN (online) 1096-0309
    ISSN 0003-2697
    DOI 10.1016/j.ab.2014.08.013
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 389: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  4. Article: Using S-adenosyl-l-homocysteine capture compounds to characterize S-adenosyl-l-methionine and S-adenosyl-l-homocysteine binding proteins

    Brown, Lindsey J / Baranowski, Matthias / Wang, Yun / Schrey, Anna K / Lenz, Thomas / Taverna, Sean D / Cole, Philip A / Sefkow, Michael

    Analytical biochemistry. 2014 Dec. 15, v. 467

    2014  

    Abstract: S-Adenosyl-l-methionine (SAM) is recognized as an important cofactor in a variety ... a method to quickly identify and characterize SAM binding proteins. The affinity of S-adenosyl-l ...

    Abstract S-Adenosyl-l-methionine (SAM) is recognized as an important cofactor in a variety of biochemical reactions. As more proteins and pathways that require SAM are discovered, it is important to establish a method to quickly identify and characterize SAM binding proteins. The affinity of S-adenosyl-l-homocysteine (SAH) for SAM binding proteins was used to design two SAH-derived capture compounds (CCs). We demonstrate interactions of the proteins COMT and SAHH with SAH–CC with biotin used in conjunction with streptavidin–horseradish peroxidase. After demonstrating SAH-dependent photo-crosslinking of the CC to these proteins, we used a CC labeled with a fluorescein tag to measure binding affinity via fluorescence anisotropy. We then used this approach to show and characterize binding of SAM to the PR domain of PRDM2, a lysine methyltransferase with putative tumor suppressor activity. We calculated the Kd values for COMT, SAHH, and PRDM2 (24.1±2.2μM, 6.0±2.9μM, and 10.06±2.87μM, respectively) and found them to be close to previously established Kd values of other SAM binding proteins. Here, we present new methods to discover and characterize SAM and SAH binding proteins using fluorescent CCs.
    Keywords S-adenosylmethionine ; anisotropy ; binding capacity ; binding proteins ; biotin ; chemical reactions ; fluorescein ; fluorescence ; methyltransferases ; peroxidase
    Language English
    Dates of publication 2014-1215
    Size p. 14-21.
    Publishing place Elsevier Inc.
    Document type Article
    ZDB-ID 1110-1
    ISSN 1096-0309 ; 0003-2697
    ISSN (online) 1096-0309
    ISSN 0003-2697
    DOI 10.1016/j.ab.2014.08.013
    Database NAL-Catalogue (AGRICOLA)

    More links

    Kategorien

    In stock of ZB MED Bonn / Germany

    Z 70/124: Show issues

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  5. Article: Fixation of distal femoral fractures above total knee arthroplasty utilizing the Less Invasive Stabilization System (L.I.S.S.).

    Kregor, P J / Hughes, J L / Cole, P A

    Injury

    2001  Volume 32 Suppl 3, Page(s) SC64–75

    Abstract: ... Invasive Stabilization System (L.I.S.S.) fixation has been utilized for the treatment of supracondylar ...

    Abstract Supracondylar femoral fractures above total knee arthroplasty remain a treatment challenge. Complication rates as high as 30% are associated with both nonoperative and operative treatment. Conventional plate fixation and rigid intramedullary nail fixation has improved the treatment of these fractures. However, problems still exist in the setting of a short distal femoral block and/or significant osteoporosis. Less Invasive Stabilization System (L.I.S.S.) fixation has been utilized for the treatment of supracondylar femoral fractures above total knee arthroplasty. Multiple fixed angle screws give optimal fixation around the femoral component. Advantages appear to include maintenance of distal femoral fixation, low infection, and low need for bone grafting.
    MeSH term(s) Bone Plates/standards ; Bone Screws/standards ; Femoral Fractures/complications ; Femoral Fractures/diagnostic imaging ; Femoral Fractures/surgery ; Fracture Fixation, Intramedullary/methods ; Fracture Fixation, Intramedullary/standards ; Humans ; Minimally Invasive Surgical Procedures/methods ; Minimally Invasive Surgical Procedures/standards ; Radiography ; Treatment Outcome
    Language English
    Publishing date 2001-12
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 218778-4
    ISSN 1879-0267 ; 0020-1383
    ISSN (online) 1879-0267
    ISSN 0020-1383
    DOI 10.1016/s0020-1383(01)00185-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 778: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 10: Show issues

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  6. Article: Distal femoral fracture fixation utilizing the Less Invasive Stabilization System (L.I.S.S.): the technique and early results.

    Kregor, P J / Stannard, J / Zlowodzki, M / Cole, P A / Alonso, J

    Injury

    2001  Volume 32 Suppl 3, Page(s) SC32–47

    Abstract: ... grew the concept of submuscular plating for distal femoral fractures, and subsequently L.I.S.S ... utilizing the L.I.S.S. for distal femoral fractures is described. The technique of L.I.S.S. fixation first ... by submuscular fixation utilizing the L.I.S.S. fixation. The L.I.S.S. can best be thought as an "internal ...

    Abstract The treatment of supracondylar femoral fractures in the past three decades has evolved from non-operative to operative treatment. While operative fixation utilizing either plate fixation or rigid intramedullary nail fixation has improved patient outcomes, the problems of malunion, nonunion, need for bone grafting, joint stiffness, and infection persist. An emphasis on maintenance of the soft tissue envelope around fractures has improved efficacy in increasing osseous healing and decreasing infection. Out of this movement grew the concept of submuscular plating for distal femoral fractures, and subsequently L.I.S.S. fixation (Less Invasive Stabilization System) for distal femoral fractures. The technique and early results utilizing the L.I.S.S. for distal femoral fractures is described. The technique of L.I.S.S. fixation first begins with traditional direct visualization and internal fixation of the articular surface. Closed reduction is then performed on the metaphyseal / diaphyseal component of the fracture, followed by submuscular fixation utilizing the L.I.S.S. fixation. The L.I.S.S. can best be thought as an "internal" external fixator.
    MeSH term(s) Bone Screws/standards ; Bone Screws/trends ; Femoral Fractures/surgery ; Fracture Fixation, Internal/methods ; Fracture Fixation, Internal/trends ; Humans ; Knee Injuries/surgery ; Minimally Invasive Surgical Procedures/methods ; Minimally Invasive Surgical Procedures/trends ; Treatment Outcome
    Language English
    Publishing date 2001-12
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 218778-4
    ISSN 1879-0267 ; 0020-1383
    ISSN (online) 1879-0267
    ISSN 0020-1383
    DOI 10.1016/s0020-1383(01)00182-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 778: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 10: Show issues

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  7. Article: Letter from Samuel Cole, M. D., Berlin, Prussia.

    Cole, Sam'l

    The Chicago medical journal

    2023  Volume 25, Issue 16, Page(s) 537–542

    Language English
    Publishing date 2023-07-06
    Publishing country United States
    Document type Journal Article
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  8. Article: Detection mechanisms in L-, M-, and S-cone contrast space.

    Cole, G R / Hine, T / McIlhagga, W

    Journal of the Optical Society of America. A, Optics and image science

    1993  Volume 10, Issue 1, Page(s) 38–51

    Abstract: ... chromatic mechanism driven by delta L/L--delta M/M with no S-cone input that was 1 order of magnitude more ... input and a blue-yellow chromatic mechanism with the S cone opposed to L and M cones. ... 9 degrees white adapting field of 1070 trolands. The spot's contrast was represented in an L-, M ...

    Abstract Detection thresholds were obtained for a 2 degrees Gaussian-blurred spot flashed for 200 ms on an 8.9 degrees white adapting field of 1070 trolands. The spot's contrast was represented in an L-, M-, and S-cone contrast space. Detection thresholds were obtained for many vectors close to specific but theoretically important planes within this space. A three-dimensional surface was fitted to the data generated by the probability summation of three mechanisms, each a weighted sum of cone contrasts. The fit revealed a red-green chromatic mechanism driven by delta L/L--delta M/M with no S-cone input that was 1 order of magnitude more sensitive than the two other mechanisms. The latter consisted of a luminance mechanism with little S-cone input and a blue-yellow chromatic mechanism with the S cone opposed to L and M cones.
    MeSH term(s) Color Perception/physiology ; Contrast Sensitivity/physiology ; Humans ; Male ; Mathematics ; Photoreceptor Cells/physiology ; Sensory Thresholds ; Visual Perception/physiology
    Language English
    Publishing date 1993-01
    Publishing country United States
    Document type Journal Article
    ZDB-ID 283633-6
    ISSN 1520-8532 ; 0740-3232 ; 1084-7529
    ISSN (online) 1520-8532
    ISSN 0740-3232 ; 1084-7529
    DOI 10.1364/josaa.10.000038
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.B 2689: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  9. Book ; Online: Chapter 7 Review: Effects of Microplastic on Zooplankton Survival and Sublethal Responses

    Yu, Sing-Pei Yu / Cole, Matthew Cole / Chan, Benny K. K.

    2020  

    Keywords Marine biology ; Volume, Todd, Swearer, Smith, S, Russell, Review, P, OMBAR, Oceanography, Marine, L, I, Hawkins, Firth, Evans, Biology, Bates,B, Annual, Allcock
    Size 1 Online-Ressource
    Publisher Taylor and Francis
    Document type Book ; Online
    Note English[eng] ; Open Access
    HBZ-ID HT021028850
    ISBN 9780367524722 ; 0367524724
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  10. Article: Perspectives on fundamental cosmology from Low Earth Orbit and the Moon.

    Bertone, Gianfranco / Buchmueller, Oliver L / Cole, Philippa S

    NPJ microgravity

    2023  Volume 9, Issue 1, Page(s) 10

    Abstract: The next generation of space-based experiments will go hunting for answers to cosmology's key open questions which revolve around inflation, dark matter and dark energy. Low earth orbit and lunar missions within the European Space Agency's Human and ... ...

    Abstract The next generation of space-based experiments will go hunting for answers to cosmology's key open questions which revolve around inflation, dark matter and dark energy. Low earth orbit and lunar missions within the European Space Agency's Human and Robotic Exploration programme can push our knowledge forward in all of these three fields. A radio interferometer on the Moon, a cold atom interferometer in low earth orbit and a gravitational wave interferometer on the Moon are highlighted as the most fruitful missions to plan and execute in the mid-term.
    Language English
    Publishing date 2023-02-01
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2823626-9
    ISSN 2373-8065
    ISSN 2373-8065
    DOI 10.1038/s41526-022-00243-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

To top