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Article ; Online: Knowledge of and stated adherence to the 2020 ACR Guideline for Gout Management: Results of a survey of US rheumatologists.

Schlesinger, Naomi / Pillinger, Michael H / Lipsky, Peter E

2024

Abstract: ... mean stated adherence score: 12.3 vs 11.3; P ≤ 0.05). Rheumatologists who claimed to see ≤75 patients ... to have seen >75 patients (P ≤ 0.05). Approximately 78% of rheumatologists claimed to follow the guideline ...

Abstract	Objective: This report evaluates rheumatologists' stated adherence to and agreement with the 2020 American College of Rheumatology (ACR) Guideline for the Management of Gout. Methods: A 57-item questionnaire was administered to US rheumatologists. Stated adherence scores were based on several guideline recommendations reported to be followed by rheumatologists in practice, whereas stated agreement scores were based on whether respondents always followed the recommendations. Results: All 201 rheumatologists completed the questionnaire. The mean overall stated adherence score was 11.5 (maximum: 15), whereas the mean overall stated agreement score was 7.7 (maximum: 14). Less experienced rheumatologists (≤8 years; n=49) were likely to claim adherence to more individual ACR recommendations than those with more experience (>8 years; n=152; mean stated adherence score: 12.3 vs 11.3; P ≤ 0.05). Rheumatologists who claimed to see ≤75 patients with gout in 6 months (n=66) had a mean stated adherence score of 12.1 versus 11.2 for those who claimed to have seen >75 patients (P ≤ 0.05). Approximately 78% of rheumatologists claimed to follow the guideline for initiating urate-lowering therapy (ULT), and 89% were likely to prescribe allopurinol as a first-line ULT. Claimed adherence to recommendations for dosing was lower (febuxostat, 43%; allopurinol, 39%). Rheumatologists from academic settings were more likely to prescribe an interleukin-1 inhibitor for gout flares. Conclusion: The self-reported practice of the surveyed US rheumatologists was generally concordant with the 2020 ACR Guideline for the Management of Gout. However, there were gaps in guideline knowledge and stated adherence among rheumatologists, mainly concerning the dosing of treatment regimens.
Language	English
Publishing date	2024-04-15
Publishing country	Canada
Document type	Journal Article
ZDB-ID	194928-7
ISSN	1499-2752 ; 0315-162X
ISSN (online)	1499-2752
ISSN	0315-162X
DOI	10.3899/jrheum.2023-0981
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Article ; Online: Biogeochemical constraints on climate change mitigation through regenerative farming

Schlesinger, William H.

Biogeochemistry. 2022 Oct., v. 161, no. 1 p.9-17

2022

Abstract: This review suggests that most of the management practices associated with regenerative agriculture are not likely to lead to a large net sequestration of organic carbon in soils. Some improved management practices, such as increased fertilizer use, ... ...

Abstract	This review suggests that most of the management practices associated with regenerative agriculture are not likely to lead to a large net sequestration of organic carbon in soils. Some improved management practices, such as increased fertilizer use, manuring, and applications of biochar, are constrained by biogeochemical stoichiometry and the availability of organic inputs. Other management practices, such as fertilizer applications, irrigation, and applications of ground silicate minerals, entail ancillary and off-site emissions of carbon dioxide that reduce the net sequestration of carbon in soils. Carbon sequestration in agricultural soils, even with best management practices, is only likely to offer a small net storage of carbon that can be marketed as a credit to emissions from other sectors of the economy.
Keywords	biochar ; carbon ; carbon dioxide ; carbon sequestration ; climate change ; credit ; fertilizer application ; fertilizers ; irrigation ; silicates ; stoichiometry ; sustainable agriculture
Language	English
Dates of publication	2022-10
Size	p. 9-17.
Publishing place	Springer International Publishing
Document type	Article ; Online
ZDB-ID	1478541-9
ISSN	1573-515X ; 0168-2563
ISSN (online)	1573-515X
ISSN	0168-2563
DOI	10.1007/s10533-022-00942-8
Database	NAL-Catalogue (AGRICOLA)

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Article ; Conference proceedings: Von der Blase in die Lunge – ein Fall aus unserem ASV-Netzwerk

Banahan, S / Orbach, H / Stamm, P / Wende, W / Schröder, J / Schlesinger, A

Pneumologie

2024 Volume 78, Issue S 01

Event/congress	64. Kongress der Deutschen Gesellschaft für Pneumologie und Beatmungsmedizin e. V., Mannheim, 2024-03-20
Language	German
Publishing date	2024-03-01
Publisher	Georg Thieme Verlag
Publishing place	Stuttgart ; New York
Document type	Article ; Conference proceedings
ZDB-ID	607630-0
ISSN	1438-8790 ; 0934-8387
ISSN (online)	1438-8790
ISSN	0934-8387
DOI	10.1055/s-0044-1778815
Database	Thieme publisher's database

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Article ; Conference proceedings: Das Kölner Lungenbett – Etablierung und Ausrichtung einer respiratory care unit innerhalb einer internistisch geführten Notaufnahme der Grund- und Regelversorgung – eine retrospektive 5 Jahres Analyse

Schlesinger, A / Paschke, S / Schröder, J / Mertens, S / Orbach, H / Liesegang, P / Bauer, F

Pneumologie

2024 Volume 78, Issue S 01

Event/congress	64. Kongress der Deutschen Gesellschaft für Pneumologie und Beatmungsmedizin e. V., Mannheim, 2024-03-20
Language	German
Publishing date	2024-03-01
Publisher	Georg Thieme Verlag
Publishing place	Stuttgart ; New York
Document type	Article ; Conference proceedings
ZDB-ID	607630-0
ISSN	1438-8790 ; 0934-8387
ISSN (online)	1438-8790
ISSN	0934-8387
DOI	10.1055/s-0044-1778838
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Article ; Online: Do differences in surgical quality account for the higher rate of R1 margins to lymph node metastases in right- versus left-sided Stage III colon cancer: A retrospective cohort study.

Smith, Henry G / Chiranth, Deepthi J / Schlesinger, Nis H

Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland

2023 Volume 25, Issue 4, Page(s) 679–687

Abstract: ... margins were more common in right-sided cancers (14.4% vs. 6.1%, P < 0.001). All three surgical ... quality indicators were higher in patients with right-sided cancers (mesocolic resection planes 81.7% vs. 69.5%, P ... < 0.001; median lymph node yield 28 vs. 25, P < 0.001; ≥5 cm to the distal colon margin 81.2% vs. 53.6 ...

Abstract	Aim: Microscopically positive (R1) margins to lymph node metastases (R1LNM) are associated with poorer oncological outcomes in patients with Stage III colon cancer. R1LNM margins are more common in right-sided cancer, although the cause of this phenomenon is unknown. We sought to investigate whether differences in surgical quality account for the higher rate of R1LNM in right-sided cancers. Method: Patients treated for Stage III colon cancer from 1 January 2016 to 31 December 2018 were identified using the Danish national cancer registry. Indicators of surgical quality (mesocolic resection grade, median lymph node yield, and length to the distal colonic margin) were compared according to tumour site and margin status. Results: In all, 1765 patients were included, 981 (55.6%) with right-sided cancers. R1LNM margins were more common in right-sided cancers (14.4% vs. 6.1%, P < 0.001). All three surgical quality indicators were higher in patients with right-sided cancers (mesocolic resection planes 81.7% vs. 69.5%, P < 0.001; median lymph node yield 28 vs. 25, P < 0.001; ≥5 cm to the distal colon margin 81.2% vs. 53.6%, P < 0.001). When stratified according to margin status, no differences in mesocolic resection planes or resectate length were noted, whilst median lymph node yield was higher in patients with R1LNM margins (29 vs. 27, P = 0.009). Conclusion: Surgical quality does not appear to be poorer in patients undergoing surgery for right-sided versus left-sided colon cancers in Denmark. Suboptimal surgery does not appear to be responsible for R1LNM margins, implying that these margins may be a surrogate for more aggressive biology.
MeSH term(s)	Humans ; Lymphatic Metastasis/pathology ; Retrospective Studies ; Colonic Neoplasms/pathology ; Lymph Nodes/surgery ; Lymph Nodes/pathology ; Lymph Node Excision ; Colectomy/adverse effects
Language	English
Publishing date	2023-01-08
Publishing country	England
Document type	Journal Article
ZDB-ID	1440017-0
ISSN	1463-1318 ; 1462-8910
ISSN (online)	1463-1318
ISSN	1462-8910
DOI	10.1111/codi.16459
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Zs.A 5799: Show issues

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Article ; Online: Incorporation of Brain Connectomics for Stereotactic Radiosurgery Treatment Planning.

Dayawansa, Sam / Schlesinger, David / Mantziaris, Georgios / Dumot, Chloe / Donahue, Joseph H / Sheehan, Jason P

Operative neurosurgery (Hagerstown, Md.)

2023 Volume 25, Issue 4, Page(s) e211–e215

Abstract: Background and importance: Neurosurgeons have integrated neuroanatomy-based tractography to avoid critical structures during dose planning. However, they have yet to integrate more comprehensive connectome networks for radiosurgical planning.: ... ...

Abstract	Background and importance: Neurosurgeons have integrated neuroanatomy-based tractography to avoid critical structures during dose planning. However, they have yet to integrate more comprehensive connectome networks for radiosurgical planning. Clinical presentation: A young man presented with a Spetzler-Martin Grade 3 right temporal arteriovenous malformation. Discussion: As proof of concept, we incorporated connectomic networks including default mode network, optic radiation and central executive network into the Gamma Knife radiosurgical treatment planning workflow. Connectome networks were created from T1 anatomic and diffusion-weighted images magnetic resonance images using Quicktome software. The resulting networks were voxel-encoded in the magnetic resonance images, imported into GammaPlan, and segmented by image thresholding. The GammaPlan Lightning optimizer was used to create radiosurgical plans with a dose of 20 Gy to the 50% isodose line delivered to the arteriovenous malformation nidus both with and without treating these networks as risk structures. When taking into account the connectome networks, a maximum dose restriction of 14 Gy was placed on each network during lightning dose planning. With default mode network, optic radiation, and central executive network as risk structures, the maximum dose and V 12Gy were reduced by 23.4% and 88.3%, 20% and 34.3%, and 29.8% and 63.2%, respectively. Conclusion: We were able to incorporate connectomes into radiosurgical dose planning approaches. This allowed for dose reductions to the networks while still achieving delivery of a therapeutic dose to the target volume.
MeSH term(s)	Male ; Humans ; Radiosurgery/methods ; Connectome ; Intracranial Arteriovenous Malformations/diagnostic imaging ; Intracranial Arteriovenous Malformations/radiotherapy ; Intracranial Arteriovenous Malformations/surgery ; Magnetic Resonance Imaging ; Software
Language	English
Publishing date	2023-08-03
Publishing country	United States
Document type	Journal Article
ZDB-ID	2767575-0
ISSN	2332-4260 ; 2332-4252
ISSN (online)	2332-4260
ISSN	2332-4252
DOI	10.1227/ons.0000000000000818
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Zs.A 1424 -ON-: Show issues

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Article ; Online: Global emissions of NH

Bray, Casey D / Battye, William H / Aneja, Viney P / Schlesinger, William H

Journal of the Air & Waste Management Association (1995)

2020 Volume 71, Issue 1, Page(s) 102–114

Abstract: Emissions of ammonia ( ... ...

Abstract	Emissions of ammonia (NH
MeSH term(s)	Ammonia ; Biomass ; Climate Change ; Nitrogen ; Nitrous Oxide
Chemical Substances	Ammonia (7664-41-7) ; Nitrous Oxide (K50XQU1029) ; Nitrogen (N762921K75)
Language	English
Publishing date	2020-12-07
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1003064-5
ISSN	2162-2906 ; 0894-0630 ; 1047-3289 ; 1096-2247
ISSN (online)	2162-2906
ISSN	0894-0630 ; 1047-3289 ; 1096-2247
DOI	10.1080/10962247.2020.1842822
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Zs.A 748: Show issues

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Article ; Online: The impact of subdivisions of microscopically positive (R1) margins on patterns of relapse in stage III colorectal cancer - A retrospective cohort study.

Smith, Henry G / Skovgaards, Daniel M / Chiranth, Deepthi / Schlesinger, Nis H

Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland

2022 Volume 24, Issue 7, Page(s) 828–837

Abstract: ... p = 0.008; R1LNM HR 1.59, CI: 1.12-2.27, p = 0.009) and disease-related death (R1 tumour HR 2.08, CI ... 1.12-3.85, p = 0.020; R1LNM HR 1.84, CI: 1.12-3.02, p = 0.016). Whereas R1 tumour margins were ...

Abstract	Aim: Microscopically positive (R1) margins are associated with poorer outcomes in patients with colorectal cancer. However, the impact of subdivisions of R1 margins, be they to the primary tumour (R1 tumour) or to lymph node metastases (R1LNM), on patterns of relapse is unknown. Methods: Patients treated for stage III colorectal cancer from 01 January 2016 to 31 December 2019 in four specialist centres were identified from the Danish national cancer registry. Patients were stratified into three groups according to margin status (R0 vs. R1 tumour vs. R1LNM). The primary outcomes were local recurrence-free survival (LRFS), distant metastases-free survival (DMFS) and disease-specific survival (DSS). Results: A total of 1,164 patients were included, with R1 margins found in 237 (20.4%). Irrespective of tumour location, R1 tumour and R1LNM margins were independent prognostic factors for systemic relapse (R1 tumour HR 1.84, CI: 1.17-2.88, p = 0.008; R1LNM HR 1.59, CI: 1.12-2.27, p = 0.009) and disease-related death (R1 tumour HR 2.08, CI: 1.12-3.85, p = 0.020; R1LNM HR 1.84, CI: 1.12-3.02, p = 0.016). Whereas R1 tumour margins were associated with poorer 3-year LRFS in both colon and rectum cancer, R1LNM margins only reduced LRFS in patients with rectal cancer. Patterns of relapse differed between R1 subdivisions, with R1 tumour margins more likely to affect multiple anatomical sites, with a predilection for extra-hepatic/pulmonary metastases. Conclusion: Subdivisions of R1 margins have a distinct impact on the oncological outcomes and patterns of disease relapse in patients with stage III colorectal cancer.
MeSH term(s)	Colorectal Neoplasms/pathology ; Colorectal Neoplasms/surgery ; Humans ; Liver Neoplasms/secondary ; Margins of Excision ; Neoplasm Recurrence, Local ; Prognosis ; Retrospective Studies ; Survival Rate
Language	English
Publishing date	2022-03-31
Publishing country	England
Document type	Journal Article
ZDB-ID	1440017-0
ISSN	1463-1318 ; 1462-8910
ISSN (online)	1463-1318
ISSN	1462-8910
DOI	10.1111/codi.16121
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Zs.A 5799: Show issues

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Article ; Online: Learning from patients: The impact of using patients' narratives on patient experience scores.

Nembhard, Ingrid M / Matta, Sasmira / Shaller, Dale / Lee, Yuna S H / Grob, Rachel / Schlesinger, Mark

Health care management review

2023 Volume 49, Issue 1, Page(s) 2–13

Abstract: ... on staff confidence in own knowledge ( p < .01). For operational measures (e.g., care coordination ...

Abstract	Background: Enthusiasm has grown about using patients' narratives-stories about care experiences in patients' own words-to advance organizations' learning about the care that they deliver and how to improve it, but studies confirming association have not been published. Purpose: We assessed whether primary care clinics that frequently share patients' narratives with their staff have higher patient experience survey scores. Approach: We conducted a 1-year study of 5,545 adult patients and 276 staff affiliated with nine clinics in one health system. We used multilevel models to analyze survey data from patients about their experiences and from staff about exposure to useful narratives. We examined staff confidence in own knowledge as a moderator because confidence can influence use of new information sources. Results: Frequency of sharing useful narratives with staff was associated with patient experience scores for all measures, conditional on staff confidence in own knowledge ( p < .01). For operational measures (e.g., care coordination), increased sharing correlated with subsequently higher performance for more confident staff and lower performance or no difference for less confident staff, depending on measure. For relational measures (e.g., patient-provider communication), increased sharing correlated with higher scores for less confident staff and lower scores for more confident staff. Conclusion: Sharing narratives with staff frequently is associated with better patient experience survey scores, conditional on confidence in knowledge. Practice implications: Frequently sharing useful patient narratives should be encouraged as an organizational improvement strategy. However, organizations need to address how narrative feedback interacts with their staff's confidence to realize higher experience scores across domains.
MeSH term(s)	Adult ; Humans ; Communication ; Information Sources ; Patient Outcome Assessment
Language	English
Publishing date	2023-11-29
Publishing country	United States
Document type	Journal Article
ZDB-ID	430366-0
ISSN	1550-5030 ; 0361-6274
ISSN (online)	1550-5030
ISSN	0361-6274
DOI	10.1097/HMR.0000000000000386
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Article ; Online: Stellungnahme der AG pneumologische Altersmedizin zu COVID-19 bei geriatrischen Patienten.

Stieglitz, S / Frohnhofen, H / Netzer, N / Haidl, P / Orth, M / Schlesinger, A

Pneumologie (Stuttgart, Germany)

2020 Volume 74, Issue 8, Page(s) 505–508

Title translation	Recommendations for the Treatment of Elderly Patients with COVID-19 from the Taskforce for Gerontopneumology.
MeSH term(s)	Aged ; Betacoronavirus ; Coronavirus/isolation & purification ; Coronavirus Infections/diagnosis ; Coronavirus Infections/drug therapy ; Geriatrics ; Germany ; Humans ; Pandemics ; Pneumonia, Viral/diagnosis ; Pneumonia, Viral/drug therapy ; Practice Guidelines as Topic ; Societies, Medical
Keywords	covid19
Language	German
Publishing date	2020-05-20
Publishing country	Germany
Document type	Journal Article
ZDB-ID	607630-0
ISSN	1438-8790 ; 0934-8387
ISSN (online)	1438-8790
ISSN	0934-8387
DOI	10.1055/a-1177-3588
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