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  1. Book ; Online: Grille d’observation des premières compétences en littératie d’élèves en situation de handicap

    Moreau, André C. / Tremblay, Karine N.

    recherche-développement et première étape de validation

    2023  

    Abstract: L’apprentissage des compétences en littératie, volet langage oral et écrit, représente un vecteur de réussite scolaire et sociale pour tous les apprenants, dont les élèves en situation de handicap découlant d’une déficience intellectuelle ou d’un déficit ...

    Abstract L’apprentissage des compétences en littératie, volet langage oral et écrit, représente un vecteur de réussite scolaire et sociale pour tous les apprenants, dont les élèves en situation de handicap découlant d’une déficience intellectuelle ou d’un déficit du langage. Pour le personnel, l’observation des acquis et de la progression des apprentissages des compétences essentielles à lire et à écrire pour planifier et réguler les interventions représentent un défi. L’objectif est de présenter une recherche-développement d’une grille d’observation aux fins de l’évaluation formative-régulative en enseignement des premières compétences en littératie auprès de ces élèves. La discussion ouvre sur les retombées pratiques, les limites et aussi les pistes de recherche.
    Keywords langage écrit ; lecture ; écriture ; situation de handicap ; déficience intellectuelle ; déficience langagière
    Language French
    Publisher Département des sciences de l'éducation
    Publishing country ca
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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  2. Article: Moving towards the implementation of pharmacogenetic testing in Quebec.

    Li, Ling Jing / Legeay, Samuel / Gagnon, Ann-Lorie / Frigon, Marie-Pier / Tessier, Laurence / Tremblay, Karine

    Frontiers in genetics

    2024  Volume 14, Page(s) 1295963

    Abstract: Clinical implementation of pharmacogenetics (PGx) into routine care will elevate the current paradigm of treatment decisions. However, while PGx tests are increasingly becoming reliable and affordable, several barriers have limited their widespread usage ...

    Abstract Clinical implementation of pharmacogenetics (PGx) into routine care will elevate the current paradigm of treatment decisions. However, while PGx tests are increasingly becoming reliable and affordable, several barriers have limited their widespread usage in Canada. Globally, over ninety successful PGx implementors can serve as models. The purpose of this paper is to outline the PGx implementation barriers documented in Quebec (Canada) to suggest efficient solutions based on existing PGx clinics and propose an adapted clinical implementation model. We conclude that the province of Quebec is ready to implement PGx.
    Language English
    Publishing date 2024-01-03
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2606823-0
    ISSN 1664-8021
    ISSN 1664-8021
    DOI 10.3389/fgene.2023.1295963
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Bacterial Biomarkers of the Oropharyngeal and Oral Cavity during SARS-CoV-2 Infection.

    Bourumeau, William / Tremblay, Karine / Jourdan, Guillaume / Girard, Catherine / Laprise, Catherine

    Microorganisms

    2023  Volume 11, Issue 11

    Abstract: 1) Background: Individuals with COVID-19 display different forms of disease severity and the upper respiratory tract microbiome has been suggested to play a crucial role in the development of its symptoms. (2) Methods: The present study analyzed the ... ...

    Abstract (1) Background: Individuals with COVID-19 display different forms of disease severity and the upper respiratory tract microbiome has been suggested to play a crucial role in the development of its symptoms. (2) Methods: The present study analyzed the microbial profiles of the oral cavity and oropharynx of 182 COVID-19 patients compared to 75 unaffected individuals. The samples were obtained from gargle screening samples. 16S rRNA amplicon sequencing was applied to analyze the samples. (3) Results: The present study shows that SARS-CoV-2 infection induced significant differences in bacterial community assemblages, with
    Language English
    Publishing date 2023-11-04
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2720891-6
    ISSN 2076-2607
    ISSN 2076-2607
    DOI 10.3390/microorganisms11112703
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  4. Article ; Online: Fear of COVID-19 and parental violence: The mediating role of parental burnout and child perceived as difficult.

    Perron-Tremblay, Roxanne / Clément, Marie-Ève / Dubois-Comtois, Karine

    Child abuse & neglect

    2023  Volume 143, Page(s) 106284

    Abstract: Background: Since the beginning of the COVID-19 pandemic, there has been a worldwide increase in the incidence of child abuse. Studies show that the pandemic context contributes to exacerbate several risk factors usually associated with the use of ... ...

    Abstract Background: Since the beginning of the COVID-19 pandemic, there has been a worldwide increase in the incidence of child abuse. Studies show that the pandemic context contributes to exacerbate several risk factors usually associated with the use of violent disciplinary practices.
    Objective: This study aims to better understand the role of parental burnout and child perceived as difficult as a parental stressor in the link between fear of COVID-19 and the use of parental violence (minor and severe physical violence and repeated psychological aggression).
    Participants: The sample includes 467 mothers living in Québec (Canada) with a child aged 5 or less.
    Method: An online questionnaire, administered one year after the beginning of the COVID-19 pandemic in Québec (March to May 2021), was used to measure parental violence, parental burnout, parental stress related to the perception of the child as difficult and fear of COVID-19. Serial mediation analyses were performed.
    Results: The main analyses confirmed the indirect association between fear of COVID-19 and the three forms of parental violence studied, through parental burnout and the child perceived as difficult. Unlike physical violence (minor and severe), the association between fear of COVID-19 and repeated psychological aggression is explained only by parental burnout.
    Conclusions: This study has identified new mechanisms that allow a better understanding of processes underlying parental violence during the pandemic. It also shows that parental violence can also occur in low-risk families. It is crucial to develop strategies to prevent the use of violent disciplinary practices in future socio-health crises such as the COVID-19 pandemic.
    MeSH term(s) Female ; Child ; Humans ; Pandemics ; COVID-19/epidemiology ; Violence/psychology ; Parents/psychology ; Fear ; Burnout, Psychological/epidemiology
    Language English
    Publishing date 2023-06-15
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 799143-5
    ISSN 1873-7757 ; 0145-2134
    ISSN (online) 1873-7757
    ISSN 0145-2134
    DOI 10.1016/j.chiabu.2023.106284
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1437: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  5. Article: Transcription Factors in the Regulation of Leydig Cell Gene Expression and Function.

    de Mattos, Karine / Viger, Robert S / Tremblay, Jacques J

    Frontiers in endocrinology

    2022  Volume 13, Page(s) 881309

    Abstract: Cell differentiation and acquisition of specialized functions are inherent steps in events that lead to normal tissue development and function. These processes require accurate temporal, tissue, and cell-specific activation or repression of gene ... ...

    Abstract Cell differentiation and acquisition of specialized functions are inherent steps in events that lead to normal tissue development and function. These processes require accurate temporal, tissue, and cell-specific activation or repression of gene transcription. This is achieved by complex interactions between transcription factors that form a unique combinatorial code in each specialized cell type and in response to different physiological signals. Transcription factors typically act by binding to short, nucleotide-specific DNA sequences located in the promoter region of target genes. In males, Leydig cells play a crucial role in sex differentiation, health, and reproductive function from embryonic life to adulthood. To better understand the molecular mechanisms regulating Leydig cell differentiation and function, several transcription factors important to Leydig cells have been identified, including some previously unknown to this specialized cell type. This mini review summarizes the current knowledge on transcription factors in fetal and adult Leydig cells, describing their roles and mechanisms of action.
    MeSH term(s) Adult ; Base Sequence ; Gene Expression ; Humans ; Leydig Cells ; Male ; Promoter Regions, Genetic ; Transcription Factors/genetics ; Transcription Factors/metabolism
    Chemical Substances Transcription Factors
    Language English
    Publishing date 2022-04-07
    Publishing country Switzerland
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 2592084-4
    ISSN 1664-2392
    ISSN 1664-2392
    DOI 10.3389/fendo.2022.881309
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Book ; Online: Littératie et situations de handicap

    Tremblay, Karine N. / Moreau, André C. / Jolicoeur, Edith / Beaulieu, Judith

    obstacles, défis et actions

    2023  

    Language French
    Publisher Département des sciences de l'éducation
    Publishing country ca
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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    Inter-library loan at ZB MED

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  7. Article: Insights Into the Roles of GATA Factors in Mammalian Testis Development and the Control of Fetal Testis Gene Expression.

    Viger, Robert S / de Mattos, Karine / Tremblay, Jacques J

    Frontiers in endocrinology

    2022  Volume 13, Page(s) 902198

    Abstract: Defining how genes get turned on and off in a correct spatiotemporal manner is integral to our understanding of the development, differentiation, and function of different cell types in both health and disease. Testis development and subsequent male sex ... ...

    Abstract Defining how genes get turned on and off in a correct spatiotemporal manner is integral to our understanding of the development, differentiation, and function of different cell types in both health and disease. Testis development and subsequent male sex differentiation of the XY fetus are well-orchestrated processes that require an intricate network of cell-cell communication and hormonal signals that must be properly interpreted at the genomic level. Transcription factors are at the forefront for translating these signals into a coordinated genomic response. The GATA family of transcriptional regulators were first described as essential regulators of hematopoietic cell differentiation and heart morphogenesis but are now known to impact the development and function of a multitude of tissues and cell types. The mammalian testis is no exception where GATA factors play essential roles in directing the expression of genes crucial not only for testis differentiation but also testis function in the developing male fetus and later in adulthood. This minireview provides an overview of the current state of knowledge of GATA factors in the male gonad with a particular emphasis on their mechanisms of action in the control of testis development, gene expression in the fetal testis, testicular disease, and XY sex differentiation in humans.
    MeSH term(s) Adult ; Animals ; Fetus/metabolism ; GATA Transcription Factors/genetics ; GATA Transcription Factors/metabolism ; GATA4 Transcription Factor/genetics ; GATA4 Transcription Factor/metabolism ; Gene Expression ; Humans ; Male ; Mammals/genetics ; Sex Differentiation/genetics ; Testis/metabolism ; Transcription Factors/metabolism
    Chemical Substances GATA Transcription Factors ; GATA4 Transcription Factor ; Transcription Factors
    Language English
    Publishing date 2022-05-26
    Publishing country Switzerland
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 2592084-4
    ISSN 1664-2392
    ISSN 1664-2392
    DOI 10.3389/fendo.2022.902198
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Moving towards the implementation of pharmacogenetic testing in Quebec

    Ling Jing Li / Samuel Legeay / Ann-Lorie Gagnon / Marie-Pier Frigon / Laurence Tessier / Karine Tremblay

    Frontiers in Genetics, Vol

    2024  Volume 14

    Abstract: Clinical implementation of pharmacogenetics (PGx) into routine care will elevate the current paradigm of treatment decisions. However, while PGx tests are increasingly becoming reliable and affordable, several barriers have limited their widespread usage ...

    Abstract Clinical implementation of pharmacogenetics (PGx) into routine care will elevate the current paradigm of treatment decisions. However, while PGx tests are increasingly becoming reliable and affordable, several barriers have limited their widespread usage in Canada. Globally, over ninety successful PGx implementors can serve as models. The purpose of this paper is to outline the PGx implementation barriers documented in Quebec (Canada) to suggest efficient solutions based on existing PGx clinics and propose an adapted clinical implementation model. We conclude that the province of Quebec is ready to implement PGx.
    Keywords pharmacogenetic testing ; pharmacogenomics ; precision medicine ; clinical implementation ; challenges pharmacogenetics testing implementation in Quebec ; Genetics ; QH426-470
    Language English
    Publishing date 2024-01-01T00:00:00Z
    Publisher Frontiers Media S.A.
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Book ; Online: Croyances à propos de l’enseignement des compétences en littératie auprès d’élèves ayant une déficience intellectuelle

    Jolicoeur, Edith / Moreau, André C. / Tremblay, Karine N. / Beaulieu, Judith

    recension des écrits scientifiques

    2023  

    Abstract: Dans les dernières années, des efforts ont été mis en place afin de favoriser l'accès à la littératie pour les élèves ayant une déficience intellectuelle (DI) (Allor et al., 2014; Sermier-Dessemontet, 2020). Cet article présente une recension d'articles ... ...

    Abstract Dans les dernières années, des efforts ont été mis en place afin de favoriser l'accès à la littératie pour les élèves ayant une déficience intellectuelle (DI) (Allor et al., 2014; Sermier-Dessemontet, 2020). Cet article présente une recension d'articles abordant les croyances de futurs enseignants, d'enseignants et d'autres acteurs scolaires au sujet de l'enseignement des compétences en littératie auprès d'élèves ayant une DI. Considérant les variations des études documentées (n=7), la discussion porte sur les résultats différenciés des articles analysés. Les différents acteurs scolaires ne croient pas être suffisamment formés pour développer les compétences en littératie des élèves ayant une DI.
    Keywords déficience intellectuelle moyenne à sévère ; littératie ; apprentissage ; croyances ; recension
    Language French
    Publisher Département des sciences de l'éducation
    Publishing country ca
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  10. Article ; Online: SB-258585 reduces food motivation while blocking 5-HT

    Pitoy, Mathilde / Gauthier, Lisa / Debatisse, Justine / Maulavé, Julie / Météreau, Elise / Beaudoin, Maude / Portier, Karine / Sgambato, Véronique / Billard, Thierry / Zimmer, Luc / Lancelot, Sophie / Tremblay, Léon

    Progress in neuro-psychopharmacology & biological psychiatry

    2024  Volume 131, Page(s) 110970

    Abstract: The interest in new 5-HT₆ agents stems from their ability to modulate cognition processing, food motivation and anxiety-like behaviors. While these findings come primarily from rodent studies, no studies on primates have been published. Furthermore, our ... ...

    Abstract The interest in new 5-HT₆ agents stems from their ability to modulate cognition processing, food motivation and anxiety-like behaviors. While these findings come primarily from rodent studies, no studies on primates have been published. Furthermore, our understanding of where and how they act in the brain remains limited. Although the striatum is involved in all of these processes and expresses the highest levels of 5-HT₆ receptors, few studies have focused on it. We thus hypothesized that 5-HT
    MeSH term(s) Animals ; Male ; Motivation ; Serotonin ; Primates ; Piperazines ; Receptors, Serotonin ; Sulfonamides
    Chemical Substances serotonin 6 receptor ; SB 258585 ; Serotonin (333DO1RDJY) ; Piperazines ; Receptors, Serotonin ; Sulfonamides
    Language English
    Publishing date 2024-02-13
    Publishing country England
    Document type Journal Article
    ZDB-ID 781181-0
    ISSN 1878-4216 ; 0278-5846
    ISSN (online) 1878-4216
    ISSN 0278-5846
    DOI 10.1016/j.pnpbp.2024.110970
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1342: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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