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  1. Article ; Online: Serum responsiveness to recombinant bovine somatotropin in buffalo: a three-month lactation study using an acid-stripping ELISA for screening.

    Castigliego, Lorenzo / Tinacci, Lara / Armani, Andrea / Boselli, Carlo / Grifoni, Goffredo / Mazzi, Marco / Guidi, Alessandra

    Drug testing and analysis

    2016  Volume 9, Issue 4, Page(s) 646–656

    Abstract: ... a new enzyme-linked immunosorbent assay (ELISA) to measure the serum responsiveness towards rbST, based ... of insulin-like growth factor 1 concentration in serum. Results showed that our ELISA could be used on its own for screening ...

    Abstract The misuse of recombinant bovine somatotropin (rbST) to increase milk yield involves buffalo not just cows. Screening methods to identify rbST-treated cattle have already been proposed. However, there have been no studies on prolonged periods with a high number of animals. In this study, we developed a new enzyme-linked immunosorbent assay (ELISA) to measure the serum responsiveness towards rbST, based on an acid-stripping procedure and relatively simple integral calculation dilution curves. We also applied the analysis to 640 serum and 96 milk samples collected from 16 buffalo treated with rbST and 16 controls, over a period of approximately three months. Its suitability as a screening method, in compliance with EU law, was also assessed. A bi-factorial approach was also evaluated, including the measurement of insulin-like growth factor 1 concentration in serum. Results showed that our ELISA could be used on its own for screening purposes, without the need to assess other biomarkers. Copyright © 2016 John Wiley & Sons, Ltd.
    MeSH term(s) Animals ; Buffaloes/blood ; Buffaloes/physiology ; Cattle ; Enzyme-Linked Immunosorbent Assay/methods ; Female ; Growth Hormone/analysis ; Growth Hormone/blood ; Insulin-Like Growth Factor I/analysis ; Lactation ; Limit of Detection ; Milk/chemistry ; Substance Abuse Detection/methods
    Chemical Substances Insulin-Like Growth Factor I (67763-96-6) ; Growth Hormone (9002-72-6)
    Language English
    Publishing date 2016-06-14
    Publishing country England
    Document type Journal Article
    ZDB-ID 2462336-2
    ISSN 1942-7611 ; 1942-7603
    ISSN (online) 1942-7611
    ISSN 1942-7603
    DOI 10.1002/dta.1994
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  2. Article: Natural and recombinant bovine somatotropin: immunodetection with a sandwich ELISA.

    Castigliego, Lorenzo / Iannone, Giorgio / Grifoni, Goffredo / Rosati, Remo / Gianfaldoni, Daniela / Guidi, Alessandra

    The Journal of dairy research

    2007  Volume 74, Issue 1, Page(s) 79–85

    Abstract: ... M. Hence, we developed a sandwich ELISA with the obtained antibodies for detection and ...

    Abstract Bovine Somatotropin (bST) is a peptide hormone secreted by the anterior pituitary gland and its recombinant form (rbST) is used for artificially boosting milk yield in cows. Identification of rbST is difficult in that there is little difference from the pituitary bST (pbST). In this work, we further studied the possibility of immunologically discriminating between rbST and pbST. With this purpose, we produced mouse monoclonal antibodies using, as antigen, a peptide mimicking the N-terminus of rbST from Monsanto (rbST-M) conjugated to keyhole limpet haemocyanin (KLH) and polyclonal antibodies in rabbits immunized with the whole bST or rbST-M. Hence, we developed a sandwich ELISA with the obtained antibodies for detection and quantification of bST in serum and compared its performance on the two worldwide commercialized rbSTs: rbST-M and rbST from LG Life Science (rbST-LG). The lowest detection limit of the assay was 0.05 ng/ml for rbST-M, 0.10 ng/ml for rbST-LG and 0.15 ng/ml for pbST. Furthermore, the assay showed the capability to amplify the signal in the presence of rbSTs, recognizing more efficiently rbST-M and rbST-LG than pbST (ECn pbST/ECn rbST: 3 and 1.6 respectively). Its employment for measuring bST levels in sera from bovines administered with rbST LG allowed us to detect exceptional values due to the treatment itself and probably further increased as a consequence of the higher affinity for rbSTs of our monoclonal antibody.
    MeSH term(s) Animals ; Antibodies, Monoclonal/immunology ; Cattle ; Enzyme-Linked Immunosorbent Assay/methods ; Enzyme-Linked Immunosorbent Assay/veterinary ; Female ; Growth Hormone/analysis ; Growth Hormone/immunology ; Mice ; Mice, Inbred BALB C ; Rabbits ; Recombinant Proteins/analysis ; Recombinant Proteins/immunology
    Chemical Substances Antibodies, Monoclonal ; Recombinant Proteins ; Growth Hormone (9002-72-6)
    Language English
    Publishing date 2007-02
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 242089-2
    ISSN 1469-7629 ; 0022-0299
    ISSN (online) 1469-7629
    ISSN 0022-0299
    DOI 10.1017/S0022029906002159
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  3. Article: Natural and recombinant bovine somatotropin: immunodetection with a sandwich ELISA

    Castigliego, L / Iannone, G / Grifoni, G / Rosati, R / Gianfaldoni, D / Guidi, A

    Journal of dairy research. 2007 Feb., v. 74, issue 1

    2007  

    Abstract: ... M. Hence, we developed a sandwich ELISA with the obtained antibodies for detection and ...

    Abstract Bovine Somatotropin (bST) is a peptide hormone secreted by the anterior pituitary gland and its recombinant form (rbST) is used for artificially boosting milk yield in cows. Identification of rbST is difficult in that there is little difference from the pituitary bST (pbST). In this work, we further studied the possibility of immunologically discriminating between rbST and pbST. With this purpose, we produced mouse monoclonal antibodies using, as antigen, a peptide mimicking the N-terminus of rbST from Monsanto (rbST-M) conjugated to keyhole limpet haemocyanin (KLH) and polyclonal antibodies in rabbits immunized with the whole bST or rbST-M. Hence, we developed a sandwich ELISA with the obtained antibodies for detection and quantification of bST in serum and compared its performance on the two worldwide commercialized rbSTs: rbST-M and rbST from LG Life Science (rbST-LG). The lowest detection limit of the assay was 0.05 ng/ml for rbST-M, 0.10 ng/ml for rbST-LG and 0.15 ng/ml for pbST. Furthermore, the assay showed the capability to amplify the signal in the presence of rbSTs, recognizing more efficiently rbST-M and rbST-LG than pbST (ECn pbST/ECn rbST: 3 and 1.6 respectively). Its employment for measuring bST levels in sera from bovines administered with rbST LG allowed us to detect exceptional values due to the treatment itself and probably further increased as a consequence of the higher affinity for rbSTs of our monoclonal antibody.
    Keywords cattle ; somatotropin ; enzyme-linked immunosorbent assay ; milk yield ; immunologic techniques ; detection ; animal models ; mice ; antibody detection ; milk ; milk analysis ; milk composition ; milk quality ; product authenticity
    Language English
    Dates of publication 2007-02
    Size p. 79-85.
    Document type Article
    ZDB-ID 242089-2
    ISSN 1469-7629 ; 0022-0299
    ISSN (online) 1469-7629
    ISSN 0022-0299
    DOI 10.1017/S0022029906002159
    Database NAL-Catalogue (AGRICOLA)

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  4. Article ; Online: Trends of thrombo-inflammation biomarkers after Tocilizumab predict treatment failure better than scores in patients with severe SARS-CoV2 related respiratory failure.

    Masotti, Luca / Cioni, Elisa / Grifoni, Elisa / Cei, Francesco / Tarquini, Roberto

    European journal of internal medicine

    2022  Volume 103, Page(s) 111–112

    MeSH term(s) Antibodies, Monoclonal, Humanized ; Biomarkers ; Humans ; Inflammation ; RNA, Viral ; Respiratory Insufficiency ; SARS-CoV-2 ; Treatment Failure ; COVID-19 Drug Treatment
    Chemical Substances Antibodies, Monoclonal, Humanized ; Biomarkers ; RNA, Viral ; tocilizumab (I031V2H011)
    Language English
    Publishing date 2022-06-06
    Publishing country Netherlands
    Document type Letter ; Comment
    ZDB-ID 1038679-8
    ISSN 1879-0828 ; 0953-6205
    ISSN (online) 1879-0828
    ISSN 0953-6205
    DOI 10.1016/j.ejim.2022.06.004
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    Zs.A 2608: Show issues Location:
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  5. Article ; Online: Interactive impacts of microplastics and arsenic on agricultural soil and plant traits.

    Grifoni, Martina / Pellegrino, Elisa / Arrighetti, Leonardo / Bronco, Simona / Pezzarossa, Beatrice / Ercoli, Laura

    The Science of the total environment

    2023  Volume 912, Page(s) 169058

    Abstract: The ability of microplastics (MPs) to interact with environmental pollutants is currently of great concern due to the increasing use of plastic. Agricultural soils are sinks for multipollutants and the safety of biodegradable MPs in field conditions is ... ...

    Abstract The ability of microplastics (MPs) to interact with environmental pollutants is currently of great concern due to the increasing use of plastic. Agricultural soils are sinks for multipollutants and the safety of biodegradable MPs in field conditions is questioned. However, still few studies have investigated the interactive effects between MPs and metals on the soil-plant system with agricultural soil and testing crops for human consumption. In this work, we tested the effect on soil and plant parameters of two common MPs, non-degradable plastic low-density polyethylene and biodegradable polymer polylactic acid at two different sizes (<250 μm and 250-300 μm) in association with arsenic (As). Lettuce (Lactuca sativa L.) was used as a model plant in a small-scale experiment lasting 60 days. Microplastics and As explained 12 % and 47 % of total variance, respectively, while their interaction explained 21 %, suggesting a higher toxic impact of As than MPs. Plant growth was promoted by MPs alone, especially when biodegradable MPs were added (+22 %). However, MPs did not affect nutrient concentrations in roots and leaves. The effect of MPs on enzyme activities was variable depending on the time of exposure (with larger effects immediately after exposure), the type and size of the MPs. On the contrary, the co-application of MP and As, although it did not change the amount of bioavailable As in soil in the short and medium term, it resulted in a significant decrease in lettuce biomass (-19 %) and root nutrient concentrations, especially when polylactic acid was applied. Generally, MPs in association with As determined the plant-soil toxicity. This work provides insights into the risk of copollution of MPs and As in agricultural soil and its phytotoxic effect for agricultural crops. However, the mechanisms of the joint effect of MP and As on plant toxicity need further investigation, especially under field conditions and in long-term experiments.
    MeSH term(s) Humans ; Soil ; Arsenic ; Microplastics ; Plastics ; Agriculture ; Crops, Agricultural ; Lactuca ; Polyethylene
    Chemical Substances Soil ; Arsenic (N712M78A8G) ; Microplastics ; Plastics ; Polyethylene (9002-88-4)
    Language English
    Publishing date 2023-12-08
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 121506-1
    ISSN 1879-1026 ; 0048-9697
    ISSN (online) 1879-1026
    ISSN 0048-9697
    DOI 10.1016/j.scitotenv.2023.169058
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  6. Article ; Online: Validation of Empoli Embolic Stroke of Undetermined Source Atrial Fibrillation (E 2 AF) Score for Detecting Atrial Fibrillation in Patients With Embolic Stroke of Undetermined Source.

    Masotti, Luca / Grifoni, Elisa / Baglini, Alessia / Sivieri, Irene / Mannini, Marianna / Iandoli, Gina / Madonia, Elisa Maria / Cosentino, Eleonora / Micheletti, Irene / Signorini, Ira / Cioni, Elisa / Sansone, Teresa / Pelagalli, Giulia / Baldini, Mariella / Giannoni, Sara / Bertini, Elisabetta / Di Donato, Ilaria

    The neurologist

    2023  Volume 28, Issue 6, Page(s) 426–428

    MeSH term(s) Humans ; Atrial Fibrillation/complications ; Atrial Fibrillation/diagnosis ; Embolic Stroke ; Heart Atria ; Stroke/complications ; Stroke/diagnosis ; Risk Factors
    Language English
    Publishing date 2023-11-01
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1361380-7
    ISSN 2331-2637 ; 1074-7931
    ISSN (online) 2331-2637
    ISSN 1074-7931
    DOI 10.1097/NRL.0000000000000497
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  7. Article ; Online: Efficacy and Safety of Edoxaban in Cancer-Associated Venous Thromboembolism: A Real World Retrospective Study.

    Grifoni, Elisa / Baroncelli, Andrea / Pinto, Gabriele / Cosentino, Eleonora / Micheletti, Irene / Signorini, Ira / Panigada, Grazia / Landini, Giancarlo / Masotti, Luca

    TH open : companion journal to thrombosis and haemostasis

    2022  Volume 6, Issue 2, Page(s) e99–e106

    Abstract: ... ...

    Abstract Introduction
    Language English
    Publishing date 2022-03-01
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2901738-5
    ISSN 2512-9465 ; 2567-3459
    ISSN (online) 2512-9465
    ISSN 2567-3459
    DOI 10.1055/a-1783-9744
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    Zs.A 7138: Show issues Location:
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  8. Article ; Online: Post-Stroke Detection of Subclinical Paroxysmal Atrial Fibrillation in Patients With Embolic Stroke of Undetermined Source in the Real World Practice: The Empoli ESUS Atrial Fibrillation (E 2 AF) Study.

    Grifoni, Elisa / Baldini, Giulia / Baldini, Mariella / Pinto, Gabriele / Micheletti, Irene / Madonia, Elisa M / Cosentino, Eleonora / Bartolozzi, Maria L / Bertini, Elisabetta / Dei, Alessandro / Signorini, Ira / Giannoni, Sara / Del Rosso, Attilio / Prisco, Domenico / Guidi, Leonello / Masotti, Luca

    The neurologist

    2023  Volume 28, Issue 1, Page(s) 25–31

    Abstract: Background: Subclinical paroxysmal atrial fibrillation (AF) is one of the main occult causative mechanisms of embolic stroke of undetermined source (ESUS). Aim of this study was to identify AF predictors, and to develop a score to predict the ... ...

    Abstract Background: Subclinical paroxysmal atrial fibrillation (AF) is one of the main occult causative mechanisms of embolic stroke of undetermined source (ESUS). Aim of this study was to identify AF predictors, and to develop a score to predict the probability of AF detection in ESUS.
    Methods: We retrospectively analyzed ESUS patients undergoing 2-week external electrocardiographic monitoring. Patients with and without AF detection were compared. On the basis of multivariate analysis, predictors of AF were identified and used to develop a predictive score, which was then compared with other existing literature scores.
    Results: Eighty-two patients, 48 females, mean age±SD 72±10 years, were included. In 36 patients (43.9%) AF was detected. The frequency of age 75 years or above and arterial hypertension, and the median CHA 2 DS 2 -VASc score were significantly higher in patients with AF compared with those without. National Institutes of Health Stroke Scale (NIHSS) score ≥8 was the only independent variable associated with AF detection. We derived the Empoli ESUS-AF (E 2 AF) score (NIHSS ≥8 5 points, arterial hypertension 3 points, age 75 years or above 2 points, age 65 to 74 years 1 point, history of coronary/peripheral artery disease 1 point, left atrial enlargement 1 point, posterior lesion 1 point, cortical or cortical-subcortical lesion 1 point), whose predictive power in detecting AF was good (area under the curve: 0.746, 95% confidence interval: 0.638-0.836) and higher than that of CHA 2 DS 2 -VASc and other scores.
    Conclusions: In our study NIHSS score ≥8 was the only independent predictor of post-ESUS-AF detection. The E 2 AF score appears to have a good predictive power for detecting AF. External validations are required.
    MeSH term(s) Aged ; Female ; Humans ; Atrial Fibrillation/complications ; Atrial Fibrillation/diagnosis ; Embolic Stroke/complications ; Hypertension/complications ; Hypertension/diagnosis ; Retrospective Studies ; Risk Factors ; Stroke/complications ; Stroke/diagnosis ; Male
    Language English
    Publishing date 2023-01-01
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1361380-7
    ISSN 2331-2637 ; 1074-7931
    ISSN (online) 2331-2637
    ISSN 1074-7931
    DOI 10.1097/NRL.0000000000000440
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  9. Article ; Online: Additional risk factors for evaluation of suspected acute aortic syndromes in the emergency department.

    Nazerian, Peiman / Ascione, Giovanni / Castelli, Matteo / Capretti, Elisa / Ranaldi, Francesco / Bonaccorsi, Lorella / Santosuosso, Ugo / Grifoni, Stefano / Morello, Fulvio

    Academic emergency medicine : official journal of the Society for Academic Emergency Medicine

    2021  Volume 28, Issue 10, Page(s) 1177–1178

    MeSH term(s) Aorta ; Emergency Service, Hospital ; Humans ; Risk Factors ; Syndrome
    Language English
    Publishing date 2021-03-23
    Publishing country United States
    Document type Letter
    ZDB-ID 1329813-6
    ISSN 1553-2712 ; 1069-6563
    ISSN (online) 1553-2712
    ISSN 1069-6563
    DOI 10.1111/acem.14238
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  10. Article ; Online: Predictive Factors for Hemorrhagic Transformation in Acute Ischemic Stroke in the REAL-World Clinical Practice.

    Grifoni, Elisa / Bini, Chiara / Signorini, Ira / Cosentino, Eleonora / Micheletti, Irene / Dei, Alessandro / Pinto, Gabriele / Madonia, Elisa Maria / Sivieri, Irene / Mannini, Marianna / Baldini, Mariella / Bertini, Elisabetta / Giannoni, Sara / Bartolozzi, Maria Letizia / Guidi, Leonello / Bartalucci, Paola / Vanni, Simone / Segneri, Antonio / Pratesi, Alessandra /
    Giordano, Antonio / Dainelli, Francesca / Maggi, Francesca / Romagnoli, Mario / Cioni, Elisa / Cioffi, Elisa / Pelagalli, Giulia / Mattaliano, Chiara / Schipani, Elena / Murgida, Giuseppe Salvatore / Di Martino, Stefania / Sisti, Eleonora / Cozzi, Andrea / Francolini, Valentina / Masotti, Luca

    The neurologist

    2023  Volume 28, Issue 3, Page(s) 150–156

    Abstract: Background: Few data exists on predictive factors of hemorrhagic transformation (HT) in real-world acute ischemic stroke patients. The aims of this study were: (i) to identify predictive variables of HT (ii) to develop a score for predicting HT.: ... ...

    Abstract Background: Few data exists on predictive factors of hemorrhagic transformation (HT) in real-world acute ischemic stroke patients. The aims of this study were: (i) to identify predictive variables of HT (ii) to develop a score for predicting HT.
    Methods: We retrospectively analyzed the clinical, radiographic, and laboratory data of patients with acute ischemic stroke consecutively admitted to our Stroke Unit along two years. Patients with HT were compared with those without HT. A multivariate logistic regression analysis was performed to identify independent predictors of HT on CT scan at 24 hours to develop a practical score.
    Results: The study population consisted of 564 patients with mean age 77.5±11.8 years. Fifty-two patients (9.2%) showed HT on brain CT at 24 hours (4.9% symptomatic). NIHSS score ≥8 at Stroke Unit admission (3 points), cardioembolic etiology (2 points), acute revascularization by systemic thrombolysis and/or mechanical thrombectomy (1 point), history of previous TIA/stroke (1 point), and major vessel occlusion (1 point) were found independent risk factors of HT and were included in the score (Hemorrhagic Transformation Empoli score (HTE)). The predictive power of HTE score was good with an AUC of 0.785 (95% CI: 0.749-0.818). Compared with 5 HT predictive scores proposed in the literature (THRIVE, SPAN-100, MSS, GRASPS, SITS-SIC), the HTE score significantly better predicted HT.
    Conclusions: NIHSS score ≥8 at Stroke Unit admission, cardioembolism, urgent revascularization, previous TIA/stroke, and major vessel occlusion were independent predictors of HT. The HTE score has a good predictive power for HT. Prospective studies are warranted.
    MeSH term(s) Humans ; Aged ; Aged, 80 and over ; Brain Ischemia/complications ; Brain Ischemia/diagnostic imaging ; Ischemic Stroke/complications ; Ischemic Stroke/diagnostic imaging ; Retrospective Studies ; Ischemic Attack, Transient ; Stroke/complications ; Stroke/diagnostic imaging ; Risk Factors
    Language English
    Publishing date 2023-05-01
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1361380-7
    ISSN 2331-2637 ; 1074-7931
    ISSN (online) 2331-2637
    ISSN 1074-7931
    DOI 10.1097/NRL.0000000000000462
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