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Article: Establishing the Minimally Important Difference for the KOOS-Joint Replacement and PROMIS Global-10 in Patients After Total Knee Arthroplasty.

Spiering, Tyler J / Firth, Andrew D / Mousoulis, Christos / Hallstrom, Brian R / Gagnier, Joel J

2024 Volume 12, Issue 2, Page(s) 23259671231218260

Abstract: Background: Despite the overall prevalence and success of total knee arthroplasty (TKA), a significant portion of patients are dissatisfied with their outcomes.: Purpose: To assess the responsiveness and determine the minimally important difference ( ... ...

Abstract	Background: Despite the overall prevalence and success of total knee arthroplasty (TKA), a significant portion of patients are dissatisfied with their outcomes. Purpose: To assess the responsiveness and determine the minimally important difference (MID) of 2 patient-reported outcome measures (PROMs)-the Knee injury and Osteoarthritis Outcome Score-Joint Replacement (KOOS-JR) and the Patient-Reported Outcomes Measurement Information System Global-10 (PROMIS 10)-in patients after TKA. Study design: Cohort study (diagnosis); Level of evidence, 3. Methods: Included were patients who underwent TKA from August 2015 through August 2019 and completed baseline and postoperative KOOS-JR and PROMIS 10 surveys. The PROMIS 10 consists of 2 domains: physical health and mental health. Estimates for the reliable change index (RCI) and MID, using anchor-based and distribution-based methods, were calculated for each PROM. Regression modeling was used to determine whether patient and clinical factors predicted MID thresholds or MID achievement. Results: A total of 1315 patients were included. Distribution-based MIDs, calculated using various methods from baseline scores, ranged from 19.3 to 31 for the KOOS-JR, and the RCI was 4.38. Of these patients, 293 (22.3%) demonstrated small or moderate improvement, and this cohort was included in the calculation of anchor-based MIDs. The anchor-based MIDs were 16.9 and 24.3 at 3-month and 1-year follow-up, respectively, and 66% of patients achieved the MID at 12 months. Higher preoperative PROM score, male sex, non-White race, and current smoker status were predictive of failing to achieve the anchor-based MID for KOOS-JR at 1 year postoperatively ( Conclusion: The study results demonstrated relevant values for interpretation of the KOOS-JR and PROMIS 10. While patient demographics did not accurately predict which patients would achieve the MID, some potential factors predicting successful patient-reported outcomes after TKA were identified.
Language	English
Publishing date	2024-02-02
Publishing country	United States
Document type	Journal Article
ZDB-ID	2706251-X
ISSN	2325-9671
ISSN	2325-9671
DOI	10.1177/23259671231218260
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Article ; Online: Musculoskeletal Components of Post-Acute Sequelae of SARS-CoV-2 Infections.

Gagnier, Joel J / Bergmans, Rachel S / Clauw, Daniel J

JBJS reviews

2022 Volume 10, Issue 11

Abstract: Musculoskeletal (MSK) sequelae of severe acute respiratory syndrome coronavirus 2 infections seem to be common.: ➢: Mechanisms of such effects are becoming clear.: ➢: There is a complex interplay of biopsychosocial effects associated with MSK ... ...

Abstract	➢: Musculoskeletal (MSK) sequelae of severe acute respiratory syndrome coronavirus 2 infections seem to be common. ➢: Mechanisms of such effects are becoming clear. ➢: There is a complex interplay of biopsychosocial effects associated with MSK symptoms after acute coronavirus disease 2019. ➢: Additional research should focus on completely describing the breadth of these MSK sequelae and related psychosocial symptoms.
MeSH term(s)	Humans ; COVID-19/complications ; SARS-CoV-2 ; Post-Acute COVID-19 Syndrome
Language	English
Publishing date	2022-11-28
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural
ISSN	2329-9185
ISSN (online)	2329-9185
DOI	e22.00088
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Article ; Online: Systematic review: preoperative psychological factors and total hip arthroplasty outcomes.

O'Connor, John P / Holden, Paige / Gagnier, Joel J

Journal of orthopaedic surgery and research

2022 Volume 17, Issue 1, Page(s) 457

MeSH term(s)	Arthroplasty, Replacement, Hip/adverse effects ; Arthroplasty, Replacement, Hip/psychology ; Humans ; Osteoarthritis/etiology ; Pain, Postoperative/etiology ; Treatment Outcome
Language	English
Publishing date	2022-10-17
Publishing country	England
Document type	Systematic Review
ZDB-ID	2252548-8
ISSN	1749-799X ; 1749-799X
ISSN (online)	1749-799X
ISSN	1749-799X
DOI	10.1186/s13018-022-03355-3
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Article: Neurostimulation as an Efficacious Nonpharmacologic Analgesic following Arthroscopic Rotator Cuff Repair.

Juncker, Ryan B / Gagnier, Joel J / Mirza, Faisal M

Case reports in anesthesiology

2022 Volume 2022, Page(s) 2133998

Abstract: This case highlights the importance of pursuing nonpharmacologic analgesic modalities in orthopedic surgery to combat the current opioid epidemic. Presented is a patient who underwent an arthroscopic rotator cuff repair and biceps tenodesis operation and ...

Abstract	This case highlights the importance of pursuing nonpharmacologic analgesic modalities in orthopedic surgery to combat the current opioid epidemic. Presented is a patient who underwent an arthroscopic rotator cuff repair and biceps tenodesis operation and through the use of neurostimulation (in the form of auricular electrostimulation), fully recovered from surgery without the usage of any opioid or nonsteroidal anti-inflammatory medications. The patient was fitted with a novel auricular electrostimulation device (DyAnsys Primary Relief) in the immediate postoperative period that provided constant neurostimulation for 10 days, this neurostimulator was the only analgesic modality used in this case, and the patient reported minimal postoperative pain. The utility of this case centers around the lack of postoperative opioid use, presenting the idea that postsurgical orthopedic pain can be managed in a nonpharmacologic capacity, combatting the fields' ongoing opioid epidemic.
Language	English
Publishing date	2022-04-15
Publishing country	United States
Document type	Case Reports
ZDB-ID	2659087-6
ISSN	2090-6390 ; 2090-6382
ISSN (online)	2090-6390
ISSN	2090-6382
DOI	10.1155/2022/2133998
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Article ; Online: Patient reported outcomes in orthopaedics.

Gagnier, Joel J

Journal of orthopaedic research : official publication of the Orthopaedic Research Society

2017 Volume 35, Issue 10, Page(s) 2098–2108

Abstract: ... 2017 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 35:2098-2108, 2017. ...

Abstract	Patient reported outcome measures (PROMs) are key tools when performing clinical research and PROM data are increasingly used to inform clinical decision-making, patient-centered care, health policy and more recently, reimbursement decisions. PROMs must possess particular properties before they are used. Thus purpose of this paper is to give an overview of PROMs, their definition, how their evidence can be assessed, how they should be reported in clinical research, how to choose PROMs, the types of PROMs available in orthopaedics, where these measures can be found, PROMs in orthopaedic clinical practice and what are some key next steps in this field. If PROMs are used in accordance with the guidance in this article, I believe we will gain considerable insight into PROMs in orthopaedics and will advance this field in a way that can contribute to science, improve patient care and save considerable resources. © 2017 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 35:2098-2108, 2017.
MeSH term(s)	Humans ; Orthopedics ; Treatment Outcome
Language	English
Publishing date	2017-10
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	605542-4
ISSN	1554-527X ; 0736-0266
ISSN (online)	1554-527X
ISSN	0736-0266
DOI	10.1002/jor.23604
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Zs.A 1879: Show issues

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Article: Reduction in opioid use with perioperative non-pharmacologic analgesia in total knee arthroplasty and ACL reconstruction: a systematic review.

Juncker, Ryan B / Mirza, Faisal M / Gagnier, Joel J

SICOT-J

2021 Volume 7, Page(s) 63

Abstract: Introduction: The world's opioid epidemic has gotten increasingly severe over the last several decades and projects to continue worsening. Orthopedic surgery is the largest contributor to this epidemic, accounting for 8.8% of postoperative opioid ... ...

Abstract	Introduction: The world's opioid epidemic has gotten increasingly severe over the last several decades and projects to continue worsening. Orthopedic surgery is the largest contributor to this epidemic, accounting for 8.8% of postoperative opioid dependence cases. Total knee arthroplasty (TKA) and anterior cruciate ligament (ACL) reconstruction are commonly performed orthopedic operations heavily reliant on opioids as the primary analgesic in the peri- and immediate postoperative period. These downfalls highlight the pressing need for an alternate, non-pharmacologic analgesic to reduce postoperative opioid use in orthopedic patients. The presented systematic review aimed to analyze and compare the most promising non-pharmacologic analgesic interventions in the available literature to guide future research in such a novel field. Methods: A systematic search of PubMed, MEDLINE, Embase, Cochrane, and Web of Science was performed for studies published before July 2020 based on the PRISMA (preferred reporting items for systematic reviews and meta-analyses) guidelines, and the obtained manuscripts were evaluated for inclusion or exclusion against strict, pre-determined criteria. Risk-of-bias and GRADE (grades of recommendation, assessment, development, and evaluation) assessments were then performed on all included studies. Results: Six studies were deemed fit for inclusion, investigating three non-pharmacologic analgesics: percutaneous peripheral nerve stimulation, cryoneurolysis, and auricular acupressure. All three successfully reduced postoperative opioid use while simultaneously maintaining the safety and efficacy of the procedure. Discussion: The results indicate that all three presented non-pharmacologic analgesic interventions are viable and warrant future research. That said, because of its slight advantages in postoperative pain control and operational outcomes, cryoneurolysis seems to be the most promising. Further research and eventual clinical implementation of these analgesics is not only warranted but should be a priority because of their vast potential to reduce orthopedics surgeries' contribution to the opioid epidemic.
Language	English
Publishing date	2021-12-17
Publishing country	France
Document type	Journal Article
ZDB-ID	2832091-8
ISSN	2426-8887
ISSN	2426-8887
DOI	10.1051/sicotj/2021063
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Article ; Online: Poor quality patient reported outcome measures bias effect estimates in orthopaedic randomized studies.

Gagnier, Joel J / Johnston, Bradley C

Journal of clinical epidemiology

2019 Volume 116, Page(s) 36–38

Abstract: Objectives: The objective was to assess the potential for biased treatment effects associated with patient-reported outcome measures (PROMs) of varying psychometric quality in randomized clinical trials (RCTs) for rotator cuff disease (RCD).: Study ... ...

Abstract	Objectives: The objective was to assess the potential for biased treatment effects associated with patient-reported outcome measures (PROMs) of varying psychometric quality in randomized clinical trials (RCTs) for rotator cuff disease (RCD). Study design and setting: We searched for RCTs published in the past 5 years (January 2011 to December 2016) in the top five 2015 impact factor orthopedic journals. We accepted RCTs including human participants with RCD, published in English, and using PROMs specific to RCD. We extracted data on study design, sample size, risk of bias for RCTs, quality of PROM used, estimates of effect, and associated measures of variance. PROMs were given numerical ratings of psychometric quality from a prior publication. Continuous measures of effect were transformed by dividing the effect estimate by the standard deviation. Multilevel linear regression analyses were performed to determine whether PROM quality was associated with the magnitude of effect. Results: Overall, we included 72 RCTs reporting 174 separate outcomes. Mean sample size was 66.8 (95% CI 62.30 to 71.27), mean risk of bias score across all studies was 7.00/10 (95% CI 6.72 to 7.29), psychometric quality summary scores ranged from -2 to 10, and the standardized mean effect estimate was 0.47 (95% CI -0.17 to 1.11). Regression revealed that higher-quality PROMs had smaller estimates of effect (β = -0.32; 95% CI -0.51 to -0.13; P = 0.001). We also found that a longer follow-up period predicted slightly increased effect estimates (β = 0.08; 95% CI 0.02 to 0.13; P = 0.007). Conclusions: PROMs with poor or unknown psychometric properties overestimate treatment effects in clinical research of RCD by 68.4% (β -0.32/standardized mean effect 0.47). To our knowledge, this is the first empirical evidence that variations in the quality of PROMs bias treatment effect estimates. Researchers and clinicians using data from PROMs must be cautious to explore the quality of that measure so as to not mislead decision-making resulting from biased outcomes.
MeSH term(s)	Bias ; Humans ; Journal Impact Factor ; Orthopedic Procedures/psychology ; Patient Reported Outcome Measures ; Psychometrics ; Randomized Controlled Trials as Topic/standards ; Research Design ; Rotator Cuff Injuries/psychology ; Rotator Cuff Injuries/surgery ; Sample Size ; Treatment Outcome
Language	English
Publishing date	2019-07-30
Publishing country	United States
Document type	Journal Article
ZDB-ID	639306-8
ISSN	1878-5921 ; 0895-4356
ISSN (online)	1878-5921
ISSN	0895-4356
DOI	10.1016/j.jclinepi.2019.07.012
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Article ; Online: The Effect of Lipid Disorders on the Risk of Rotator Cuff Disease: A Systematic Review and Meta-Analysis.

Lai, Jianyu / Gagnier, Joel J

JB & JS open access

2018 Volume 3, Issue 3, Page(s) e0018

Abstract: Background: Rotator cuff disease has a high prevalence and is associated with shoulder pain and disability. Dyslipidemia might be an intrinsic factor related to the development of the disease as it might increase tendon stiffness and result in tendon ... ...

Abstract	Background: Rotator cuff disease has a high prevalence and is associated with shoulder pain and disability. Dyslipidemia might be an intrinsic factor related to the development of the disease as it might increase tendon stiffness and result in tendon problems. The purposes of the present study were (1) to systematically review the association between lipid disorders and the risk of rotator cuff disease and (2) to provide physicians with guidance to prevent rotator cuff disease. Methods: Six databases were searched through July 6, 2016: MEDLINE, Embase, CINAHL, Web of Science, SPORTDiscus, and the Cochrane Central Register of Controlled Trials. Eligible studies were assessed for risk of bias and strength of evidence. Meta-analysis was performed for the effect of dyslipidemia on the presence of rotator cuff disease, with the effect being expressed as an odds ratio. The overall effect was estimated, and heterogeneity across studies was expressed with the I Results: Three cross-sectional studies, 1 cohort study, and 3 case-control studies involving 505,852 participants were selected, with 6 of these studies being eligible for meta-analysis. The main-effect meta-analysis yielded a pooled odds ratio of 2.17 (95% confidence interval, 1.46 to 3.23; p < 0.001; I Conclusions: We found that dyslipidemia was associated with high occurrence of rotator cuff disease. We recommend that physicians examine tendon conditions if their patients have severe dyslipidemia. Level of evidence: Prognostic Level IV. See Instructions for Authors for a complete description of levels of evidence.
Language	English
Publishing date	2018-09-13
Publishing country	United States
Document type	Journal Article
ISSN	2472-7245
ISSN (online)	2472-7245
DOI	10.2106/JBJS.OA.18.00018
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Article ; Online: Measures of Adult Knee Function.

McHugh, Michael / Droy, Erin / Muscatelli, Stefano / Gagnier, Joel J

Arthritis care & research

2020 Volume 72 Suppl 10, Page(s) 219–249

MeSH term(s)	Humans ; Joint Diseases ; Knee ; Outcome Assessment, Health Care
Language	English
Publishing date	2020-10-14
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	645059-3
ISSN	2151-4658 ; 0893-7524 ; 2151-464X
ISSN (online)	2151-4658
ISSN	0893-7524 ; 2151-464X
DOI	10.1002/acr.24235
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Zs.A 2446: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: COSMIN reporting guideline for studies on measurement properties of patient-reported outcome measures.

Gagnier, Joel J / Lai, Jianyu / Mokkink, Lidwine B / Terwee, Caroline B

Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation

2021 Volume 30, Issue 8, Page(s) 2197–2218

Abstract: Purpose: To develop a set of consensus and empirically based reporting recommendations for primary studies of the measurement properties of patient-reported outcome measures (PROMs).: Methods: This study included four phases: 1. Conducting an ... ...

Abstract	Purpose: To develop a set of consensus and empirically based reporting recommendations for primary studies of the measurement properties of patient-reported outcome measures (PROMs). Methods: This study included four phases: 1. Conducting an extensive literature review of recommendations for reporting of studies testing measurement properties of PROMs; 2. Preparing for the Delphi study by identifying experts; 3. Conducting three Delphi rounds aiming for consensus on the item list of recommendations found in phase 1; 4. Developing the COSMIN reporting guideline and user manual. Results: The literature review resulted in 93 reporting items, included in the first Delphi round. A total of 84 individuals (from 12 countries) agreed to participate in the Delphi study, with 47, 30 and 25 responding in rounds one, two and three, respectively. After three rounds, we achieved consensus on a set of 71 items separated into a set of 35 "common" items (relevant to all studies on measurement properties) and 41 "specific" items (exclusively relevant to one of the nine measurement properties). Conclusion: Consensus was achieved on a set of 71 items for inclusion in a reporting guideline for studies on measurement properties of PROMs. These items will guide researchers on the necessary information to include in their reports of investigations of measurement properties of PROMs. This guideline will likely improve the completeness of reporting of these important studies.
MeSH term(s)	Consensus ; Delphi Technique ; Guidelines as Topic ; Humans ; Patient Reported Outcome Measures ; Quality of Life/psychology
Language	English
Publishing date	2021-04-05
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	1161148-0
ISSN	1573-2649 ; 0962-9343
ISSN (online)	1573-2649
ISSN	0962-9343
DOI	10.1007/s11136-021-02822-4
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