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  1. Book ; Thesis: Zahnheilkunde und Zahnärzte im Kanton und in der Stadt S[ank]t Gallen von 1798 - 1902

    Lüthi, Andreas

    mit e. bes. Würdigung d. Lebens u. Wirkens von Zahnarzt Christian Emil Locher, 1826 - 1907

    1987  

    Keywords History of Dentistry / Sankt Gallen <Kanton> ; History of Dentistry / Sankt Gallen ; Dentists / biography
    Size 121 S. : Ill., graph. Darst.
    Publishing country Switzerland
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Zürich, Univ., Diss., 1987
    HBZ-ID HT003161771
    Database Catalogue ZB MED Medicine, Health

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  2. Article ; Online: Ongoing MRI remodeling 3-7 years after collagen meniscus implantation in stable knees.

    Schenk, L / Bethge, L / Hirschmann, A / Berbig, R / Lüthi, U / Arnold, M P / Hirschmann, Michael T

    Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA

    2019  Volume 28, Issue 4, Page(s) 1099–1104

    Abstract: Purpose: The purpose of the present study was to evaluate the clinical and radiological 3-7 years outcomes of patients who underwent collagen meniscus implantation in stable or stabilized knees. It was the hypothesis that using the collagen meniscus ( ... ...

    Abstract Purpose: The purpose of the present study was to evaluate the clinical and radiological 3-7 years outcomes of patients who underwent collagen meniscus implantation in stable or stabilized knees. It was the hypothesis that using the collagen meniscus (CMI) good clinical 3-7 years outcomes with low pain levels are achieved.
    Methods: Thirty-nine patients (male:female = 30:9, mean age 34 ± 10 years) underwent arthroscopic CMI after subtotal medial (n = 32) or lateral meniscectomy (n = 7). A 7-mm CMI was performed due to prophylactic (n = 25) or therapeutic indication (n = 14). IKDC score, Tegner score preinjury, preoperatively and at follow-up, Lysholm score and visual analogue scale for pain and satisfaction (follow-up rate 90%) were assessed. MRI scans were analyzed according to the Genovese criteria (n = 19). Implant failure was defined as infection or mechanical failure of the device. The minimum follow-up time was 36 months (range 36-84 months).
    Results: The mean VAS satisfaction preoperatively and at follow-up was 4.0 ± 0 and 1.6 ± 1.0. The mean VAS pain was 4.3 ± 3.2 preoperatively and at last follow-up 2.1 ± 1.7. The median Tegner score preinjury was 7 (range 3-10), it decreased preoperatively to median 3.5 (range 1-8) and nearly reached the preinjury level at last follow-up 6 (range 3-10). The mean Lysholm score before surgery was 66 ± 20 and 91 ± 8 at last follow-up. Seven patients (38.9%) had a normal total IKDC score (A), 10 patients were nearly normal (B) and 1 patient slightly abnormal (C). In MRI the CMI was entirely resorbed in 4 patients (21%) and partially resorbed in 15 (79%). In 4 patients (21%) the CMI was isointense, in 14 (74%) slightly hyperintense and in 1 (5%) highly hyperintense. Ten patients (53%) showed marked signs of bone marrow edema. In 13 patients (68%) an extrusion of the meniscus > 3 mm at last follow-up was found.
    Conclusions: Meniscal substitution with the CMI showed good to excellent clinical 3-7 results. The CMI shows an ongoing remodelling with decreased signal intensity and decreased size. However, as meniscus extrusion remained at the same level and bone marrow edema decreased from 1 year to longer term follow-up, it appears that the remodeling comes to an end at about 5 years after CMI.
    Level of evidence: IV.
    MeSH term(s) Adult ; Arthroscopy/methods ; Bone Marrow Diseases/etiology ; Collagen ; Edema/etiology ; Female ; Follow-Up Studies ; Humans ; Magnetic Resonance Imaging ; Male ; Meniscectomy ; Menisci, Tibial/surgery ; Orthopedic Procedures/methods ; Pain/etiology ; Pain Measurement ; Postoperative Complications ; Prosthesis Implantation ; Tibial Meniscus Injuries/diagnostic imaging ; Tibial Meniscus Injuries/surgery ; Treatment Outcome
    Chemical Substances Collagen (9007-34-5)
    Language English
    Publishing date 2019-09-18
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1159064-6
    ISSN 1433-7347 ; 0942-2056
    ISSN (online) 1433-7347
    ISSN 0942-2056
    DOI 10.1007/s00167-019-05714-w
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Onkologie- und Hämatologiezentrum Thun-Berner Oberland

    Lüthi, J.-M. / Rauch, D. / Gick, U. / Solenthaler, M. / Burmeister, H. / Sauter, M. / Winkler, A. / Lüthi, A. / Flügel, V.

    Schweizer Krebs-Bulletin

    2018  Volume 38, Issue 4, Page(s) 350–357

    Language English ; French ; German
    Document type Article
    ZDB-ID 1340924-4
    Database Current Contents Medicine

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  4. Article ; Online: NF-κB drives epithelial-mesenchymal mechanisms of lung fibrosis in a translational lung cell model.

    Sieber, Patrick / Schäfer, Anny / Lieberherr, Raphael / Caimi, Silvia L / Lüthi, Urs / Ryge, Jesper / Bergmann, Jan H / Le Goff, François / Stritt, Manuel / Blattmann, Peter / Renault, Bérengère / Rammelt, Patrick / Sempere, Bruno / Freti, Diego / Studer, Rolf / White, Eric S / Birker-Robaczewska, Magdalena / Boucher, Maxime / Nayler, Oliver

    JCI insight

    2023  Volume 8, Issue 3

    Abstract: In the progression phase of idiopathic pulmonary fibrosis (IPF), the normal alveolar structure of the lung is lost and replaced by remodeled fibrotic tissue and by bronchiolized cystic airspaces. Although these are characteristic features of IPF, ... ...

    Abstract In the progression phase of idiopathic pulmonary fibrosis (IPF), the normal alveolar structure of the lung is lost and replaced by remodeled fibrotic tissue and by bronchiolized cystic airspaces. Although these are characteristic features of IPF, knowledge of specific interactions between these pathological processes is limited. Here, the interaction of lung epithelial and lung mesenchymal cells was investigated in a coculture model of human primary airway epithelial cells (EC) and lung fibroblasts (FB). Single-cell RNA sequencing revealed that the starting EC population was heterogenous and enriched for cells with a basal cell signature. Furthermore, fractions of the initial EC and FB populations adopted distinct pro-fibrotic cell differentiation states upon cocultivation, resembling specific cell populations that were previously identified in lungs of patients with IPF. Transcriptomic analysis revealed active NF-κB signaling early in the cocultured EC and FB, and the identified NF-κB expression signatures were found in "HAS1 High FB" and "PLIN2+ FB" populations from IPF patient lungs. Pharmacological blockade of NF-κB signaling attenuated specific phenotypic changes of EC and prevented FB-mediated interleukin-6, interleukin-8, and CXC chemokine ligand 6 cytokine secretion, as well as collagen α-1(I) chain and α-smooth muscle actin accumulation. Thus, we identified NF-κB as a potential mediator, linking epithelial pathobiology with fibrogenesis.
    MeSH term(s) Humans ; NF-kappa B/metabolism ; Lung/pathology ; Idiopathic Pulmonary Fibrosis/pathology ; Fibrosis ; Signal Transduction ; Collagen Type I
    Chemical Substances NF-kappa B ; Collagen Type I
    Language English
    Publishing date 2023-02-08
    Publishing country United States
    Document type Journal Article
    ISSN 2379-3708
    ISSN (online) 2379-3708
    DOI 10.1172/jci.insight.154719
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  5. Article: The CASBAH: a searchable database of caspase substrates.

    Lüthi, A U / Martin, S J

    Cell death and differentiation

    2007  Volume 14, Issue 4, Page(s) 641–650

    Abstract: Apoptosis is coordinated by members of the caspase family of aspartic acid-specific proteases. Other members of this protease family also play essential roles in inflammation where they participate in the maturation of pro-inflammatory cytokines. To date, ...

    Abstract Apoptosis is coordinated by members of the caspase family of aspartic acid-specific proteases. Other members of this protease family also play essential roles in inflammation where they participate in the maturation of pro-inflammatory cytokines. To date, almost 400 substrates for the apoptosis-associated caspases have been reported and there are likely to be hundreds more yet to be discovered. Thus, the fraction of the proteome that is degraded (the degradome) by caspases during the demolition phase of apoptosis appears to be quite substantial. Despite this, we still know surprisingly little concerning how caspases provoke some of the signature events in apoptosis, such as membrane phosphatidylserine externalization, cellular retraction, chromatin condensation and apoptotic body production. The inflammatory caspases appear to be much more specific proteases than those involved in apoptosis and only two confirmed substrates for these proteases have been described to date. Here, we have compiled a comprehensive list of caspase substrates and describe a searchable web resource (The Casbah; www.casbah.ie) which contains information pertaining to all currently known caspase substrates. We also discuss some of the unresolved issues relating to caspase-dependent events in apoptosis and inflammation.
    MeSH term(s) Animals ; Apoptosis ; Caspases/chemistry ; Caspases/classification ; Caspases/metabolism ; Databases, Protein ; Enzyme Activation ; Humans ; Information Storage and Retrieval ; Inhibitor of Apoptosis Proteins/chemistry ; Inhibitor of Apoptosis Proteins/metabolism ; Internet ; Models, Biological ; Proteins/chemistry ; Proteins/metabolism ; Proteome/chemistry ; Proteome/metabolism ; Signal Transduction/physiology ; Substrate Specificity ; User-Computer Interface
    Chemical Substances Inhibitor of Apoptosis Proteins ; Proteins ; Proteome ; Caspases (EC 3.4.22.-)
    Language English
    Publishing date 2007-04
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 1225672-9
    ISSN 1350-9047
    ISSN 1350-9047
    DOI 10.1038/sj.cdd.4402103
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Du bist, was du isst.

    Lüthi, U

    Krankenpflege. Soins infirmiers

    2001  Volume 94, Issue 1, Page(s) 7

    Title translation You are what you eat.
    MeSH term(s) Feeding Behavior ; Humans ; Nurse's Role ; Nutritional Sciences/education
    Language German
    Publishing date 2001-01
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 80459-9
    ISSN 0253-0465
    ISSN 0253-0465
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    Zs.A 862: Show issues Location:
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  7. Article: "Irchel-Tagung" der SGGP. Brückenschlag.

    Lüthi, U

    Krankenpflege. Soins infirmiers

    2001  Volume 92, Issue 11, Page(s) 19–21

    Title translation Irchel Congress of SGGP. Building bridges.
    MeSH term(s) Humans ; Leadership ; Nurse's Role ; Physician-Nurse Relations ; Switzerland
    Language German
    Publishing date 2001-11-28
    Publishing country Switzerland
    Document type Congress
    ZDB-ID 80459-9
    ISSN 0253-0465
    ISSN 0253-0465
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  8. Article: 23. Delegiertenversammlung. 1,5 Millionen für den Aktionsfonds.

    Lüthi, U

    Krankenpflege. Soins infirmiers

    2001  Volume 94, Issue 8, Page(s) 20–1, 74–5, 94–5

    Title translation 23rd Delegate Meeting. 1.5 million for the action fund.
    MeSH term(s) Fund Raising ; Humans ; Politics ; Societies, Nursing ; Switzerland
    Language Italian
    Publishing date 2001-11-28
    Publishing country Switzerland
    Document type Congress
    ZDB-ID 80459-9
    ISSN 0253-0465
    ISSN 0253-0465
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  9. Article: Der Weg zurück in die Zukunft.

    Lüthi, U

    Krankenpflege. Soins infirmiers

    2001  Volume 94, Issue 5, Page(s) 9

    Title translation The way back into the future.
    MeSH term(s) Education, Nursing, Graduate/trends ; Forecasting ; Humans ; Job Satisfaction ; Specialties, Nursing/education ; Switzerland
    Language German
    Publishing date 2001-05
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 80459-9
    ISSN 0253-0465
    ISSN 0253-0465
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Medikamentensicherheit. Ein Fehler ist passiert....

    Lüthi, U

    Krankenpflege. Soins infirmiers

    2001  Volume 94, Issue 6, Page(s) 8–12

    Title translation Medication safety. An error happened.....
    MeSH term(s) Humans ; Medication Errors/nursing ; Medication Errors/prevention & control ; Nurse's Role ; Risk Management ; Switzerland
    Language German
    Publishing date 2001-06
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 80459-9
    ISSN 0253-0465
    ISSN 0253-0465
    Database MEDical Literature Analysis and Retrieval System OnLINE

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