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  1. Book: Staging in gynaecological cancers

    Bhatla, Neerja

    (Best practice & research : Clinical obstetrics and gynaecology ; 29,6)

    2015  

    Author's details Neerja Bhatla ..., guest ed
    Series title Best practice & research : Clinical obstetrics and gynaecology ; 29,6
    Best practice & research
    Best practice & research ; Clinical obstetrics and gynaecology
    Collection Best practice & research
    Best practice & research ; Clinical obstetrics and gynaecology
    Language English
    Size S. 766 - 895, A14 S. : Ill.
    Publisher Elsevier
    Publishing place Amsterdam u.a.
    Publishing country Netherlands
    Document type Book
    HBZ-ID HT018750622
    Database Catalogue ZB MED Medicine, Health

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  2. Article: Primary leiomyosarcoma of the vulva - a  rare occurrence.

    Rathore, Ruchi / Singh, Anju / Bhatla, Neerja / Mathur, Sandeep

    Polish journal of pathology : official journal of the Polish Society of Pathologists

    2023  Volume 74, Issue 1, Page(s) 56–58

    Abstract: Vulval tumours are rare, representing merely 4% of all gynaecological neoplasms. 98% of vulvar lesions are benign, and only 2% are malignant. Of all vulvar malignancies, while squamous cell carcinoma is the most common malignancy, leiomyosarcomas of the ... ...

    Abstract Vulval tumours are rare, representing merely 4% of all gynaecological neoplasms. 98% of vulvar lesions are benign, and only 2% are malignant. Of all vulvar malignancies, while squamous cell carcinoma is the most common malignancy, leiomyosarcomas of the vulva are extremely rare. Usually these tumours have nonspecific clinical manifestations, often leading to misdiagnoses of Bartholin cysts or abscesses. We describe a case of a 47-year-old woman who presented with a nonspecific painless swelling in the left vulva for 2 months which was diagnosed as leiomyosarcoma of the vulva on biopsy as well as resection.
    MeSH term(s) Female ; Humans ; Middle Aged ; Leiomyosarcoma ; Vulva ; Biopsy ; Carcinoma, Squamous Cell
    Language English
    Publishing date 2023-05-26
    Publishing country Poland
    Document type Case Reports
    ZDB-ID 1283064-1
    ISSN 1233-9687 ; 0031-3114
    ISSN 1233-9687 ; 0031-3114
    DOI 10.5114/pjp.2023.127293
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: FIGO Cancer Report 2021.

    Kehoe, Sean / Bhatla, Neerja

    International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics

    2021  Volume 155 Suppl 1, Page(s) 5–6

    MeSH term(s) Endometrial Neoplasms/pathology ; Female ; Humans ; Neoplasm Staging
    Language English
    Publishing date 2021-10-20
    Publishing country United States
    Document type Editorial
    ZDB-ID 80149-5
    ISSN 1879-3479 ; 0020-7292
    ISSN (online) 1879-3479
    ISSN 0020-7292
    DOI 10.1002/ijgo.13882
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Population-based human papillomavirus testing: The new paradigm for cervical cancer screening.

    Joseph, Anu N / Bhatla, Neerja

    The National medical journal of India

    2021  Volume 34, Issue 1, Page(s) 36–37

    MeSH term(s) Alphapapillomavirus ; Early Detection of Cancer ; Female ; Humans ; Mass Screening ; Papanicolaou Test ; Papillomaviridae ; Uterine Cervical Neoplasms/diagnosis ; Uterine Cervical Neoplasms/epidemiology
    Language English
    Publishing date 2021-08-16
    Publishing country India
    Document type Journal Article ; Comment
    ZDB-ID 645116-0
    ISSN 0970-258X
    ISSN 0970-258X
    DOI 10.4103/0970-258X.323447
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Borderline tumours of ovary and fertility preservation-Outcomes from a tertiary care center in India.

    Kumari, Sarita / Bhatla, Neerja / Ray, Chandrima / Arora, Bhawna / Mathur, Sandeep / Kumar, Sunesh / Kumar, Lalit

    Current problems in cancer

    2024  Volume 50, Page(s) 101097

    Abstract: Objective: Borderline ovarian tumors (BOT) are characterized by atypical epithelial proliferation without stromal invasion and majority are diagnosed in women of reproductive age group desirous of fertility preservation.: Methods: A retrospective ... ...

    Abstract Objective: Borderline ovarian tumors (BOT) are characterized by atypical epithelial proliferation without stromal invasion and majority are diagnosed in women of reproductive age group desirous of fertility preservation.
    Methods: A retrospective review of medical records of patients diagnosed with BOT and on regular follow up at the All India Institute of Medical Sciences New Delhi, during a nine-year study period from March 2014 to March 2023 was performed. Surgical treatment was classified as radical or fertility sparing surgery (FSS). Surgical staging was defined as complete, partial or un-staged.
    Results: Median age of 91 women was 34 years. Follow up period ranged from 4 to 222 months (median 77 months). Among 68 premenopausal women, 31 (46 %) underwent radical surgery and FSS in 37 (54 %) cases. Median time to conception in 29 women with future fertility wishes was 13 months (range, 4 to38 m). Seven of 29 cases (29 %) required ovulation induction. The pregnancy rate was 82.7 % and live birth rate was 80 %. Eight cases (8.7 %) had a recurrence (7- un-staged, 1- partially staged) and median time to recur was 36 months. There was no significant difference in recurrence between cystectomy/oophorectomy. Ovary was the site of recurrence in all surgically salvaged cases except peritoneal cavity in 1 case with mortality. Relapse free survival at 5 and 10 years in FSS and radical surgery group were similar.
    Conclusion: FSS is a safe procedure and should be considered in young patients desirous of future fertility along with a comprehensive peritoneal staging. Reproductive outcomes are excellent.
    Language English
    Publishing date 2024-04-09
    Publishing country United States
    Document type Journal Article
    ZDB-ID 441816-5
    ISSN 1535-6345 ; 0147-0272
    ISSN (online) 1535-6345
    ISSN 0147-0272
    DOI 10.1016/j.currproblcancer.2024.101097
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Surgical Outcomes and Feasibility of Transvaginal Sacrospinous Ligament Fixation through Anterior Approach for Women with Pelvic Organ Prolapse.

    Agrawal, Mohini / Kumari, Rajesh / Sharma, J B / Nisha, N / Manasi, Deoghare / Bhatla, Neerja

    Journal of mid-life health

    2024  Volume 14, Issue 4, Page(s) 280–284

    Abstract: Introduction: Supporting vaginal vault or apex is a central component of primary therapy and to prevent recurrence of prolapse. This study aims to review the surgical outcomes and feasibility of the anterior approach following both sacrospinous fixation ...

    Abstract Introduction: Supporting vaginal vault or apex is a central component of primary therapy and to prevent recurrence of prolapse. This study aims to review the surgical outcomes and feasibility of the anterior approach following both sacrospinous fixation (SSF) and sacrospinous hysteropexy (SSHP) in a single center over a specific period. And also to review its impact on quality of life.
    Materials and methods: This was a retrospective study that included all women who underwent unilateral SSF or SSHP through anterior approach for pelvic organ prolapse (POP) from May 2021 to May 2023 after institutional ethical approval for the study. The anterior approach was undertaken in 47 patients which were included in final review. A retrospective case note review to assess urinary symptoms was undertaken at baseline and 3 months by urinary distress inventory 6 score. The main outcome measure was recurrence of prolapse, predominant compartment for prolapse, presenting complaints, concomitant surgeries performed, and associated urinary complaints.
    Results: The mean age was 56.17 ± 11.95 years and the average body mass index was 26.12 ± 3.11 kg/m
    Conclusion: Anterior unilateral sacrospinous ligament fixation is a safe, effective strategy to treat POP and other concomitant surgery can also be well combined with it.
    Language English
    Publishing date 2024-02-23
    Publishing country India
    Document type Journal Article
    ZDB-ID 2595412-X
    ISSN 0976-7819 ; 0976-7800
    ISSN (online) 0976-7819
    ISSN 0976-7800
    DOI 10.4103/jmh.jmh_224_23
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: FIGO stage IIB cervical cancer prognostication in low-resource settings.

    Kehoe, Sean / Bhatla, Neerja

    International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics

    2020  Volume 149, Issue 2, Page(s) 254

    MeSH term(s) Disease-Free Survival ; Female ; Health Resources ; Humans ; Neoplasm Staging ; Uterine Cervical Neoplasms
    Language English
    Publishing date 2020-04-03
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 80149-5
    ISSN 1879-3479 ; 0020-7292
    ISSN (online) 1879-3479
    ISSN 0020-7292
    DOI 10.1002/ijgo.13138
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Hydrogen sulfide promotes migration of trophoblast cells by a Rho GTPase mediated actin cytoskeleton reorganization.

    Gupta, Sunil Kumar / Mochan, Sankat / Arora, Pallavi / Rani, Neerja / Luthra, Kalpana / Dwivedi, Sadanand / Bhatla, Neerja / Kshetrapal, Pallavi / Dhingra, Renu

    Placenta

    2023  Volume 142, Page(s) 135–146

    Abstract: Introduction: Preeclampsia (PE) arises due to defective spiral artery remodelling which may be due to deficient migration of trophoblast cells. Migration of human endothelial cells has been shown to be promoted via Hydrogen sulphide(H: Methods: ... ...

    Abstract Introduction: Preeclampsia (PE) arises due to defective spiral artery remodelling which may be due to deficient migration of trophoblast cells. Migration of human endothelial cells has been shown to be promoted via Hydrogen sulphide(H
    Methods: Placental tissues were obtained post-delivery from consented preeclamptic and normotensive mothers (n = 60). The protein expression levels of cystathionine-gamma-lyase (CSE) and cystathionine-beta-synthase (CBS) along with its downstream migratory molecules were compared in both the arms. The pro-migratory role of H
    Results: H
    Discussion: Exogenous H
    Language English
    Publishing date 2023-09-15
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 603951-0
    ISSN 1532-3102 ; 0143-4004
    ISSN (online) 1532-3102
    ISSN 0143-4004
    DOI 10.1016/j.placenta.2023.09.004
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Expression of DKK1 in Endometrial Endometrioid Carcinoma and Its Correlation with Wnt/β-catenin Signalling Pathway.

    Das, Abhijit / Mathur, Sandeep R / Kumar, Sunesh / Bhatla, Neerja

    Sultan Qaboos University medical journal

    2023  Volume 23, Issue 3, Page(s) 303–310

    Abstract: Objectives: Endometrial cancer is the most prevalent form of cancer affecting female reproductive organs. The most common histologic type, endometrioid carcinoma, accounts for 75-80% of all endometrial cancer cases. Studies on DKK1 expression profiles ... ...

    Abstract Objectives: Endometrial cancer is the most prevalent form of cancer affecting female reproductive organs. The most common histologic type, endometrioid carcinoma, accounts for 75-80% of all endometrial cancer cases. Studies on DKK1 expression profiles and their inhibitory role in the Wnt signalling pathway in the genesis and development of endometrial carcinoma are scarce. This study aimed to investigate DKK1 expression in endometrial carcinoma and its correlation with the Wnt/β-catenin pathway.
    Methods: A total of 160 formalin-fixed paraffin-embedded samples were included in this study (50 cases of endometrial atypical hyperplasia, 50 cases of endometrioid endometrial carcinoma, 30 cases of proliferative endometrium and 30 cases of secretory endometrium). The expression patterns of DKK1, E-cadherin, β-catenin and c-Myc in endometrial atypical hyperplasia and carcinoma were investigated and compared with that of proliferative and secretory endometrium. Immunohistochemistry and analysis were performed from July 2018 to June 2020.
    Results: A decreasing pattern of immunopositivity for DKK1, E-cadherin and β-catenin from proliferative/secretory endometrium to endometrial atypical hyperplasia and endometrioid carcinoma was found. Increasing c-Myc immunopositivity was noted from proliferative/secretory endometrium to endometrial atypical hyperplasia and endometrioid carcinoma. Moreover, decreasing DKK1 immunopositivity was well correlated with E-cadherin, β-catenin and c-Myc immunopositivity.
    Conclusion: Decreasing DKK1 positivity from benign endometrium to endometrioid carcinoma suggests a negative regulatory function of DKK1 in endometrioid carcinoma. DKK1 is downregulated in the Wnt signalling pathway in endometrioid endometrial carcinoma. Therefore, DKK1 is promising as a biomarker for screening endometrioid carcinoma. Future studies should examine the reactivation of the DKK1 gene, which may be a valuable strategy for antagonising the Wnt signalling pathway.
    MeSH term(s) Female ; Humans ; Carcinoma, Endometrioid/genetics ; beta Catenin ; Hyperplasia ; Endometrial Neoplasms/genetics ; Cadherins ; Intercellular Signaling Peptides and Proteins
    Chemical Substances beta Catenin ; Cadherins ; DKK1 protein, human ; Intercellular Signaling Peptides and Proteins
    Language English
    Publishing date 2023-08-28
    Publishing country Oman
    Document type Journal Article
    ZDB-ID 2650196-X
    ISSN 2075-0528 ; 2075-0528
    ISSN (online) 2075-0528
    ISSN 2075-0528
    DOI 10.18295/squmj.12.2022.066
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Prognostic Significance of HE4 Tissue Expression in Serous Epithelial Ovarian Carcinoma.

    Sethi, Ankita / Kumar, Lalit / Mathur, Sandeep / Mahey, Reeta / Kachhawa, Garima / Bhatla, Neerja

    South Asian journal of cancer

    2022  Volume 11, Issue 2, Page(s) 125–132

    Abstract: Neerja Bhatla ...

    Abstract Neerja Bhatla
    Language English
    Publishing date 2022-02-27
    Publishing country India
    Document type Journal Article
    ZDB-ID 2719571-5
    ISSN 2278-4306 ; 2278-330X
    ISSN (online) 2278-4306
    ISSN 2278-330X
    DOI 10.1055/s-0042-1742711
    Database MEDical Literature Analysis and Retrieval System OnLINE

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