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Article ; Online: The COVID-19 Pandemic and the Ongoing Genocide of Black and Indigenous Peoples in Brazil

Barreto, Raimundo C.

Int J Lat Am Relig

Abstract: Cardinal Czerny has compared COVID-19 with a magnifying glass and an X-ray; this article reflects on the tragedy of the Brazilian experience with the COVID-19 pandemic and the deeper wounds it reveals and magnifies. Drawing from journalistic reports, ... ...

Abstract	Cardinal Czerny has compared COVID-19 with a magnifying glass and an X-ray; this article reflects on the tragedy of the Brazilian experience with the COVID-19 pandemic and the deeper wounds it reveals and magnifies. Drawing from journalistic reports, firsthand accounts, statistics, and existing academic literature on race and racism in Brazil, this article interrogates Brazilian racialized society and how the racial divide and economic disparities have been exacerbated through the devastating impact of the pandemic upon a large parcel of the Brazilian people, focusing particularly on how the pandemic magnifies and intensifies the genocide of black and indigenous Brazilians. The article also underscores how Bolsonaro’s strong man politics aggravates the situation, and scrutinizes the ambiguous role of religion in the construction and exacerbation of structural racism as well as in offering creative responses to the current situation.
Keywords	covid19
Publisher	PMC
Document type	Article ; Online
DOI	10.1007/s41603-020-00126-y
Database	COVID19

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Article: Serum Biochemistry of Greater Rhea (

Minervino, Antonio Humberto Hamad / Araújo, Carolina A S C / Soares, Herbert S / Picanço, Eloine M B / Silva, Yasmine R Batista / Mori, Clara Satsuki / Gennari, Solange Maria / Barrêto Júnior, Raimundo Alves / Ortolani, Enrico Lippi

Animals : an open access journal from MDPI

2023 Volume 13, Issue 13

Abstract: We investigated the biochemical profile of greater rheas ( ...

Abstract	We investigated the biochemical profile of greater rheas (
Language	English
Publishing date	2023-06-25
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2606558-7
ISSN	2076-2615
ISSN	2076-2615
DOI	10.3390/ani13132103
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Article ; Online: Serum Biochemistry of Greater Rhea (Rhea americana) in Captivity in the Northeast of Brazil

Minervino, Antonio Humberto Hamad / Araújo, Carolina A. S. C. / Soares, Herbert S. / Picanço, Eloine M. B. / Silva, Yasmine R. Batista / Mori, Clara Satsuki / Gennari, Solange Maria / Barrêto Júnior, Raimundo Alves / Ortolani, Enrico Lippi

Animals. 2023 June 25, v. 13, no. 13

2023

Abstract: We investigated the biochemical profile of greater rheas (Rhea americana) in captivity and correlated these values according to the birds’ sex. A total of 69 serum samples were collected from a breeding site in Mossoró, northeastern Brazil, and analyzed ... ...

Abstract	We investigated the biochemical profile of greater rheas (Rhea americana) in captivity and correlated these values according to the birds’ sex. A total of 69 serum samples were collected from a breeding site in Mossoró, northeastern Brazil, and analyzed to quantify serum biochemical parameters (total protein, albumin, cholesterol, calcium, phosphorus, uric acid, urea, creatinine, ALP, AST, and CK). The birds had levels of urea, creatinine, total cholesterol, aspartate aminotransferase, calcium, and phosphorus similar to the values reported for ratite and ostrich species. By sex, females showed higher values (p < 0.05) of calcium (3.5 mmol/L), total cholesterol (7.5 mmol/L), and uric acid (435.3 μmol/L) than males, which had 3.1 mmol/L, 3.8 mmol/L, and 390.7 μmol/L, respectively. This can be attributed to the difference in diet, the productive phase of females, or stress at the time of sampling. The data present a wide spectrum of biochemical results regarding the health of greater rheas, contributing to the veterinary clinical practice of this species.
Keywords	Rhea americana ; albumins ; aspartate transaminase ; blood chemistry ; blood serum ; calcium ; captive animals ; cholesterol ; creatinine ; diet ; ostriches ; phosphorus ; protein content ; rheas ; urea ; uric acid ; Brazil
Language	English
Dates of publication	2023-0625
Publishing place	Multidisciplinary Digital Publishing Institute
Document type	Article ; Online
ZDB-ID	2606558-7
ISSN	2076-2615
ISSN	2076-2615
DOI	10.3390/ani13132103
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Serum Biochemistry of Greater Rhea ( Rhea americana ) in Captivity in the Northeast of Brazil

Antonio Humberto Hamad Minervino / Carolina A. S. C. Araújo / Herbert S. Soares / Eloine M. B. Picanço / Yasmine R. Batista Silva / Clara Satsuki Mori / Solange Maria Gennari / Raimundo Alves Barrêto Júnior / Enrico Lippi Ortolani

Animals, Vol 13, Iss 2103, p

2023 Volume 2103

Abstract: We investigated the biochemical profile of greater rheas ( Rhea americana ) in captivity and correlated these values according to the birds’ sex. A total of 69 serum samples were collected from a breeding site in Mossoró, northeastern Brazil, and ... ...

Abstract	We investigated the biochemical profile of greater rheas ( Rhea americana ) in captivity and correlated these values according to the birds’ sex. A total of 69 serum samples were collected from a breeding site in Mossoró, northeastern Brazil, and analyzed to quantify serum biochemical parameters (total protein, albumin, cholesterol, calcium, phosphorus, uric acid, urea, creatinine, ALP, AST, and CK). The birds had levels of urea, creatinine, total cholesterol, aspartate aminotransferase, calcium, and phosphorus similar to the values reported for ratite and ostrich species. By sex, females showed higher values ( p < 0.05) of calcium (3.5 mmol/L), total cholesterol (7.5 mmol/L), and uric acid (435.3 μmol/L) than males, which had 3.1 mmol/L, 3.8 mmol/L, and 390.7 μmol/L, respectively. This can be attributed to the difference in diet, the productive phase of females, or stress at the time of sampling. The data present a wide spectrum of biochemical results regarding the health of greater rheas, contributing to the veterinary clinical practice of this species.
Keywords	biochemical profile ; Brazil ; captivity ; Rhea americana ; Veterinary medicine ; SF600-1100 ; Zoology ; QL1-991
Subject code	590
Language	English
Publishing date	2023-06-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Map2Check: Using Symbolic Execution and Fuzzing: (Competition Contribution)

Rocha, Herbert / Menezes, Rafael / Cordeiro, Lucas C. / Barreto, Raimundo

Tools and Algorithms for the Construction and Analysis of Systems

Abstract: ... invariants. It automatically checks safety properties in C programs by adopting source code instrumentation ...

Abstract	Map2Check is a software verification tool that combines fuzzing, symbolic execution, and inductive invariants. It automatically checks safety properties in C programs by adopting source code instrumentation to monitor data (e.g., memory pointers) from the program’s executions using LLVM compiler infrastructure. For SV-COMP 2020, we extended Map2Check to exploit an iterative deepening approach using LibFuzzer and Klee to check for safety properties. We also use Crab-LLVM to infer program invariants based on reachability analysis. Experimental results show that Map2Check can handle a wide variety of safety properties in several intricate verification tasks from SV-COMP 2020.
Keywords	covid19
Publisher	PMC
Document type	Article ; Online
DOI	10.1007/978-3-030-45237-7_29
Database	COVID19

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Article ; Online: Inhibition of murine colorectal cancer metastasis by targeting M2-TAM through STAT3/NF-kB/AKT signaling using macrophage 1-derived extracellular vesicles loaded with oxaliplatin, retinoic acid, and Libidibia ferrea.

de Carvalho, Thaís Gomes / Lara, Pablo / Jorquera-Cordero, Carla / Aragão, Cícero Flávio Soares / de Santana Oliveira, Artur / Garcia, Vinicius Barreto / de Paiva Souza, Shirley Vitória / Schomann, Timo / Soares, Luiz Alberto Lira / da Matta Guedes, Paulo Marcos / de Araújo Júnior, Raimundo Fernandes

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

2023 Volume 168, Page(s) 115663

Abstract: Colorectal cancer is still unmanageable despite advances in target therapy. However, extracellular vesicles (EVs) have shown potential in nanomedicine as drug delivery systems, especially for modulating the immune cells in the tumor microenvironment (TME) ...

Abstract	Colorectal cancer is still unmanageable despite advances in target therapy. However, extracellular vesicles (EVs) have shown potential in nanomedicine as drug delivery systems, especially for modulating the immune cells in the tumor microenvironment (TME). In this study, M1 Macrophage EVs (M1EVs) were used as nanocarriers of oxaliplatin (M1EV1) associated with retinoic acid (M1EV2) and Libidibia ferrea (M1EV3), alone or in combination (M1EV4) to evaluate their antiproliferative and immunomodulatory potential on CT-26 and MC-38 colorectal cancer cell lines and prevent metastasis in mice of allograft and peritoneal colorectal cancer models. Tumors were evaluated by qRT-PCR and immunohistochemistry. The cell death profile and epithelial-mesenchymal transition process (EMT) were analyzed in vitro in colorectal cancer cell lines. Polarization of murine macrophages (RAW264.7 cells) was also carried out. M1EV2 and M1EV3 used alone or particularly M1EV4 downregulated the tumor progression by TME immunomodulation, leading to a decrease in primary tumor size and metastasis in the peritoneum, liver, and lungs. STAT3, NF-kB, and AKT were the major genes downregulated by of M1EV systems. Tumor-associated macrophages (TAMs) shifted from an M2 phenotype (CD163) to an M1 phenotype (CD68) reducing levels of IL-10, TGF-β and CCL22. Furthermore, malignant cells showed overexpression of FADD, APAF-1, caspase-3, and E-cadherin, and decreased expression of MDR1, survivin, vimentin, and PD-L1 after treatment with systems of M1EVs. The study shows that EVs from M1 antitumor macrophages can transport drugs and enhance their immunomodulatory and antitumor activity by modulating pathways associated with cell proliferation, migration, survival, and drug resistance.
MeSH term(s)	Animals ; Mice ; Cell Line, Tumor ; Colorectal Neoplasms/pathology ; Extracellular Vesicles/metabolism ; Macrophages/metabolism ; NF-kappa B/metabolism ; Oxaliplatin/pharmacology ; Oxaliplatin/therapeutic use ; Proto-Oncogene Proteins c-akt/metabolism ; Tretinoin ; Tumor Microenvironment
Chemical Substances	NF-kappa B ; Oxaliplatin (04ZR38536J) ; Proto-Oncogene Proteins c-akt (EC 2.7.11.1) ; Tretinoin (5688UTC01R)
Language	English
Publishing date	2023-10-11
Publishing country	France
Document type	Journal Article
ZDB-ID	392415-4
ISSN	1950-6007 ; 0753-3322 ; 0300-0893
ISSN (online)	1950-6007
ISSN	0753-3322 ; 0300-0893
DOI	10.1016/j.biopha.2023.115663
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Article ; Online: Cognitive Effort during Visuospatial Problem Solving in Physical Real World, on Computer Screen, and in Virtual Reality.

da Silva Soares, Raimundo / Ramirez-Chavez, Kevin L / Tufanoglu, Altona / Barreto, Candida / Sato, João Ricardo / Ayaz, Hasan

Sensors (Basel, Switzerland)

2024 Volume 24, Issue 3

Abstract: Spatial cognition plays a crucial role in academic achievement, particularly in science, technology, engineering, and mathematics (STEM) domains. Immersive virtual environments (VRs) have the growing potential to reduce cognitive load and improve spatial ...

Abstract	Spatial cognition plays a crucial role in academic achievement, particularly in science, technology, engineering, and mathematics (STEM) domains. Immersive virtual environments (VRs) have the growing potential to reduce cognitive load and improve spatial reasoning. However, traditional methods struggle to assess the mental effort required for visuospatial processes due to the difficulty in verbalizing actions and other limitations in self-reported evaluations. In this neuroergonomics study, we aimed to capture the neural activity associated with cognitive workload during visuospatial tasks and evaluate the impact of the visualization medium on visuospatial task performance. We utilized functional near-infrared spectroscopy (fNIRS) wearable neuroimaging to assess cognitive effort during spatial-reasoning-based problem-solving and compared a VR, a computer screen, and a physical real-world task presentation. Our results reveal a higher neural efficiency in the prefrontal cortex (PFC) during 3D geometry puzzles in VR settings compared to the settings in the physical world and on the computer screen. VR appears to reduce the visuospatial task load by facilitating spatial visualization and providing visual cues. This makes it a valuable tool for spatial cognition training, especially for beginners. Additionally, our multimodal approach allows for progressively increasing task complexity, maintaining a challenge throughout training. This study underscores the potential of VR in developing spatial skills and highlights the value of comparing brain data and human interaction across different training settings.
MeSH term(s)	Humans ; Problem Solving ; Prefrontal Cortex ; Virtual Reality ; Brain ; Cognition
Language	English
Publishing date	2024-02-02
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2052857-7
ISSN	1424-8220 ; 1424-8220
ISSN (online)	1424-8220
ISSN	1424-8220
DOI	10.3390/s24030977
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Article ; Online: Impact of blood storage duration on hematologic, blood gas, biochemical, and oxidative stress variables in sheep undergoing allogeneic blood transfusions.

Sousa, Rejane S / Minervino, Antonio H H / Oliveira, Francisco Leonardo C / Araújo, Carolina Akiko Sato C / Rodrigues, Frederico Augusto M L / Zaminhan, Janayna Larissa R / Vale, Rodolfo G / Tavares, Marcondes D / Mori, Clara S / de Paula, Valéria V / Ortolani, Enrico L / Barrêto Júnior, Raimundo A

Veterinary clinical pathology

2020 Volume 49, Issue 4, Page(s) 545–556

Abstract: Background: Hemotherapy in ruminants is limited to whole blood transfusions, sometimes with stored blood for up to 42 days, but little attention has been given to the effect of blood storage times and recipient responses after transfusions.: ... ...

Abstract	Background: Hemotherapy in ruminants is limited to whole blood transfusions, sometimes with stored blood for up to 42 days, but little attention has been given to the effect of blood storage times and recipient responses after transfusions. Objectives: We aimed to evaluate the hematologic and serum biochemical effects after allogeneic blood transfusion with either fresh or stored blood in sheep. We also sought to examine hematologic and biochemical analyte changes in the store blood. Methods: Eighteen sheep underwent a single phlebotomy to remove 40% of their blood volume. The sheep were divided into three experimental groups, G0, G15, and G35, which included six animals, each receiving 20 mL/kg of either fresh blood or blood stored in citrate, phosphate, dextrose, and adenine (CPDA-1) bags for 15 and 35 days, respectively. Biochemical, hematologic, coagulation, blood gas, lipid peroxidation, and oxidative stress test evaluations were performed using the blood samples gathered at T0 (before transfusion), 30 minutes (T30m), 6, 12, 24, 48, 72, and 96 hours (T6h-T96h), 8 days (T8d), and 16 days (T16d) after transfusions. Results: Sheep exhibited increases in packed cell volumes, red blood cell counts, and total hemoglobin concentrations at T30m (P < .05). G35 animals had greater plasma hemoglobin concentrations at T12h and decreased blood pH values at T6h, characterized by slight metabolic acidemia. Regarding oxidative stress, G35 animals had decreased catalase activities from T0 at T30m, T6h, T12h, and T24h, indicating that hemolysis had occurred, which was supported by concomitant increases in bilirubin. Conclusions: Sheep transfused with 35-day stored blood exhibited greater hematologic, blood gas, biochemical, and oxidative alterations; however, anemic animals without comorbidities effectively reversed those alterations.
MeSH term(s)	Animals ; Blood Preservation/veterinary ; Blood Transfusion/veterinary ; Glucose ; Hematopoietic Stem Cell Transplantation/veterinary ; Oxidative Stress ; Sheep
Chemical Substances	Glucose (IY9XDZ35W2)
Language	English
Publishing date	2020-12-05
Publishing country	United States
Document type	Journal Article
ZDB-ID	2114702-4
ISSN	1939-165X ; 0275-6382
ISSN (online)	1939-165X
ISSN	0275-6382
DOI	10.1111/vcp.12917
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Article ; Online: Adherence to a Mediterranean diet, lifestyle and age-related macular degeneration: the Coimbra Eye Study - report 3.

Raimundo, Miguel / Mira, Filipe / Cachulo, Maria da Luz / Barreto, Patrícia / Ribeiro, Luísa / Farinha, Cláudia / Laíns, Inês / Nunes, Sandrina / Alves, Dalila / Figueira, João / Merle, Bénédicte Mj / Delcourt, Cécile / Santos, Lèlita / Silva, Rufino

Acta ophthalmologica

2018 Volume 96, Issue 8, Page(s) e926–e932

Abstract: ... with increased consumption of caffeine, fibres, beta-carotene, vitamin C and vitamin E (p < 0.05).: Conclusion ...

Abstract	Purpose: To characterize the lifestyle and nutritional risk profile associated with the Mediterranean diet in a Portuguese population with and without age-related macular degeneration (AMD). Methods: Nested case-control study (n = 883) within the Coimbra Eye Study, including 434 subjects with AMD and 449 age- and sex-matched subjects without AMD. All enrolled subjects underwent a full risk assessment, including lifestyle-related risk factors and a thorough food frequency questionnaire. This allowed us to build an adherence score to the Mediterranean diet (mediSCORE, range 0-9) constructed from individual food intakes. Food intake was also further analysed by conversion to micronutrient consumption. Results: Our results suggest that physical activity has a protective role in AMD [p = 0.018 after multivariate adjustment, OR: 0.69 (0.51-0.93)]. High (mediSCORE ≥6) was also found to be protective [p = 0.041, OR: 0.62 (95% CI: 0.38-0.97)]. Food group analysis unveiled a specific protective role for increased fruits consumption (p = 0.029). Finally, micronutrient analysis revealed a protective role associated with increased consumption of caffeine, fibres, beta-carotene, vitamin C and vitamin E (p < 0.05). Conclusion: High mediSCORE appears to confer protection against the development of AMD in a Mediterranean population. This effect is driven by increased consumption of fruits and some antioxidant micronutrients, which emerged as statistically significant protective factors. Further studies are required to establish dietary recommendations with clinical application.
MeSH term(s)	Aged ; Case-Control Studies ; Cross-Sectional Studies ; Diet, Mediterranean ; Female ; Humans ; Life Style ; Macular Degeneration/diet therapy ; Macular Degeneration/epidemiology ; Male ; Patient Compliance ; Population Surveillance ; Portugal/epidemiology ; Prevalence ; Prognosis ; Risk Assessment ; Risk Factors ; Rural Population/statistics & numerical data
Language	English
Publishing date	2018-09-14
Publishing country	England
Document type	Journal Article ; Multicenter Study
ZDB-ID	2408333-1
ISSN	1755-3768 ; 1755-375X
ISSN (online)	1755-3768
ISSN	1755-375X
DOI	10.1111/aos.13775
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Article ; Online: Adherence to a Mediterranean diet and its association with age-related macular degeneration. The Coimbra Eye Study-Report 4.

Nunes, Sandrina / Alves, Dalila / Barreto, Patrícia / Raimundo, Miguel / da Luz Cachulo, Maria / Farinha, Cláudia / Laíns, Inês / Rodrigues, João / Almeida, Carlos / Ribeiro, Luísa / Figueira, João / Santos, Lelita / Silva, Rufino

Nutrition (Burbank, Los Angeles County, Calif.)

2018 Volume 51-52, Page(s) 6–12

Abstract: ... linoleic acid, vitamins A and C, carotene, alpha-tocopherol, folate, magnesium, iron, and zinc were ...

Abstract	Objectives: This study aimed to characterize the association of lifestyle and nutritional risk profiles with age-related macular degeneration (AMD) in two subpopulations with differing AMD prevalence. Methods: This case-control study (n = 1992) included 768 patients with AMD and 1224 age- and sex-matched participants without AMD with a single visit at a primary health care unit. Enrolled participants completed a validated lifestyle and food frequency questionnaire. A score to measure adherence to the Mediterranean diet (mediSCORE; Range, 0-9) was constructed from individual food intakes, which were further analyzed by conversion to nutrient consumption. Results: Higher adherence to the Mediterranean diet (mediSCORE ≥6) was significantly associated with no AMD (odds ratio [OR] = 0.73; P = 0.009). The subpopulation with lower AMD prevalence presented significantly higher adherence to the Mediterranean diet in relation to all individual food groups that comprised the mediSCORE (P < 0.014) with the exception of cereals. Food group analysis showed significant associations between the increased consumption of vegetables (OR = 0.63; P < 0.001) and fruit and nuts (OR = 0.78; P = 0.010) with no AMD. Nutrient analysis revealed that an increased ingestion of water, fibers, total fat, monounsaturated and polyunsaturated fatty acids, linoleic acid, vitamins A and C, carotene, alpha-tocopherol, folate, magnesium, iron, and zinc were significantly associated with no AMD (P < 0.0013). Finally, regular physical activity was associated with no AMD (P = 0.003). Conclusions: High adherence to a Mediterranean diet and regular physical activity seem to be protective factors for AMD in a Portuguese population. The effect of the diet is likely driven by the increased consumption of vegetables, fruits, and nuts.
MeSH term(s)	Aged ; Case-Control Studies ; Cross-Sectional Studies ; Diet, Mediterranean/statistics & numerical data ; Exercise ; Female ; Geriatric Assessment/statistics & numerical data ; Humans ; Life Style ; Macular Degeneration/epidemiology ; Macular Degeneration/prevention & control ; Male ; Patient Compliance/statistics & numerical data ; Portugal/epidemiology ; Prevalence
Language	English
Publishing date	2018-03-13
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	639259-3
ISSN	1873-1244 ; 0899-9007
ISSN (online)	1873-1244
ISSN	0899-9007
DOI	10.1016/j.nut.2017.12.010
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