Article ; Online: Developmental epigenomic effects of maternal financial problems.
Development and psychopathology
2024 , Page(s) 1–14
Abstract: Early-life adversity as neglect or low socioeconomic status is associated with negative physical/mental health outcomes and plays an important role in health trajectories through life. The early-life environment has been shown to be encoded as changes in ...
Abstract | Early-life adversity as neglect or low socioeconomic status is associated with negative physical/mental health outcomes and plays an important role in health trajectories through life. The early-life environment has been shown to be encoded as changes in epigenetic markers that are retained for many years.We investigated the effect of maternal major financial problems (MFP) and material deprivation (MD) on their children's epigenome in the Avon Longitudinal Study of Parents and Children (ALSPAC) cohort. Epigenetic aging, measured with epigenetic clocks, was weakly accelerated with increased MFP. In subsequent EWAS, MFP, and MD showed strong, independent programing effects on children's genomes. MFP in the period from birth to age seven was associated with genome-wide epigenetic modifications on children's genome visible at age 7 and partially remaining at age 15.These results support the hypothesis that physiological processes at least partially explain associations between early-life adversity and health problems later in life. Both maternal stressors (MFP/MD) had similar effects on biological pathways, providing preliminary evidence for the mechanisms underlying the effects of low socioeconomic status in early life and disease outcomes later in life. Understanding these associations is essential to explain disease susceptibility, overall life trajectories and the transition from health to disease. |
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Language | English |
Publishing date | 2024-04-24 |
Publishing country | United States |
Document type | Journal Article |
ZDB-ID | 1036173-x |
ISSN | 1469-2198 ; 0954-5794 |
ISSN (online) | 1469-2198 |
ISSN | 0954-5794 |
DOI | 10.1017/S095457942400083X |
Database | MEDical Literature Analysis and Retrieval System OnLINE |
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