LIVIVO - Search results -

Search results

Result 1 - 10 of total 97

Search options

Article: Chemodivergence in Pd-catalyzed desymmetrization of allenes: enantioselective [4+3] cycloaddition, desymmetric allenylic substitution and enynylation.

Luo, Pengfei / Li, Long / Mao, Xinfang / Sun, Zheng / Wang, Yingcheng / Peng, Fangzhi / Shao, Zhihui

2023 Volume 14, Issue 39, Page(s) 10812–10823

Abstract: A class of prochiral allenylic di-electrophiles have been introduced for the first time as three-atom synthons in cycloadditions, and a new type of [4+3] cycloaddition involving transition metal-catalyzed enantioselective sequential allenylic ... ...

Abstract	A class of prochiral allenylic di-electrophiles have been introduced for the first time as three-atom synthons in cycloadditions, and a new type of [4+3] cycloaddition involving transition metal-catalyzed enantioselective sequential allenylic substitution has been successfully developed, enabling challenging seven-membered exocyclic axially chiral allenes to be accessed in good yields with good enantioselectivity. Through the addition of a catalytic amount of
Language	English
Publishing date	2023-09-21
Publishing country	England
Document type	Journal Article
ZDB-ID	2559110-1
ISSN	2041-6539 ; 2041-6520
ISSN (online)	2041-6539
ISSN	2041-6520
DOI	10.1039/d3sc04581a
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

Article ; Online: Optical Remote Sensing of Oil Spills in the Ocean

Chuanmin Hu / Yingcheng Lu / Shaojie Sun / Yongxue Liu

Journal of Remote Sensing, Vol

What Is Really Possible?

2021 Volume 2021

Abstract: Optical remote sensing (ORS) of reflected sun light has been used to assess oil spills in the ocean ...

Abstract	Optical remote sensing (ORS) of reflected sun light has been used to assess oil spills in the ocean for several decades. While most applications are toward simple presence/absence detections based on the spatial contrast between oiled water and oil-free water, recent advances indicate the possibility of classifying oil types and quantifying oil volumes based on their spectral contrasts with oil-free water. However, a review of the current literature suggests that there is still confusion on whether this is possible and, if so, how. Here, based on the recent findings from numerical models, laboratory measurements, and applications to satellite or airborne imagery, we attempt to clarify this situation by summarizing (1) the optics behind oil spill remote sensing, and in turn, (2) how to interpret optical remote sensing imagery based on optical principles. In the end, we discuss the existing limitations and challenges as well as pathways forward to advance ORS of oil spills.
Keywords	Environmental sciences ; GE1-350 ; Physical geography ; GB3-5030
Language	English
Publishing date	2021-01-01T00:00:00Z
Publisher	American Association for the Advancement of Science (AAAS)
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

Full text online

Full text

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article: The Relationship Between Short-Term Surrogate Endpoint Indicators and mPFS and mOS in Clinical Trials of Malignant Tumors: A Case Study of Approved Molecular Targeted Drugs for Non-Small-Cell Lung Cancer in China.

Rui, Mingjun / Wang, Zijing / Fei, Zhengyang / Wu, Yao / Wang, Yingcheng / Sun, Lei / Shang, Ye / Li, Hongchao

Frontiers in pharmacology

2022 Volume 13, Page(s) 862640

Abstract: Objective: ...

Abstract	Objective:
Language	English
Publishing date	2022-03-16
Publishing country	Switzerland
Document type	Systematic Review
ZDB-ID	2587355-6
ISSN	1663-9812
ISSN	1663-9812
DOI	10.3389/fphar.2022.862640
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Interactive Similarity-Based Search of Clinical Trials.

Sun, Yingcheng / Tang, Jiaqi / Butler, Alex / Liu, Cong / Fang, Yilu / Weng, Chunhua

Studies in health technology and informatics

2022 Volume 290, Page(s) 309–313

Abstract: The rapid growth of clinical trials launched in recent years poses significant challenges for accurate and efficient trial search. Keyword-based clinical trial search engines require users to construct effective queries, which can be a difficult task ... ...

Abstract	The rapid growth of clinical trials launched in recent years poses significant challenges for accurate and efficient trial search. Keyword-based clinical trial search engines require users to construct effective queries, which can be a difficult task given complex information needs. In this study, we present an interactive clinical trial search interface that retrieves trials similar to a target clinical trial. It enables user configuration of 13 clinical trial features and 4 metrics (Jaccard similarity, semantic-based similarity, temporal overlap and geographical distance) to measure pairwise trial similarities. Among 1,007 coronavirus disease 2019 (COVID-19) trials conducted in the United States, 91.9% were found to have similar trials with the similarity threshold being 0.85 and 43.8% were highly similar with the threshold 0.95. A simulation study using 3 groups of similar trials curated by COVID-19 clinical trial reviews demonstrates the precision and recall of the search interface.
MeSH term(s)	Benchmarking ; COVID-19 ; Data Collection ; Humans ; Search Engine ; Semantics
Language	English
Publishing date	2022-06-08
Publishing country	Netherlands
Document type	Journal Article
ISSN	1879-8365
ISSN (online)	1879-8365
DOI	10.3233/SHTI220085
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article ; Online: Synthesis of microcapsules containing a formaldehyde scavenger for the sustainable control of hazardous chemical release from particleboard.

Liu, Yu / Zhao, Aichen / Sun, Lei / Zhou, Hui / Xia, Guangda / Hu, Yingcheng / Zhu, Xiaodong

Journal of hazardous materials

2022 Volume 443, Issue Pt A, Page(s) 130156

Abstract: Formaldehyde scavenger microcapsules were introduced into particleboard to prepare an ecofriendly particleboard with a low pollution release in response to the problem of long-term unstable free formaldehyde release from particleboards. By analyzing key ... ...

Abstract	Formaldehyde scavenger microcapsules were introduced into particleboard to prepare an ecofriendly particleboard with a low pollution release in response to the problem of long-term unstable free formaldehyde release from particleboards. By analyzing key parameters of formaldehyde emission from particleboard, the effects of microcapsules on the diffusion, migration and inhibition of free formaldehyde in particleboard pore structures was discussed. The results showed that microencapsulated formaldehyde scavenger prepared by an emulsification cross-linking method with chitosan as the wall material and urea as the core material resulted in a good long-term controlled release effect on formaldehyde emission. Compared with that of the control panel, the formaldehyde emission of the particleboard with microcapsules decreased by 51.4 % and 25.8 % at 28 d and 180 d, respectively. The addition of formaldehyde scavenger microcapsules increased the particleboard macroscopic pore volume, which facilitated the conversion of adsorbed formaldehyde into free formaldehyde in the pore structure, thereby promoting its migration and diffusion in the particleboard pores. Moreover, the synergistic effect of the addition-condensation and nucleophilic cross-linking of the core and wall materials quickly captured the free formaldehyde in the panels and reduced the releasable concentration of formaldehyde in the material, thus achieving the long-term effective control of formaldehyde emission.
MeSH term(s)	Capsules ; Hazardous Substances ; Formaldehyde/chemistry ; Urea
Chemical Substances	Capsules ; Hazardous Substances ; Formaldehyde (1HG84L3525) ; Urea (8W8T17847W)
Language	English
Publishing date	2022-10-11
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1491302-1
ISSN	1873-3336 ; 0304-3894
ISSN (online)	1873-3336
ISSN	0304-3894
DOI	10.1016/j.jhazmat.2022.130156
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: A knowledge base of clinical trial eligibility criteria.

Liu, Hao / Chi, Yuan / Butler, Alex / Sun, Yingcheng / Weng, Chunhua

Journal of biomedical informatics

2021 Volume 117, Page(s) 103771

Abstract: Objective: We present the Clinical Trial Knowledge Base, a regularly updated knowledge base of discrete clinical trial eligibility criteria equipped with a web-based user interface for querying and aggregate analysis of common eligibility criteria.: ... ...

Abstract	Objective: We present the Clinical Trial Knowledge Base, a regularly updated knowledge base of discrete clinical trial eligibility criteria equipped with a web-based user interface for querying and aggregate analysis of common eligibility criteria. Materials and methods: We used a natural language processing (NLP) tool named Criteria2Query (Yuan et al., 2019) to transform free text clinical trial eligibility criteria from ClinicalTrials.gov into discrete criteria concepts and attributes encoded using the widely adopted Observational Medical Outcomes Partnership (OMOP) Common Data Model (CDM) and stored in a relational SQL database. A web application accessible via RESTful APIs was implemented to enable queries and visual aggregate analyses. We demonstrate CTKB's potential role in EHR phenotype knowledge engineering using ten validated phenotyping algorithms. Results: At the time of writing, CTKB contained 87,504 distinctive OMOP CDM standard concepts, including Condition (47.82%), Drug (23.01%), Procedure (13.73%), Measurement (24.70%) and Observation (5.28%), with 34.78% for inclusion criteria and 65.22% for exclusion criteria, extracted from 352,110 clinical trials. The average hit rate of criteria concepts in eMERGE phenotype algorithms is 77.56%. Conclusion: CTKB is a novel comprehensive knowledge base of discrete eligibility criteria concepts with the potential to enable knowledge engineering for clinical trial cohort definition, clinical trial population representativeness assessment, electronical phenotyping, and data gap analyses for using electronic health records to support clinical trial recruitment.
MeSH term(s)	Algorithms ; Clinical Trials as Topic ; Databases, Factual ; Electronic Health Records ; Humans ; Knowledge Bases ; Natural Language Processing
Language	English
Publishing date	2021-04-01
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	2057141-0
ISSN	1532-0480 ; 1532-0464
ISSN (online)	1532-0480
ISSN	1532-0464
DOI	10.1016/j.jbi.2021.103771
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Metronomic therapy in advanced breast cancer and NSCLC: vinorelbine as a paradigm of recent progress.

Xu, Binghe / Sun, Tao / Wang, Shusen / Lin, Yingcheng

Expert review of anticancer therapy

2020 Volume 21, Issue 1, Page(s) 71–79

Abstract: Introduction: Metronomic chemotherapy (MCT) is based on frequent dosing of the drug. . This leads to pharmacologically active but low plasma concentrations that reduce toxicity. MCT seems to work primarily via indirect effects on tumor cells and their ... ...

Abstract	Introduction: Metronomic chemotherapy (MCT) is based on frequent dosing of the drug. . This leads to pharmacologically active but low plasma concentrations that reduce toxicity. MCT seems to work primarily via indirect effects on tumor cells and their microenvironment, rather than direct antitumor effects. Oral vinorelbine is one of the most widely studied MCT approaches in both advanced breast cancer and non-small cell lung cancer. Expert opinion: MCT with vinorelbine has proven efficacy, tolerability and quality of life benefits both as monotherapy and in combination with other MCTs or targeted agents, in first-line therapy and in previously treated patients. Key populations are emerging who may be particularly well suited to metronomic vinorelbine, including those with indolent disease, older individuals, and those with multiple comorbidities and/or bone metastases. Ongoing trials should help to further delineate these target groups. Additional work is needed to better understand the optimal vinorelbine regimen, particularly when used in combination or in non-Caucasian patients. Markers are also required to help identify individuals who are most likely to respond. Nonetheless, the efficacy and tolerability of MCT, allied to improved patient convenience, reduced need for medical engagement and lower cost, make it an appealing option - particular in resource-constrained healthcare environments.
MeSH term(s)	Administration, Metronomic ; Antineoplastic Agents, Phytogenic/administration & dosage ; Antineoplastic Agents, Phytogenic/adverse effects ; Biomarkers, Tumor/metabolism ; Breast Neoplasms/drug therapy ; Breast Neoplasms/pathology ; Carcinoma, Non-Small-Cell Lung/drug therapy ; Carcinoma, Non-Small-Cell Lung/pathology ; Female ; Humans ; Lung Neoplasms/drug therapy ; Quality of Life ; Tumor Microenvironment ; Vinorelbine/administration & dosage ; Vinorelbine/adverse effects
Chemical Substances	Antineoplastic Agents, Phytogenic ; Biomarkers, Tumor ; Vinorelbine (Q6C979R91Y)
Language	English
Publishing date	2020-10-22
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	2112544-2
ISSN	1744-8328 ; 1473-7140
ISSN (online)	1744-8328
ISSN	1473-7140
DOI	10.1080/14737140.2021.1835478
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Cologne/Königswinter

Zs.A 5907: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾

Article: Chemical exchange saturation transfer (CEST) magnetic resonance imaging (MRI) quantification of transient ischemia using a combination method of 5-pool Lorentzian fitting and inverse Z-spectrum analysis.

Zhang, Lihong / Xu, Chongxin / Li, Zhen / Sun, Junding / Wang, Xiaoli / Hou, Beibei / Zhao, Yingcheng

Quantitative imaging in medicine and surgery

2022 Volume 13, Issue 3, Page(s) 1860–1873

Abstract: Background: Chemical exchange saturation transfer (CEST) is a promising method for the detection of biochemical alterations in cancers and neurological diseases. However, the sensitivity of the currently existing quantitative method for detecting ... ...

Abstract	Background: Chemical exchange saturation transfer (CEST) is a promising method for the detection of biochemical alterations in cancers and neurological diseases. However, the sensitivity of the currently existing quantitative method for detecting ischemia needs further improvement. Methods: To further improve the quantification of the CEST signal and enhance the CEST detection for ischemia, we used a quantitative analysis method that combines an inverse Z-spectrum analysis and a 5-pool Lorentzian fitting. Specifically, a 5-pool Lorentzian simulation was conducted with the following brain tissue parameters: water, amide (3.5 ppm), amine (2.2 ppm), magnetization transfer (MT), and nuclear Overhauser enhancement (NOE; -3.5 ppm). The parameters were first calculated offline and stored as the initial value of the Z-spectrum fitting. Then, the measured Z-spectrum with the peak value set to 0 was fitted via the stored initial value, which yielded the reference Z-spectrum. Finally, the difference between the inverse of the Z-spectrum and the inverse of the reference Z-spectrum was used as the CEST definite spectrum. Results: The simulation results demonstrated that the Z-spectra of the rat brain were well simulated by a 5-pool Lorentzian fitting. Further, the proposed method detected a larger difference than did either the saturation transfer difference or the 5-pool Lorentzian fitting, as demonstrated by simulations. According to the results of the cerebral ischemia rat model, the proposed method provided the highest contrast-to-noise ratio (CNR) between the contralateral and the ipsilateral striatum under various acquisition conditions. The results indicated that the difference of fitted amplitudes generated with a 5-pool Lorentzian fitting in amide at 3.5 ppm (6.04%±0.39%; 6.86%±0.39%) was decreased in a stroke lesion compared to the contralateral normal tissue. Moreover, the difference of the residual of inversed Z-spectra in which 5-pool Lorentzian fitting was used to calculate the reference Z-spectra ( Conclusions: M
Language	English
Publishing date	2022-12-05
Publishing country	China
Document type	Journal Article
ZDB-ID	2653586-5
ISSN	2223-4306 ; 2223-4292
ISSN (online)	2223-4306
ISSN	2223-4292
DOI	10.21037/qims-22-420
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Cost-effectiveness analysis of sintilimab + chemotherapy versus camrelizumab + chemotherapy for the treatment of first-line locally advanced or metastatic nonsquamous NSCLC in China.

Rui, Mingjun / Fei, Zhengyang / Wang, Yingcheng / Zhang, Xueke / Ma, Aixia / Sun, Haikui / Li, Hongchao

Journal of medical economics

2022 Volume 25, Issue 1, Page(s) 618–629

Abstract: Background and objective: Sintilimab is a selective PD-1 inhibitor with efficacy in advanced or metastatic nonsquamous non-small-cell lung cancer (NSCLC) patients. This study evaluated the cost-effectiveness of sintilimab + chemotherapy versus ... ...

Abstract	Background and objective: Sintilimab is a selective PD-1 inhibitor with efficacy in advanced or metastatic nonsquamous non-small-cell lung cancer (NSCLC) patients. This study evaluated the cost-effectiveness of sintilimab + chemotherapy versus camrelizumab + chemotherapy as the first-line treatment for locally advanced or metastatic nonsquamous NSCLC in Chinese patients. In addition, this study aimed to reveal the impact of the reference treatment choice on the incremental cost-effectiveness ratio (ICER) results. Methods: A partitioned survival model (PSM) with three health states was constructed in a 3-week cycle with a lifetime horizon from the Chinese healthcare system perspective. Anchored matching adjusted indirect comparison was used for survival analyses based on individual patient data from Orient-11. Sintilimab + chemotherapy was chosen as the reference treatments in scenarios 1 and 2, while the camrelizumab + chemotherapy was chosen as the reference treatments in scenario 3. The utility values of different health states were derived from the patient-level European Organization for Research and Treatment Quality of Life Questionnaire-Core 30 (EORTC QLQ-C30) scores by mapping to the EQ-5D-5L, and QALYs were calculated as the health outcomes. One-way deterministic sensitivity analysis (DSA) and probability sensitivity analysis (PSA) were performed to explore model uncertainty. Results: Compared to camrelizumab + chemotherapy, sintilimab + chemotherapy was associated with higher effectiveness (incremental QALYs ranged from 0.13-0.62) and lower total costs (incremental costs ranged from $1,099-$5,201), resulting in an ICER ranging from $6,440-$8,454/QALY. Conclusions: Sintilimab + chemotherapy is a cost-effective option compared with camrelizumab + chemotherapy as the first-line treatment for locally advanced or metastatic nonsquamous NSCLC in China.
MeSH term(s)	Antibodies, Monoclonal, Humanized ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Carcinoma, Non-Small-Cell Lung/pathology ; Cost-Benefit Analysis ; Humans ; Lung Neoplasms/pathology ; Quality of Life ; Quality-Adjusted Life Years
Chemical Substances	Antibodies, Monoclonal, Humanized ; camrelizumab (73096E137E) ; sintilimab (8FU7FQ8UPK)
Language	English
Publishing date	2022-05-16
Publishing country	England
Document type	Journal Article
ZDB-ID	2270945-9
ISSN	1941-837X ; 1369-6998
ISSN (online)	1941-837X
ISSN	1369-6998
DOI	10.1080/13696998.2022.2071066
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 6450: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article: Lightweight, High-Strength Wood Prepared by Deep Eutectic Solvent Treatment as a Green Structural Material

Fan, Zixuan / Sun, Hao / Zhang, Luoyuan / Zhao, Xin / Hu, Yingcheng

ACS sustainable chemistry & engineering. 2022 July 11, v. 10, no. 29

2022

Abstract: Wood is a green, environmentally sustainable, high-performance structural material that is an attractive candidate to replace nonenvironmental structural materials. However, the mechanical performance of natural wood is generally insufficient in many ... ...

Abstract	Wood is a green, environmentally sustainable, high-performance structural material that is an attractive candidate to replace nonenvironmental structural materials. However, the mechanical performance of natural wood is generally insufficient in many advanced engineering structures and applications. Herein, we report a simple and effective strategy in a new type of green-enhanced wood development to synthesize a high mechanical biomass structure material from renewable wood resources. In this process, the lignin of the natural wood is partially removed, and the hard cell walls become pliable and easy to handle. After treatment, the wood fiber structure is preserved, and the wood fibers are closely arranged after densification, which shows the reinforced wood with high mechanical properties. The resulting reinforced wood is 8 times stronger than the starting wood and comparable to widely used structure materials such as concrete, stainless steel, aluminum alloy, and magnesium alloy. This method of manufacturing reinforced wood with green, rich, and renewable natural wood is extremely attractive for the sustainable development of engineering structural materials, which broadens the potential of wood as structural materials.
Keywords	aluminum alloys ; biomass ; concrete ; green chemistry ; lignin ; magnesium ; reinforced wood ; solvents ; stainless steel ; sustainable development ; wood ; wood fibers
Language	English
Dates of publication	2022-0711
Size	p. 9600-9611.
Publishing place	American Chemical Society
Document type	Article
ISSN	2168-0485
DOI	10.1021/acssuschemeng.2c02606
Database	NAL-Catalogue (AGRICOLA)

Order via subito

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

To top

More links

Kategorien

Order via subito

Full text online

More links

Kategorien

Inter-library loan at ZB MED

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito

Inter-library loan at ZB MED

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito

Full text online

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito

Inter-library loan at ZB MED