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  1. Article ; Online: Infection rates are high across the multiple myeloma continuum, not just with bispecific antibodies.

    Rubinstein, Samuel M / Derman, Benjamin A

    European journal of cancer (Oxford, England : 1990)

    2023  Volume 189, Page(s) 112926

    MeSH term(s) Humans ; Multiple Myeloma ; Antibodies, Bispecific/therapeutic use ; T-Lymphocytes ; CD3 Complex
    Chemical Substances Antibodies, Bispecific ; CD3 Complex
    Language English
    Publishing date 2023-06-10
    Publishing country England
    Document type Letter
    ZDB-ID 82061-1
    ISSN 1879-0852 ; 0277-5379 ; 0959-8049 ; 0964-1947
    ISSN (online) 1879-0852
    ISSN 0277-5379 ; 0959-8049 ; 0964-1947
    DOI 10.1016/j.ejca.2023.05.014
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 456: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 583: Show issues

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  2. Article ; Online: Thrombosis in the modern era of multiple myeloma.

    Rubinstein, Samuel M / Tuchman, Sascha A

    Blood

    2020  Volume 136, Issue 9, Page(s) 1019–1021

    MeSH term(s) Humans ; Multiple Myeloma/complications ; Multiple Myeloma/therapy ; Randomized Controlled Trials as Topic ; Thrombosis/etiology
    Language English
    Publishing date 2020-06-29
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 80069-7
    ISSN 1528-0020 ; 0006-4971
    ISSN (online) 1528-0020
    ISSN 0006-4971
    DOI 10.1182/blood.2020006648
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Uh III Zs.140: Show issues Location:
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    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 364: Show issues

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  3. Article ; Online: How to Screen for Monoclonal Gammopathy in Patients With a Suspected Amyloidosis.

    Rubinstein, Samuel M / Stockerl-Goldstein, Keith

    JACC. CardioOncology

    2021  Volume 3, Issue 4, Page(s) 590–593

    Language English
    Publishing date 2021-10-19
    Publishing country United States
    Document type Journal Article ; Review
    ISSN 2666-0873
    ISSN (online) 2666-0873
    DOI 10.1016/j.jaccao.2021.07.001
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: COVID-19 and haematological malignancy: navigating a narrow strait.

    Rubinstein, Samuel M / Warner, Jeremy L

    The Lancet. Haematology

    2020  Volume 7, Issue 10, Page(s) e701–e703

    MeSH term(s) Betacoronavirus ; COVID-19 ; Cohort Studies ; Coronavirus Infections ; Hematologic Neoplasms/epidemiology ; Humans ; Italy ; Pandemics ; Pneumonia, Viral ; Retrospective Studies ; Risk Factors ; SARS-CoV-2
    Keywords covid19
    Language English
    Publishing date 2020-08-13
    Publishing country England
    Document type Journal Article ; Comment
    ISSN 2352-3026
    ISSN (online) 2352-3026
    DOI 10.1016/S2352-3026(20)30252-0
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: CancerLinQ: Origins, Implementation, and Future Directions.

    Rubinstein, Samuel M / Warner, Jeremy L

    JCO clinical cancer informatics

    2019  Volume 2, Page(s) 1–7

    Abstract: Rapid-learning health systems have been proposed as a potential solution to the problem of quality in medicine, by leveraging data generated from electronic health systems in near-real time to improve quality and reduce cost. Given the complex, dynamic ... ...

    Abstract Rapid-learning health systems have been proposed as a potential solution to the problem of quality in medicine, by leveraging data generated from electronic health systems in near-real time to improve quality and reduce cost. Given the complex, dynamic nature of cancer care, a rapid-learning health system offers large potential benefits to oncology practice. In this article, we review the rationale for developing a rapid-learning health system for oncology and describe the sequence of events that led to the development of ASCO's CancerLinQ (Cancer Learning Intelligence Network for Quality) initiative, as well as the current state of CancerLinQ, including its importance to efforts such as the Beau Biden Cancer Moonshot. We then review the considerable challenges facing optimal implementation of a rapid-learning health system such as CancerLinQ, including integration of rapidly expanding multiomic data, capturing big data from a variety of sources, an evolving competitive landscape, and implementing a rapid-learning health system in a way that satisfies many stakeholders, including patients, providers, researchers, and administrators.
    MeSH term(s) Big Data ; Delivery of Health Care/methods ; Humans ; Machine Learning ; Neoplasms/economics ; Quality of Health Care
    Language English
    Publishing date 2019-01-16
    Publishing country United States
    Document type Journal Article ; Review
    ISSN 2473-4276
    ISSN (online) 2473-4276
    DOI 10.1200/CCI.17.00060
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: COVID-19 and haematological malignancy

    Rubinstein, Samuel M / Warner, Jeremy L

    The Lancet Haematology

    navigating a narrow strait

    2020  Volume 7, Issue 10, Page(s) e701–e703

    Keywords Hematology ; covid19
    Language English
    Publisher Elsevier BV
    Publishing country us
    Document type Article ; Online
    ISSN 2352-3026
    DOI 10.1016/s2352-3026(20)30252-0
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article ; Online: Treatment of Localized Amyloid Light Chain Amyloidosis With External Beam Radiation Therapy.

    Hall, Jacob / Rubinstein, Samuel / Lilly, Amy / Blumberg, Jeffrey M / Chera, Bhishamjit

    Practical radiation oncology

    2022  Volume 12, Issue 6, Page(s) 504–510

    Abstract: Purpose: Localized amyloidosis is a condition characterized by deposits of fibrillary proteins confined to a single organ. The most common subtype is amyloid light chain amyloidosis, which is caused by secretion of amyloidogenic light chain by a ... ...

    Abstract Purpose: Localized amyloidosis is a condition characterized by deposits of fibrillary proteins confined to a single organ. The most common subtype is amyloid light chain amyloidosis, which is caused by secretion of amyloidogenic light chain by a monoclonal population of plasma cells. We present a review and discussion of the literature in the context of a case presentation of localized amyloid light chain amyloidosis of the nasopharynx treated with radiation alone.
    Methods and materials: We reviewed literature relevant to this topic from 1970 to the present. Relevant studies, reports, and articles were summarized in table form.
    Results: Surgical resection has historically been the primary therapeutic modality for these patients, with radiation being reserved for recurrent lesions or for those unfit for surgery. Although the data are limited to small retrospective series, radiation has been shown to provide good control with mild toxicity that is as good as or better than surgery. Doses range from 20 to 45 Gy, conventionally fractionated. There is no known risk of progression to systemic disease without local therapy.
    Conclusions: We recommend local therapy for symptomatic patients after systemic disease has been excluded. We generally recommend radiation in the setting of recurrent lesions, unacceptable toxicity with surgery, poor surgical candidates, and as the initial modality in select patients (elderly individuals with bothersome but nonobstructive lesions).
    MeSH term(s) Humans ; Aged ; Retrospective Studies ; Amyloidosis/radiotherapy
    Language English
    Publishing date 2022-09-08
    Publishing country United States
    Document type Review ; Journal Article
    ZDB-ID 2655748-4
    ISSN 1879-8519 ; 1879-8500
    ISSN (online) 1879-8519
    ISSN 1879-8500
    DOI 10.1016/j.prro.2022.03.011
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: COVID-19 in Patients with Hematologic Malignancies: Outcomes and Options for Treatments.

    Martínez, José Carlos / Sica, R Alejandro / Stockerl-Goldstein, Keith / Rubinstein, Samuel M

    Acta haematologica

    2022  Volume 145, Issue 3, Page(s) 244–256

    Abstract: Patients with hematologic malignancies are particularly vulnerable to infections due to underlying humoral and cellular immune dysfunction, cytotoxic chemotherapy regimens, advanced age, and the presence of comorbid conditions. Infection from severe ... ...

    Abstract Patients with hematologic malignancies are particularly vulnerable to infections due to underlying humoral and cellular immune dysfunction, cytotoxic chemotherapy regimens, advanced age, and the presence of comorbid conditions. Infection from severe acute respiratory syndrome coronavirus 2, the causative agent of the COVID-19 pandemic, has become a leading cause of death globally and has disproportionally affected this high-risk population. Here, we review the cumulative evidence demonstrating worse outcomes for patients with hematologic malignancies when compared to patients with solid tumors and the general population. We examine risk factors shared with the general population (age, sex, comorbid conditions, and race) and those that are cancer-specific (cytotoxic chemotherapy, progressive disease, and cancer type), all of which confer an increased risk of severe COVID-19. Despite the historical exclusion of cancer patients from COVID-19 therapy trials, we review the emerging evidence that patients with hematologic malignancies benefit from specific treatments such as convalescent plasma. Although COVID-19 vaccines are significantly less effective in this patient population, encouraging results are observed in a subset of these patients after receiving a booster dose.
    MeSH term(s) COVID-19/complications ; COVID-19/therapy ; COVID-19 Vaccines ; Hematologic Neoplasms/complications ; Hematologic Neoplasms/epidemiology ; Hematologic Neoplasms/therapy ; Humans ; Immunization, Passive ; Neoplasms ; Pandemics
    Chemical Substances COVID-19 Vaccines
    Language English
    Publishing date 2022-02-08
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 80008-9
    ISSN 1421-9662 ; 0001-5792
    ISSN (online) 1421-9662
    ISSN 0001-5792
    DOI 10.1159/000522436
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Ud II Zs.145: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  10. Article ; Online: Standardizing Chemotherapy Regimen Nomenclature: A Proposal and Evaluation of the HemOnc and National Cancer Institute Thesaurus Regimen Content.

    Rubinstein, Samuel M / Yang, Peter C / Cowan, Andrew J / Warner, Jeremy L

    JCO clinical cancer informatics

    2020  Volume 4, Page(s) 60–70

    Abstract: Purpose: Due to decades of nonstandardized approaches to the naming of chemotherapy regimens, representation in electronic health records and secondary systems is highly variable. This hampers efforts to understand patterns of chemotherapy usage at the ... ...

    Abstract Purpose: Due to decades of nonstandardized approaches to the naming of chemotherapy regimens, representation in electronic health records and secondary systems is highly variable. This hampers efforts to understand patterns of chemotherapy usage at the population level. In this article, we describe a proposal for rules to standardize the nomenclature of chemotherapy regimens and illustrate applications of these rules.
    Methods: Through our experience with building HemOnc.org, which has been under construction since 2011, we formulated a set of guidelines and recommendations for the standard representation of chemotherapy regimen names. We then performed a mapping between the HemOnc and National Cancer Institute Thesaurus vocabulary's regimens and evaluated conformance with the naming conventions. Finally, we assembled a database of acronyms and names for multiple myeloma regimens to illustrate the scope of the problem.
    Results: For the first use case, 242 of 527 (45.1%) of the regimen names differed. The schema was able to allocate a preferred source for 217 (89.4%) of these regimens. For the second use case, we expanded 130 multiple myeloma regimens to 1,138 unique regimen names and demonstrate ways in which the schema can collapse these into disambiguated, but abbreviated, regimen names.
    Conclusion: To our knowledge, this is the first proposal to normalize chemotherapy regimen nomenclature. If our recommendations are adopted, we expect that the uniformity of treatment exposure representation in hematology/oncology will increase, which will enable large-scale efforts such as ASCO's CancerLinQ to achieve better standardization.
    MeSH term(s) Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Databases, Factual ; Hematology/standards ; Humans ; Medical Informatics/standards ; Medical Oncology/standards ; National Cancer Institute (U.S.) ; Neoplasms/drug therapy ; Terminology as Topic ; United States ; Vocabulary, Controlled
    Language English
    Publishing date 2020-01-28
    Publishing country United States
    Document type Evaluation Study ; Journal Article
    ISSN 2473-4276
    ISSN (online) 2473-4276
    DOI 10.1200/CCI.19.00122
    Database MEDical Literature Analysis and Retrieval System OnLINE

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