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Article ; Online: Cannabidiol and mental health: possibilities, uncertainties, and controversies for addiction treatment.

Kessler, Felix H / von Diemen, Lisia / Ornell, Felipe / Sordi, Anne O

Revista brasileira de psiquiatria (Sao Paulo, Brazil : 1999)

2021 Volume 43, Issue 5, Page(s) 455–457

MeSH term(s)	Behavior, Addictive ; Cannabidiol/therapeutic use ; Humans ; Mental Disorders/drug therapy ; Mental Health ; Uncertainty
Chemical Substances	Cannabidiol (19GBJ60SN5)
Language	English
Publishing date	2021-06-04
Publishing country	Brazil
Document type	Editorial
ZDB-ID	2024119-7
ISSN	1809-452X ; 1809-452X
ISSN (online)	1809-452X
ISSN	1809-452X
DOI	10.1590/1516-4446-2021-1838
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: The Sum of Fears in Cancer Patients Inside the Context of the COVID-19.

Bandinelli, Lucas / Ornell, Felipe / von Diemen, Lisia / Kessler, Felix Henrique Paim

Frontiers in psychiatry

2021 Volume 12, Page(s) 557834

Abstract: The pandemic resulting from COVID-19 has led to the collapse of the health system in dozens of countries. Parallel to clinical risk, the appearance or intensification of psychiatric symptoms has also been documented. The identification of groups at risk ... ...

Abstract	The pandemic resulting from COVID-19 has led to the collapse of the health system in dozens of countries. Parallel to clinical risk, the appearance or intensification of psychiatric symptoms has also been documented. The identification of groups at risk is essential for the establishment of preventive and therapeutic strategies. Cancer patients appear to be especially vulnerable both from a clinical and psychiatric perspective. Problems related to contamination and the cancer treatments themselves are intertwined, causing a sum of patients' fears to arise, which can cause mental effects. This study aims to review and investigate the impact of COVID-19 on the mental health of cancer patients and indicate possible support strategies.
Language	English
Publishing date	2021-04-07
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2564218-2
ISSN	1664-0640
ISSN	1664-0640
DOI	10.3389/fpsyt.2021.557834
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: A network analysis of early trauma and impulsive behavior in individuals with mono- and poly-dependence of alcohol and crack cocaine.

Volpatto, Vanessa Loss / Schuch, Jaqueline Bohrer / Rabelo-da-Ponte, Francisco Diego / Borgonhi, Ellen Mello / de Freitas, Júlia Corrêa / Ornell, Felipe / Proença, Ramon Agostini / Pio, Rodrigo Pereira / von Diemen, Lisia / Kessler, Felix Henrique Paim

Revista brasileira de psiquiatria (Sao Paulo, Brazil : 1999)

2024

Abstract: Objective: To investigate the relationship between impulsivity and early trauma through a network analysis in individuals diagnosed with different substance use disorders (SUD).: Methods: This cross-sectional study includes a sample of 556 men with ... ...

Abstract	Objective: To investigate the relationship between impulsivity and early trauma through a network analysis in individuals diagnosed with different substance use disorders (SUD). Methods: This cross-sectional study includes a sample of 556 men with SUD (195 with alcohol use, 157 with crack cocaine use and 214 with multiple substance use). The Childhood Trauma Questionnaire was applied to investigate early trauma and the Barratt Impulsiveness Scale to assess impulsive behavior. The connection between trauma and impulsivity was assessed using network analysis through Fused Graphical Lasso algorithm. Results: No connection was observed between impulsivity and trauma networks in individuals with alcohol use. In cocaine users, networks were linked through the motor domain and sexual abuse nodes. Inversely connections were observed between emotional neglect node and perseverance and not planning nodes. In poly-use, the connection between impulsivity and trauma networks was weak, with cognitive complexity being the node that connects to the trauma network through physical abuse. There were inversely proportional connections between motor domain and emotional neglect nodes, and cognitive instability and physical neglect. Conclusions: Our results suggest that the relationship between the type of early (childhood) trauma and the expression of impulsivity could lead to a different substance use profile.
Language	English
Publishing date	2024-03-06
Publishing country	Brazil
Document type	Journal Article
ZDB-ID	2024119-7
ISSN	1809-452X ; 1809-452X
ISSN (online)	1809-452X
ISSN	1809-452X
DOI	10.47626/1516-4446-2023-3265
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Association between telomere length with alcohol use disorder and internalizing/externalizing comorbidities in a Brazilian male sample.

Moura, Helena Ferreira / Schuch, Jaqueline Bohrer / Ornell, Felipe / Bandeira, Cibele Edom / Massuda, Raffael / Dotto Bau, Claiton Henrique / Grevet, Eugenio Horácio / Kessler, Felix H P / von Diemen, Lisia

Alcohol (Fayetteville, N.Y.)

2024

Abstract: Background: Shortening telomere length (TL) is an important ageing marker associated with substance use disorder (SUD). However, the influence of psychiatric and clinical comorbidities and alcohol-related outcomes has not been much explored in the ... ...

Abstract	Background: Shortening telomere length (TL) is an important ageing marker associated with substance use disorder (SUD). However, the influence of psychiatric and clinical comorbidities and alcohol-related outcomes has not been much explored in the context of TL in individuals with alcohol use disorder (AUD) and may be a source of heterogeneity in AUD studies. Therefore, our aim was to investigate the influence of AUD, alcohol-related outcomes, and common psychiatric comorbidities on TL in men with AUD and healthy controls (HC). Methods: Men with AUD (n=108, mean age=52.4, SD=8.6) were recruited in a detoxification unit, and HC (n=80, mean age=50.04, SD=9.1) from the blood bank, both located in Brazil. HC had no current or lifetime diagnosis of any substance use disorder. Psychiatric comorbidities were assessed using SCID-I. TL ratio was measured in triplicates using quantitative multiplex PCR. Results: Telomere length did not differ between individuals with AUD and HC (p=0.073) or was associated with AUD-related outcomes, trauma, or clinical comorbidities. Individuals with externalizing disorders had longer TL when comparing with those with internalizing disorders (p=0.018) or without comorbidity (p=0.018). Conclusion: Our findings indicate that TL was influenced by the presence of psychiatric comorbidity rather than case or control status. These results were adjusted for potential confounders, such as age.
Language	English
Publishing date	2024-04-13
Publishing country	United States
Document type	Journal Article
ZDB-ID	605912-0
ISSN	1873-6823 ; 0741-8329
ISSN (online)	1873-6823
ISSN	0741-8329
DOI	10.1016/j.alcohol.2024.04.004
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Article ; Online: "Pandemic fear" and COVID-19: mental health burden and strategies.

Ornell, Felipe / Schuch, Jaqueline B / Sordi, Anne O / Kessler, Felix Henrique Paim

Revista brasileira de psiquiatria (Sao Paulo, Brazil : 1999)

2020 Volume 42, Issue 3, Page(s) 232–235

MeSH term(s)	COVID-19 ; Coronavirus Infections/prevention & control ; Coronavirus Infections/psychology ; Fear/psychology ; Health Policy ; Humans ; Inpatients/psychology ; Mental Disorders/prevention & control ; Mental Disorders/psychology ; Pandemics/prevention & control ; Pneumonia, Viral/prevention & control ; Pneumonia, Viral/psychology ; Quarantine/psychology
Keywords	covid19
Language	English
Publishing date	2020-04-03
Publishing country	Brazil
Document type	Editorial
ISSN	1809-452X
ISSN (online)	1809-452X
DOI	10.1590/1516-4446-2020-0008
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Article ; Online: Problematic consumption of online pornography during the COVID-19 pandemic: clinical recommendations.

Marchi, Nino Cesar / Fara, Letícia / Gross, Luana / Ornell, Felipe / Diehl, Alessandra / Kessler, Felix Henrique Paim

Trends in psychiatry and psychotherapy

2021

Abstract: The coronavirus disease (COVID-19) pandemic is one of the greatest contemporary challenges. Feelings of fear and uncertainty triggered by this pandemic have had noxious effects on people's mental health. This seems to have increased during quarantine and ...

Abstract	The coronavirus disease (COVID-19) pandemic is one of the greatest contemporary challenges. Feelings of fear and uncertainty triggered by this pandemic have had noxious effects on people's mental health. This seems to have increased during quarantine and there is evidence of an intensification of rewarddirected behavior. Nevertheless, there are few studies dealing with pornography consumption during this period. The aim of this manuscript is to contextualize this phenomenon during the pandemic and suggest some clinical recommendations on the matter.
Language	English
Publishing date	2021-05-21
Publishing country	Brazil
Document type	Journal Article
ZDB-ID	2708374-3
ISSN	2238-0019 ; 2238-0019
ISSN (online)	2238-0019
ISSN	2238-0019
DOI	10.47626/2237-6089-2020-0090
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: The hidden stigma of aging and COVID-19: aggravating factors and strategies to mitigate the impact of the pandemic in older adults, a text mining analysis.

Borelli, Wyllians Vendramini / Xavier, Laura de Lima / Ornell, Felipe / Schuch, Jaqueline Bohrer / Von Diemen, Lisia

Aging & mental health

2021 Volume 26, Issue 5, Page(s) 881–889

Abstract: Objective: To identify factors associated with mental health of older adults during the pandemic and to provide strategies to mitigate their psychosocial impact in the elderly.: Method: An integrative text mining analysis in Medline was performed to ... ...

Abstract	Objective: To identify factors associated with mental health of older adults during the pandemic and to provide strategies to mitigate their psychosocial impact in the elderly. Method: An integrative text mining analysis in Medline was performed to identify studies on the mental health of older adults during the pandemic. Subsequently, statistical topic modeling was performed to identify the most prevalent terms and topics discussed in included studies. Results: A total of 29 studies were retrieved until July 1st 2020, including a majority of letters (12 studies) and commentaries (8 studies). The most frequent terms overall were: loneliness ( Conclusion: These factors demonstrate the importance of developing strategies for psychosocial support that take into consideration the particularities of the elderly. Different levels of care are immediately necessary to diminish the devastating impact of the pandemic in the mental health of older adults.
MeSH term(s)	Aged ; Aging ; COVID-19/epidemiology ; Data Mining ; Humans ; Pandemics ; Social Stigma
Language	English
Publishing date	2021-05-05
Publishing country	England
Document type	Journal Article
ZDB-ID	1474804-6
ISSN	1364-6915 ; 1360-7863
ISSN (online)	1364-6915
ISSN	1360-7863
DOI	10.1080/13607863.2021.1910793
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Article ; Online: Fatores associados à exposição ao HIV em usuários de álcool

Suelen Soares Fernandes / Daniela Benzano / Aline F. Paz / Felipe Ornell / Felix H. P. Kessler / Jaqueline B. Schuch / Lisia Von Diemen

Clinical and Biomedical Research, Vol 43, Iss

2023 Volume 1

Abstract: Introdução: A prevalência de HIV é maior em Porto Alegre comparada ao restante do país. O abuso de álcool afeta o juízo crítico, sendo associado a comportamentos de risco que podem levar à contaminação pelo HIV. Objetivo: Analisar fatores associados à ... ...

Abstract	Introdução: A prevalência de HIV é maior em Porto Alegre comparada ao restante do país. O abuso de álcool afeta o juízo crítico, sendo associado a comportamentos de risco que podem levar à contaminação pelo HIV. Objetivo: Analisar fatores associados à exposição ao HIV em alcoolistas com práticas sexuais de risco comparando com aqueles que se previnem. Métodos: Estudo transversal com 126 homens alcoolistas (HIV negativo), divididos em 2 grupos: Exposto Sexual (n=42) e Pouco Exposto Sexual (n=84), considerando uso de preservativo e número de parceiros sexuais. Resultados: A maioria dos sujeitos do grupo Exposto Sexual era solteiro, sem ocupação laboral, com histórico de moradia de rua e de relação com profissional do sexo, apresentavam maior preocupação com infecção por HIV (p<0,05). Conclusão: Sugere-se o desenvolvimento e monitoramento de intervenções preventivas específicas, considerando as características do abuso de álcool e seu papel na transmissão do HIV.
Keywords	HIV ; Infecção sexualmente transmissível ; Álcool ; Adição ; Transtorno por uso de álcool ; Medicine ; R
Language	English
Publishing date	2023-05-01T00:00:00Z
Publisher	Hospital de Clinicas de Porto Alegre
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Proposing an integrative, dynamic and transdiagnostic model for addictions: dysregulation phenomena of the three main modes of the predostatic mind.

Loreto, Bibiana Bolten Lucion / Sordi, Anne Orgler / de Castro, Melina Nogueira / Ornell, Felipe / Guarnieri, Eduardo Pegoraro / Roza, Thiago Henrique / Schuch, Jaqueline Bohrer / Cima, Marcos da Silveira / Pechansky, Flavio / Grevet, Eugênio Horácio / Grassi-Oliveira, Rodrigo / von Diemen, Lisia / Kessler, Felix Henrique Paim

Frontiers in psychiatry

2024 Volume 14, Page(s) 1298002

Abstract: Several theories have been proposed to explain the complex diagnostic aspects related to addiction disorders and their development. Recent frameworks tend to focus on dimensional perspectives of symptoms rather than categorical systems, since substance ... ...

Abstract	Several theories have been proposed to explain the complex diagnostic aspects related to addiction disorders and their development. Recent frameworks tend to focus on dimensional perspectives of symptoms rather than categorical systems, since substance use disorders are frequently comorbid with other psychiatric and especially personality disorders. However, useful transdiagnostic models that could integrate clinical evaluation derived from neuroscientific theories are lacking. In the present manuscript, the authors propose a model based on a new paradigm, in an attempt to better explain this complex, multifaceted phenomenon. The new paradigm presupposes that emotions and behavior are a response to risk prediction. Individuals make choices and engage in actions to manage potential risks/rewards in order to seek or maintain homeostasis in their internal and external environments - a mechanism that the authors call predostatic (predictive mechanism with homeostatic purpose). The model considers three main modes of the predostatic mind: (1) Alarm Mode, activated by high and/or imminent risk prediction; (2) Seek Mode, activated by long-term risk or reward prediction; and (3) Balance Mode, a self-regulating state of mind related to low risk prediction, a soothing system and a calm state. Addiction is seen as a chronic dysregulation of organism systems leading to internalizing or externalizing phenomena mainly related to the Seek and Alarm Modes, which are persistently activated by reward and risk prediction, respectively, thus hindering Balance. Addiction neuroscience research has shown that chronic drug use or engagement in addictive behaviors can lead to neuroadaptations in the brain reward circuitry, disrupting normal balance and the regulation of reward processes. This dysregulation can contribute to persistent drug-seeking/addictive behaviors despite negative consequences. This newly proposed dynamic and integrative model, named dysregulation based on externalizing and internalizing phenomena of the three main modes of the predostatic mind (DREXI3), proposes six dysregulation dimensions with basic emotional and behavioral symptoms, such as neurophysiological alterations, impulsivity, compulsion, cognitive impairment/psychosis, mood, and anxiety/anger. In this paper, the authors explain the rationale behind DREXI3 and present some hypothetical clinical examples to better illustrate the use of the model in clinical practice. The development of this innovative model could possibly guide tailored treatment interventions in the addiction field.
Language	English
Publishing date	2024-01-11
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2564218-2
ISSN	1664-0640
ISSN	1664-0640
DOI	10.3389/fpsyt.2023.1298002
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Childhood trauma subtypes may influence the pattern of substance use and preferential substance in men with alcohol and/or crack-cocaine addiction.

Hoffmann, Aline / Benzano, Daniela / Ornell, Felipe / Kessler, Felix H P / von Diemen, Lisia / Schuch, Jaqueline B

Revista brasileira de psiquiatria (Sao Paulo, Brazil : 1999)

2022

Abstract: Objective: To compare the prevalence and subtypes of childhood maltreatment (CM) between individuals with and without substance use disorder (SUD) and investigate the influence of different traumas on the preferential use of substances and the severity ... ...

Abstract	Objective: To compare the prevalence and subtypes of childhood maltreatment (CM) between individuals with and without substance use disorder (SUD) and investigate the influence of different traumas on the preferential use of substances and the severity of dependence. Methods: The sample consisted of 1,040 men with SUD (alcohol users [n=315], crack-cocaine users [n=406], multiple-substance users [n=319]) and 201 controls. The Childhood Trauma Questionnaire (CTQ) and the Addiction Severity Index-6 (ASI-6) were used to assess CM and drug-use patterns. Results: Individuals with SUD had a higher prevalence of CM than controls (63.4 vs. 28.1%, respectively). Exposure to physical trauma was associated with alcohol use disorder and severity of alcohol use. In contrast, emotional trauma was associated with use of multiple substances and severity of drug use in crack-cocaine users. Conclusions: This study corroborates the association of CM with SUD susceptibility. Our results suggest that the type of CM may influence preferential substance use and addiction severity. In this sense, physical traumas are more associated with alcohol use, while emotional and sexual traumas favor use of multiple drugs, especially crack cocaine. These findings may help the development of tailored prevention and intervention strategies.
Language	English
Publishing date	2022-06-23
Publishing country	Brazil
Document type	Journal Article
ZDB-ID	2024119-7
ISSN	1809-452X ; 1809-452X
ISSN (online)	1809-452X
ISSN	1809-452X
DOI	10.47626/1516-4446-2021-2352
Database	MEDical Literature Analysis and Retrieval System OnLINE

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