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  1. Article ; Online: The COVID-19 pandemic and palliative care units: A cross-sectional survey of the informational needs of caregivers.

    Kim, Ginah Lee / Berall, Anna / Gardner, Sandra / Brookes, Jahnel / Natadiria, Marsha / Perri, Giulia-Anna

    Palliative medicine

    2021  Volume 35, Issue 3, Page(s) 627–631

    MeSH term(s) COVID-19 ; Caregivers ; Cross-Sectional Studies ; Health Services Needs and Demand ; Humans ; Information Seeking Behavior ; Palliative Care ; Pandemics
    Language English
    Publishing date 2021-01-22
    Publishing country England
    Document type Letter
    ZDB-ID 639247-7
    ISSN 1477-030X ; 0269-2163
    ISSN (online) 1477-030X
    ISSN 0269-2163
    DOI 10.1177/0269216321989562
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2285: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: Modulation of the resorption and osteoconductivity of alpha-calcium sulfate by histone deacetylase inhibitors.

    Jung, Hong-Moon / Song, Gin-Ah / Lee, Yong-Keun / Baek, Jeong-Hwa / Ryoo, Hyun-Mo / Kim, Gwan-Shik / Choung, Phil-Hoon / Woo, Kyung Mi

    Biomaterials

    2010  Volume 31, Issue 1, Page(s) 29–37

    Abstract: Calcium sulfate (CS) is an osteoconductive material with a long history of clinical use. However, its resorptive properties are not optimal for bone regeneration. Recently, histone deacetylase inhibitors (HDIs) have been suggested as bone regeneration ... ...

    Abstract Calcium sulfate (CS) is an osteoconductive material with a long history of clinical use. However, its resorptive properties are not optimal for bone regeneration. Recently, histone deacetylase inhibitors (HDIs) have been suggested as bone regeneration tools. In this study, we investigated the effects of the HDIs sodium butyrate and trichostatin A on alpha-form CS (alphaCS) performance. MC3T3-E1 pre-osteoblasts cultured on alphaCS containing either HDI (alphaCS/HDI) showed higher levels of alkaline phosphatase activity than those cultured on alphaCS alone. The expression of genes characteristic of the osteoblast phenotype, including Runx2, osteocalcin, and bone sialoprotein, was strongly promoted by alphaCS/HDI. When cultured on alphaCS/HDIs, the osteoclastic differentiation of RAW264.7 monocytes was substantially suppressed, as measured by tartrate-resistant acid phosphatase (TRAP) activity and the expression levels of calcitonin receptor and TRAP. Neither HDI affected the CS setting time, compressive strength, or dissolution in a simulated body fluid. In a rat calvarial model of critical size bone defects, alphaCS/HDIs enhanced osteoblast differentiation, led to new bone formation, and delayed resorption, as confirmed by micro-computed tomography and histological analyses.
    MeSH term(s) 3T3 Cells ; Acid Phosphatase/metabolism ; Animals ; Base Sequence ; Bone and Bones/drug effects ; Bone and Bones/metabolism ; Calcium Sulfate/metabolism ; Cell Line ; DNA Primers ; Gene Expression ; Histone Deacetylase Inhibitors/pharmacology ; Isoenzymes/metabolism ; Mice ; Rats ; Tartrate-Resistant Acid Phosphatase
    Chemical Substances DNA Primers ; Histone Deacetylase Inhibitors ; Isoenzymes ; Acid Phosphatase (EC 3.1.3.2) ; Acp5 protein, mouse (EC 3.1.3.2) ; Tartrate-Resistant Acid Phosphatase (EC 3.1.3.2) ; Calcium Sulfate (WAT0DDB505)
    Language English
    Publishing date 2010-01
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 603079-8
    ISSN 1878-5905 ; 0142-9612
    ISSN (online) 1878-5905
    ISSN 0142-9612
    DOI 10.1016/j.biomaterials.2009.09.019
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.B 2371: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

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