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  1. Book: Intermediate filament proteins

    Omary, M. Bishr / Liem, Ronald K. H.

    (Methods in enzymology ; volume 568)

    2016  

    Author's details edited by M. Bishr Omary, Ronald K.H. Liem
    Series title Methods in enzymology ; volume 568
    Collection
    Keywords Filament ; Zellskelett
    Subject Cytoskelett ; Zytoskelett
    Language English
    Size xxv, 791 Seiten, Illustrationen, Diagramme
    Edition First edition
    Publisher Elsevier
    Publishing place Amsterdam
    Publishing country Netherlands
    Document type Book
    Note Literaturangaben
    HBZ-ID HT018883124
    ISBN 978-0-12-803470-5 ; 0-12-803470-X
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    Se 222 -568- verfügbar in Königswinter Königswinter

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  2. Article ; Online: Presentation of the AGA William Beaumont Prize in Gastroenterology to Anil K. Rustgi, MD.

    Wang, Timothy C / Omary, M Bishr

    Gastroenterology

    2023  Volume 165, Issue 1, Page(s) 293–296

    MeSH term(s) Humans ; Gastroenterology/history ; Awards and Prizes ; Gastrointestinal Tract
    Language English
    Publishing date 2023-05-24
    Publishing country United States
    Document type Editorial
    ZDB-ID 80112-4
    ISSN 1528-0012 ; 0016-5085
    ISSN (online) 1528-0012
    ISSN 0016-5085
    DOI 10.1053/j.gastro.2023.04.019
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: The AGA 2020 Year in Review.

    Omary, M Bishr

    Gastroenterology

    2021  Volume 160, Issue 4, Page(s) 982–984

    MeSH term(s) Congresses as Topic ; Gastroenterology/economics ; Gastroenterology/history ; Gastroenterology/organization & administration ; History, 21st Century ; Societies, Medical/economics ; Societies, Medical/history ; Societies, Medical/organization & administration ; United States
    Language English
    Publishing date 2021-01-13
    Publishing country United States
    Document type Historical Article ; Journal Article
    ZDB-ID 80112-4
    ISSN 1528-0012 ; 0016-5085
    ISSN (online) 1528-0012
    ISSN 0016-5085
    DOI 10.1053/j.gastro.2021.01.022
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Book: Intermediate filament cytoskeleton

    Omary, M. Bishr

    (Methods in cell biology ; 78)

    2004  

    Author's details ed. by M. Bishr Omary
    Series title Methods in cell biology ; 78
    Collection
    Keywords Intermediärfilament ; Proteine ; Genregulation ; Säugetiere ; Labortechnik
    Subject Laboratorium ; Laboratoriumstechnik ; Labormethode ; Eiweiss ; Protein ; Mammalia ; Säuger ; Säugetier ; Genetische Regulation ; Transkription ; Genaktivität
    Language English
    Size XXIX, 886 S., [19] Bl. : Ill., graph. Darst.
    Publisher Elsevier, Acad. Press
    Publishing place Amsterdam u.a.
    Publishing country Netherlands
    Document type Book
    HBZ-ID HT014109994
    ISBN 0-12-564173-7 ; 978-0-12-564173-9
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    Se 375 -78- verfügbar in Königswinter Königswinter

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  5. Article ; Online: Gastroenterology climate action opportunities via education, empowerment of trainees and research.

    Shaukat, Aasma / Shah, Brijen / Fritz, Cassandra Dl / Omary, M Bishr

    Gut

    2023  Volume 72, Issue 12, Page(s) 2219–2221

    MeSH term(s) Humans ; Gastroenterology/education ; Educational Status ; Gastrointestinal Tract ; Education, Medical, Graduate
    Language English
    Publishing date 2023-11-24
    Publishing country England
    Document type Journal Article
    ZDB-ID 80128-8
    ISSN 1468-3288 ; 0017-5749
    ISSN (online) 1468-3288
    ISSN 0017-5749
    DOI 10.1136/gutjnl-2023-331093
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Climate change: a survey of global gastroenterology society leadership.

    Leddin, Desmond / Omary, M Bishr / Metz, Geoffrey / Veitch, Andrew M

    Gut

    2022  

    Language English
    Publishing date 2022-06-10
    Publishing country England
    Document type Journal Article
    ZDB-ID 80128-8
    ISSN 1468-3288 ; 0017-5749
    ISSN (online) 1468-3288
    ISSN 0017-5749
    DOI 10.1136/gutjnl-2022-327832
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Climate Change, Health, and Health Care Systems: A Global Perspective.

    Setoguchi, Soko / Leddin, Desmond / Metz, Geoffrey / Omary, M Bishr

    Gastroenterology

    2022  Volume 162, Issue 6, Page(s) 1549–1555

    MeSH term(s) Climate Change ; Delivery of Health Care ; Global Health ; Humans
    Language English
    Publishing date 2022-03-02
    Publishing country United States
    Document type Journal Article
    ZDB-ID 80112-4
    ISSN 1528-0012 ; 0016-5085
    ISSN (online) 1528-0012
    ISSN 0016-5085
    DOI 10.1053/j.gastro.2022.02.037
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Opinion: Here's how we restore productivity and vigor to the biomedical research workforce in the midst of COVID-19.

    Omary, M Bishr / Hassan, Mahmud

    Proceedings of the National Academy of Sciences of the United States of America

    2020  Volume 117, Issue 33, Page(s) 19612–19614

    MeSH term(s) Biomedical Research/economics ; Biomedical Research/standards ; COVID-19 ; Coronavirus Infections/economics ; Coronavirus Infections/prevention & control ; Efficiency ; Financing, Government ; Humans ; Pandemics/economics ; Pandemics/prevention & control ; Pneumonia, Viral/economics ; Pneumonia, Viral/prevention & control ; Quarantine/economics
    Keywords covid19
    Language English
    Publishing date 2020-07-29
    Publishing country United States
    Document type Journal Article
    ZDB-ID 209104-5
    ISSN 1091-6490 ; 0027-8424
    ISSN (online) 1091-6490
    ISSN 0027-8424
    DOI 10.1073/pnas.2014730117
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Reply.

    Williams, John A / Kao, John Y / Omary, M Bishr

    Gastroenterology

    2020  Volume 159, Issue 2, Page(s) 799

    MeSH term(s) Climate Change ; Humans
    Language English
    Publishing date 2020-06-14
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 80112-4
    ISSN 1528-0012 ; 0016-5085
    ISSN (online) 1528-0012
    ISSN 0016-5085
    DOI 10.1053/j.gastro.2020.06.020
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Hypoosmosis alters hepatocyte mitochondrial morphology and induces selective release of carbamoyl phosphate synthetase 1.

    Li, Pei / Kuo, Ning / Patel, Rajesh / Omary, M Bishr

    American journal of physiology. Gastrointestinal and liver physiology

    2023  Volume 325, Issue 4, Page(s) G334–G346

    Abstract: Carbamoyl phosphate synthetase 1 (CPS1) is the most abundant hepatocyte mitochondrial matrix protein. Hypoosmotic stress increases CPS1 release in isolated mouse hepatocytes without cell death. We hypothesized that increased CPS1 release during ... ...

    Abstract Carbamoyl phosphate synthetase 1 (CPS1) is the most abundant hepatocyte mitochondrial matrix protein. Hypoosmotic stress increases CPS1 release in isolated mouse hepatocytes without cell death. We hypothesized that increased CPS1 release during hypoosmosis is selective and associates with altered mitochondrial morphology. Both ex vivo and in vivo models were assessed. Mouse hepatocytes and livers were challenged with isotonic or hypoosmotic (35 mosM) buffer. Mice were injected intraperitoneally with water (10% body weight) with or without an antidiuretic. Mitochondrial and cytosolic fractions were isolated using differential centrifugation, then analyzed by immunoblotting to assess subcellular redistribution of four mitochondrial proteins: CPS1, ornithine transcarbamylase (OTC), pyrroline-5-carboxylate reductase 1 (PYCR1), and cytochrome c. Mitochondrial morphology alterations were examined using electron microscopy. Hypoosmotic treatment of whole livers or hepatocytes led to preferential or increased mitochondrial release, respectively, of CPS1 as compared with two mitochondrial matrix proteins (OTC/PYCR1) and with the intermembrane space protein, cytochrome c. Mitochondrial apoptosis-induced channel opening using staurosporine in hepatocytes led to preferential CPS1 and cytochrome c release. The CPS1-selective changes were accompanied by dramatic alterations in ultrastructural mitochondrial morphology. In mice, hypoosmosis/hyponatremia led to increased liver vascular congestion and increased CPS1 in bile but not blood, coupled with mitochondrial structural alterations. In contrast, isotonic increase of intravascular volume led to a decrease in mitochondrial size with limited change in bile CPS1 compared with hypoosmotic conditions and absence of the hypoosmosis-associated histological alterations. Taken together, hepatocyte CPS1 is selectively released in response to hypoosmosis/hyponatremia and provides a unique biomarker of mitochondrial injury.
    MeSH term(s) Animals ; Mice ; Carbamyl Phosphate/metabolism ; Ornithine Carbamoyltransferase/metabolism ; Cytochromes c/metabolism ; Hyponatremia/metabolism ; Hyponatremia/pathology ; Hepatocytes/metabolism ; Carbamoyl-Phosphate Synthase (Ammonia)/metabolism ; Liver Diseases/metabolism ; Mitochondria/metabolism ; Urea/metabolism
    Chemical Substances Carbamyl Phosphate (590-55-6) ; Ornithine Carbamoyltransferase (EC 2.1.3.3) ; Cytochromes c (9007-43-6) ; Carbamoyl-Phosphate Synthase (Ammonia) (EC 6.3.4.16) ; Urea (8W8T17847W)
    Language English
    Publishing date 2023-07-25
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 603840-2
    ISSN 1522-1547 ; 0193-1857
    ISSN (online) 1522-1547
    ISSN 0193-1857
    DOI 10.1152/ajpgi.00018.2023
    Database MEDical Literature Analysis and Retrieval System OnLINE

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